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Proenkephalin Mediates the Enduring Effects of Adolescent Cannabis Exposure Associated with Adult Opiate Vulnerability

INTRODUCTION Drug addiction is a chronic and relapsing disease that often begins during adolescence. Epidemiological evidence documents an association between marijuana use during adolescence and subsequent abuse of drugs such as heroin and cocaine (1, 2). While many factors including societal pressures, family, culture, and drug availability can contribute to this apparent `gateway’ association, little […]

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Cannabis Boosts Risk Of Stroke And Heart Attack, Independent Of Tobacco, New Study Finds

Cannabis has recently been legalised in many US states Cannabis itself is harmful to cardiovascular health and increases the chance of early death regardless of related factors such as smoking tobacco, new research reveals. Data taken from more than 1,000 US hospitals found that people who used the drug had a 26 per cent higher […]

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Patterns Of Cannabis Use During Adolescence And Their Association With Harmful Substance Use Behaviour

Findings From A UK Birth Cohort ABSTRACT Background Evidence on the role of cannabis as a gateway drug is inconsistent. We characterise patterns of cannabis use among UK teenagers aged 13–18 years, and assess their influence on problematic substance use at age 21 years. Methods We used longitudinal latent class analysis to derive trajectories of […]

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Drug Abuse-Associated Mortality Across The Lifespan: A Population-Based Longitudinal Cohort And Co-Relative Analysis.

ABSTRACT PURPOSE: Nationwide data have been lacking on drug abuse (DA)-associated mortality. We do not know the degree to which this excess mortality results from the characteristics of drug-abusing individuals or from the effects of DA itself. METHOD: DA was assessed from medical, criminal, and prescribed drug registries. Relative pairs discordant for DA were obtained […]

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Ketamine: From Anaesthesia to Popular Club Drug to Fast-Acting Antidepressant

Ketamine Continues to Impress and Confound Researchers A novel glutamatergic hypothesis of depression, using a 50-year-old anaesthesia medicine, has had a remarkable run as of late. First an anaesthetic, then a popular club drug in the 90s known as “Special K” (and currently still popular in Hong Kong as a “Rave Drug”), and now a […]

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Marijuana Legalization Has Led To More Use And Addiction While Illegal Market Continues To Thrive

It comes as no surprise that the prevalence of marijuana use has significantly increased over the last decade. With marijuana legal for recreational use in four states and the District of Columbia and for medical use in an additional 31 states, the public perception about marijuana has shifted, with more people reporting that they support […]

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Variance in Cannabis Use and Gender Affect Size of Important Brain Regions

Cannabis Use, Gender and the Brain Cannabis is the most widely used illicit drug in the U.S. and, as a result of legalization efforts for both medical remedy and for recreational use, is now the second leading reason (behind alcohol) for admission to addiction treatment in the U.S. The health consequences, cognitive changes, academic performance […]

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The Conundrum of Chronic Pain, Opioid Use in America and the Consequences

Author: Mark Gold, MD Mortality resulting from opioid use (over 33,000 in 2015) is now epidemic in the U.S., exceeding drug-related deaths from all other intoxicants. Dr. Ted Cicero of Washington University, Dr. William Jacobs, Medical Director of Bluff Plantation, and I discussed the opioid over-prescribing and switch to heroin at DEA Headquarters on November […]

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Statement by President of Smart Approaches to Marijuana on Senators Booker and Gillibrand’s Marijuana Legislation to Bypass FDA

Today, Dr. Kevin Sabet, president of Smart Approaches to Marijuana (SAM), a national group promoting evidence-based marijuana laws, issued the following statement regarding medical marijuana legislation introduced by Senators Booker (D-NJ) and Gillibrand (D-NY) and Rep. Steve Cohen (D-TN): “No one wants to deprive chronically ill patients of medication that could be helpful for them, […]

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Marijuana use during pregnancy associated with many risks, studies reveal

SPOKANE, Wash. – The release of more data on the effects of marijuana on a baby has led researchers to the conclusion that moms should think twice before using pot during and after pregnancy. Many moms turn to marijuana for relief of symptoms such as nausea and anxiety, yet scientific research is emerging that identifies […]

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Legal Marijuana Sales Creating Escalating Damage To The Environment

Marijuana sales have created an economic boom in U.S. states that have fully or partially relaxed their cannabis laws, but is the increased cultivation and sale of this crop also creating escalating environmental damage and a threat to public health? In an opinion piece published by the journal Environmental Science and Technology, researchers from the […]

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Do Medical Marijuana Laws Promote Illicit Cannabis Use And Disorder?

Illicit cannabis use and cannabis use disorders increased at a greater rate in states that passed medical marijuana laws than in other states, according to new research at Columbia University’s Mailman School of Public Health and Columbia University Medical Center. The findings will be published online in JAMA Psychiatry. Laws and attitudes regarding cannabis have […]

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Teen Cannabis Use And Illicit Drug Use In Early Adulthood Linked

One in 5 adolescents at risk of tobacco dependency, harmful alcohol consumption and illicit drug use Researchers from the University of Bristol have found regular and occasional cannabis use as a teen is associated with a greater risk of other illicit drug taking in early adulthood.   The study by Bristol’s Population Health Science Institute, published […]

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THC And CBD In Blood Samples And Seizures In Norway: Does CBD Affect THC-Induced Impairment In Apprehended Subjects?

Highlights · •Cannabidiol appears often in Norwegian THC-positive blood samples. · •Cannabidiol does not appear to protect against THC-induced impairment. · •Cannabidiol may be detected in blood for more than 2 h after cannabis intake. · •Hashish has revealed far lower THC/cannabidiol ratios than marijuana in Norway. Abstract Background and aims Several publications have suggested […]

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Prenatal exposure to smoke, alcohol may increase behaviour problems in kids

Prenatal exposure to smoke and alcohol may increase the risk of children developing conduct problems in adolescence, researchers said. Conduct disorder (CD) is a mental disorder where children demonstrate aggressive behaviour that causes or threatens harm to other people or animals such as bullying or intimidating others, often initiating physical fights, or being physically cruel […]

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The ‘United Kingdom Drug Situation: Focal Point Annual Report 2016’

Patterns of illicit drug use in each UK country analysed in annual report An overview of illicit drug use across the whole of the UK in 2016 has been published by the Home Office. The ‘United Kingdom Drug Situation: Focal Point Annual Report 2016’ has collated data across all four home nations and includes specific […]

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Stirring the Pot: Potential Drug Interactions With Marijuana

Warfarin. A single published case report describes an interaction with a patient taking warfarin who also regularly smoked tobacco and marijuana. The patient had multiple comorbidities and was taking at least 10 other medications. On at least two occasions, the patient’s international normalized ratio (INR) increased to values over 10 with episodes of bleeding. The […]

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Overdose Deaths From Fentanyl are on the Rise: What You Should Know

The Centers for Disease Control and Prevention (CDC) stated that 33,091 people died from opioid overdoses in 2015, which accounts for 63 percent of all drug overdose deaths in the same year. A recent report from the CDC found that drug deaths from fentanyl and other synthetic opioids, other than methadone, rose 72 percent in […]

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Drug Overdose Is Now The Leading Cause Of Death For Americans Under The Age Of 50

Deputy Attorney General Rod Rosenstein said on Tuesday morning. Rosenstein, along with acting head of the Drug Enforcement Agency, Chuck Rosenberg, and other prominent officials in law enforcement addressed the media at the DEA’s headquarters in Arlington, VA to discuss the ongoing response to the nation’s staggering opioid epidemic. “We’re not talking about a slight […]

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Proof Cannabis DOES Lead Teenagers To Harder Drugs

Study Finds Users Are 26 Times More Likely To Turn To Other Substances By The Age Of 21 Study is first clear evidence that cannabis is gateway to cocaine and heroin Teen marijuana smokers are 37 times more likely to be hooked on nicotine Findings from Bristol University provide authoritative support for those warning against […]

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Letter fromTim Farron to Mary Brett 5/6/17

– Mary’s Comments in bold I fully understand your doubts because this subject has been hotly debated within the Party in recent conferences.  I hope that I can persuade you of the validity of the arguments that have swayed the majority of our membership. Research disproves these arguments, as follows. The approach to cannabis has […]

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Grey Death compound in Jacksonville & Florida

DATE: June 1, 2017 DISTRIBUTION: All First Responders ANALYST: Ralph Little/904-256-5940 SUBJECT: Grey Death compound in Jacksonville & Florida NARRATIVE:  The compound opioid known as Grey Death has been detected for the first time in North Florida. Although Purchased in March in St. Augustine, the basic drugs were from Jacksonville and may have been purchased […]

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Marijuana use dampens brain’s response to reward over time, U-M study finds

Changes may increase risk of continued drug use and addiction ANN ARBOR, Mich. — Most people would get a little ‘rush’ out of the idea that they’re about to win some money. In fact, if you could look into their brain at that very moment, you’d see lots of activity in the part of the […]

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Teen Marijuana-Related Visits to Colorado ER Rose Rapidly After Legalization

A Colorado children’s hospital reports visits by teens to its emergency department and satellite urgent care centers more than quadrupled after the state legalized marijuana, a new study finds. Researchers examined the hospital’s records for 13- to 21-year-olds between 2005 and 2015. Colorado legalized medical marijuana in 2010 and recreational marijuana in 2014. The annual […]

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High-Potency Marijuana May Damage Nerve Fibers in Brain, Study Suggests

A new study suggests smoking high-potency marijuana may cause damage to nerve fibers responsible for communication between the brain’s two hemispheres. The study included MRI scans of 99 people, including some who were diagnosed with psychosis, HealthDay reports.  The researchers found an association between frequent use of high-potency marijuana and damage to the corpus callosum, […]

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Open Letter to : Arkansas Attorney General Leslie Rutledge and Secretary of State Mark Martin

Sirs, I believe that a state’s Attorney General and Secretary of State have the obligation to reject any petition that is obviously in violation of any law. Whether a ballot initiative is properly worded or not, if it proposes, facilitates or allows the violation of any law – it is illegal. EXCERPT:  “In an opinion […]

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26 Overdoses in Just Hours: Inside a Community on the Front Lines of the Opioid Epidemic

HUNTINGTON, W.Va. — Officer Sean Brinegar arrived at the house first — “People are coming here and dying,” the 911 caller had said — and found a man and a woman panicking. Two people were dead inside, they told him. Brinegar, 25, has been on the force in this Appalachian city for less than three […]

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Drinking in pregnancy: Where Next For Preventing Foetal Alcohol Spectrum Disorders in the UK?

In this guest blog, Kate Fleming, Senior Lecturer, Public Health Institute, Liverpool John Moores University, and Raja Mukherjee, Consultant Psychiatrist, Lead Clinician UK National FASD clinic, Surrey and Borders Partnership NHS Foundation Trust consider the context and future for Foetal Alcohol Spectrum Disorders in the UK. A recent opinion piece in The Guardian entitled Nothing […]

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‘Narco-deforestation’: Cocaine Trade Destroying Swathes of Central America

Drug trade’s efforts to launder profits by creating agricultural land results in loss of millions of acres, researchers say. A hillside in Jocotán, eastern Guatemala, damaged by deforestation. Photograph: Marvin Recinos/AFP/Getty Images Cocaine traffickers attempting to launder their profits are responsible for the disappearance of millions of acres of tropical forest across large swaths of […]

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Study: Marijuana Use Tied to Poor School Performance

Researchers at Canada’s Waterloo University studied what happens to academic goals, engagement, preparedness, and performance when high school students shift from no marijuana use to marijuana use. Their sample included 26,475 students in grades 9-12 in the COMPASS study, Canada’s largest survey of youth substance use. The researchers found that compared to students who do […]

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‘’False hope’’ Driving Claims Medicinal Cannabis is ‘’Magic Pill’’ for Chronic Pain Relief

Prescribing medicinal cannabis for patients with chronic non-cancer pain is not going to revolutionise their treatment and should not be supported until there is substantial proof of its effectiveness, according to a leading pain specialist. Professor Milton Cohen is presenting Medicinal cannabis for chronic non-cancer pain: promise or pothole? at the Australian and New Zealand […]

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"When representing a cause (almost) lost, sound your trumpet, mount your steed and go for the very last charge, failing which you will die of sad old age in the depths of the forgotten fortress, no longer besieged because life has abandoned it for greener pastures."

Jean Raspail
From the website of jeanraspail.net

"Universal prevention initiatives are important elements of a comprehensive prevention strategy that should include selective and indicated prevention initiatives as well. In order to prevent the development of dependence you need all three - and you cannot do without universal prevention. Norms, attitudes, availability are important risk factors for developing drug use problems as well as neighbourhood disorganization and weak family bonds."

Christina Gynna, Deputy National Drugs Policy Co-ordinator, Sweden,
at the ICAA conference in Budapest, 24 October 2005

 
 

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