Cannabinoid AMB-FUBINACA in New York<\/p>\n
ABSTRACT<\/p>\n
BACKGROUND<\/p>\n
New psychoactive substances constitute a growing and dynamic class of abused drugs in the United States. On July 12, 2016, a synthetic cannabinoid caused mass intoxication of 33 persons in one New York City neighborhood, in an event described in the popular press as a \u201czombie\u201d outbreak because of the appearance of the intoxicated persons.<\/p>\n
METHODS<\/p>\n
We obtained and tested serum, whole blood, and urine samples from 8 patients among the 18 who were transported to local hospitals; we also tested a sample of the herbal \u201cincense\u201d product \u201cAK-47 24 Karat Gold,\u201d which was implicated in the outbreak. Samples were analyzed by means of liquid chromatography\u2013quadrupole time-of-flight mass spectrometry.<\/p>\n
RESULTS<\/p>\n
The synthetic cannabinoid methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3-methylbutanoate (AMB-FUBINACA, also known as MMB-FUBINACA or FUB-AMB) was identified in AK-47 24 Karat Gold at a mean (\u00b1SD) concentration of 16.0\u00b13.9 mg per gram. The de-esterified acid metabolite was found in the serum or whole blood of all eight patients, with concentrations ranging from 77 to 636 ng per milliliter.<\/p>\n
CONCLUSIONS<\/p>\n
The potency of the synthetic cannabinoid identified in these analyses is consistent with strong depressant effects that account for the \u201czombielike\u201d behavior reported in this mass intoxication. AMB-FUBINACA is an example of the emerging class of \u201cultrapotent\u201d synthetic cannabinoids and poses a public health concern. Collaboration among clinical laboratory staff, health professionals, and law enforcement agencies facilitated the timely identification of the compound and allowed health authorities to take appropriate action.<\/p>\n
Source: New England Journal of Medicine;\u00a0 10.1056\/NEJMoa1610300<\/em><\/p>\n","protected":false},"excerpt":{"rendered":" Cannabinoid AMB-FUBINACA in New York ABSTRACT BACKGROUND New psychoactive substances constitute a growing and dynamic class of abused drugs in the United States. On July 12, 2016, a synthetic cannabinoid caused mass intoxication of 33 persons in one New York City neighborhood, in an event described in the popular press as a \u201czombie\u201d outbreak because […]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[63,68,92,19],"tags":[],"class_list":["post-13024","post","type-post","status-publish","format-standard","hentry","category-brain-and-behaviour","category-drug-use-various-effects","category-synthetics","category-usa"],"_links":{"self":[{"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/posts\/13024","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/comments?post=13024"}],"version-history":[{"count":0,"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/posts\/13024\/revisions"}],"wp:attachment":[{"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/media?parent=13024"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/categories?post=13024"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/tags?post=13024"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}