{"id":14777,"date":"2018-08-02T18:08:48","date_gmt":"2018-08-02T18:08:48","guid":{"rendered":"https:\/\/drugprevent.org.uk\/ppp\/?p=14777"},"modified":"2018-11-01T19:14:13","modified_gmt":"2018-11-01T19:14:13","slug":"endocannabinoid-mediates-excitatory-synaptic-function-of-%ce%b2-neurexins-commentary-%ce%b2-neurexins-control-neural-circuits-by-regulating-synaptic-endocannabinoid-signaling","status":"publish","type":"post","link":"https:\/\/drugprevent.org.uk\/ppp\/2018\/08\/endocannabinoid-mediates-excitatory-synaptic-function-of-%ce%b2-neurexins-commentary-%ce%b2-neurexins-control-neural-circuits-by-regulating-synaptic-endocannabinoid-signaling\/","title":{"rendered":"Endocannabinoid Mediates Excitatory Synaptic Function of \u03b2-Neurexins. Commentary: \u03b2-Neurexins Control Neural Circuits By Regulating Synaptic Endocannabinoid Signaling"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"color: #0000ff; font-family: verdana, geneva, sans-serif; font-size: 10pt;\">Introduction<\/span><br \/>\n<span style=\"color: #0000ff; font-family: verdana, geneva, sans-serif; font-size: 10pt;\">Synaptic cell-adhesion molecules and their interactions with other molecular pathways affect both synapse formation and its function (Varoqueaux et al., 2006;\u00a0Sudhof, 2008;\u00a0Bemben et al., 2015a). Neurexins are presynaptic cell-adhesion molecules that interact with neuroligins and other postsynaptic partners. Neurexins are encoded by three genes, each of which encodes a long and short isoform, termed \u03b1- and \u03b2-neurexins, respectively (Sudhof, 2008). Interestingly, despite studies linking neurexins to autism and other neuropsychiatric disorders (Leone et al., 2010;\u00a0Rabaneda et al., 2014), the precise cellular mechanisms underlying the role of neurexins in cognition remain poorly understood.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #0000ff; font-family: verdana, geneva, sans-serif; font-size: 10pt;\">Since most biochemical studies of neurexins have focused on \u03b2-neurexins, investigating the synaptic actions of \u03b2-neurexins is particularly imperative. In their timely\u00a0Cell\u00a0article, Anderson et al. reported that \u03b2-neurexins selectively modulate synaptic strength at excitatory synapses by regulating postsynaptic endocannabinoid synthesis, describing an unexpected trans-synaptic mechanism for \u03b2-neurexins to control neural circuits via endocannabinoid signaling.\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #0000ff; font-family: verdana, geneva, sans-serif; font-size: 10pt;\">Source:\u00a0<a style=\"color: #0000ff;\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2016.00203\/full\" target=\"_blank\" rel=\"noopener\">https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2016.00203\/full<\/a><\/span><\/p>\n<p><span style=\"color: #0000ff; font-family: verdana, geneva, sans-serif; font-size: 10pt;\">See also:<\/span><\/p>\n<p><span style=\"font-family: verdana, geneva, sans-serif; font-size: 10pt;\"><a href=\"https:\/\/drugprevent.org.uk\/ppp\/2018\/08\/%CE%B2-neurexins-control-neural-circuits-by-regulating-synaptic-endocannabinoid-signaling\/\">https:\/\/drugprevent.org.uk\/ppp\/2018\/08\/%CE%B2-neurexins-control-neural-circuits-by-regulating-synaptic-endocannabinoid-signaling\/<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Introduction Synaptic cell-adhesion molecules and their interactions with other molecular pathways affect both synapse formation and its function (Varoqueaux et al., 2006;\u00a0Sudhof, 2008;\u00a0Bemben et al., 2015a). Neurexins are presynaptic cell-adhesion molecules that interact with neuroligins and other postsynaptic partners. Neurexins are encoded by three genes, each of which encodes a long and short isoform, termed [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30,64,106],"tags":[],"class_list":["post-14777","post","type-post","status-publish","format-standard","hentry","category-cannabis-marijuana","category-health","category-medical-studies-papers"],"_links":{"self":[{"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/posts\/14777","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/comments?post=14777"}],"version-history":[{"count":0,"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/posts\/14777\/revisions"}],"wp:attachment":[{"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/media?parent=14777"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/categories?post=14777"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/tags?post=14777"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}