{"id":2104,"date":"2009-07-17T14:36:11","date_gmt":"2009-07-17T13:36:11","guid":{"rendered":"https:\/\/drugprevent.org.uk\/ppp\/?p=2104"},"modified":"2009-07-17T14:36:11","modified_gmt":"2009-07-17T13:36:11","slug":"study-finds-marijuana-ingredient-promotes-tumour-growth-impairs-anti-tumour-defences","status":"publish","type":"post","link":"https:\/\/drugprevent.org.uk\/ppp\/2009\/07\/study-finds-marijuana-ingredient-promotes-tumour-growth-impairs-anti-tumour-defences\/","title":{"rendered":"Study Finds Marijuana Ingredient Promotes Tumour Growth, Impairs Anti-Tumour Defences"},"content":{"rendered":"

Researchers report in the July 2000 issue of the \u201cJournal of Immunology\u201d that tetrahydrocannabinol (THC), the major psychoactive component of marijuana, can promote tumor growth by impairing the body\u2019s anti-tumor immunity system.\u00a0 While previous research has shown that THC can lower resistance to both bacterial and viral infections, this is the first time that its possible tumor-promoting activity has been reported.<\/span><\/span>
\nA team of researchers at UCLA\u2019s Jonsson Comprehensive Cancer Center found in experiments in mice that THC limits immune response by increasing the availability of two forms (IL-b and TGF-13) of cytokine, a potent, tumor-specific, immunity suppresser.<\/span><\/span>
\nThe authors also suggest that smoking marijuana may be more of a cancer risk than smoking tobacco.\u00a0 The tar portion of marijuana smoke, compared to that of tobacco, contains higher concentrations of carcinogenic hydrocarbons, including benzapyrene, a key factor in promoting human lung cancer.\u00a0 And marijuana smoke deposits four times as much tar in the respiratory tract as does a comparable amount of tobacco, thus increasing exposure to carcinogens.<\/span><\/span>
\nDr. Steven M. Dubinett, head of the research team that conducted the study, says, \u201cWhat we already know about marijuana smoke, coupled with our new finding that THC may encourage tumor growth, suggests that regular use of marijuana may increase the risk of respiratory tract cancer and further studies will be needed to evaluate this possibility.\u201d<\/span><\/span>
\nThe UCLA researchers examined the effects of THC on the immune response to lung cancer in mice.\u00a0 Over a two-week period, the animals were injected four times per week with either THC or a saline solution.\u00a0 Fourteen days after the injections were started, murine Lewis lung cancer and line 1 alveolar cell cancer cells were implanted in the mice.\u00a0 The mice continued to receive THC or saline injections after the tumor cells were implanted, and tumor growth was assessed three times each week.\u00a0 To test the hypothesis that THC impairs tumor-specific immune system response, a group of mice with compromised immune systems was also studied.<\/span><\/span>
\nThe researchers found that in the mice with normal immune systems there was significant enhancement of tumor growth, but THC had no effect on tumor growth in the immunodeficient mice.\u00a0 The study also showed that when lymphocytes from the THC-treated mice were injected into untreated mice, the immune deficit was transferred and tumor growth was accelerated in the normal controls.<\/span><\/span>
\nAdditionally, the UCLA research team demonstrated that when anti-IL-10 and anti-TGF-B were administered, there was no acceleration of tumor growth in THC-treated mice.\u00a0 These results suggest that enhanced tumor growth is prompted by THC\u2019s ability to stimulate production of IL-10 and TGF-B, which inhibits anti-tumor immune response.<\/span><\/span><\/p>\n

Roun et al. Biological Psychology Laboratory at Maclean Hospital Limited in haemorrhage Notes Vol. 15, No. 1<\/span><\/span><\/em><\/div>\n","protected":false},"excerpt":{"rendered":"

Researchers report in the July 2000 issue of the \u201cJournal of Immunology\u201d that tetrahydrocannabinol (THC), the major psychoactive component of marijuana, can promote tumor growth by impairing the body\u2019s anti-tumor immunity system.\u00a0 While previous research has shown that THC can lower resistance to both bacterial and viral infections, this is the first time that its […]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30,64],"tags":[],"class_list":["post-2104","post","type-post","status-publish","format-standard","hentry","category-cannabis-marijuana","category-health"],"_links":{"self":[{"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/posts\/2104","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/comments?post=2104"}],"version-history":[{"count":0,"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/posts\/2104\/revisions"}],"wp:attachment":[{"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/media?parent=2104"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/categories?post=2104"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/tags?post=2104"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}