{"id":6535,"date":"2010-05-01T11:23:34","date_gmt":"2010-05-01T11:23:34","guid":{"rendered":"https:\/\/drugprevent.org.uk\/ppp\/?p=6535"},"modified":"2010-05-15T13:41:47","modified_gmt":"2010-05-15T13:41:47","slug":"prenatal-cannabis-exposure-increases-heroin-seeking-with-allostatic-changes-in-limbic-enkephalin-systems-in-adulthood","status":"publish","type":"post","link":"https:\/\/drugprevent.org.uk\/ppp\/2010\/05\/prenatal-cannabis-exposure-increases-heroin-seeking-with-allostatic-changes-in-limbic-enkephalin-systems-in-adulthood\/","title":{"rendered":"Prenatal cannabis exposure increases heroin seeking with allostatic changes in limbic enkephalin systems in adulthood."},"content":{"rendered":"<p><span style=\"font-size: 10pt; font-family: Verdana;\"> Abstract: Spano MS, Ellgren M, Wang X, Hurd YL.<\/p>\n<p>Karolinska Institute, Department of Clinical Neuroscience, Psychiatry Section, S-17176 Stockholm, Sweden.<\/p>\n<p>BACKGROUND: Prenatal cannabis exposure is a growing concern with little known about the long-term consequences on behavior and neural systems relevant for reward and emotional processing.<br \/>\nMETHODS: We used an animal model to study the effects of prenatal exposure to Delta(9)-tetrahydrocannabinol (THC) on heroin self-administration behavior and opioid neural systems in adult males (postnatal day 62). Rats were exposed to THC (.15 mg\/kg) or vehicle from gestational day 5 to postnatal day 2. RESULTS: Both pretreatment groups showed similar heroin intake, but THC-exposed rats exhibited shorter latency to the first active lever press, responded more for low heroin doses, and had higher heroin-seeking during mild stress and drug extinction. THC exposure reduced preproenkephalin (PENK) mRNA expression in the nucleus accumbens during early development, but was elevated in adulthood; no adult striatal changes on preprodynorphin mRNA or PENK in caudate-putamen. PENK mRNA was also increased in the central and medial amygdala in adult THC-exposed animals. THC animals had reduced heroin-induced locomotor activity and nucleus accumbens mu opioid receptor coupling.<br \/>\nCONCLUSIONS: This study demonstrates enduring effects of prenatal THC exposure into adulthood that is evident on heroin-seeking behavior during extinction and allostatic changes in mesocorticolimbic PENK systems relevant to drug motivation\/reward and stress response.<\/p>\n<p><em>Source: : Biol Psychiatry. 2007 Feb 15;61(4):554-63. Epub 2006 Jul 28.<br \/>\n<\/em><br \/>\n<span style=\"font-size: 10pt; font-family: Verdana;\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract: Spano MS, Ellgren M, Wang X, Hurd YL. Karolinska Institute, Department of Clinical Neuroscience, Psychiatry Section, S-17176 Stockholm, Sweden. BACKGROUND: Prenatal cannabis exposure is a growing concern with little known about the long-term consequences on behavior and neural systems relevant for reward and emotional processing. METHODS: We used an animal model to study the [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30,41,64],"tags":[],"class_list":["post-6535","post","type-post","status-publish","format-standard","hentry","category-cannabis-marijuana","category-drug-use-effects-on-foetus","category-health"],"_links":{"self":[{"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/posts\/6535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/comments?post=6535"}],"version-history":[{"count":0,"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/posts\/6535\/revisions"}],"wp:attachment":[{"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/media?parent=6535"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/categories?post=6535"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/drugprevent.org.uk\/ppp\/wp-json\/wp\/v2\/tags?post=6535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}