2025 April

How do I know if a child is being abused/neglected? In 2023, there were over 546,000 reported cases of child abuse and neglect across the U.S. That same year, approximately 2,000 children died from abuse and neglect – a 9.6% rise in child fatalities from 2019. 1

The lifetime economic cost of child maltreatment was estimated at $218 billion in 2018, which is higher than chronic illnesses like heart disease and diabetes.2

Child abuse and neglect involve any mistreatment by a parent, caregiver, or another person in a custodial role that causes harm, risk of harm, or the threat of harm. This can include physical abuse, emotional abuse, sexual abuse, or neglect.2,3

Recognizing the signs of child abuse and neglect are essential for ensuring a child’s safety and well-being.

Signs and symptoms that are present in the child can include:

  • Physical abuse is the deliberate use of physical force that injures a child, such as hitting or shaking.2,3
    Emotional abuse involves actions that damage a child’s self-esteem or emotional health, like shaming, name-calling, or withholding affection.2,3
  • Sexual abuse refers to any attempted or completed sexual act or contact with a child by a caregiver, such as penetration, fondling, or exposing the child to sexual activity.2,3
  • Neglect is the failure to provide for a child’s basic emotional, medical, and physical needs, like housing, food, and clothing.2,3
  • Sudden changes in behavior – such as anger, hostility, constant exhaustion, or hyperactivity – or changes in academic performance.3,4,5
  • A child who exhibits poor hygiene, severe body odor, or consistently wearing soiled clothing or clothing that is significantly too large, too small or in need of repair.3,5,6
  • Frequently lacking necessary medical care or treatment, such as prescribed medications, assistive devices or other essential heath interventions.5
  • Food hoarding and lack of adequate nutrition.3
  • Unexplained injuries and may be accompanied by a child providing contradictory, questionable, or inconsistent explanations.3,4
  • Untreated physical or medical issues that parents are aware of.3,4
  • Struggles with learning or concentration without a clear physical or psychological cause.4
  • Appears constantly alert, expecting something bad to happen.4
  • Arrives early, leaves late, or reluctant to go home.4
  • Lacking adequate adult supervision, which may lead to children taking on inappropriate responsibilities for their age.3,4
  • Hesitation to be near a specific individual.4Parental Substance UseParental substance misuse can lead to child abuse, neglect, and an increased likelihood of children witnessing intimate partner violence (IPV).7,8 It disrupts secure parent-child attachment, diminishes the parent’s ability to nurture, and creates unsafe home environments, increasing the risk of maltreatment for the child.8,9,10From 2015 to 2019, on average, over 21 million children in the United States lived with a parent who misused substances and more than 2 million lived with a parent with a substance use disorder (SUD). Marijuana was the most used substance.9

    Parental substance misuse was a leading factor in children entering foster care nationwide, accounting for 33% of all cases in 2022.11 Parental opioid misuse was associated with over 200,000 reports of child abuse and neglect, over 95,000 children entering foster care, and almost $3 billion in child welfare system costs between 2011 and 2016.12

    In 2022, nearly 18% of child deaths in Florida (43 out of 237) were attributed to maltreatment, with 60.5% resulting from neglect and 39.5% from abuse. Among cases where caregiver impairment was documented, 31.2% of caregivers were found to be impaired.13 Additionally, in 2021, most caregivers of children who died had a history of substance misuse, with 67.4% reporting a history of marijuana use.14

    Parental marijuana use is associated with increased risk of marijuana, tobacco use, as well as opioid misuse, among both adolescents and young adult children, and is also associated with higher alcohol use among adolescent children.15

    Parental substance misuse can have a lasting effect on a child’s health, resulting in a higher risk of injuries, infectious diseases, hyperactivity, anxiety, depression, self-harm, suicidal behavior, and substance use in adolescence.8,16

    Children of parents with an alcohol use disorder are nine times more likely to have poor school performance and twice as likely to repeat a grade. They are also more likely to need special classes, referrals to school psychologists, and report higher absenteeism, which in turn
    impacts school performance.16

    Engaging parents in appropriate evidence-based treatment can improve their quality of life, reduce negative health outcomes, and decrease child welfare involvement.9,17

    Signs and symptoms that parents can exhibit:

  • Denies or blames the child for their issues at school or home.3
  • Requests teachers or caregivers to use physical punishment for misbehavior.4
  • Views the child as completely bad, worthless or a burden.4
  • Expects the child to meet unattainable physical and academic standards.3,4
  • Relies on the child to fulfill the parent’s emotional needs.4
  • Shows minimal concern for the child’s wellbeing, such as constantly missing or canceling appointments.3,4Barriers to Treatment
    Barriers to engaging in treatment services and recovery include waitlists, delays in appointment scheduling, mental health comorbidities, unemployment, economic challenges, homelessness, lack of childcare, and transportation.17Access to treatment is particularly difficult for parents, especially mothers, due to limited childcare options and strict program requirements, such as time-sensitive screenings and mandatory attendance. These barriers, along with penalties for missed appointments, can complicate their recovery process.19The financial burden of childcare further restricts access to treatment, as parents may be unable to afford both recovery services and the cost of childcare.17,19Mothers often face stigma and fear judgement or custody loss if they seek treatment for substance use disorders.10,18,19 This stigma, especially prevalent in the healthcare system, discourages many from seeking prenatal or postnatal care, further exacerbating health issues for both mother and child.19

    Healthcare providers’ negative perceptions of individuals with SUD often leads to discrimination.19 This stigma results in people being labeled as “untrustworthy” or “irresponsible,” contributing to fewer treatment-seeking behaviors and long-term negative outcomes for both parents and children.19

    Source: Copy of original file Sent to NDPA by Drug Free America Foundation  17 March 2025 

by Leah Kuntz –  Psychiatric Times  – Vol 42, Issue 3 –
Key Takeaways
  • Personality-focused programs like PreVenture significantly reduce adolescent SUD rates by targeting personality-specific skills and self-efficacy.
  • Understanding SUD prevalence and severity across age cohorts aids in policy-making and clinical service improvement.

National Drug and Alcohol Facts Week 2025 occurs from March 17 through March 23. This annual event focuses on educating youth about drug use and addiction and making informed decisions about substances. Accordingly, we have gathered a selection of recent research concerning adolescents and substance use disorder (SUD).

School-Based Personality-Focused Prevention Program on Adolescent SUD

A recent study investigated the 5-year SUD outcomes following a selective drug and alcohol prevention program that targeted personality risk factors for adolescent substance abuse.1 Many school-based prevention programs are standardized and utilize testimonials, flyers, peer education, and alcohol- and drug-free activities; research proves these have weak positive or even negative effects.2 However, programs that promote general coping and drug refusal skills show higher success rates.3-5

Investigators sought to observe the efficacy of PreVenture—a 2-workshop, school-based cognitive behavioral program that focuses on building personality-specific skills and self-efficacy—in reducing youths’ desire to use substances to cope with challenges. Previous randomized trials have shown that the program is effective in reducing alcohol use, drug use, and mental health symptoms by a notable 30% to 80% among secondary students.6,7

Investigators used mixed-effects multilevel Bayesian models to estimate the effect of the PreVenture intervention on the year-by-year change in probability of SUD in a group of seventh-graders. Students included in the study reported elevated scores on 1 of 4 personality subscales of the validated Substance Use Risk Profile Scale, as this has been shown to identify 90% of all students who go on to develop substance use difficulties over a 2-year period.8

When baseline differences were controlled for, a time-by- intervention interaction revealed positive growth in SUD rate for the control group (SE = 0.143; OR, 3.97) and reduced growth for the intervention group (SE = 0.173; 95% CI, −0.771 to −0.084; OR, 0.655), indicating a 35% reduction in the annual increase in SUD rate in the intervention condition relative to the control condition. Secondary analyses revealed no significant intervention effects on growth of anxiety, depression, or total mental health difficulties over the 4 follow-up periods. This study showed for the first time that personality-targeted interventions might protect against longer-term development of SUD.

Prevalence by Substance Class, Severity, and Age

“There is a need to understand the epidemiological landscape of specific SUDs—including by severity—within the critical period ranging from early adolescence through emerging adulthood,” wrote study authors Adams et al.9 To address this need, investigators sought to describe the national prevalence and severity of DSM-5 SUDs among US adolescents and emerging adults by using age cohorts that represent short time bands across adolescence (ages 12-13, 14-15, 16-17) and that correspond to important early adulthood milestones (ages 18-20, 21-25). They asked participants to report their past year’s usage of substances like alcohol, cannabis, cocaine, heroin, methamphetamine, and misused prescription medications. SUDs were identified and then classified by DSM-5 defined severity: mild, moderate, and severe. A series of χ2 tests of independence were then used to describe (1) the prevalence of any past-year substance use across age cohorts, (2) the prevalence and severity of SUDs across age cohorts, (3) and the prevalence and severity of SUDs across age cohorts among those who endorsed past-year use of each substance.

Investigators found that in youth with past-year substance use, many met criteria for an SUD. Past-year rates for alcohol and cannabis use were higher overall as the age cohort increased. The prevalence of abuse and distribution of SUD severity did not differ across age cohorts among those who used alcohol and cannabis in the past year. The prevalence and severity of SUDs generally did vary across age groups among those who reported past-year use of less commonly used substances like heroin and methamphetamine. Identifying the scope of SUDs in specific detail concerning substance class and severity can help guide policy decisions, improve clinical services, and inform clinician decision-making.

Protective Factors Against Addictive Substances

Feeling ostracized may influence adolescent attitudes toward substance use. To explore this connection, investigators highlighted risk factors like ostracism and protective factors like self-control and hope in a cross-sectional data analysis of 787 students (52.50% boys, 47.50% girls; mean age of 15.69, SD = 1.12).10

Previous research links feelings of exclusion, alienation, and meaninglessness with harmful behaviors like substance use.11,12 Additionally, those with lower self-control are at a greater risk for abusing substances.13 However, hope can be a mitigating factor: Hope is associated with greater self-confidence, well-being, coping flexibility, and emotion regulation skills,14 and thus can be considered a protective factor in preventing substance use.

The results showed that ostracism had a significant positive predictive effect on self-control (P < .001) and hope (P < .001). Furthermore, ostracism (P < .05), self-control (P < .001), and hope (P < .001) had significant positive predictive effects on attitudes toward addictive substances.

“This study highlights individual risk and protective factors related to attitudes toward addictive substances and offers new perspectives on ways to prevent and reduce adolescents’ positive attitudes toward substance use,” shared the study authors. “School counselors and educators should help students strengthen skills such as hope and self-control to prevent them from developing positive attitudes toward substance use in the future.”

References (These have been kept on this occasion because they give a useful listing of papers on the topic)

1. Conrod P, Stewart SH, Seguin J, et al. Five-year outcomes of a school-based personality-focused prevention program on adolescent substance use disorder: a cluster randomized trial. Am J Psychiatry. Published online January 15, 2025.

2. Sloboda Z, Stephens RC, Stephens PC, et al. The Adolescent Substance Abuse Prevention Study: a randomized field trial of a universal substance abuse prevention program. Drug Alcohol Depend. 2009;102(1-3):1-10.

3. US Department of Health and Human Services. Facing Addiction in America: The Surgeon General’s Report on Alcohol, Drugs, and Health. November 2016. Accessed February 10, 2025. https://www.hhs.gov/sites/default/files/facing-addiction-in-america-surgeon-generals-report.pdf

4. Faggiano F, Galanti MR, Bohrn K, et al; EU-Dap Study Group. The effectiveness of a school-based substance abuse prevention program: EU-Dap cluster randomised controlled trial. Prev Med. 2008;47(5):537-543.

5. Newton NC, Stapinski LA, Slade T, et al. The 7-year effectiveness of school-based alcohol use prevention from adolescence to early adulthood: a randomized controlled trial of universal, selective, and combined interventions. J Am Acad Child Adolesc Psychiatry. 2022;61(4):520-532.

6. Conrod PJ, Castellanos-Ryan N, Strang J. Brief, personality-targeted coping skills interventions and survival as a non-drug user over a 2-year period during adolescence. Arch Gen Psychiatry. 2010;67(1):85-93.

7. Conrod PJ, O’Leary-Barrett M, Newton N, et al. Effectiveness of a selective, personality-targeted prevention program for adolescent alcohol use and misuse: a cluster randomized controlled trial. JAMA Psychiatry. 2013;70(3):334-342.

8. Castellanos‐Ryan N, O’Leary‐Barrett M, Sully L, Conrod P. Sensitivity and specificity of a brief personality screening instrument in predicting future substance use, emotional, and behavioral problems: 18-month predictive validity of the Substance Use Risk Profile Scale. Alcohol Clin Exp Res. 2013;37(suppl 1):E281-E290.

9. Adams ZW, Dellucci TV, Agley J, et al. Estimated prevalence of substance use disorders among US adolescents and emerging adults by substance class, severity, and age, 2021. JAACAP Open. 2025. Published online January 22, 2025.

10. Cengiz S, Turan ME, Ҫelik E. Attitudes of adolescents toward addictive substances: hope and self-control as protective factors. Children (Basel). 2025;12(1):106.

11. Ali H, Hameed M, Abbasi MA, et al. Ostracism predicting suicidal behavior and risk of relapse in substance use disorders. Cureus. 2024;16(6):e61519.

12. Sprunger JG, Hales A, Maloney M, et al. Alcohol, affect, and aggression: an investigation of alcohol’s effects following ostracism. Psychol Violence. 2020;10(6):585-593.

13. Schaefer BP, Vito AG, Marcum CD, et al. Examining adolescent cocaine use with social learning and self-control theories. Deviant Behav. 2015;36(10):823-833.

14. D’Souza JM. The Unique Effects of Hope, Optimism, and Self-efficacy on Subjective Well-being and Depression in German Adults. Master’s thesis. University of Houston; 2019. Accessed February 10, 2025. https://core.ac.uk/download/pdf/276539773.pdf

Source: https://www.psychiatrictimes.com/view/adolescent-substance-use-research-honoring-national-drug-and-alcohol-facts-week

by Dr Max Pemberton (The Mind Doctor) in the Daily Mail on 17 March 2025.

Source: Dr Max Pemberton (The Mind Doctor) in the Daily Mail on 17 March 2025.  

by Amanda Zong, BS et al.

Collation by Lynda Charters – Ophthalmology Times- 

Key Takeaways

  • Cannabis users with autoimmune hyperthyroidism have a higher risk of developing TED outcomes, particularly within the first year.
  • The study utilized a cohort design with data from 36,186 patients, including cannabis users, cigarette smokers, and controls.

The authors noted that while an association between cigarette smoking and TED has been well established, an association between TED and cannabis use has not been determined.

Amanda Zong, BS, and Anne Barmettler, MD, from the Department of Ophthalmology and Visual Sciences, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, reported that cannabis users had a significantly increased risk for thyroid eye disease (TED) outcomes.1 They published their study in Ophthalmic Plastic and Reconstructive Surgery.

They conducted this study to identify an association between TED and cannabis use in patients who were diagnosed with autoimmune hyperthyroidism. The investigators pointed out that while the association between cigarette smoking and TED has been well established, an association between TED and cannabis use has not been determined.

Study design and results

The researchers conducted a cohort study that included patient data in TriNetX, an electronic health record platform, for patients with autoimmune hyperthyroidism over a 20-year period.

The primary study outcomes were TED presentation, ie, exophthalmos, eyelid retraction, eyelid edema, orbital edema, strabismus, and optic neuropathy, and treatments (teprotumumab, Tepezza, Horizon Therapeutics), methylprednisolone, tarsorrhaphy, and orbital decompression, among patients who used cannabis, those who smoked cigarettes, and control patients.

The relative risks among the cohorts were calculated for each outcome in 6-month and 1- and 2-year intervals after autoimmune hyperthyroidism was diagnosed.

The investigators identified 36,186 patients with autoimmune hyperthyroidism, of whom 783 used cannabis, 17,310 used nicotine, and 18,093 were control patients who used neither substance.

“Compared with control patients, cannabis users were more likely to be younger, male, Black/African American, and have anxiety or depression. After propensity matching, cannabis users were 1.9 times more likely to develop exophthalmos (p = 0.03) and 1.6 times more likely to develop any TED presentation (p = 0.049) during the 1-year interval. The differences were not significant in the 2-year interval,” Zong and Barmettler reported.

The authors concluded that patients with autoimmune hyperthyroidism who used cannabis had a significantly increased risk for TED outcomes in the 1-year interval. They advised that further research is needed regarding the management of TED.

Source: https://www.ophthalmologytimes.com/view/study-finds-cannabis-users-face-higher-risk-of-thyroid-eye-disease

Short title: STOP Act

What is the Sober Truth on Preventing Underage Drinking Act (STOP Act) Grant Program?

Underage drinking is one of our nation’s most significant public health concerns. It has been associated with negative consequences for youth, including impaired brain function, decreased academic performance, injury, an increased risk of developing an alcohol use disorder later in life, and alcohol-related death. Alcohol remains the most widely used substance among America’s youth, with a higher proportion of young people consuming alcohol than tobacco or other drugs. (Report to Congress on the Prevention and Reduction of Underage Drinking, 2023)

This public health challenge prompted Congress in 2006 to enact the STOP Act, establishing the Programs to Reduce Underage Drinking grant program (also known as STOP Act Grant Program) along with SAMHSA’s national media campaign, “Talk. They Hear You.”

STOP Act grantees establish and implement community-driven plans to reduce underage drinking by:

  • Addressing norms regarding alcohol use among youth.
    Example: STOP Act grantees are changing the perceived norms around and social acceptability of alcohol by reducing marketing of alcohol and discouraging youth’s access to alcohol.
  • Reducing opportunities for underage drinking.
    Example: Leading interventions to decrease alcohol availability by regulating alcohol outlet density, maintaining the legal purchase age of 21, and limiting the hours and days that establishments can sell alcohol.
  • Creating change in underage drinking enforcement efforts.
    Example: Strengthening restrictions and regulations on alcohol use in public places and at community events. This can also include increasing compliance checks at retail establishments to ensure they follow the law and don’t sell alcohol to minors.
  • Addressing penalties for underage use.
    Example: Localities passing ordinances limiting what alcohol products retailers can sell and where and when they can sell them, checking that retailers have the correct license or permit to sell alcohol products, and ensuring retailers maintain consistent enforcement of the new local ordinance.
  • Reducing negative consequences associated with underage drinking.
    Example: Implementing measures that lead to reductions in local alcohol-related violence and crime, sexually transmitted infections, motor vehicle crashes and fatalities, and sexual assaults.

 Awards Details

Administered by: Center for Substance Abuse Prevention

Funding Mechanism: Grant

Number of Current Grantees: 156 Active Grants (FY 2024)

Current Funding Information (FY 2025 Notice of Funding Opportunity):

  • Total Available Funding: Up to $750,000
  • Number of Awards: 13
  • Award Amount: Up to $60,000

Authorization: Section 519B (42 U.S.C. 290bb-25b) of the Public Health Service Act, as amended.

Year Established: 2006

Who does STOP Act grants serve?

Youth, young adults, families, and communities.

Who is eligible to apply for STOP Act grants?

Eligible applicants are domestic public and private nonprofit entities that are current or former Drug Free Community (PDF | 231 KB) recipients, which include:

  • Federally recognized American Indian/Alaska Native tribes, tribal organizations, urban Indian organizations, and consortia of tribes or tribal organizations.
  • Public or private universities and colleges.
  • Community- and faith-based organizations.
  • Government agencies.

Program Highlights

  • To date, the total number of individuals reached (i.e., the number of people exposed to the message or campaign) is 15,149,847 across the country.
  • To date, the total number of individuals served (i.e., the number of people directly impacted by this Grant program) is 744,549 nationwide.
  • This grant program has contributed to the continued Downward Trend (PDF | 2.3 MB) in Past-Year Alcohol Use for 8th, 10th, and 12th Grade Students from 2004-2023 nationwide.

A map of the United States and territories with the title, “Sober Truth on Preventing Underage Drinking Act – STOP Act Grant Program” A detailed description of the image is available (PDF | 52 KB)

Source: https://www.samhsa.gov/substance-use/prevention/sober-truth-preventing-underage-drinking-act

Filed under: Alcohol,USA,Youth :

by Drug and Alcohol Testing Association of CanadaMar 25, 2025

“If a young person is reporting very high levels of these traits, they’re more likely to use substances as a way to manage those traits,” said Dr. Patricia Conrod, founder of the PreVenture program, a psychiatry professor at the Université de Montréal and scientist at Sainte-Justine hospital in Montreal, in her interview with CBC News.

Specifically, the study showed that the program helped reduce the increase in the odds of substance use disorder by 35% year over year when compared to a control group. PreVenture helps teenagers manage traits that are linked to substance abuse, which include impulsivity, sensation seeking, anxiety sensitivity, and hopelessness. It includes two 90-minute workshops provided to Grade 7 students, helping them understand their personalities and teaching them tools to manage them. Moreover, PreVenture uses cognitive behavioural therapy, interactive exercises, and group discussions to find personality-specific coping strategies.

The program is currently offered in schools in five Canadian provinces, including Quebec, Ontario, and British Columbia, as well as in several U.S. states. “Some substance use disorders are preventable, and we should be making sure that young people have access to the programs and the resources they need,” said Dr. Conrod. However, she noted that despite the evidence of its effectiveness, Canadian schools need sustained funding from federal and provincial sources in order to be able to make the program more accessible.

According to Christine Schwartz, professor at the Children’s Health Policy Centre at Vancouver’s Simon Fraser University, policy-makers often prioritize treatment over prevention when it comes to substance use. “It’s a little bit harder for policy-makers to put the money towards prevention knowing they may not see the benefits — and there will be benefits in many of these cases, but they’re not going to see them for several years,” she said in her interview with CBC News. “There’s been a long history of using programs that haven’t necessarily been effective… What’s happening now is that policy-makers are increasingly turning to the research evidence.”

Source: https://datac.ca/prevention-program-has-reduced-odds-of-teen-drug-use-study/

Inhaling the vapors from chemical products has become a dangerous practice among teenagers and young adults. Often referred to as “huffing,” inhaling chemical vapors can become addictive — leading to both short-term and long-term health consequences including death. Most people have no idea how dangerous it is to inhale a chemical substance.

In the US:

  • Over 6 million children ages 12-17 use an inhalant each year to get high.
  • Inhalants tend to be a drug that is tried first by children.
  • 59% of children are aware of friends huffing at age 12.
  • Inhalants tend to be a drug that is tried first by children.
  • 1 in 4 students in America has intentionally abused a common household product to get high by the time they reach the 8th grade.
  • In Louisiana, according to the statewide Caring Communities Youth Survey, the reported inhalant usage (both lifetime and past 30-day usage) has decreased among 6th-, 8th-, 10th- and 12th-graders.

Louisiana’s Response – House Concurrent Resolution No. 24 of the 2016 Regular Legislative Session urged the Louisiana Department of Health, Office of Behavioral Health to raise awareness of addictive disorders involving abuse of inhalants and make efforts to reduce the prevalence of inhalant abuse.

What are Inhalants?

According to the National Institute on Drug Abuse of the National Institutes of Health, although other abused drugs can be inhaled, the term “inhalant” is reserved for a variety of substances including, but not limited to, solvents, gases, and aerosols that can alter moods and create a high. Nitrites (poppers and snappers) can also be inhaled and are believed to create sexual stimulation and enhancement.

How are Inhalants Abused?

People inhale chemical vapors through their nose, mouth, or both. This includes sniffing, snorting, or spraying the inhalant directly into the nose or mouth. Some people put the substance into a bag or other container and then inhale from there or put the vapor onto a rag to inhale.

How Do Inhalants Cause Medical Harm?

Inhalants are absorbed by parts of the brain and nervous system. They can slow down the body’s functions, similar to the effects of drinking alcohol. Other effects include:

Short-Term Long-Term
Seizures Weight loss
Nosebleeds Sores on nose and mouth
Loss of appetite Impaired kidneys
Headaches Impaired liver
Abdominal pain Lung damage

Source: https://ldh.la.gov/office-of-behavioral-health/inhalant-abuse-prevention

This article, reporting on research by Profs Stuart Reece and Gary Hulse, is seen as seminal contribution to the current concerns about the effects of cannabis use on autism. Accordingly, NDPA has written to JF Kennedy Jnr as below:

Date: 20th April 2025

Importance: High

To Robert F. Kennedy Jnr, Secretary of Health and Human Services, Government of the United States

Sir,

I understand that you and President Trump are becoming extremely concerned about the US autism epidemic.

Please see the attached paper above suggesting that Maternal Cannabis use and CUD may be a factor.

This paper attached is independently supportive of the other Australian work by Professors Reese and Hulse.

https://www.youtube.com/watch?v=x8bDLzEInWA&t=935s

The Reese/Hulse work indicates strong concordance between Cannabis legalization States and an those same States having an increase in ASD.

Yours sincerely,

David Raynes, Senior Advisor, NDPA (UK)

UK NATIONAL DRUG PREVENTION ALLIANCE

+44 7967708568

<<<<<<<<<<<<<<<<<<<<<<<<NDPA>>>>>>>>>>>>>>>>>>>>>>>>>>

Psychiatry Research

Volume 337July 2024, 115971
Exposure to maternal cannabis use disorder and risk of autism spectrum disorder in offspring: A data linkage cohort study.

by Abay Woday Tadesse et al.    School of Population Health, Curtin University, Kent Street, Bentley, WA, 6102, Australia

Highlights

  • •     This study involved over 222,000 mother-offspring pairs.
  • •     Maternal prenatal CUD is linked to higher ASD risk, with a stronger risk in male offspring.
  • •     More research is needed to understand these gender-specific effects.

Abstract

This study aimed to investigate the association between pre-pregnancy, prenatal and perinatal exposures to cannabis use disorder (CUD) and the risk of autism spectrum disoder (ASD) in offspring. Data were drawn from the New South Wales (NSW) Perinatal Data Collection (PDC), population-based, linked administrative health data encompassing all-live birth cohort from January 2003 to December 2005. This study involved 222 534 mother-offspring pairs. . The exposure variable (CUD) and the outcome of interest (ASD) were identified using the 10th international disease classification criteria, Australian Modified (ICD-10-AM). We found a three-fold increased risk of ASD in the offspring of mothers with maternal CUD compared to non-exposed offspring. In our sensitivity analyses, male offspring have a higher risk of ASD associated with maternal CUD than their female counterparts. In conclusion, exposure to maternal CUD is linked to a higher risk of ASD in offspring, with a stronger risk in male offspring. Further research is needed to understand these gender-specific effects and the relationship between maternal CUD and ASD risk in children.

To access the full document:

Click on the ‘Source’ link below.

Source: https://www.sciencedirect.com/science/article/pii/S0165178124002567

by Ben Stevens in Business of Cannabis EuropeCBDHemp  – April 17, 2025

It comes just days after Article 18 of Italy’s Security Bill, which equates industrial hemp (inflorescences) flower with high-THC cannabis, was forced through under emergency measures, decimating the industry.

One mild reprieve following this brutal crackdown was that it only banned CBD oils obtained from flowers, so those extracted from the leaves or stems would still be legal for over-the-counter sale.

However, with this latest ruling U-turn by the Court, which twice rejected this crackdown based on a lack of scientific evidence, the restriction now applies to all oral compositions of CBD extracted from the cannabis plant, regardless of whether the extract comes from flowers, leaves, or stalks.

Timeline of the CBD oil ban

  • 2020: The initial decree listing oral CBD as a narcotic was introduced by then-Health Minister Roberto Speranza. However, it was immediately suspended, pending input from scientific authorities, the Superior Health Council and Istituto Superiore di Sanità (ISS), and never enforced.
  • August 2023: Under the new government led by Minister Orazio Schillaci, the 2020 decree was reinstated without new opinions from the relevant health bodies. This move triggered immediate legal challenges.
  • October 2023: The TAR issued a ruling blocking the enforcement of the decree, citing the lack of supporting scientific evidence and reinforcing the argument that CBD is non-psychoactive.
  • June 27, 2024: The Ministry of Health reissued the decree, now backed by new opinions from the ISS and the CSS, asserting that oral CBD may present health risks, particularly in relation to its potential interaction with THC.
  • September 11 & October 24, 2024: The TAR again suspended the decree, citing a scientific report by Professor Costantino Ciallella, a former forensic medicine director at La Sapienza University, who concluded that CBD does not cause psychophysical dependence and lacks psychoactive effects.

Court’s U-turn

In a ruling on April 16, 2025, the TAR ultimately rejected the appeal brought by hemp industry associations Canapa Sativa Italia, Giantec S.r.l., Biochimica Galloppa S.r.l., and Orti Castello.

Following the decision, Italy has effectively banned the sale of oral CBD products as food or supplements, limiting them to prescription-only medicines, dealing a final blow to an industry already on its knees.

In their challenge of the decree, issued on June 27, 2024, the associations argued that the classification was unjustified, economically damaging, and lacked scientific merit.

However, after twice rejecting the bill, the court sided with the Ministry, accepting its application of the precautionary principle, a European legal doctrine that allows preventive regulation when scientific uncertainty exists about potential health risks.

The Ministry based its decision on evaluations from Italy’s National Health Institute (ISS) and Higher Health Council (CSS), both of which raised concerns about the safety and regulatory oversight of CBD products derived from plant extracts.

These concerns included the potential for liver toxicity, psychiatric side effects, contamination with THC or synthetic cannabinoids, and discrepancies in product labelling.

The court emphasised that the ruling does not equate to listing pure CBD as a narcotic, nor does it affect products containing synthetic CBD.

“In light of uncertain but credible risks to public health, precautionary regulatory intervention is justified,” the judges wrote, citing the Ministry’s duty to protect consumers even in the absence of definitive scientific consensus.

Business of Cannabis will be exploring the rulings and their impact on the industry in the coming days. (They say)

Source: https://businessofcannabis.com/italys-hemp-industry-dealt-2nd-major-blow-as-cbd-oil-classified-as-narcotic/?

“Money alone won’t solve it,” Kennedy told attendees at a Nashville convention addressing addiction 

by J. Holly McCall – April 24, 2025 12:55 pm
Hecklers interrupted a speech Thursday by U.S. Health and Human Services Secretary Robert F. Kennedy, Jr. at a conference on opioid addiction in Nashville.

The Rx and Illicit Drug Summit 2025 drew law enforcement officials, addiction prevention counselors, social workers and public health officers to the Gaylord Opryland Resort & Convention Center for the three-day event.

For years, Kennedy has drawn ire and disapproval for his anti-vaccine messages and, more recently, for belittling comments about people with autism and budget cuts in his department.

“Believe science!,” shouted a protester before security rushed him from the room.Another protester held aloft a sign that read, “Vaccines save lives.”

Kennedy’s speech was apolitical and focused on his own history in recovery from an addiction to heroin and his recommendations for dealing with the nation’s opioid crisis — many of which focused less on medical or treatment solutions and more on the need to build community, embrace spirituality and take personal responsibility.

After touting a $4 billion budget at HHS, Kennedy said that “money alone won’t fix this.”

“We have a whole generation of children who have lost faith in our country and their future,” Kennedy said. “Policy should reestablish hope for the future.”

Alexis Pleus of Binghamton, New York, and another woman unfurled a banner saying “Cuts Kill” before being ejected.

Pleus, who came to Nashville with other members of a group called Moms United to End the War on Drugs, lost her son to a drug overdose and said budget cuts at HHS spurred her attendance.

The Trump administration — and Kennedy — have proposed to restructure HHS, including dismantling the Substance Abuse and Mental Health Services Administration (SAMHSA), cutting research funding and funding for addiction treatment and mental health care.

“All these changes are impacting people on the ground,” Pleus said. “People who are struggling with addiction can’t get help already and now they’re going to have an even harder time.”

The conference was sponsored by HMP Global, which provides continuing medical education.

Past speakers have included former Presidents Joe Biden, Barack Obama and Bill Clinton. President Donald Trump spoke to the group in 2019 during his first term in office.

In addition to Kennedy, 2025 speakers included U.S. Attorney General Pam Bondi, Tennessee senior U.S. Sen. Marsha Blackburn and Dr. Ralph Alvarado, commissioner of the Tennessee Department of Health.

Source: https://tennesseelookout.com/2025/04/24/health-and-human-services-secretary-robert-kennedy-jr-urges-community-as-fix-to-opioid-crisis/

by Health News Florida and by Associated Press – published April 25, 2025

Health and Human Services Secretary Robert F. Kennedy Jr. speaks at the Rx and Illicit drug Summit, Thursday, April 24, 2025, in Nashville, Tenn. Photo: George Walker IV – AP

Speaking at a conference on drug addiction, HHS Secretary Robert F. Kennedy Jr. said young people need a sense of purpose and a connection to family to prevent them from turning to drugs.

U.S. Health Secretary Robert F. Kennedy Jr. told a personal story of his own heroin addiction, spiritual awakening and recovery at a conference on drug addiction Thursday and emphasized that young people need a sense of purpose in their lives to prevent them from turning to drugs.

Kennedy called addiction “a source of misery, but also a symptom of misery.” In a speech that mentioned God more than 20 times, he pointed to his own experience feeling as though he had been born with a hole inside of himself that he needed to fill.

“Every addict feels that way in one way or another — that they have to fix what’s wrong with them, and the only thing that works are drugs. And so threats that you might die, that you’re going to ruin your life are completely meaningless,” he said.

Speaking to about 3,000 people at the Rx and Illicit Drug Summit in Nashville, Tennessee, Kennedy did not address recent budget and personnel cuts or agency reorganizations that many experts believe could jeopardize public health, including recent progress on overdose deaths.

Kennedy drew cheers when he said that we need to do “practical things” to help people with addictions, like providing them with Suboxone and methadone. He also said there should be rehabilitation facilities available for anyone who is ready to seek help. But he focused on the idea of prevention, signaling his view of addiction as a problem fueled by deteriorating family, community and spiritual life.

“We have this whole generation of kids who’ve lost hope in their future,” he said. “They’ve lost their ties to the community.”

Kennedy said policy changes could help reestablish both of those things. Though Kennedy offered few concrete ideas, he recommended educating parents on the value of having meals without cellphones and providing opportunities for service for their children.

The best way to overcome depression and hopelessness, he said, is to wake up each morning and pray “please make me useful to another human being today. ”

He suggested that cellphones are a pernicious influence on young people and that banning them in schools could help decrease drug addiction. He cited a recent visit to a Virginia school that had banned cellphones, saying that grades were up, violence was down and kids were talking to one another in the cafeteria.

Kennedy told attendees that he was addicted to heroin for 14 years, beginning when he was a teenager. During those years, he was constantly making promises to quit, both to himself and to his family.

“I didn’t want to be someone who woke up every morning thinking about drugs,” he said, noting that one of the worst parts of addiction was his total “incapacity to keep contracts with myself.”

Kennedy said he eventually stumbled upon a book by Swiss psychiatrist Carl Jung that claimed people who believed in God got better faster and had more enduring recoveries, so he worked to rekindle his faith and started attending 12-step meetings.

Kennedy was interrupted several times by hecklers shouting things like, “Believe science!” He has been heavily criticized by scientists and public health experts for pushing fringe theories about diet, vaccines, measles and autism, among other things.

One heckler was escorted out of the ballroom with a raised middle finger. Without responding directly to the hecklers, Kennedy said that he tries to learn from every interaction, even with people who give him the finger because they don’t like his driving.

“God talks to me most through those people,” he told the group.

University of Washington researcher Caleb Banta-Green was among those escorted out after he stood up and shouted, “Believe science! Respect spirituality! Respect choice! Respect government workers!” “Spirituality is an essential part of recovery for some people; 12 step works great for the people it works for, however, it should never be mandated,” Banta-Green said in an email after the program. He added, “We have decades of science-based interventions that are proven effective for supporting recovery and reducing death from substance use disorder. The problem we have is massive underfunding.”

Source: https://health.wusf.usf.edu/health-news-florida/2025-04-25/rfk-recounts-heroin-addiction-and-spiritual-awakening-urges-focus-on-prevention-and-community

by Jan Hoffman, NY Times – 25 April 2025

The opioid overdose reversal medication commercially known as Narcan saves hundreds of thousands of lives a year and is routinely praised by public health experts for contributing to the continuing drop in opioid-related deaths. But the Trump administration plans to terminate a $56 million annual grant program that distributes doses and trains emergency responders in communities across the country to administer them, according to a draft budget proposal.

In the document, which outlines details of the drastic reorganization and shrinking planned for the Department of Health and Human Services, the grant is among many addiction prevention and treatment programs to be zeroed out.

States and local governments have other resources for obtaining doses of Narcan, which is also known by its generic name, naloxone. One of the main sources, a program of block grants for states to use to pay for various measures to combat opioid addiction, does not appear to have been cut.

But addiction specialists are worried about the symbolic as well as practical implications of shutting down a federal grant designated specifically for naloxone training and distribution.

“Reducing the funding for naloxone and overdose prevention sends the message that we would rather people who use drugs die than get the support they need and deserve,” said Dr. Melody Glenn, an addiction medicine physician and assistant professor at the University of Arizona, who monitors such programs along the state’s southern border.

Neither the Department of Health and Human Services nor the White House’s drug policy office responded to requests for comment.

Although budget decisions are not finalized and could be adjusted, Dr. Glenn and others see the fact that the Trump administration has not even opened applications for new grants as another indication that the programs may be eliminated.

Other addiction-related grants on the chopping block include those offering treatment for pregnant and postpartum women; peer support programs typically run by people who are in recovery; a program called the “youth prevention and recovery initiative”; and programs that develop pain management protocols for emergency departments in lieu of opioids.

The federal health secretary, Robert F. Kennedy Jr., has long shown a passionate interest in addressing the drug crisis and has been outspoken about his own recovery from heroin addiction. The proposed elimination of addiction programs seems at odds with that goal. Last year, Mr. Kennedy’s presidential campaign produced a documentary that outlined federally supported pathways out of addiction.

The grants were awarded through the Substance Abuse and Mental Health Services Administration, an agency within the federal health department that would itself be eliminated under the draft budget proposal, though some of its programs would continue under a new entity, the Administration for a Healthy America.

In 2024, recipients of the naloxone grants, including cities, tribes and nonprofit groups, trained 66,000 police officers, fire fighters and emergency medical responders, and distributed over 282,500 naloxone kits, according to a spokesman for the substance abuse agency.

“Narcan has been kind of a godsend as far as opioid epidemics are concerned, and we certainly are in the middle of one now with fentanyl,” said Donald McNamara, who oversees naloxone procurement and training for the Los Angeles County Sheriff’s Department. “We need this funding source because it’s saving lives every day.”

Matthew Cushman, a fire department paramedic in Raytown, Mo., said that through the naloxone grant program, he had trained thousands of police officers, firefighters and emergency medical responders throughout Kansas City and western rural areas. The program provides trainees with pouches of naloxone to administer in the field plus “leave behind” kits with information about detox and treatment clinics.

In 2023, federal figures started to show that national opioid deaths were finally declining, progress that many public health experts attribute in some measure to wider availability of the drug, which the Food and Drug Administration approved for over-the-counter sales that year.

Tennessee reports that between 2017 and 2024, 103,000 lives saved were directly attributable to naloxone. In Kentucky, which trains and supplies emergency medical workers in 68 rural communities, a health department spokeswoman noted that in 2023, overdose fatalities dropped by nearly 10 percent.

And though the focus of the Trump administration’s Office of National Drug Control Policy is weighted toward border policing and drug prosecutions, its priorities, released in an official statement this month, include the goal of expanding access to “lifesaving opioid overdose reversal medications like naloxone.”

“They immediately reference how much they want to support first responders and naloxone distribution,” said Rachel Winograd, director of the addiction science team at the University of Missouri-St. Louis, who oversees the state’s federally funded naloxone program. “Juxtaposing those statements of support with the proposed eliminations is extremely confusing.”

Mr. Cushman, the paramedic in Missouri, said that ending the naloxone grant program would not only cut off a source of the medication to emergency responders but would also stop classes that do significantly more than teach how to administer it.

His cited the insights offered by his co-instructor, Ray Rath, who is in recovery from heroin and is a certified peer support counselor. In training sessions, Mr. Rath recounts how, after a nasal spray of Narcan yanked him back from a heroin overdose, he found himself on the ground, looking up at police officers and emergency medical responders. They were snickering.

“Ah this junkie again, he’s just going to kill himself; we’re out here for no reason,” he recalled them saying.

Mr. Rath said he speaks with trainees about how the individuals they revive are “people that have an illness.”

“And once we start treating them like people, they feel like people,” he continued. “They feel cared about, and they want to make a change.”

He estimated that during the years he used opioids, naloxone revived him from overdoses at least 10 times. He has been in recovery for five years, a training instructor for the last three. He also works in homeless encampments in Kansas, offering services to people who use drugs. The back of his T-shirt reads: “Hope Dealer.”

Source: https://www.nytimes.com/live/2025/04/25/us/trump-news#narcan-grants-cuts-kennedy

Note:Links to References not given here.

Abstract

 Family separation has long served as a mechanism of social control and punishment in the United States, disproportionately targeting Black, Indigenous, and other marginalized families under the guise of child welfare. Family separation remains the family policing systems primary intervention in families, including families targeted because one parent is using substances. Recent legislation, such as the Families First Prevention Services Act, aims to reduce family separation by funding preventive services. However, the punitive approach entrenched in the family policing system remains resistant to reform. This Essay argues that the family policing system, steeped in a legacy of racialized control and punitive policies, fundamentally obstructs efforts to prioritize family preservation over child removal in cases of parental drug use.

Through an institutional theory lens, this Essay examines how the family policing systems historical emphasis on punishment and surveillance resists even well-intentioned legislative changes. Despite the inclusion of family-centered services in recent legislation addressing the opioid crisis, implementation barriers and institutional inertia within family policing agencies perpetuate default practices of policing and removal.

This Essay argues for a fundamental reimagining of family support systems that divests from punitive family policing frameworks and centers on family preservation.

Introduction

Chanetto Rivers smoked marijuana at a family barbecue before giving birth; New York City’s Administration for Children’s Services then placed her baby in foster care, even though marijuana was legal in New York at the time.1 Susan Horton ate a salad with poppy seeds before giving birth; California’s Sonoma County Human Services Department took her newborn into protective custody.2 Police and caseworkers from the Administration for Children’s Services raided L.B.’s Brooklyn home without a warrant at 5:30 A.M., terrorizing and traumatizing L.B. and her then-seven-year-old son after the state’s child welfare hotline received an anonymous and erroneous report of drug use.3 Alicia Johansen and Fred Thornten, whose child was removed due to their drug use, spent more than two years fighting the intervening foster parents for custody of their child, even after they met every requirement imposed by a Colorado judge for regaining custody.4

These parents experienced the all-too-common phenomenon of family surveillance and separation as a result of alleged drug use. Thirty-nine percent of all children forcibly removed from their parents’ care and custody in 2021 by so-called “child protective services”—more accurately called the family policing system5—were removed in whole or in part due to parental “drug abuse.”6 As of September 2022, in twenty-three states, evidence of parental “drug abuse” alone could be used to initiate child removal proceedings.7 Some state actors, like “child protective” agents,8 interpret “drug abuse” to include not only chaotic use9 of illicit drugs, but also recreational use of licit drugs (including alcohol and marijuana).10 Studies have found that substance use does not preclude people from being fit parents.11 Further, there is substantial evidence that the removal itself and the placement of the child in the foster-care system cause actual harm.12

If the risk of harm solely due to parental substance use or misuse is tenuous, and the harm to the child caused by removal and placement in state custody is a surety, why do state governments (aided by federal law and funds) remove children due to parental drug use alone? Professor Dorothy Roberts has convincingly argued that the family policing system is not designed to protect or to improve the welfare of children.13 Roberts argues: “‘Policing’ is the word that captures best what the system does to America’s most disenfranchised families. It subjects them to surveillance, coercion, and punishment. It is a family-policing system.”14

In this Essay, we apply an institutional theory lens15 to extend Roberts’s and others’16 assertions to the system’s treatment of parental drug use. We argue that punishment and social control are so deeply institutionalized in the family policing system that recent reform efforts will inevitably fail.17 While several articles have discussed the content, promises, and failures of the Families First Prevention Services Act (FFPSA),18 this Essay adds to the literature by providing an analysis of the legislative history and legislative discourse that gave rise to the enactment of FFPSA.

We support the claim that reform efforts will inevitably fail by first reviewing the family policing system’s history. We demonstrate that the system was created to remove children from parents whom the state deemed “undeserving” or “unworthy.”19 We show that, since the system’s creation, it has particularly targeted Black, Indigenous, and nonwhite immigrants.20 We describe how states have historically removed children from families as a form of social control and as punishment for conditions that are frequently rooted in the lasting impacts of enslavement, colonialism, structural racism, and poverty.

Second, we illustrate how decades of federal legislation (and funding) favored out-of-home placements over programs that prioritize providing services and keeping children within their homes. This approach further institutionalized surveillance, investigations into deservingness, and family separation as responsibilities of the agencies tasked with implementing these laws.21

Third, we address recent legislative attempts to respond to parental drug use in ways that preserve the family, such as by providing needed healthcare and assistance to parents who use drugs. The success of these attempts has been minimal. We attribute this lack of success to institutional inertia and to state family policing agencies’ incapacity to provide the family-centered services needed to support family preservation in cases of parental substance use.22 We conclude by recommending a new approach that would institutionalize the idea of family preservation and by describing what this reimagined approach might look like.23

I. the institutionalization of coercion and punishment in the family policing system

The current punitive approach to addressing parental substance use did not arise in a vacuum. Since the colonial era, American states have wielded family separation as an extractive tool of racialized social control and capitalism against Black, Indigenous, and nonwhite immigrant families.24 The system of family policing was designed to punish parents deemed “undeserving” of parenting because of their living conditions,25 which family policing agencies treated as individual failings or flaws.26 The removal of children from the home developed as part of that punishment.

Today, removal is a central tool of what we now call the “child welfare” or “child protection” system.27 Supporters of family policing as an institution have justified it as benevolent and necessary to protect children from actual harm.28 And yet the founding institutions—and the web of law, policies, and practices that make up family policing—continue to be rooted in the philosophies that children need protection from bad parents29 and that undeserving parents should lose their constitutional right to parent30 as a form of punishment.31 Early organizations and agencies created for “child protection” were developed to achieve these ends.32

Understanding the development of the institution of family policing is crucial to grasping why recent legislative reforms, which aim to address parental substance use without defaulting to child removal, face significant institutional inertia.33 Institutional theory suggests administrative agencies and the professionals operating within them will resist changes that contradict the systemically ingrained purposes of the institution.34 Here, as the desire for social control was institutionalized in the laws and policies of the family policing system, that desire became an element of the institution. As an element, it impacted the cultures, strategies, structures, and processes of regulatory bodies (such as state and federal legislatures and administrative agencies) and organizational participants (such as family policing agencies).35 Because the “child welfare” system was established to police families and punish those deemed unfit by permanently terminating parental rights, its strategies, structures, and processes inevitably incorporate punitive elements.36 Consequently, when reforms are introduced to prioritize family preservation, the regulatory and organizational bodies within the institution will often default to family policing—a phenomenon explored in depth in Part III.

A. Slavery, Colonialism, and the Birth of the Institution of Family Policing

The modern family policing system uses the threat of child removal and the permanent termination of parental rights as punitive measures for parental drug use.37 This type of family separation has a deep-rooted history in this country as a punitive tool to exercise racialized social control over Black, Indigenous, and other nonwhite immigrant families.38

Family policing existed long before the early predecessors of modern child protection agencies were created in the late nineteenth century.39 As Roberts wrote, “Family destruction has historically functioned as a chief instrument of group oppression in the United States.”40 Later in this Section, we will discuss the colonial history of the American family policing institution, which focused exclusively on the needs of white children living in poverty.41 However, for a more complete picture of the family policing institution, one must understand its inattention to Black families—who are now disproportionately policed by the modern family policing system.42 This disregard, combined with the existence of slavery, ensured that “child welfare institutions could develop in this country without concern for the majority of Black children,” creating the conditions for “an inherently racist child welfare system.”43 This system incorporated the brutal domination and destruction of Black families that the institution of slavery developed.44

As Professor Alan J. Detlaff has documented, during slavery, the tearing apart of families through sales of enslaved people served as “a means of maintaining power and control by a system of white supremacy that is foundational to this country’s origins.”45 Further, laws enacted during slavery monetized racial heritage by making the child of an enslaved person enslaved—thereby creating a perverse incentive for sexual violence as a means of enriching the enslaver and laying the foundation for family separation as a tool for racial capitalism, because enslavers would be financially enriched through the sales of enslaved people.46 Similarly, the history of land theft, displacement, and physical and cultural genocide of the Indigenous people in the United States created an enduring legacy in the development and function of child welfare institutions.47

These dual legacies of enslavement and genocide stretched beyond the period of land dispossession and slavery. This is evident from the advent of Black Codes, which compelled many newly emancipated Black families in the South to apprentice their children during the Reconstruction era,48 and the kidnapping and coercive placement of Indigenous children in Native American residential schools (guided by General Richard Henry Pratt’s infamous notion of “kill the Indian and save the man”).49 Each of these efforts was propelled by the idea that Black and Indigenous parents did not deserve their children and could not raise children who could productively serve society’s needs—a problem that could be remedied by children’s removal from their environments.50 This legacy of family separation as a tool of pain and punishment persists today.

As Roberts has argued, it is only against this backdrop and legacy of family separation as a “terroristic weapon against Black and Native communities” that we can consider “the emergence of modern child welfare agencies for white children in the United States.”51 James Morone’s Hellfire Nation describes how Puritan beliefs heavily influenced early American social welfare institutions, shaping policies that are deeply embedded in American institutions.52 These early Puritan beliefs led colonial society to view children living in poverty as needing salvation.53 However, it was not until the beginning of the nineteenth century—when waves of immigration and increasing industrialization turned wealthy reformers’ attention to the plight of poor, mostly white, immigrant children—that permanent family separation became a more widespread response to perceived parental deviance.54 These family separation efforts were primarily driven by anti-immigrant narratives that again characterized immigrant communities, much like families in poverty during the Puritan era, as prone to deviance.55 Rarely were efforts made to reunify families once children were removed.56

It was against this backdrop that the predecessors to modern foster care and child protection—organizational elements of the contemporary family policing system—were formed. Fueled by anti-immigrant sentiment, the Children’s Aid Society in New York developed a model of saving poor children from the “evils of urban life” by sending them to “good” Christian farmers in the country, where they could work and receive moral guidance.57 Substance use was understood as an innate sin that could be passed from mother to child.58 The New York Society for the Protection of Cruelty to Children sprung up in 1874, and by the 1910s, more than two hundred Societies for the Protection of Cruelty to Children (SPCCs) existed around the country.59 The SPCCs focused on investigating abuse allegations, instituting legal action, and encouraging the prosecution of the parents for “cruelty.”60 The vilification of parents, most of whom lived in poverty, and the use of child removal as a form of punishment reinforced the idea that it was the purpose of these child protection agencies to remove children from bad homes and put them in better homes; they operated with the intent to exert social control.61 Beginning in 1854, an estimated 100,000 children were sent on “Orphan Trains” from cities to smaller farm communities in the Midwest—marking the start of formalized foster care.62 This approach, however, was not concerned with reuniting children with their parents or even with ensuring that children’s welfare had improved.63

SPCCs created the institutional framework that gave rise to the modern family policing system: an institution that punished undeserving parents through permanent family separation. In 1935, the funding mechanism for state child protection systems became federalized through the Social Security Act,64 which encouraged states to create family policing agencies and programs modeled after the existing SPCCs, thereby incorporating these early models of family policing into the state and local agencies that exist today.65 In institutional-theory terms, the Act explicitly created structures and processes that were institutionalized into organizations, which adopted and incorporated the ethos of the SPCCs into the fabric of their operations. Thus, the family policing agencies were born.

B. Institutionalizing the Disproportionate Policing of Black and Indigenous Families

While Black and Indigenous children were largely not part of the equation for the SPCCs and other Progressive Era institutions focused on child-saving, this began to shift in the twentieth century.66 Ironically, Black liberation movements and civil rights advocacy opened the doors to the institutions that would become the family policing system, creating what Roberts has described as “a Pyrrhic victory.”67 At the root of this shift was a fight over federal financial support for low-income single mothers. In the early part of the twentieth century, Progressive Era feminists advocated for federal public welfare programs to benefit unmarried mothers. Black and Indigenous women were predominantly excluded from these benefits, either by law or practice.68 But in the mid-twentieth century, Black women and children were at the forefront of successful desegregation and civil rights movements that helped open the welfare system to Black and Indigenous mothers.69

In response, government officials, particularly in southern states, began to promote a racist and sexist narrative about Black mothers. For Black women, the institution of marriage was largely inaccessible due to structural racism, economic inequality, and public benefits laws that discouraged marriage. But rather than recognizing this reality, government officials often depicted Black mothers as draining public resources by accessing public benefits for their “illegitimate” children.70 In order to curtail Black women’s access to benefits, states enacted laws to police and surveil their behavior.71 For example, so-called “suitable home” laws deputized state family policing agencies to assess whether the home environments of children receiving public benefits were “suitable” based on whether unmarried mothers had ceased all “illicit” relationships.72 The purpose of these assessments was to evaluate each mother’s morality and, thus, her eligibility for public benefits; if public benefits ceased, her child would frequently be removed to foster care.73 These suitability laws share the same puritanical motivations that underpin many modern laws governing morality or perceived sins such as drug use.74 Additional research is needed to determine the full extent to which parental drug use motivated removals during this era. However, the stigmatizing depictions of Black women as “welfare queens” in the media and policy discourse, along with the depiction of the “crack-cocaine epidemic” as a problem affecting Black communities in the 1980s and 1990s, suggest that ideals of suitability and deservingness endured beyond the mid-twentieth century.75

Similar to Black mothers, as Native American mothers attempted to access welfare benefits, they opened themselves up to scrutiny and removal of their children to foster care.76 As historian Laura Briggs has written, involvement with welfare meant the application of white, heteronormative, middle-class standards to Native families:

Welfare workers disparaged the poverty of reservations and shamed unmarried mothers and others who cared for children because they thought heterosexual nuclear families were the only proper homes for children. They refused to acknowledge indigenous kinship systems and the important role of elders and other adults in child rearing.77 

Civil rights organizers appealed to the federal government to deem these suitability laws unconstitutional, calling attention to how suitability laws were fueling segregation (by driving Black families out of southern states) and starving Black children (by denying their mothers welfare benefits), but they were unsuccessful.78 Rather than address the inequities caused by these suitability laws, in 1961, Arthur Flemming, the Secretary of Health, Education, and Welfare for the Eisenhower Administration, found a workaround: states could deny mothers welfare benefits but could not leave their children without financial support simply because their caretakers were unsuitable.79 This so-called “Flemming Rule” required states either to (1) provide “services” to make a home suitable or (2) remove the child to “suitable” care while providing financial support to the child.80 It was not accompanied by additional allocations of federal funds to accomplish either of these objectives.81

Amendments to the Social Security Act in 1961 incentivized the removal of children from these homes (and from other families living in poverty) by permitting the use of federal funds to pay for removal and out-of-home placement of children (foster care).82 The 1961 Amendments did not include funding allocations to pay for services to make the home more suitable or to provide services to preserve the family unit.83

The influx of federal funding for foster care led to the formalization of the modern “foster care” system.84 As Roberts has documented, from 1945 to 1961, the proportion of Black children in foster care nearly doubled; yet from 1980 through 1999, the number of children total in foster care nearly doubled, and the proportion of Black children more than doubled.85 Further, “[f]rom 1960 through 1980, roughly 25-35 percent of Native children were separated from their families and placed in foster care, adoptive homes, or institutions, most of which were outside of their original communities and family system.”86

The history and analysis presented thus far demonstrate how the state increasingly punished parents it deemed undeserving through family separation and curtailment of their constitutional parental rights. Through a web of federal rules and legislation, federal dollars encouraged the creation of state and local family policing agencies and then encouraged family separation. In sum, separation was embedded into the framework for the modern family policing system, ensuring this approach would endure and fueling the influx of Black and Indigenous children into foster care.

C. The Institutionalization of Mandatory Reporting and Its Intersections with Healthcare

In 2019, thirty-four percent of all family policing investigations for infants were initiated by medical professionals.87 In some states, as many as eighty percent of these 2019 referrals were for parental substance use.88 As medical historian Mical Raz has demonstrated in her critical book, Abusive Policies: How the American Child Welfare System Lost Its Way, one cannot underestimate the legacy of Dr. C. Henry Kempe’s seminal 1962 article, The Battered Child Syndrome, which adopted a medicalized approach to child abuse that has been the framework for modern child protection efforts, including investigations of parental drug use.89

Kempe’s article argued that healthcare providers were uniquely situated to identify serious physical child abuse, which state child protection agencies could investigate.90 States swiftly responded, and by 1967, all fifty states had passed mandatory reporting laws. Some expanded what should be reported and investigated as alleged child abuse and neglect, reaching far beyond what Kempe had recommended.91

By 1974, Congress passed the Child Abuse Prevention and Treatment Act (CAPTA), which provided states with grant funding in exchange for compliance with specific requirements—including requirements that states implement mandatory reporting laws if they had not done so already.92 Although CAPTA did not explicitly include a mandatory reporting requirement for suspected parental substance use, federal guidance cautioned that parental drug use during pregnancy indicated a “high risk” for child maltreatment and encouraged physicians to “identify” infants who may be exposed to parental drug use during pregnancy so that the pregnant parent could be connected with needed services.93 CAPTA did not, however, provide any additional federal funding to cover the costs of necessary substance use or mental health services.94 It did, however, continue to fund out-of-home placements in foster care.95

A pause in the chronological sequence of this analysis is warranted because CAPTA was amended in 2003 to encourage states to develop policies and procedures that

address the needs of infants born and identified as being affected by illegal substance abuse or withdrawal symptoms resulting from prenatal drug exposure, including a requirement that health care providers involved in the delivery or care of such infants notify the child protective services system of the occurrence of such condition in such infants.96 

This notification requirement was accompanied by an express condition that the notification “shall not be construed to (I) establish a definition under Federal law of what constitutes child abuse; or (II) require prosecution for any illegal action.”97 Specifically, CAPTA provides:

The Secretary is authorized to make grants to States for the purpose of assisting child welfare agencies, social services agencies, substance use disorder treatment agencies, hospitals with labor and delivery units, medical staff, public health and mental health agencies, and maternal and child health agencies to facilitate collaboration in developing, updating, implementing, and monitoring plans of safe care described in section 5106(b)(2)(B)(iii) of this title.98 

Notably, this statutory language differs from CAPTA’s mandate in a different section that required states to enact laws to ensure child abuse and neglect are reported and investigated. This difference suggests that the notification requirement was not to be equated with a report of child abuse or neglect. Further, the statute’s emphasis on “developing, updating, implementing, and monitoring plans of safe care”99 signifies a focus on providing treatment and suggests that evidence of substance use is not per se child abuse or neglect.

But while the notification requirement was not intended to be a report of child abuse or neglect, it has increased the surveillance and policing of pregnancies by healthcare providers for reasons we explore in Part III.100 Most importantly for the current analysis, this requirement created additional processes and procedures in family policing agencies to deal with notifications from healthcare providers, further institutionalizing the policing function of these agencies.101 As is a recurring theme, the 2003 amendments did not include additional allocations to pay for services for the parent that would prevent removal—or even require that services to the parent be provided.102 In practice, it is not uncommon for these notifications to result in referrals for investigations of alleged child abuse and neglect, further driving families’ entanglement in the family policing system.103 As institutional theory predicts, family policing agencies—created for the purpose of policing parental behavior—implemented these notifications with the same punitive approach they had used for eighty years.104

Mandatory reporting has fueled the rapid expansion of the family policing system since the passage of CAPTA, as states have broadened their definitions of child maltreatment and expanded the categories of mandatory reporters.105 The influx of millions of reports each year—many of them unsubstantiated—overwhelms the system, leading to invasive investigations and child removals that often harm families without effectively preventing abuse and neglect.106 Studies also show that the discrimination and stigmatization that parents who use substances experience in seeking treatment, along with the very real legal risks of mandatory reporting and family separation, constitute a significant deterrent to seeking help or treatment.107

The influx of children into foster care, and the rising federal costs of financing it, prompted Congress in 1980 to consider the impacts that removals were having on parental rights while balancing the competing goal of providing children languishing in foster care with “permanency” (via the involuntary termination of parental rights and adoption).108 Congress enacted the Adoption Assistance and Child Welfare Act of 1980 (AACWA), which required agencies to make “reasonable efforts” to preserve the family before removing a child from the home. To support this requirement, the law also amended the Social Security Act (SSA) to fund services to prevent child removal, including parental counseling and substance use treatment, through what is commonly referred to as Social Security Title IV-B Programs funding.109 However, the reasonable effort requirement was secondary to AACWA’s emphasis on achieving the competing goal of “permanency” for children.110 And despite the amendment to the SSA, AACWA’s prevention and reunification services were and are still underfunded—an issue that we discuss further in Part III.111 AACWA did not contain a funded mandate to reunite families.112

AACWA was responsible for an estimated decline in the number of children in foster care from over 520,000 in 1977 to 275,000 by 1984.113 However, this decline is attributable to AACWA’s encouragement of more parental rights terminations and the facilitation of adoptions rather than the increase in reunifications.114 Near the turn of the century, Congress again intervened to facilitate more terminations of parental rights and adoption with the enactment of the Adoption and Safe Families Act of 1997 (ASFA).115

Rather than preventing child removal and providing services to keep families together, ASFA created mandatory timelines by which parents needed to reunify with their children or risk the termination of their parental rights and adoption of their children. The law did so by requiring states to file to terminate parental rights if a child had spent fifteen of the last twenty-two months in foster care.116 Advocates for ASFA fueled the imaginations of legislators with accounts of child abuse that allegedly occurred in homes where children were not removed due to family preservation efforts or after children were reunified with their parents following foster care.117 Although there was no systematic data presented to Congress to support these contentions,118 Congress passed AFSA anyway. And while ASFA has increased the number of family policing cases resulting in adoption,119 it has also created many “legal orphans”—youth whose parents’ legal rights were terminated but for whom no adoption is ever completed.120

The horrific impact of ASFA on families with a substance-using parent over the past twenty-six years cannot be underestimated. The timelines, coupled with the threat of termination of parental rights, greatly impacted parents who struggled with substance use for several reasons. First, it is not uncommon for parents to spiral into chaotic substance use121 as a result of family separation. When parents experience an episode of relapse into chaotic substance use, it prolongs foster care stays.122 Prolonged foster care stays, in turn, decrease the likelihood of reunification and, because of federally mandated timelines,123 increase the likelihood of parents having their parental rights terminated and losing their child forever.124 Rather than fund family preservation efforts or help families to reunify, ASFA further solidified the family policing system’s institutional commitment to removing children from “bad” parents, allegedly for the children’s safety and well-being.

In summary, the institutional history of the family policing system provides a clear map as to why the system is not only ill-suited to help parents who use substances but, in fact, is not designed to help them. As we have briefly reviewed above, federal funding mechanisms for the system have incentivized out-of-home placements and institutionalized a punitive approach that threatens parents who use substances with the termination of their parental rights to induce behavior change.125

Yet, by 2018, as overdose death rates remained high126 along with high rates of foster care placements due to parental opioid use,127 there was a documented shift in policy narratives about addiction. Rather than framing it as primarily a moral or criminal-legal issue, policymakers began to frame it as a public health issue.128 Unlike parental substance use more broadly, the opioid crisis was also characterized as a medical or health issue that impacts primarily the white middle class.129 Given this narrative shift and the health-oriented federal legislation to address the opioid epidemic,130 one might expect states to retreat from removals based on substance use alone—at least in the short term.

Although legislators claimed to have adopted a public health approach in response to the nation’s opioid overdose crisis,131 the approach failed to truly prioritize public health in the family policing context. Indeed, it merely tasked the family policing system with responsibilities that either reinforced its policing tendencies or exceeded what the system was equipped to handle. As public health researchers have shown, when policing agencies try to engage in public health efforts, they cannot help but resort to their policing training and functions.132 In the family policing context, a genuine public health approach to substance use would require addressing the upstream causes of parental drug use,133 employing a harm reduction approach to current substance use (which meets the person who is using drugs “where they are at”),134 and prioritizing providing services that do not necessitate removal when possible.

II. the opioid crisis and the not-so-public health approach to parental substance use

It was not until 2016—in response to an opioid crisis portrayed as predominantly affecting white communities in suburban America135—that Congress expanded the federal requirement to identify children exposed to substances in utero to include a mandate for developing Plans of Safe Care addressing the needs of both the infant and the mother. This addition came with the enactment of the Comprehensive Addiction and Recovery Act (CARA) of 2016.136 Along with the attention paid to the rising number of opioid overdose deaths, there was a new moral panic over infants exposed in utero to opioids.137 This panic was over Neonatal Abstinence Syndrome (NAS), which was initially attributed to prescription opioid use or side effects of medications to treat opioid-use disorder.138 Addiction medicine specialists warned that “[d]eclaring war on this condition risks stigmatizing effective therapy, leaving mothers more vulnerable to relapse, overdose, and death.”139 Their warnings were not heeded.

CARA also responded to the moral panic about NAS by expanding the notification requirements for infants “affected by substance abuse or withdrawal symptoms,” now requiring healthcare providers to identify infants exposed to both prescription and illicit drugs instead of just the latter.140 CARA explicitly included an acknowledgment by Congress that addiction and overdose were public health issues.141 And yet, in the same legislative breath, Congress expanded the population of infants and families subject to the family policing system.142

When answering questions about whether a notification or referral pursuant to this provision constitutes a report of abuse or neglect, the Administration for Children and Families (ACF), the federal agency charged with the enforcement and implementation of CAPTA, hedged. ACF responded:

Not necessarily. The CAPTA provision as originally enacted and amended requires the referral of certain substance-exposed infants to [child protective services] and makes clear that the requirement to refer infants affected by substance abuse does not establish a federal definition of child abuse and neglect. Rather, the focus of the provision is on identifying infants at risk due to prenatal substance exposure and on developing a plan to keep the infant safe and address the needs of the child and caretakers. (See CWPM, Section 2.1F, Questions 1 and 2.) Further, the development of a plan of safe care is required whether or not the circumstances constitute child maltreatment under state law.143 

This hedging implies that ACF knew that mandating notification risked increasing the likelihood that an investigation and removal would ensue.

In a positive step forward, CARA did require that the Plans of Safe Care also address the health and substance use disorder treatment needs of the infant’s family or caretakers.144 However, CARA still did not address the harm that interactions with the family policing system cause parents who use substances and their children. Although CARA purported to be public health-oriented, in reality, it maintained and reinforced the policing structure of all policy responses to drug use. 145 The law cloaked this policing structure by using public health rhetoric and shifting some of the policing and surveillance of parents to healthcare actors.146

In October 2018, Congress enacted the Substance Use-Disorder Prevention that Promotes Opioid Recovery and Treatment for Patients and Communities Act (SUPPORT).147 The legislation included an amendment to CAPTA authorizing grants to states to facilitate collaboration in developing and implementing Plans of Safe Care—again reinforcing that legislators were interested and willing to amend CAPTA in order to better respond to the opioid crisis, but also signaling broad bipartisan support for increased surveillance and reporting.148

In 2021, Congress’s reauthorization of CAPTA updated the idea of Plans of Safe Care, renaming them Family Care Plans. Congress stated that the 2021 CAPTA “promotes a public health response for family care plans (formerly plans for safe care) to ensure the safety, permanency, and well-being of infants and their caregivers affected by substance use disorder.”149 Congress claimed CAPTA did this by appropriating additional monies to improve access to treatment.150 It stressed that the mandated reporting of substance exposure of the infant did not require an investigation by the agency and that CAPTA was not meant to provide a federal definition of child maltreatment that included parental substance use.151 However, the 2021 reauthorization did not recommend that infants remain with their parents while substance use treatment services are provided152—despite the evidence suggesting that these services can lead to better outcomes.153 And as scholars have noted, while the purpose of the CAPTA notification requirements for substance-exposed infants is to identify families who need services before removal becomes necessary and to do so in a nonpunitive way, this goal conflicts with current criminal legal approaches to substance use in pregnancy, which are focused on surveilling, reporting, and punishing pregnant parents.154

Further, there is ample evidence that mandatory reporting creates a significant disincentive for substance using pregnant people155 to seek prenatal medical care.156 This disincentive is particularly strong for Black pregnant people because of the pervasive and illegal reality that they and their babies are far more likely to be tested for substances, usually without consent.157

In sum, despite the widely available evidence that outcomes are better for children, parents, and the whole family when infants are not removed from their parents’ care due to exposure to a substance in utero,158 federal legislation has not gone so far as to require states to provide access to such evidence-based programs instead of out-of-home placement. Worse yet, federal law maintains healthcare providers as police and decreases the likelihood that pregnant people will seek healthcare.159

A. The Families First Prevention Services Act and the Promise of Reform

The Families First Prevention Services Act (FFPSA), enacted in 2018, was supposed to “begin a new era for the child welfare system.”160 It was first introduced in the House of Representatives in 2016, alongside several other pieces of legislation aimed at addressing the opioid overdose crisis.161 Its drafters wanted to redesign the current family policing system to emphasize a preventative model that kept children in their caretakers’ homes while providing the services that caretakers may need to keep children safe.162 To achieve this, the drafters of FFPSA proposed an amendment to current federal funding structures to provide more funding for “prevention services for children and families that are at risk for entering foster care.”163 The law amended Title IV-E of the SSA to allow family policing agencies to use federal funds to support evidence-based prevention efforts for mental health, substance-abuse prevention and treatment services, and in-home parenting skills training for a maximum of twelve months.164 FFPSA also permits agencies to use funds to pay for residential, family-based substance use treatment providers, which allow children to live with their parents while they undergo treatment for substance use disorder (SUD).165 This feature of the law was backed by evidence demonstrating that many parents with substance use disorders can safely care for their child without the child being separated from them.166 It was also supported by studies that have found that children, particularly infants born exposed to substances, fare worse if removed from their parents’ care and custody.167 Outcomes for both children and parents are significantly better when child protective services and courts use family-centered approaches to substance use treatment instead.168 These approaches allow children to remain in the care and custody of their parents while the parents receive evidence-based substance use treatment and support.169

Despite having support from many prominent family policing agencies as well as advocates in the Obama Administration’s Office of National Drug Control Policy, FFPSA passed in the House but did not make it out of committee in the Senate when it was first introduced in 2016.170 FFPSA had bipartisan support, and one of its drafters and primary sponsors was a Republican. Surprisingly, opposition to the bill came from Democrats over where its funding would come from. Democrats opposed using financial incentives previously awarded to the states for supporting adoption services to fund prevention services instead.171

FFPSA was introduced again in the Senate in 2017, where it died in committee.172 This is a common fate for legislation that does not have enough support among the chairs of committees of the controlling party, which in 2017 was the Republican Party. Most of the provisions of FFPSA were eventually enacted as part of Division E of the Bipartisan Budget Act of 2018.173 Congress has increasingly used “riders,” policy changes within budget legislation, mainly because some of the procedural hurdles to legislative enactment are suspended for appropriation bills, making them easier to pass than standalone legislation.174 The failure of FFPSA to make it out of committee suggests that the law did not have the congressional support that CARA or SUPPORT had. Despite this, FFPSA was enacted in 2018.

B. Implementation Barriers: Congressional Inquiries into the Implementation of FFPSA

FFPSA’s enactment has been flanked by implementation barriers. After the passage of FFPSA, the bill’s sponsors were quick to tout its success and claim credit for the declining number of foster care placements in 2018. In comments in front of Congress on November 20, 2019, Senator Grassley said: Mr. President, in recent years, the opioid epidemic has resulted in steadily climbing numbers of kids entering foster care. However, in 2018, the number of children in foster care has declined for the first time since 2011. This is evidence that prevention programs are working.175 Indeed, the number of children that have entered foster care has decreased from its height of 273,000 in 2016 to 207,000 in 2021.176 However, the numbers were trending down before the enactment of FFPSA, and FFPSAs funding provisions did not go into effect until October 1, 2018.177 The fact that the number of children entering foster care declined before FFPSA went into effect suggests that the initial downward trend cannot be attributed directly to FFPSA.

Further, FFPSA has been hard to implement, contributing to only seventeen states and one tribe using FFPSA funds in 2022.178 And FFPSA has fallen short of furthering actual systems reform for several institutional reasons.

First, FFPSA does not truly prevent removal, as it is not triggered unless there is an imminent risk of family policing involvement.179 Advocates have asked Congress to expand the definition of who is eligible for FFPSA services to any family who is at risk of family policing involvement as opposed to only those who are at imminent risk of family policing involvement.180 FFPSA gives states wide latitude to determine what imminent risk of harm means. The federal government has issued guidance stating it applies to anyone who would likely enter foster care without intervention.181

Second, as other advocates and experts have argued, the underfunding of Social Security Title IV-B Programs, which were created in the 1990s to support family support and family preservation services, is also stymying the systems change FFPSA aims to promote. Title IV-B programs have been leveraged to ensure that social workers visit children in foster care regularly rather than to support families to prevent removal.182 As the Executive Director of the Utah Department of Health and Human Services explained, Title IV-B funding offers states tremendous flexibility to meet the needs of families and prevent removal.183 During her congressional testimony, the Director gave the example of a family of five that was at risk for child removal.184 In that particular case, the social worker had identified that the cause of the removal was poverty-related and had used Title IV-B funds to provide short-term resources to pay rent and access medical care.185 Despite the benefits of these funds, the Director noted that they only make up 2.5% of Utah’s total family policing budget.186 As Dr. David Sanders, Executive Vice President of Systems Improvement at the Case Family Programs, explained to the Senate Finance Committee, “Family First focuses on children right at the doorstep of foster care, and Title IV-B provides more flexibility for [s]tates to address issues at an earlier point and strengthen families who might be at risk.”187

Third, the overall institutional structure financing the family policing system creates tremendous administrative complexity that may prevent states from applying for FFPSA funding. FFPSA funding comes with reporting requirements. State child welfare agency directors have explained that the current family policing systems federal funding structure—with different federal funding buckets accompanied by their own rigorous reporting requirements—is so complex that even small states have to hire twenty administrative personnel just to manage the federal financing and reporting requirements for all of the various streams of funding for family services.188 This complexity adds to the administrative burdens of an already-taxed system, and the siloing of budgets and social services makes it difficult for agencies to address upstream causes and prevent removal. In 2024, Senator Ron Wyden blamed the federal government for this administrative complexity, stating as part of a more extensive critique of the federal implementation of FFPSA: [L]ast year, the federal government spent just $182 million on prevention services, while we spent over $4 billion on traditional foster care. Clearly priorities are out of whack. The government can and must do better to get this funding out the door to states that ask for it.189 In sum, the administrative complexity may be preventing states from accessing FFPSA funds, which would provide an alternative to removal—leaving states to resort to their family policing functions.

Fourth, numerous stakeholders have explained that satisfying the rigorous requirements to receive confirmation that an intervention is “evidence-based,” and thus eligible for FFPSA funds, is time-intensive and costly. They have also described how the approval process is arduous and opaque.190 Based on communications between Congress and the Secretary of Health and Human Services (HHS), which Congress tasked with implementing the Act, members of Congress have argued that HHS has treated the legislative requirement that FFPSA fund only evidence-based programs as including a need for a rigorous, “academic” evaluation of each program.191 Congress has stated that HHS has frequently made decisions without communicating with study authors.192

This has led to HHS approving only a “relatively small number of interventions” for states to choose from.193 Even after interventions are cleared as fulfilling the arduous requirements of being “evidence-based,” many of these interventions may not be available in states because they are relatively new.194 HHS’s narrow interpretation of “evidence-based” means states must invest in the start-up costs of developing interventions from the ground up.195

Finally, a critique absent from the congressional discourse is that FFPSA leaves the current family policing system intact, including the expansion of reporting requirements for infants exposed to substances in utero. Miriam Mack, Policy Director of the Bronx Defenders’ Family Defense Practice, has written that FFPSA “in no way challenges the fundamental pillars upon which the family regulation system rests.”196 FFPSA does not fully separate the family policing system from its roots in centuries of institutionalization of racism and classism, reviewed in depth in Part II of this Essay. FFPSA continues to allow states wide latitude in defining child maltreatment, or the imminent risk of child maltreatment, as including parental drug use alone—rather than requiring states to demonstrate the risk of actual harm to the child resulting from that substance use.197 Some states, like Colorado, have explicitly stated in their substance legalization laws that possession or use of certain substances does not constitute child abuse or neglect unless it threatens the health or welfare of the child.198 Other states, like Michigan, have issued regulatory guidance stating that parental substance use alone does not meet the definition of child maltreatment.199 Yet despite these positive trends in some states, state legislatures continue to propose laws that would add parental substance use to definitions of child maltreatment.200

Moreover, agencies continue to remove children for parental drug use, often when it occurs in utero. FFPSA does nothing to address the punitive responses adopted by many states in addressing perinatal or maternal substance use. This continues despite evidence that these types of policies do not address either the underlying substance use or the potential risk of harm to the child—and could even make the problem worse.201

While FFPSA is an important step in permitting states to engage in family preservation activities for parents who use substances, it falls short of addressing the centuries of institutionalization of family policing and surveillance, which continue to shape the practices of local agencies responding to complaints of parental substance use. To actualize the goals of the drafters of FFPSA, we must interrogate the current system.

III. the path forward

In this Essay, we have outlined in detail both the deeply embedded structural problems with the current family policing model, including its longstanding focus on punishing parents deemed “undeserving,” and how federal legislation has further institutionalized this punitive approach in addressing problems that may be exacerbated by parental substance use. While FFPSA funding allocations for prevention services and substance use treatment that prioritize keeping children with their parents are commendable, the implementation barriers discussed above bolster the claims of scholars, advocates, and impacted families who are calling for the abolition of family policing rather than its continued reform.202 In envisioning a path forward, we join and amplify that chorus.

Family policing is not built to help families, particularly those with parents who use substances.203 As abolitionist lawyer and organizer Andrea J. Ritchie writes in Practicing New Worlds: Abolition and Emergent Strategies, “We can’t continue to organize in ways that replicate and legitimize the systems we are seeking to dismantle.”204 Thus, she explains, abolition is as much about envisioning and creating the world we wish to live in as it is about dismantling oppressive systems.205 Renowned activist and scholar Angela Y. Davis has explained that abolition “is not only, or not even primarily, about . . . a negative process of tearing down, but it is also about building up, about creating new institutions.”206 Accordingly, the remainder of this Essay is devoted to laying out a set of principled “non-reformist reforms”207 that should guide future policymaking to provide support and care to families with parents who use substances, rather than surveil and punish those families. Non-reformist reforms, as abolitionist scholar Ruth Wilson Gilmore has described, are “changes that, at the end of the day, unravel rather than widen the net of social control through criminalization[.]”208 These suggestions are not meant to be exhaustive, in part because, in the practice of abolitionism, the families most impacted by family policing must lead the way in designing the future path.

A. Families Are Calling for Abolition: Listen to Them!

A burgeoning movement of families impacted by the family policing system is calling for a radical reimagination of safety for families—namely, through the abolition of the family policing system.209 These families, including parents and (former) youth who have lived experience with the family policing system, are calling attention to the many harms perpetrated by the system, particularly for Black and Indigenous families.210 Although the family policing system is premised on the narrative that state intervention is benevolent and necessary for the care and protection of children, these families’ experiences underscore the many myths that are woven into the law, policy, and practice of family policing.211 Not only must states listen to families’ narratives, but the very families most impacted by family policing must help design new approaches that support families with parents who use substances. Some of the approaches to community care already identified by families most impacted are named below.

B. Decouple Access to Services from Family Policing and End Mandatory Reporting of Substance Use During Pregnancy

As discussed above, the current policy framework—as articulated by FFPSA and related federal and state family policing law—requires parents who use substances to engage, or risk engagement with, the family policing system to access help and treatment. Doing so comes at significant risk of mandatory reporting and family separation, and as a result, disincentivizes seeking help and care.212 Further, mandated reporting requirements for suspicions of infant exposure to substances in utero disincentivize pregnant persons who use substances from seeking both treatment for SUD and prenatal care.213 Parents who use substances need a way to access care that does not result in the punishment inherent in the family policing system. To meet that need, the state should provide parents with ways of accessing medical care, SUD treatment, and harm reduction services that do not automatically trigger mandatory reporting and possible family separation. For example, the Family-Based Recovery model includes “[i]n-home treatment that provides concurrent psychotherapy, substance use treatment and parent-child dyadic therapy.”214 Models like these offer evidence-based and effective alternatives to family separation.

Research shows that both parents who use substances and their children thrive when they are able to stay together while the parent receives treatment for their substance use.215 Rather than funneling federal money to the states via the family policing system and conditioning access to treatment on a finding of imminent risk of harm, funding should go to flexible, evidence-based treatment that prioritizes family stability and integrity and addresses the upstream causes of substance use and child maltreatment.

Ending mandatory reporting would make a significant difference in substance-using parents’ ability to access treatment. Since CAPTA’s inception, its requirements—especially its mandatory reporting provisions—have been a primary driver of family separation. Many have called for the end of this practice.216 As scholars and advocates have documented, because of the structural racism embedded in family policing, Black and Indigenous families are more likely to be reported and more likely to be separated as a result of family policing intervention.217 The racialized enforcement of the war on drugs further compounds these racial disparities. As explained in Part II, mandatory reporting can deter parents from accessing help and treatment.218 Ending mandatory reporting would focus service providers’ efforts on providing assistance and care to families, rather than acting as agents of family policing surveillance.219 As Joyce McMillan, who founded the New York City-based organization JMac for Families, has argued, we should have mandated support instead of mandatory reporting.220 Such an approach would permit parents who use substances to seek care, treatment, and other support without the very real risk of family policing involvement and family separation.

C. Prohibit the Use of Federal Funds to Pay for Removals and Neglect Findings Based Solely on Substance Use

As noted above, CAPTA creates a floor for states to define neglect, but it permits states to drastically expand their definitions of neglect—which they have done.221 Just as poverty should not be the basis for a finding of neglect, so too substance use should not be a per se basis for a finding of neglect. Most parents who use substances can safely care for their children. Congress should amend federal laws to reflect that reality. As previously discussed, the availability of federal funds to pay for foster care services dramatically shaped state behaviors in terms of prioritizing removal and foster-care placement as the appropriate response. By amending CAPTA to exclude federal funding for removals and foster care in cases with findings of neglect based solely on evidence of parental substance use, Congress can incentivize states to change their definitions of child maltreatment without infringing on states’ police powers.

Conclusion

As detailed throughout this Essay, there are numerous institutional and organizational barriers embedded in the family policing system that prevent it from being a source of meaningful help or care to families with parents who use substances. Reform efforts cannot overcome the impact of these institutional and organizational barriers. The failure of FFPSA and other piecemeal reforms demonstrates the family policing system’s inability to shed its institutional commitment to the punishment and surveillance of families.

The current family policing system does not work. Rather than institutionalizing existing approaches to substance use within the family policing system, we must pursue a new, family-centered approach that centers the lived experience of parents who use substances and is rooted in evidence—not in stigmatizing narratives and a desire to moralize and control. If we do not change our approach, we will continue to witness the impacts of an ineffective, costly, and inefficient system of family policing that harms families more than it helps them.

* * *

Dr. Taleed El-Sabawi is Assistant Professor of Law, Wayne State University, School of Law. Dr. El-Sabawi is supported by the National Institute of Health, National Institute of Drug Abuse, Grant No. 1K01DA057414-01A1. Professor Sarah Katz is Clinical Professor of Law, Temple University Beasley School of Law and Senior Fellow, Stoneleigh Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the Stoneleigh Foundation. The authors are grateful for the able research assistance of Anna Manu Fineanganofo, J.D. Expected, May 2025, Temple University Beasley School of Law.

Source: https://www.yalelawjournal.org/forum/deinstitutionalizing-family-separation-in-cases-of-parental-drug-use

by International Journal of Drug Policy – Volume 139, May 2025 – Brandon del Pozo et al.

Highlights
  • Studies show an association between police opioid seizures and fatal overdose.
  • This model presents physical and behavioral causes of this positive relationship.
  • Reducing the disruptive outcomes of police opioid seizures can reduce overdose.
  • Police opioid seizures can worsen the problem of overdose they intend to address.

Abstract

Context

Police seizures of illicit opioids remain a dominant strategy for addressing problematic substance use and overdose in the United States and throughout the world, yet qualitative accounts and quantitative analyses exhibit positive associations between police opioid seizures and ensuing risk of fatal overdose at the local level of individual incidents. Since these associations run counter to the commonly held belief that removing potent illicit substances from the community is protective of overdose, a causal model is needed to demonstrate this association and convey the overdose risks that follow from police opioid seizures.

Methods

Leveraging well-established biological and psychological outcomes of opioid use disorder and opioid supply interruption, our analysis presents the Police Opioid Seizure Temporal Risk (POSTeR) Model, an individual-level casual model that begins at the point of opioid dependence, introduces an interruption to an individual’s supply of opioids as the result of a police drug seizure, and presents the physical and behavioral outcomes that increase the ensuing temporal risk of fatal overdose.

Results

The aftermath of a police opioid seizure can increase a person’s risk of fatal overdose. The urgent need to prevent or reduce acute opioid withdrawal symptoms leads people to seek a replacement supply, while reduced opioid tolerance resulting from post-seizure involuntary abstinence combines with the uncertain potency of a replacement supply of illicit opioids to significantly increase the difficulty of administering a safe but effective dose. In the face of these hazards, people in withdrawal often have a reduced aversion to risk, prompting them to consume this uncertain dose in a manner that increases their exposure to overdose.

Conclusions

Strategies that emphasize police opioid seizures as an acceptable way to reduce the prevalence of illicit drugs in a community without accounting for the elevated risk of fatal overdose that results can worsen one of the most significant problems they are meant to address.

Introduction

A growing body of evidence shows that when a person is dependent on opioids, temporarily interrupting their supply of the drug exposes them to an increased risk of overdose (Hochstatter et al., 2023Mark & Parish, 2019Williams et al., 2020). The first studies about interruptions originating from police drug seizures explored this assertion qualitatively, finding that people problematically dependent on opioids reported this increased risk when asked about their personal experiences (Carroll et al., 2020Rhodes et al., 2019Victor et al., 2020). Conversely, these and other studies found people who use drugs (PWUD) with steady access to a supplier they could trust, who provided a basically consistent supply, could warn of inconsistencies, and who might supply naloxone, was protective of overdose (Carroll et al., 2020Hedden-Clayton et al., 2024). More recently, quantitative analyses have found a statistically significant spatiotemporal association between police opioid seizures and overdose during a multiyear periods in Indianapolis, Indiana (Ray et al., 2023), and San Francisco, California (Kral, et al., 2025). In accordance with studies that show ecological associations at the state and county levels (Cano et al., 2024), the analysis found that fatal overdoses doubled within three weeks of the police seizure, in a radius of up to 500 m from the seizure’s site, and this association held when considering all quantities of opioids seized, regardless of whether they were taken from a dealer or an individual who uses drugs (Ray et al., 2023).
Many people find the conclusion that police drug seizures increase overdose risk strongly counterintuitive, considering that governments act to interrupt the supply of illicit drugs to ostensibly reduce risk and save lives. To that end, the presumption is that reducing the quantity of illicit drugs in circulation and interrupting their consumption by people dependent on opioids is believed to reduce risk. But at least in the proximate sense, the evidence does not bear this presumption out. To address this gap between emerging research findings and many people’s intuitions, and to promote the rigorous interrogation of this proposition, this paper presents the discrete causal model by which increased exposure to overdose arises from the aftermath of a police drug seizure, a phenomenon that has critical implications for our present public health and drug enforcement policies. In doing so, it intends to bolster our understanding of the health outcomes of police drug enforcement and suggest ways to interrupt the causal chain to reduce overdose mortality. Barring such a model, the evidence we produce to explore this relationship will continue to face its inherent limitations. Qualitative research conveys the lived experience of increased exposure to overdose in the aftermath of police drug seizures with nuance, but the method inherently precludes broad generalizability. In contrast, quantitative analyses of administrative data can demonstrate statistically significant associations, but do not readily illuminate the causal pathways that suggest where to effectively intervene. Both veins of research would benefit from the development of a model that conveys how personal experience and quantitative correlation can be understood as causation. By presenting such a model here, this paper provides guidance about where future research on this topic should go, and what intervention designs might look like.
The model we present takes policing as its primary focus. It concerns the events that we commonly understand to be police drug seizures: the arrest of people for drug possession, the seizure of contraband drugs that people preemptively discard to avoid arrest by police, and the arrest of distributors and suppliers accompanied by the seizure of their drugs as evidence. It does not distinguish between the volume or target of the seizure; it could consist of the arrest of an individual person and the seizure of their own supply, or the seizure of a dealer one or more steps up the supply chain. The inclusion criteria for the model are only that opioids are seized by police, and in a manner that ultimately interrupts supply at an individual level. The model therefore operates at these lower geographic resolutions, during the relatively short time frames considered in Ray et al. (2023) and Kral et al. (2025), and does not intend to offer explanatory power across larger ecologies such as cities, counties, or states, or over longer periods of time.
The model here takes up overdose as the exclusive outcome of interest, although there is evidence that police drug seizures can increase the risk of other harms as well. In the aftermath of police contact, people may change the way they consume drugs, for example, speeding the act of injection or sharing syringes (Cooper et al., 2005Werb et al., 2008), thereby increasing the risk of abscess and infectious disease (Baker et al., 2020). To keep our causal model as direct and compelling as possible, these other outcomes will not be its focus. In the same vein, while the model here pertains to policing, and is not intended for general application across the criminal justice system. Release from a period of incarceration is a prime example of another event that substantially increases risk of overdose (Binswanger et al., 20112007), and researchers have presented the corresponding conceptual framework (Joudrey et al., 2019), while emphasizing the particular role of fentanyl in generating these overdoses (Brinkley-Rubinstein et al., 2018). We intend to complement this research with a pragmatic realist account (Cherryholmes, 1992) of overdose risks that occur upstream, at the point of police encounters, prior to a period of imprisonment. In its realist approach, our account asserts that prevalent scientific and behavioral theories accurately describe the aspects of the world they were created to explain (Leplin, 1984Psillos, 2005). We further assert that their individual explanatory mechanisms can combine to produce an accurate, predictive understanding of an overall phenomenon (Leplin, 1984), in this case, increased overdose risk after a police drug seizure. In this way, our approach is in the tradition of scientific realist evaluation (Pawson & Tilley, 1997), where outcomes arise from interactions between mechanisms and their social contexts, and causal mechanisms can be reliably identified through reductionist theorizing (Jagosh, 2020). The model’s pragmatism lies in providing insights and recommendations that acknowledge the current political and social contexts of substance use and policing.
The paper will proceed as follows: it will present widely accepted principles of pharmacology, accounts of how opioid dependency biologically influences the behavior of PWUD, and research about how both the mechanics and social dynamics of policing and substance use further affect these behaviors. Taken in sum, we will argue they combine to elevate overdose risk, and we will present these relationships in a graphical model, i.e., a causal diagram (Greenland & Brumback, 2002) entitled the Police Opioid Seizure Temporal Risk (POSTeR) Model. We close by discussing several policy responses to the risks the model presents, stressing that there are potential ways to mitigate overdose risks that result from seizures, although they vary in feasibility and acceptability given individual contexts and political climates. We then discuss POSTeR Model’s limitations and suggest avenues for further research.

Principles underlying overdose as a result of drug seizures

There are five factors that drive our model, each one an evidence-based premise that combines to increase fatal overdose risk when a personal drug supply is interrupted by a police drug seizure. They may present as contributory causes that are insufficient to decisively increase fatal overdose on their own, but that synthesize to do so. In that sense, they build on each other to produce increased risk. The principles are as follows:

  • 1)
    Supply interruption sends people who are physically dependent on opioids into withdrawal, and the most common outcome is that they will avoid or reduce the condition with a replacement supply of opioids (Frank et al., 2023Hall et al., 2024). Opioid dependence is defined by the physical experience of opioid withdrawal, its psychological toll, and the ways in which they guide and modify behavior (Pergolizzi Jr et al., 2020). The most common responses to the onset of opioid withdrawal are to avoid it, reduce it, or reverse it (Bardwell et al., 2021Frank et al., 2023Mateu-Gelabert et al., 2010), which sets the stage for the challenges presented by the other principles below. For many people, relief requires gaining access to a replacement supply of opioids (which could include treatment medications) or being forced to endure a period of detoxification that is, by all accounts, extremely painful and difficult to bear (Dunn et al., 2023Shah & Huecker, 2018). Its symptoms can last weeks (Ware & Dunn, 2023), and are potentially life-threatening (El-Sabawi, 2024), and therefore motivate strong survival behaviors. The idea that a person with problematic opioid dependence can detoxify by enduring a few days of discomfort reflects a deep misunderstanding of the physiological processes and changes to the body and brain that have occurred when a person is heavily dependent on opioids (Monroe & Radke, 2023). In response, some may attempt to manage the symptomatic presentations of their withdrawal by means such as benzodiazepines, sedatives, cannabis, or other substances, which may provide some relief to individual symptoms without alleviating withdrawal themselves, and which may present the additional risks discussed in Principle 5 below.
  • 2)
    Supply interruption reduces a person’s tolerance of opioids to a degree they cannot measure with precision, making dosing more hazardous. Withdrawal, in and of itself, is insufficient to elevate a person’s overdose risk. If a person were to know the dose necessary to alleviate it, and had reliable access to that dose, the resulting risk would be reduced. An initial challenge, therefore, is establishing a safe dose, since even short interruptions in the supply of opioids affect a person’s tolerance of the substance. As prolonged use generally increases tolerance, such that greater quantities are necessary to avoid withdrawal, produce a euphoric effect, or simply maintain bodily homeostasis (Dumas & Pollack, 2008Freye & Latasch, 2003), interruptions have the opposite effect (Kesten et al., 2022), which is why physicians may alter the dose of patients who use prescribed opioids if there is cause to believe they have diminished tolerance (Gökçınar et al., 2022Jeffery et al., 2020).
    It is critical to note, however, that several factors affect the actual loss of tolerance, from genetic predispositions to body composition (Byanyima et al., 2023Lötsch et al., 2004Na et al., 2024Wilder-Smith, 2005), preventing the precise measurement of this reduction. While these variables and a lack of research prevent accurate predictions about the tolerance lost by a particular person after a given period of time, the warnings provided to patients about resuming opioid use after discharge from inpatient detoxification advise that a potentially fatal loss of tolerance can occur within a few days (META PHI, 2024). In sum, when a person resumes consumption, it will be with a tolerance for opioids that is reduced by an uncertain amount, making dosing much more a matter of estimation than it would otherwise be.
  • 3)
    The replacement supply of illicitly produced opioids sought in the aftermath of a seizure event is likely to be of a different, uncertain potency than the interrupted one, further compounding the hazards of dosing. While an indeterminate reduction in tolerance prevents a person from gauging the dose necessary to safely and effectively address withdrawal symptoms, the replacement opioids procured in an illicit market compound this risk by being of an unknown potency regardless (Rosenblum et al., 2020). In saying this, it is critical to note that we do not mean the new supply is likely to be more potent. In presenting our model to nonspecialist audiences at practitioner-oriented conferences as an accompaniment to quantitative findings about the relationship between police opioid seizures and overdose, one misconception that frequently arose was that initial heroin supplies were replaced with a resupply of fentanyl. Our model does not depend on pharmaceutically produced opioids or heroin being replaced by fentanyl. Instead, it presumes that fentanyl has saturated the nation’s illicit opioid markets (Zoorob, 2019Zoorob et al., 2024), is what people who use illicit opioids are likely to consume, and what replacement supplies most likely consist of. The variability in potency that powers the model here arises from the heterogeneity in which illicit opioids are cut for distribution to the end user (Ivsins et al., 2020Larnder et al., 2022Tobias et al., 2021), and the unsuspected presence of fentanyl in counterfeit analgesic pills (Friedman & Ciccarone, 2025O’Donnell et al., 2023). Since illicit manufacturing and packaging processes are not carried out to any standard, or with reliable precision, barring the illicit consumption of pharmaceutically produced opioid analgesics, there will most likely be variance between the potency of an initial supply of illicit opioids and its replacement.
  • 4)
    People experiencing opioid withdrawal have a reduced aversion to risk, causing them to discount these hazards. Finally, while PWUD who use drugs often understand the preceding problems, the risks they pose are often insufficient to deter them from consuming replacement opioids, or doing so in a safer, more cautious manner (Hall et al., 2024). It is well-documented that the symptoms of opioid withdrawal range from extreme discomfort to acute pain and trauma (Bluthenthal et al., 2020). The motivation to reduce these symptoms is compelling, and can lead people to take risks solely for the need to escape the sensation of withdrawal (Frank et al., 2023). Such risks are wide-ranging, and while many do not apply to this model, they illustrate the powerful forces at work. For example, people may engage in criminal activity to obtain funds for drugs, patronize unfamiliar drug dealers with uncertain reputations, use replacement substances of unknown quality (perhaps using them by a new and unfamiliar route of administration), and engage in unprotected, risky sex work. In our model, however, we posit that one of the risks a person will be significantly less averse to is consuming a replacement opioid supply of an uncertain potency, and doing so in a more risky manner than if they were not experiencing withdrawal (Mateu-Gelabert et al., 2010), such as by rushing consumption, neglecting to test the dose for potency, or to ensure other people are present in the event of an emergency, preferably with naloxone on hand. In other words, not only is a person in these circumstances likely to encounter an uncertain replacement supply that will have an unknown interaction with their newly-reduced tolerance, but they will be less averse to consuming it regardless, and to doing so with few or reduced protective measures, even if they are aware of the attendant risks.
  • 5)
    Efforts at self-medication after a police opioid seizure can also increase risk of overdose. If a person loses their supply of opioids and begins to experience withdrawal, other factors may contribute to their overall overdose risk in addition to ones directly tied to a sequence of withdrawal, loss of tolerance, replacement supplies of uncertain potency, and reduced aversion to risk. For example, people may seek sedatives or other substances to alleviate symptoms until they can resume opioid use or fully detoxify, such as by taking prescribed or illicit benzodiazepines or kratom (Boyer et al., 2008Preiss et al., 2022). This alternative poses its own set of risks. Benzodiazepines compound the respiratory depression of opioids, and can cause overdose if they are consumed together or in close succession (Sun et al., 2017). Moreover, the illicit market for sedatives has been heavily compromised by counterfeit pills (Friedman & Ciccarone, 2025), introducing the dangers of uncertain dosing discussed above (O’Donnell et al., 2023).
There is also an ancillary factor that plays a role in the model: the margin of error for correctly dosing fentanyl and other powerful synthetic opioids is very small. The challenge of safely dosing illicitly-supplied fentanyl is driving the present wave of the nation’s overdose epidemic (Zoorob, 2019Zoorob et al., 2024), since a comparatively small difference in the volume of this powerful synthetic in a given dose, or its presence in other substances, can spell the difference between safe use and overdose for many consumers. Not only does dosing vary by supply source, merchant, and batch (given the ad-hoc means of preparing and packaging drugs for smuggling and consumption), but for any unit of difference in the amount of opioid in a supply, the dose is going to be much more potent if it is a unit of fentanyl than some type of less potent alternative. We consider this an ancillary factor because the model suggests people whose supply of illicit opioids are interrupted by a police seizure will suffer an increased risk of fatal overdose regardless of the type of opioid involved. Rather, highly potent synthetic opioids such as fentanyl greatly increase the magnitude of this risk because any given unit of inconsistency represents a much greater variance in potency than the variance per unit found in heroin or pharmaceutically produced analgesic pills.

The causal model

The POSTeR Model proceeds through the eleven parts presented in Fig. 1 as follows. The figure’s solid arrows represent causal relationships with no alternatives in the model, and the dotted arrows represent possible branches. Green arrows signal ways to lower risk, and red signals a pathway to elevated risk. The underlying principles presented above appear in the figure both when they first manifest, and then when they combine to ultimately produce elevated overdose risk.

Fig. 1. The Police Opioid Seizure Temporal Risk (POSTeR) Model of increased exposure to fatal overdose.

Parts 1 through 4 present the basic stasis of consistent supply for people who have transitioned from opioid use to a state of dependence. A person with opioid dependence (1) exhibits increasing physical and psychological dependence on opioids (2), as well as an increasing pharmacological tolerance for the effects of the drug (2). As their tolerance increases, the general consistency of their supply (3) allows them to adjust their dose accordingly. There is still risk to this behavior, including instances of polydrug use that can introduce unpredictable variables (Peppin et al., 2020) and the inherent instability of an illicit drug supply (Holland et al., 2024), but this general consistency in comparison to a seizure event means that the person’s opioid supply is not exceedingly difficult to dose as needed, thereby reducing overdose risk (Carroll et al., 2020). Overdose may still occur, but these protective factors make it less likely to be fatal (4), or imprecise dosing may not be sufficient to alleviate withdrawal and lead to the risks that arise from repeat dosing (4). The result is the continued cycle of opioid dependence as described above, which can last for years or decades. People may exit this cycle over time, in which case they would leave the model by completing the withdrawal period and not re-initiating use, or by entering treatment (5). It is worth noting most people who are dependent on opioids do not fatally overdose (Degenhardt et al., 2011), can age out of problematic use (Jones et al., 2020Kelly et al., 2017), may contend with intermittent cycles of substance use and recovery over the course of years or decades (Hser et al., 20012015), and may enter remission of their own accord (Mocenni et al., 2019).
For the person actively dependent on opioids, the path toward an elevated exposure to fatal overdose begins with the type of supply interruption that results from a police opioid seizure (6). The interruption could be the result of an arrest of the person, or their supplier; either event deprives the person of the opioids necessary to maintain their cycle of use and suffices to bring about the physical effects of involuntary abstinence: withdrawal and decreased tolerance (7). These effects produce efforts to avoid withdrawal with a new opioid supply or self-manage it using sedatives or cannabis combined with reduced aversion to the risks associated with consuming these substances (8). The result is seeking a replacement substance of uncertain potency, especially if it is from a new dealer, although this variance is ultimately dependent on the structure and sources of the community’s drug supply network (9). Consuming the replacement supply constitutes an elevated hazard because it occurs at the nexus of two risk factors and a catalyst: a reduced but indeterminate tolerance to opioids, an uncertain potency that precludes accurate dosing (compounded by not knowing what that dose should be in light of lowered tolerance), and the reduced aversion to risk that comes with avoiding or escaping opioid withdrawal (10). This reduced aversion means that even if a person apprehends the pending hazards, they will disregard them, and/or engage in the additional risk behaviors described in the next section. This results in a significantly increased exposure to the risk of fatal overdose (11).
At any point in the model, a person can attempt to enter treatment, and if it was effective, they would leave this causal pathway. A return to use, however, will place them back in the pathway at (9), facing overdose risk. While many factors motivate a person’s return to use, from social pressures to trauma, pain, stress, and deeply-ingrained triggers (Childress et al., 1988Dennis, 2016Massaly et al., 2016), the decision necessarily indicates they have become less averse to the risks of opioid misuse. Since their new drug supply will be of an unknown potency, and their tolerance will be significantly reduced by some indeterminate amount, it may affect them in unknown ways. This accords with research that a return to use after a period of abstinence poses an elevated risk of overdose compared to the risks a person faced if they were consistently supplied when they were dependent on opioids (Hser et al., 2015Kumar 2016). The model as related here is therefore neither directed, nor acyclic. People can remain in a basic stasis given a consistent supply of opioids, although escalating frequency and volume of use as dependence and tolerance increase, and treatment can either remove them from the cycle entirely, or, with a nonfatal relapse, can return them to the provisional stasis expressed by steps (1) through (4) of the model.

Other behavioral responses to police drug seizures

Our model is principally driven by physiological factors. For example, reduced aversion to risk arises from the need to limit acute physical withdrawal symptoms. There are other behavioral factors, however, that emerge from a risk calculus that is not driven by biological and pharmacological concerns but instead result from decisions meant to reduce the probability of additional supply interruptions by police, or tactics to quickly reduce or reverse withdrawal that constitute riskier behaviors. We describe five of them here and note in step (10) that they fit our model as additional causes of risk at the point of consumption that compound those arising from the causal process described above.

  • Use in private places. In order to avoid the attention of police, especially when a prior seizure was the result consuming drugs in public, people who use drugs may shift to doing in more secluded or private places, such as indoors, in tents, or in vehicles. Using in private spaces decreases the likelihood that someone who is overdosing will be discovered and revived in time to avert death or irreversible injury.
  • Using alone. Regardless of whether the person is using in public or not, solitary use increases the risk of fatal overdose. Many people consume drugs alone to protect themselves from exposure to police or to limit their visibility to other people, who may call police or otherwise express the stigma associated with drug use (Hanoa et al., 2024). When someone is in withdrawal, using alone rather than seeking out trusted people who can observe the results may be a response to the need for rapid abatement of physical symptoms, which can increase such risk-taking behavior (Rosen et al., 2023).
  • Electing not to keep naloxone on hand. PWUD and their associates may believe carrying naloxone elevates the suspicion of police and may increase the risk of a seizure (Bennett et al., 2020Smyth, 2017). If that is the case, PWUD may elect not to have it on hand in the hopes of averting seizures, creating the risk that it will not be available to avert a fatal overdose.
  • Rushed consumption. If a person believes they have no option but to consume drugs in public, but a prior seizure leads them to fear police intervention, they may rush the process of consumption (Suen et al., 2022Ti et al., 2015), which runs counter to the harm reduction adage of “start low, go slow” (Aleixo et al., 2024Collins et al., 2024). When consuming a new supply of drugs, a user can test a small quantity of the substance and then adjust the dose as its potency becomes clear, but rushed consumption increases risk as people use a larger amount sooner, either to avoid arrest or to abate withdrawal.
  • Hesitance to seek help for an overdose. People present at the scene of an overdose may be hesitant to seek help if it ultimately means calling 9–1–1, for fear that police will respond and make arrests (Weisenthal et al., 2022). People in recent contact with police that resulted in a drug seizure may likewise hesitate to seek help when they witness an overdose or call 9–1–1 if they witness one, out of the fear of arrest and another drug seizure (Byles et al., 2024van der Meulen et al., 2021). This may lead them to hope the overdose passes without turning fatal rather than try to reverse it. When they do call, people may downplay or obscure the fact that an overdose emergency is occurring (Atkins et al., 2024). Although this may result in medical personnel being dispatched without police, it may also delay the administration of naloxone of police officers who were poised to arrive first (Pourtaher et al., 2022White et al., 2022), elevating the risk of death or serious morbidities.

Implications for policy and practice

The POSTeR Model allows us to examine the points at which overdose risk can be averted or reduced. We present them along a general arc from the interventions that are likely to be the most feasible and acceptable given the present policy environment to the ones that would require more significant shifts in norms, laws, and culture, with the interventions requiring the most significant shifts likely to be the ones that offer the greatest potential to reduce the overdose risks described by this model. In sum, these interventions work by either preventing the move from risky use (10) to fatal overdose (11) by shunting people back toward a comparatively safer stasis or better equipping them with safer supplies (1–4) by referring them to medications to treat opioid dependence (5), or moving further upstream and preventing disruptive supply interruptions (6) in the first place, promoting the ability of people with opioid dependence to consume drugs with a greater level of consistency prior to entering treatment (5), which is in and of itself a possible intervention. Another possibility, as discussed above, is that a person may eventually desist from substance use over time (Jones et al., 2020Kelly et al., 2017), an outcome common to many problematic social behaviors (Sampson & Laub, 1993), since most people with opioid dependence do not fatally overdose (Degenhardt et al., 2019). Given this approach, the following are possible changes to policy and practice that would prevent, interrupt, or reduce overdose risk related to opioid seizures.

Cautionary publicity about police drug seizures, especially notable incidents

Official acknowledgement that police drug seizures can increase risk of overdose would alert people dependent on opioids to the impending hazards and empower them to better manage the risks. Such an acknowledgment could also pave the way for warnings about particularly notable seizure incidents. For example, public officials in Manchester, New Hampshire issued a warning to the community that police had made a significant high-level drug seizure, and deployed overdose response teams to the area concerned as a protective measure, emphasizing both harm reduction measures and linkages to MOUD (Barndollar, 2023McFadden, 2023). In doing so, they explicitly cited the Ray et al. (2023) study that associated police drug enforcement with increased overdose. Such public measures remain rare, however, since they hinge on the still counterintuitive recognition that police drug seizures, despite the goal of reducing harm, can have the proximate effect of increasing them.

Linkage to MOUD

Linking people with opioid dependence to the medications that can effectively treat it interrupts the pathway to overdose by removing the risks associated with consuming illicit opioids of any potency (National Academies of Sciences Engineering & Medicine, 2019). In our model, it forecloses overdose risk by statically positioning the person at step (5). It does not, however, address the risks faced by people who are pre-contemplative about treatment and seek a replacement supply as withdrawal sets in, which will be most of the population of concern at any given time. Moreover, as our model reflects, relapse from treatment back to substance use places a person at elevated risk by moving them through the model to (10), as a person will resume substance use with a supply of unknown potency and a diminished but unknown tolerance as discussed above. Linkage to MOUD also requires that there be sufficient and immediate access to medications in the aftermath of a seizure.
Despite these limitations, linkage to MOUD in the aftermath of a police drug seizure will remain an appealing policy option because it is the least contested and controversial response: it signals a person’s efforts to make a decisive change in their own exposure to overdose risk that is less susceptible to the stigma and biases that typically accompany harm reduction efforts and legal reforms. Despite this appeal, as a response that intends to prevent overdose and save lives, linkage to MOUD will not offer protection to most people whose drug supply is interrupted by a police opioid seizure. Even the most robust, low-barrier linkages to MOUD will only impact people who actively seek out the medication or choose to engage with the treatment that is offered to them. This is a small minority of the at-risk population of PWUD at any time, most of whom are not contemplating treatment and would not accept MOUD if it were offered to them.
Because successful engagement with MOUD requires a change in behaviors entrenched by habits and biological dependence, assessing where an intervention offers its protections among the Stages of Change (Norcross et al., 2011Prochaska & Norcross, 2001) can clarify the subpopulation of PWUD it is most likely to reach, and help assess the collective reach of an array of measures. By such an analysis, MOUD does not reach people in a state of precontemplation, i.e., the majority of PWUD at a given time (Mann, 2023Patton & Best, 2024). As illustrated in Fig. 2, the interventions below are more likely to fill the resulting gap by offering protection from overdose prior to a decision to change drug consumption habits or enter recovery. It suggests the most effective lifesaving response is a comprehensive one.

Fig. 2. Interventions to prevent overdose in the aftermath of a police drug seizure mapped onto the Stages of Change.

Community naloxone distribution

While the distribution of naloxone to lay persons in the community for the purposes of overdose reversal has gained increasing political and cultural acceptance, its success depends on saturating at risk communities with a quantity of naloxone substantial enough to be used in a meaningful number of overdose events. Success in this regard would require a large, sustained investment in naloxone programs targeted to PWUD and the people who are present with them when they consume drugs (Doe-Simkins & Wheeler, 2025). At the individual level, community naloxone distribution would interrupt the model when two conditions are satisfied: a person uses drugs in the presence of someone who abstains from risky drug use or coordinates their own use to prevent simultaneous overdose, and that person has access to, or can feasibly summon a bystander with naloxone. Meeting these two conditions, moves people from instances of dangerous use (10) back toward stasis (1–4). Given Ray et al. (2023)’s findings that overdoses increase withing 500 m of a seizure event over the following weeks, the targeted distribution of community naloxone in the aftermath of a seizure could be particularly effective.

Access to harm reduction services and education

Harm reduction interventions would directly supply people dependent on opioids with naloxone and the knowledge necessary for its effective administration, in doing so reducing risk among people well prior to the point of substantial change in their drug use behavior (see Fig. 2). As people in drug-using communities facing greatly elevated overdose risks, this manner of naloxone distribution has the potential to be more effective than widespread distribution or distribution to first responders (Townsend et al., 2020) by making the medication more likely to be present at the times and places where overdose occur, especially if PWUD are more likely to consume drugs together, rather than in the presence of non-using community members. Harm reduction services can also offer education and training about the importance of “going slow” (i.e., not rushing consumption), and not consuming drugs alone, while innovative measures include prescribing medications such as single-dose buprenorphine (Ahmadi et al., 20182020) or using cannabis or sedatives as a temporary form of withdrawal support (Meacham et al., 2022Wiese & Wilson-Poe, 2018), thereby reducing the risks that come with withdrawal-motivated behaviors. Together, these interventions can reduce the probability that a person proceeds from step (10) of the model to fatal overdose (11) by shunting them back toward comparative stasis (1–4), and decreasing the incidence of other risky behaviors that can occur after a seizure discussed above. Harm reduction services can also provide people dependent on opioids with linkage to treatment (5).

Drug checking services

Analyses of the composition of drugs performed by community drug checking programs can likewise reduce overdose risk by providing reliable information about what a replacement substance may contain Green et al. (2022).They may be especially useful if a person resorts to a replacement substance such as opioid pills, or non-opioids such as benzodiazepines for the purposes of managing withdrawal symptoms before resupply, both of which are likely to be counterfeit and contain unpredictable amounts of fentanyl. As with other harm reduction services, the knowledge gained from drug checking could be leveraged to promote safer use behaviors, which can move people from steps (10) to steps (1–4) rather than (11), providing protection not only in cases if uncertain potency, but when PWUD utilize other substances to try to mitigate the effects of withdrawal.

Overdose prevention centers

Places where people consume drugs under supervision and are revived if they overdose, offer the potential to eliminate the risk of fatal overdose after a person with a reduced, uncertain tolerance uses drugs of uncertain potency. As with other harm reduction services, the user is fully exposed to the risks of supply interruption as a result of seizure (10) but mitigates them by preventing what would otherwise be a fatal overdose (11) either through an effective reversal, or preventive measures, moving the person to point (4) in the model. Similar efforts may also reduce risk through remote observation, such as via phone, app, biometric sensors, or motion detectors (Lombardi et al., 2023).

Decriminalization of drug possession

Attempted in Oregon 2021 and subsequently reversed in 2024, decriminalization could partially mitigate the hazards of a supply interruption (6) for people dependent on opioids. It would do so by preventing or limiting the duration of the supply interruptions that occur when PWUD are arrested for possession and detained or possibly incarcerated, which are associated with increased risk of overdose (Victor et al., 2022Zhang et al., 2022). It would not, however, prevent the interruptions that come from the apprehension of drug sellers and the seizure of their inventory, since the law did not decriminalize the distribution of drugs. In this way, successful decriminalization programs that still enforce laws against drug dealing like the one implemented in Portugal would not eliminate the risks of our model. Rather, they would lessen incidence of personal drug seizures, and the duration of supply interruptions from incarceration, thereby lessening symptoms of withdrawal and reductions in tolerance (7). The Portuguese system of decriminalization also offers immediate, no-cost linkage to medications that treat opioid dependence (5), lowering the risks of a supply interruption through that pathway as well (Laqueur, 2015Rego et al., 2021). The very low rate of overdose in Portugal, where heroin rather than fentanyl remains the principal source of illicit opioids, may support the hypothesis that the severity of the overdose risk described by our model is greatly increased by fentanyl’s potency, and small margin of error in dosing.

Safer supply

The consistent and uninterrupted provision of opioids of known potency to people with opioid dependence, such as analgesics or pharmaceutically manufactured heroin Ivsins et al. (2020), could limit overdose by keeping people in comparative stasis (1–4) rather than subjecting them to supply interruptions (6). While some Canadian jurisdictions have embarked on such an initiative (Young et al., 2022), the programs have high barriers for enrollment, serve small numbers of clients, and have faced implementation hurdles (Karamouzian et al., 2023), limiting their ability to reduce the overdose risk resulting from drug seizures in the larger population. The rationale for safer supply also suggests that our model may see fewer overdoses if the illicit opioids were the pharmaceutically produced analgesics that were the origin of the present opioid epidemic, although erratically dosed counterfeit pills, which have proliferated throughout the illicit opioid market (Friedman & Ciccarone, 2025Green et al., 2022), would likely confound such a reduction.

Legalization and regulation

As with safer supply, legalization and regulation would bring the manufacture of recreationally used opioids under a regime that would closely monitor their consistency and potency and provide a means for commercial distribution that would preclude dealer-related supply interruptions. This would do two things: prevent the supply interruptions arising from police drug seizures in the first place (6) and ensure that the drugs consumed by people were regulated to the extent that their potency was consistent and well-known, regardless of whether a user experiences some type of interrupted supply or not (3 or 9).
Legalization, especially when accompanied by safer supply practices, would also likely lessen the circumstances in which people experienced withdrawal and reductions in tolerance due to extended supply interruptions (7), providing several means to escape the causal pathway from a supply interruption to fatal overdose (Emerson & Haden, 2021). It would also likely decrease the frequency of several other behaviors that contribute to overdose risk, such as rushed use, clandestine use, and variance across suppliers and between batches. Regardless of the theoretical effectiveness of this measure, it is critical to note that all of this is said without regard to the political reality that legalization is currently the least likely of the drug policy interventions discussed here to be implemented, due to a pronounced lack of political and cultural acceptance of the idea.

Discussion

The extent to which police drug seizures impact the broader community in terms of the availability and consistency of the drug supply is ultimately unknown, likely to be highly dependent on local contexts, and deserves further study. We do know, however, that police opioid seizures certainly affect the person the drugs are taken from, and their direct connections, and our model explains the elevated overdose risk that results. The strength of the POSTeR Model lies in its reliance on well-known features of opioid dependence and withdrawal, and a well-established understanding of certain basic mechanics of the illicit drug market. That people who consistently consume opioids will experience increasingly acute dependence and greater tolerance is not open to debate, and neither is the intense desire—or physiological need—for people dependent on opioids to avoid or mitigate withdrawal, which is a known motivator of risky behavior (Frank et al., 2023). The same can be said of the decreased opioid tolerance that comes from abstinence, whether voluntary or involuntary. The inconsistency in the potency and contents of the illicit drug supply in the case of heroin and fentanyl are also well-established, which underlies the main argument for safer supply initiatives (Ivsins et al., 2020).
In showing how these factors come together, the model moves from anecdotal accounts and quantitative research to a logic model that illustrates the causal chain between a drug seizure, the ensuing supply interruption, and increased exposure to overdose, underwriting our prior spatiotemporal analysis of the association between the two. If the four premises presented at the outset of this paper are correct, then they are sufficient to establish the validity of the model. It is important to recall that this validity does not depend on an actual increase in fatal overdose, but an increase in its risk, which can then be reduced by taking the appropriate precautions. We posit that many fatal overdoses occur because the desire to avoid withdrawal in the aftermath of a supply interruption is very strong, and often the reason people do not take the recommended precautions. The behavioral factors presented after the formal model further exacerbate this risk, but it does not depend on them for its validity.
Despite such strengths, our model has limitations that call for both caution and further research. Although it is an ancillary aspect of or model, we do not know how much of an elevated overdose risk can be attributed a general variance in the composition of the opioid supply, versus a variance in the composition of the fentanyl supply in particular, where small changes can yield comparably large increases in potency. The makeshift production processes employed by the illicit market, which can take place in private residences and other crude, repurposed spaces, is far removed from a proper pharmaceutical manufacturing operation, resulting in variance in the volume of the active opioid per dose. We hypothesize that compared to pharmaceutically produced and heroin-based opioids, powerful illicitly packaged synthetics such as fentanyl are inherently more difficult to safely dose, since even the smallest variations in the volume of the active opioid could yield great differences in potency.
It is also worth noting that the POSTeR Model only considers the near-term spatiotemporal effects of police drug seizures. The research findings that motivated this model considered overdose up to three weeks after a police drug seizure (Ray et al., 2023), and POSTeR Model is meant to provide a causal explanation for events on this time horizon. It does not examine the long-term effects of drug seizures on a community, especially large ones that might have a more significant impact on the drug market. So, while we are unaware of any police drug seizure that was significant enough to have a durable effect on the price and/or availability of illicit drugs in the US, our model is not meant to describe mid- to long-term effects. It therefore cannot rule out the possibility that drug seizures of a size and type sufficient to cause a sustained supply shortage may foreclose the induction of new drug users, or promote treatment seeking among existing users, therefore lowering the community’s overall rate of opioid dependence, or the extent to which this may offset the negative effects we describe here at the population level. Given the constant occurrence of police drug seizures across the nation, and the persistence and worsening of the overdose crisis, we would hypothesize this population level effect is minimal in comparison to the elevated risk of overdose.
Relatedly, as a model that draws on data from urban centers, it is unclear how the overdose risks it produces could be exacerbated or reduced by seizures in rural areas which may pose unique concerns (Dunn et al., 2016). The considerably greater distances and smaller populations involved in rural illicit drug distribution may matter (Fadanelli et al., 2020), as may economic precarity, which can limit options for replacement supplies (Pear et al., 2019). They could relate to longer timeframes for resupply that increase withdrawal symptoms with reduced access to harm reduction resources, or it may increase the likelihood that a replacement substance comes from a different supply chain with an inherently different or more volatile potency. Conversely, the tight-knit nature of small rural populations may yield more transparency and trust across dealer networks. More research is necessary to understand how geography affects the model.
Another limitation to the POSTeR Model is that it describes the effects of a supply interruption at the individual level, which can be caused by either a direct encounter with a police officer that results in an arrest of the PWUD, or the police takedown of a distributor who supplies a significant number of people in the community. In either case, the logic of the model is identical, and indicates an increase in overdose risk, but it does not distinguish between the intensity, duration, and breadth of the risk in different cases. It also does not distinguish how the risk is experienced by individuals in different ways, such as sex workers, unhoused people, or those with the financial resources or networks of trusted dealers that may better insulate them from supply interruptions. While these differences should be researched to further refine the model, one of its strengths may be its versatility across cases and populations. That said, the POSTeR Model does not account for the complexities of polysubstance use, i.e., the co-use of depressants and stimulants, or of different drug types within each class. Polysubstance use, which is increasingly common among people who use opioids (Cicero et al., 2020Lim et al., 2021), can exacerbate overdose risks (Pergolizzi Jr et al., 2021), and our model does not account for these interaction effects.
Critically, this analysis does not adjudicate the competing priorities that drive narcotics enforcement and police drug seizures in many communities. There may be reasons for enforcement and the accompanying seizures that communities and their elected officials find compelling despite their iatrogenic effects. For example, police seizures might provide a way to reduce serious violence among drug suppliers, or a drug selling operation may have a significant negative impact on the public order of a neighborhood, and there is a strong desire among community members for the police to reduce or eliminate it. The role of policies and laws in addressing these issues—or failing to do so—is complex and far beyond the scope of this paper. What our model does do, however, is suggest that there may be serious negative health outcomes associated with law enforcement to address these concerns, even though the approach may have community support, and be culturally ingrained in our approach to problematic substance use. If that is the case, it is incumbent upon communities to account for these outcomes. It is counter-intuitive that drug seizures can increase overdose risk, making the public’s recalcitrance is understandable, so the causal model discussed here may offer a critical means to foster a public understanding that could shape future support for evidence-based drug policy proposals.
The fact that policing routinely creates conditions sufficient for fatal overdose, and that they occur with considerable frequency, suggests the proposed model is a critical component of understanding how policing exacerbates the health risks faced by people with opioid dependence. In doing so, it demonstrates a significant tension between the police role of protection and rescue, in which they are expected to prioritize the sanctity of human life in a manner broadly consistent with public health (del Pozo, 2022Goulka et al., 2021), and the potentially fatal risks generated by their principal strategy for addressing problematic substance use.

Conclusion

The POSTeR Model contributes to the body of knowledge about how criminal justice interventions intended to address the effects of addiction and overdose can have iatrogenic consequences that worsen health outcomes of people dependent on opioids. It is a problem that manifests across the criminal justice system. In the case of imprisonment, for example, the moral consequences of punishment are meant to be complemented by a period of detoxification and abstinence intended to promote recovery. Despite the underleveraged potential for evidence-based treatment to lessen these risks (Berk et al., 2022), this type of forced abstinence is neither effective nor safe for the people it is imposed on: release from jail or prison is believed to be one of the highest periods of overdose risk for people dependent on opioids (Binswanger et al., 20132007). By the account here, the drug seizures by police that precede incarceration, whether they are from an individual who possesses drugs for personal use or someone with large quantities intended for distribution, comprise another mechanism that can increase fatal overdose despite being intended to reduce it. It is critical that future research continues to explore this outcome, assesses its prevalence across settings, estimates the magnitude of the effect, discerns which variables are protect against risk, and brings greater clarity to the risks imposed at the individual and community levels. While it is possible that police view the reduction in supply that results from drug seizures as prima facie evidence of a successful outcome, this model and the accompanying research suggest this is not the case if a reduced supply is meant to deliver the proximate public health goal of mortality reduction.
If research continues to exhibit a positive relationship between seizures and overdose, legalization and regulation of opioids would broadly incentivize the drug market to reduce or eliminate products of uncertain potency, decisively lowering the overdose risks resulting from uncertain dosing, as well as moderate the risky behaviors that result from the fear of drug seizures. Legalization, however, has yet to be even a remotely feasible political possibility in the United States, as nascent efforts at more modest forms of decriminalization were met with resistance, implemented poorly, and eventually repealed (del Pozo, 2024Kim, 2024Smiley-McDonald et al., 2023). It is likely that police drug seizures will remain a core feature of our response to illicit substances, and that such enforcement efforts will intensify, as the criminal enforcement of drug possession holds perpetual appeal in communities that hope it will reduce risk. To safeguard health, it is critical that we understand the full range of consequences for these and other policies based on police drug seizures.

Declaration of competing interest

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:
Brandon del Pozo reports financial support was provided by National Institute on Drug Abuse. Traci Green reports financial support was provided by NIH National Institute of General Medical Sciences. Bradley Ray reports was provided by Centers for Disease Control and Prevention. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Source: https://www.sciencedirect.com/science/article/pii/S095539592500088X

by United Nations – Office on Drugs and Crime – April 3rd 2025

The United Nations Office on Drugs and Crime (UNODC) recently developed Friends in Focus, a new youth-based peer-to-peer drug prevention programme that aims to meaningfully involve young people in prevention efforts. It was peer-reviewed by a global group of experts in the field of prevention, together with youth from the UNODC Youth Initiative. Starting in 2025, UNODC is prototyping the new programme by engaging with youths and local stakeholders from various countries. Building on its recent launch of the first pre-pilot conducted in Serbia (Empowering Serbian Youth to Lead in Prevention: First Pre-Pilot Implementation of UNODC’s Friends in Focus), UNODC also initiated the second pre-pilot testing of the new programme in Italy last week. From 25 to 27 March 2025, youths from northern Italy came together to receive a 3-day Training of Trainers workshop in Arco (Trentino), Italy.

made possible with the support of the government of Italy, this Phase 1 (Training of Trainers) brought together 18 youths eager to learn about Friends in Focus, its content, and facilitation techniques for their own delivery of sessions to their younger peers. Youths from various territories of Trentino, Parma and Lombardia gathered to learn about preventative thinking, understand the risk and protective factors to drug use, and reflect how group dynamics play a role on peer selection processes and peer influence regarding substance use. And through try-out sessions, they also directly experienced their role as future youth facilitators with the preparation and delivery of the mock sessions, giving each other feedback and examining trainer-trainee dynamics.

With the understanding and skills acquired through the three-day training, youth trainers will return to their hometowns to begin their own implementation of Friends in Focus with the support of the national coordinating team and partner organisations that are supporting this pre-pilot phase. In particular, a wide range of partners, including regional governments, municipalities, public welfare entities, non-profit organizations, social cooperative organizations, and local initiatives, came together to embrace the new programme into the region during this pre-pilot, in order to support the youth trainers and peers through the 6 sessions of Friends in Focus and beyond. This unique infrastructure, characterized by a multi-stakeholder approach, exemplifies the value of enhanced inter-regional collaboration and maximized sustainability. Local authorities and community-based organizations are integrating Friends in Focus into their communities, showcasing a commitment to fostering positive change, building resilience among youth, and supporting community development.

The motivation, reflections, and dynamic energy seen through the Training of Trainers demonstrated how participants resonated with the core messages and also discovered how interactive games could be transformed into insightful reflections on real-life scenarios. In addition to the feedback received on the 3-day training, further insights from the youths’ cascade trainings will feed into the enhancement process of the Friends in Focus prototype.

For more information about Friends in Focus, please click on the following:

Source: United Nations – Office on Drugs and Crime

 

 

 

The Administration will focus on six key areas in its first year

Today, the White House Office of National Drug Control Policy (ONDCP) is announcing the release of the Trump Administration’s Drug Policy Priorities, a comprehensive and coordinated blueprint to reduce the devastating impact of illicit drugs on American society. The Statement lays out the urgent, first-year steps that must be taken to address the scourge of illicit drug use that continues plaguing our nation and taking American lives. The implementation of these priorities will complement President Trump’s tireless efforts to stop Foreign Terrorist Organizations, cartels, and drug traffickers from harming Americans, and will help build a safer, healthier future for America.

In the next year, the White House will work across the government to implement the following six priorities:

  1. Reduce the Number of Overdose Fatalities, with a Focus on Fentanyl
  2. Secure the Global Supply Chain Against Drug Trafficking
  3. Stop the Flow of Drugs Across our Borders and into Our Communities
  4. Prevent Drug Use Before It Starts
  5. Provide Treatment That Leads to Long-Term Recovery
  6. Innovate in Research and Data to Support Drug Control Strategies

“Terrorists, cartels, and other drug traffickers are taking hundreds of thousands of American lives by poisoning them for profit,” said Jon Rice, the ONDCP Senior Official Performing the Duties of the Director. “To meet the urgent need of this moment, the Trump Administration is launching an unprecedented whole-of-government effort to stop these drugs from entering our communities and hold drug traffickers accountable. The priorities in this framework outline the first steps to kick cartels out of our country, free Americans from the deadly grip of addiction, and guide America back to health and safety.”

To achieve our vision of a safer, healthier future for Americans, we will disrupt the supply chain from tooth to tail. We will continue to take decisive action and exploit all existing authorities, both punitive and economic, to eliminate the production and distribution networks that allow these drugs to reach the United States. We will develop bold policy choices, employ innovative and sophisticated technology, and create a skilled, recovery-ready workforce to combat this crisis and ensure the safety of all Americans. Domestically, we must acknowledge the complexity of substance use disorder and addiction. The statistics surrounding drug use and overdose deaths mandate a comprehensive approach that emphasizes drug use prevention and increases access to recovery and overdose prevention and reversal services. Recognizing that a sustainable solution requires coordination across all levels of government, we will collaborate with law enforcement, first responders, healthcare providers, community-based organizations, and individuals to ensure the health and well-being of all Americans.

The staggering loss of life caused by illicit drugs underscores the severity of the challenge, but the Trump Administration has already taken critical steps to confront this crisis through a series of Executive Orders that secure our borders, combat foreign terrorist organizations and drug trafficking organizations, and demand reform by source countries from which illicit drugs and precursor chemicals flow into the United States. Critically, the Trump Administration will identify and hold accountable those responsible for exacerbating the flow of drugs within our borders.

While these Policy Priorities outline the broad areas of effort for the first year, the President’s drug control policy will evolve to keep pace with the changing landscape of illicit drug trafficking and ensure that our borders, communities, and schools are secure from the destructive influence of illicit drugs.

Source: https://www.whitehouse.gov/articles/2025/04/7856/

Filed under: Political Sector,USA :

by Rodielon Putol – Earth.com staff writer – 04-06-2025

Nitrous oxide, better known as laughing gas, is making headlines for all the wrong reasons. Despite warnings from the Food and Drug Administration (FDA), more people across the U.S. are misusing the substance – often with tragic results.

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Once a common feature in dental offices and whipped cream canisters, this gas is now tied to a sharp increase in poisonings, hospitalizations, and even deaths.

Researchers from the University of Mississippi and the University of Illinois at Urbana-Champaign are investigating this growing trend, sounding the alarm about its risks.

“This is a chemical that is commonly used as a sedative or anesthetic, but what we’re seeing is a rise in recreational use,” said Andrew Yockey, University of Mississippi assistant professor of public health.

“But what we’re also seeing is also a rise in hospitalizations, in poisonings and in deaths.”

Nitrous oxide deaths are doubling

According to the 2023 National Survey on Drug Use and Health, over 13 million Americans have misused nitrous oxide at some point in their lives.

And the Centers for Disease Control and Prevention (CDC) reports that deaths from nitrous oxide poisoning have more than doubled – rising over 110% between 2019 and 2023.

While the number of deaths remains relatively low compared to other drugs, the speed of the increase is cause for concern.

“The preliminary findings of our study are that deaths have remained fairly small compared to other dangerous substances,” said Rachel Hoopsick, assistant professor of health and kinesiology at the University of Illinois at Urbana-Champaign.

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“But what we’re seeing is that over the last couple of years, those rates have increased exponentially. At that continued rate, we could be looking at a much larger problem.”

Why nitrous oxide slips under the radar

Whippets – another name for nitrous oxide canisters – have long been used for a quick, euphoric high.

But the side effects are no joke. The FDA warns that repeated inhalation can lead to brain damage, frostbite, numbness, blood clots, and even paralysis.

Despite these warnings, the gas remains widely accessible and largely unregulated.

Unlike many controlled substances, nitrous oxide is easy to buy online or at local shops. A simple search brings up brightly packaged, flavored options – clearly designed to catch the attention of younger audiences.

“Think back to big tobacco; they deliberately targeted young people with cartoons, fun flavors and flashy colors,” said Hoopsick. “That is a parallel we’re seeing now with nitrous oxide.”

The product is often marketed as a whipped cream propellant. But some of the available options make the culinary angle hard to believe.

“I really doubt anyone is buying flavored nitrous oxide to make blueberry mango whipped cream,” Yockey said. “Or ‘Bomb Pop.’ But I can have it delivered to my house in a couple of days.”

Marketing tactics that mimic big tobacco

What’s even more alarming is how sellers downplay the risks.

“We have evidence that nitrous oxide poisoning is a very real danger, but this is very often ignored or trivialized,” said Hoopsick.

“Sellers of nitrous oxide rarely, if ever, provide health warnings. I think the public sees it as a party drug.”

And like many dangerous trends, social media is making things worse. Videos of teens and young adults inhaling the gas are easy to find online, often glamorized with hashtags and flashy effects.

“We know that if you watch videos of someone else doing it, you’re more likely to try it,” said Yockey.

“I worry about the high school and college-aged adolescents who see this online and decide to buy a fruit-punch flavored tank. Because right now, that’s perfectly legal.”

A call for policy change

The researchers believe that more data is needed to understand the full impact of nitrous oxide misuse. But they also stress that legislation must catch up with reality.

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“Policy level interventions are what are lacking at the moment,” Hoopsick said.

“If we have some guardrails on who can sell this, who can buy it and how it’s marketed, maybe we can get ahead of the problem.”

For now, the listings keep growing. And with speedy shipping options, the danger is just a few clicks away.

“Some of these brands were not here even a week ago,” Yockey said, scrolling through listings on his screen. “What they’re doing here is very ingenious, but it’s also incredibly dangerous.”

Source: https://www.earth.com/news/laughing-gas-crisis-nitrous-oxide-misuse-and-abuse-is-rising-in-the-u-s/

by DFAF – Save Our Society From Drugs <clincoln-dfaf.org@shared1.ccsend.com> 10 April 2025

 

Rather than investing in prevention strategies and expanding access to treatment and recovery services, British Columbia, Canada, chose to enact radical harm reduction policies—policies that are now being linked to a significant worsening of the opioid crisis.

In March 2020, British Columbia launched its safer opioid supply policy, allowing physicians and nurse practitioners to prescribe pharmaceutical-grade opioids to individuals at risk of overdose. Then, in January 2023, the province implemented a decriminalization policy, removing criminal penalties for possession of small quantities (up to 2.5g) of drugs including opioids, cocaine, methamphetamine, and MDMA.

The result? A public health disaster.

Hospitalizations due to opioid poisoning increased by 33% (93 additional hospitalizations) following the rollout of the safer supply program. After decriminalization was added, these hospitalizations rose another 58% (164 more hospitalizations), relative to the pre-policy period.

The safer opioid supply guidelines allowed prescribers to offer powerful opioids such as up to 14 hydromorphone tablets per day and two oral morphine (80 to 240 mg) capsules per day, with the option of supervised ingestion at the prescriber’s discretion. While advocates argue that these policies shield people from contaminated street drugs, a critical question remains: Who is tracking where these powerful drugs end up—and what’s being done to move people into treatment and recovery?

The evidence is troubling. Diversion is happening. Only about 3% of opioid users have accessed these so-called safer opioids. This means the vast majority of high-dose prescriptions may be going unused by intended recipients—fueling black market activity and increasing the risk of exposure for opioid-naïve individuals, especially youth. Rather than reduce harm, these diverted drugs may be driving overdose and addiction deeper into communities.

Decriminalization only exacerbates the issue by removing legal consequences, making it harder for law enforcement to respond and opening the door for increased public use, street-level trafficking, and easier circulation of diverted substances.

As for opioid-related deaths, there were increases during the safer supply period, although these findings lost statistical significance after deeper analysis. Nonetheless, the trend raises serious concerns, especially given the surge in hospitalizations.

The authors also noted rising reports of public drug use, which contributed to the government’s decision to recriminalize drug use in public spaces—a walk-back of the initial policy.

These policies may have been introduced with good intentions, but the outcomes are clear: they are not working. By prioritizing access to drugs over prevention, treatment, and accountability, British Columbia has intensified the crisis it sought to solve.

If other jurisdictions consider similar approaches, British Columbia’s experience should serve as a warning—not a model.

 

Source:  https://doi.org/10.1001/jamahealthforum.2025.0101

 

by Drug Free America Foundation <hhorning> 10 April 2025 15:45

 

As marijuana becomes more accessible across the U.S., it’s easy to assume that legality equals safety. But that assumption can put both individuals and workplaces at risk. Whether you’re a small business owner trying to protect your team or an employee navigating changing laws, here’s the truth: legal doesn’t mean harmless.

 

With more than half of U.S. states allowing marijuana in some form, and ongoing federal discussions around reclassifying the drug to a lower-risk category, many people are wondering if this means marijuana is “officially safe.” The answer isn’t so simple.

 

Health experts and addiction researchers caution that the reclassification—or legalization—of marijuana does not erase its risks. In fact, the marijuana available today is much more potent than in decades past, and regular use is linked to a variety of health and safety concerns, including:

·    Addiction: Around 30% of users may develop cannabis use disorder (CUD).

·    Impaired judgment and motor skills, increasing the risk of workplace accidents.

·    Mental health issues, such as anxiety, depression, and in more and more cases, marijuana-induced psychosis.

·    Cognitive impairment, especially harmful during adolescence and young adulthood.

·    Decreased productivity and increased absenteeism in workplace settings.

 

Additionally, what many people don’t realize is how dramatically marijuana has evolved. The THC content (the chemical responsible for the “high”) has skyrocketed—by up to 20 times compared to marijuana from the 1960s–1980s. That higher potency means stronger effects, more intense impairment, and greater risk of dependence.

 

As a small business owner, it’s your job to keep your workplace safe and your team informed. That starts with clear policies, open communication, and a basic understanding of the facts:

·    Marijuana may be legal in your state, but you can still set limits in your workplace, especially for safety-sensitive roles.

·    Employees might be confused by changing laws or think rescheduling makes marijuana “safe”—education is key.

·    Workplace drug testing policies may need updates to reflect new realities while maintaining your drug-free goals.

 

Dr. Deepak D’Souza, a psychiatrist and marijuana researcher at Yale, warns that the health effects of marijuana are still not fully understood. “We’ve done a very bad job of educating people,” he says, adding that many turn to celebrities instead of scientists for information.

Legalization and regulation are evolving. But as an employer or employee, it’s crucial to separate policy from perception. Just because something is allowed doesn’t make it appropriate—or safe—for every situation.

At the end of the day, a safe, productive, and healthy work environment depends on informed choices. Let’s make sure everyone in your workplace has the facts to make them.

 

Source: 

Easing marijuana laws doesn’t mean the drug is safer. (n.d.). WebMD. https://www.webmd.com/mental-health/addiction/news/20240501/reclassification-of-marijuana-doesnt-mean-its-safer

 

 Kyle Jaeger – April 10, 2025

The Drug Enforcement Administration (DEA) has notified an agency judge that the marijuana rescheduling process is still on hold—with no future actions currently scheduled as the matter sits before the acting administrator, who has called cannabis a “gateway drug” and linked its use to psychosis.

It’s been almost three months since DEA Administrative Law Judge (ALJ) John Mulrooney temporarily paused hearings on a proposal to move cannabis from Schedule I to Schedule III of the Controlled Substances Act (CSA) that was initiated under the Biden administration.

Pursuant to the Tribunal’s January 13, 2025 Order, the United States Department of Justice, Drug Enforcement Administration (Government or DEA), by and through undersigned counsel, hereby submits the ordered Joint Status Report on behalf of the Government and Movants,” attorneys for DEA said in a joint status report on Thursday.

“To date, Movants’ interlocutory appeal to the Acting Administrator regarding their Motion to Reconsider remains pending with the Acting Administrator,” DEA said in the joint update, which was also signed by, or otherwise submitted for review to, pro-rescheduling witnesses. “No briefing schedule has been set.”

What this means for the fate of rescheduling isn’t clear. But if the decision-making is left up to DEA Acting Administrator Derek Maltz, it likely wouldn’t bode especially well for supporters of rescheduling.

The official, who retired from DEA in 2014 after 28 years of service, has made a series of sensational comments about cannabis—at one point linking marijuana use to school shootings, for example.

He also repeatedly insisted that the Biden administration “hijacked” the rescheduling process from DEA for political purposes. “It sure seems to me that DOJ has prioritized politics and votes over public health and safety!” Maltz said last May, for example.

Originally, hearings were set to commence on January 21, but those were cancelled when Mulrooney granted the appeal motion. He ordered DEA and the witnesses to provide a joint status update within 90 days, which would be this coming Sunday.

The appeal came after the judge denied a motion that sought DEA’s removal from the rescheduling proceedings altogether, arguing that it is improperly designated as the chief “proponent” of the proposed rule given the allegations of ex parte communications with anti-rescheduling witnesses that “resulted in an irrevocable taint” to the process.

Meanwhile, the Justice Department told a federal court in January that it should pause a lawsuit challenging DEA’s marijuana rescheduling process after Mulrooney cancelled the hearings.

Also in January, Mulrooney condemned DEA over its “unprecedented and astonishing” defiance of a key directive related to evidence it is seeking to use in the marijuana rescheduling proposal.

At issue was DEA’s insistence on digitally submitting tens of thousands of public comments it received in response to the proposed rule to move cannabis to Schedule III.

Mulrooney hasn’t been shy about calling out DEA over various procedural missteps throughout this rescheduling process.

For example, in December he criticized the agency for making a critical “blunder” in its effort to issue subpoenas to force Food and Drug Administration (FDA) officials to testify in hearings—but he allowed the agency to fix the error and ultimately granted the request.

Relatedly, a federal judge also dismissed a lawsuit seeking to compel DEA to turn over its communications with the anti-cannabis organization.

Mulrooney had separately denied a cannabis research company’s request to allow it to add a young medical marijuana patient and advocate as a witness in the upcoming rescheduling hearing.

Also, one of the nation’s leading marijuana industry associations asked the judge to clarify whether it will be afforded the opportunity to cross-examine DEA during the upcoming hearings on the cannabis rescheduling proposal.

Further, a coalition of health professionals that advocates for cannabis reform recently asked that the DEA judge halt future marijuana rescheduling hearings until a federal court is able to address a series of allegations they’re raising about the agency’s witness selection process.

Meanwhile, two GOP senators introduced a bill in February that would continue to block marijuana businesses from taking federal tax deductions under Internal Revenue Service (IRS) code 280E—even if it’s ultimately rescheduled.

Beyond the hearing delays, another complicating factor is the change in leadership at DEA under the Trump administration.

Trump’s nominee to serve as DEA administrator, Terrance Cole, has previously voiced concerns about the dangers of marijuana and linked its use to higher suicide risk among youth.

U.S. Department of Health and Human Services (HHS) Secretary Robert F. Kennedy Jr. was previously vocal about his support for legalizing cannabis, as well as psychedelics therapy. But during his Senate confirmation process in February, he said that he would defer to DEA on marijuana rescheduling in his new role.

Former Rep. Matt Gaetz (R-FL)—Trump’s first pick for U.S. attorney general this term before he withdrew from consideration—said recently that “meaningful” marijuana reform is “on the horizon” under the current administration, praising the president’s “leadership” in supporting rescheduling.

After Gaetz withdrew from consideration to lead DOJ, Trump then picked former Florida Attorney General Pam Bondi (R) to run the department, and the Senate confirmed that choice. During her confirmation hearings, Bondi declined to say how she planned to navigate key marijuana policy issues. And as state attorney general, she opposed efforts to legalize medical cannabis.

Former officials with DEA and HHS said this week that, without proactive advocacy for marijuana rescheduling from Trump personally, the process could stall indefinitely.

Supporters of rescheduling got an unwelcome update last week, however, as the White House Office of Drug Control Policy (ONDCP) released a report that outlined the administration’s top drug policy priorities for Trump’s first year of his second term—and it notably did not mention rescheduling or other cannabis reforms.

A marijuana industry-funded political action committee (PAC) recently attacked Biden’s cannabis policy record as well as the nation of Canada, with new ads promoting sometimes misleading claims about the last administration while making the case that Trump can deliver on reform.

Source: https://www.marijuanamoment.net/dea-says-stalled-marijuana-rescheduling-process-awaits-action-from-agency-head-who-called-cannabis-a-gateway-drug/

 

Note: To access the Joint Status Report – Dkt No. 24-44 , contributed by Tom Angell (Marijuana Moment) visit the Source as indicated above.

by AddictionPolicy Forum – Apr 3, 2025

Adults under 50 who use marijuana may face a significantly higher risk of heart attack, according to a new study published in the Journal of the American College of Cardiology (JACC)

Researchers analyzed data from more than 4.6 million adults and found that individuals under 50 who use cannabis were more than six times as likely to suffer a heart attack compared to non-users. The study also found that those who use cannabis are four times more likely to experience an ischemic stroke, three times more likely to experience major adverse cardiovascular events, and twice as likely to experience heart failure.
“Asking about cannabis use should be part of clinicians’ workup to understand patients’ overall cardiovascular risk, similar to asking about smoking cigarettes,” said Ibrahim Kamel, MD, clinical instructor at the Boston University Chobanian & Avedisian School of Medicine and internal medicine resident at St. Elizabeth’s Medical Center in Boston and the study’s lead author in a press release. “At a policy level, a fair warning should be made so that the people who are consuming cannabis know that there are risks.”

The findings applied even to individuals who did not use tobacco products, suggesting marijuana may be an independent risk factor for cardiovascular disease.

The Centers for Disease Control and Prevention (CDC) notes that marijuana use can increase heart rate and blood pressure — both of which may contribute to cardiovascular strain. Researchers believe these effects could play a role in damaging blood vessels and increasing the risk of blood clots.

Experts advise that cannabis should be considered alongside other recognized risk factors when evaluating heart health, particularly in younger adults. “Until we have more solid data, I advise users to try to somehow put some regulation in the using of cannabis,” said Ahmed Mahmoud with Boston University. “We are not sure if it’s totally, 100% safe for your heart by any amount or any duration of exposure.”
Source: https://mailchi.mp/addictionpolicy.org/halt-fentanyl-act-sign-on-letter-16446882?e=67079d94e3

by Robyn Oster – April 2025

It lays out 6 priorities:

  1. Reduce the Number of Overdose Fatalities, with a Focus on Fentanyl: This includes harm reduction efforts including increasing availability of naloxone and drug test strips, educational campaigns on overdose prevention, and diverting people from incarceration to supportive services. However, it also includes pursuing “the harshest available penalties” for those who sell fentanyl that results in overdose deaths.
  2. Secure the Global Supply Chain Against Drug Trafficking: This includes law enforcement and regulatory actions with other countries to address global drug trafficking, including exercising the administration’s “economic powers to demand change” when other countries “fail to take action.”
  3. Stop the Flow of Drugs Across our Borders and into Our Communities: This includes enhancing border security to prevent the smuggling of drugs into the U.S., with the goal of decreasing the domestic availability. The administration will use “both punitive and economic” measures and will “hold states and localities accountable for committing appropriate resources” to these efforts. The administration “will prosecute those individuals responsible for disseminating drugs within our communities and pursue severe penalties against the most culpable actors.”
  4. Prevent Drug Use Before It Starts: This includes educational campaigns and evidence-based prevention programs in schools and communities, including building resilience in youth and promoting healthy behaviors. The administration will also use social media to educate on dangers, overdose prevention, and treatment and recovery services.
  5. Provide Treatment That Leads to Long-Term Recovery: The administration will ensure effective, timely, and evidence-based treatment is available to all who need it. This includes expanding access to medications for opioid use disorder, improving integration of mental health and recovery support services, and strengthening the peer recovery support workforce and infrastructure.
  6. Innovate in Research and Data to Support Drug Control Strategies: The includes collecting and analyzing data to inform policy and modernizing technologies/systems for data collection and sharing. The administration will monitor trends to identify and address emerging threats.

Source: https://drugfree.org/drug-and-alcohol-news/trump-administrations-drug-policy-priorities-unveiled/

Filed under: Political Sector,USA :

 

by Nicolas Traino with Lucie Valais – 20/03 /25, then PL with AFP – 04/09 /25

The Academy of Medicine relies on certain studies carried out in countries where cannabis has been legalized to reaffirm its opposition to legalization in France.

The French Academy of Medicine reiterated, this Wednesday, April 9, its long-standing opposition to the legalization of cannabis in France, citing certain recent studies which point to negative effects in terms of public health in countries which have authorized the consumption of this drug.

 

“The legalization of the ‘recreational’ use of cannabis would cause serious problems in terms of public health”, said this institution in a press release, which aims to express medical consensus on a given subject.

This position has been assumed for several decades by the Academy of Medicine, which expresses itself above all on the consequences of legalization in matters of public health and not, for example, crime.

 

An opinion based on studies carried out in other countries

The institution explains this new communication by the fact that the scientific literature has recently been expanded based on the experience of several territories having legalized cannabis, including Canada and more and more American states.

“Recently published medical data confirms (…) the problems that have arisen in countries that have carried out such legalization”, says the Academy.

Among the studies cited, one, carried out in Canada and published in 2022 in the New England Journal of Medicine, shows that with legalization, the proportion of patients testing positive for tetrahydrocannabinol (THC), the main active substance in cannabis has doubled among motorists hospitalized after an accident.

 

Also in Canada, a study, published in 2025 in the Jama Network Open, showed that, among patients hospitalized for schizophrenia, the proportion associated with cannabis use tripled, going from around 3% to more than 10%.

 

The Academy’s position is also part of a political context where deputies – from the left and Macronist ranks – proposed at the start of the year to legalize the use and the possession of cannabis, according to a “closely regulated model”.

Conversely, the institution insists on “maintaining the ban in France on the sale and consumption of cannabis” and on increasing prevention among young people.

 

Source: https://www.bfmtv.com/sante/un-soulagement-enorme-le-processus-vers-la-legalisation-du-cannabis-therapeutique-relance-par-le-gouvernement_AV-202503200126.html

Filed under: Cannabis/Marijuana,Europe :

The new top federal prosecutor in Massachusetts underscored her opposition this week to supervised drug use sites and issued a “guarantee” that the Trump administration will never allow states like Massachusetts to skirt the federal law criminalizing the long-debated facilities.

U.S. Attorney Leah Foley, who took office in January, issued a statement Wednesday responding to an editorial in which the Lowell Sun suggested the federal government could turn a “blind eye” to the issue and asked, “Has the time finally arrived to challenge prevailing federal law in an effort to save addicts’ lives?”

Foley, a former deputy chief of the office’s Narcotics & Money Laundering Unit who has previously said she would oppose supervised drug use sites, said her response was simple: “No.”

“As to the hope for a blind eye, I guarantee that such a time will never come during this Administration,” she said. “‘Safe injections sites,’ ‘harm reduction sites,’ or however they are branded by advocates, are categorically illegal and do nothing to help people overcome their addictions. To the contrary, they facilitate destructive behavior that ruins lives, consumes families and devastates communities.”

Activists have been pushing state government for years to pass a bill authorizing overdose prevention centers and federal law has consistently been identified as the primary barrier. In 2018, Trump-appointed U.S. Attorney Andrew Lelling said anyone who uses or works at such a facility could face federal charges “regardless of any state law or study.”

Gov. Maura Healey’s administration announced its support for the idea of supervised drug use sites in 2023, and the Senate approved language last year allowing municipalities to open locations as part of a broader addiction and substance use bill. That provision was dropped in negotiations with the House.

Supporters of the idea say allowing medically trained professionals to monitor street drug use, then intervene and try to prevent an overdose from turning fatal, would help prevent fatal overdoses as powerful synthetics flood the drug supply and could serve as an opportunity to connect addicts with treatment or other services.

Foley said Wednesday that policymakers needs to look only as far as the intersection of Massachusetts Avenue and Melnea Cass Boulevard to see “the direct result of the ill-conceived experiment allowing drug users to flout the law.”

“Businesses left and have not come back. Creating environments that assist people with pumping poisons into their bodies is neither compassionate nor constructive,” the U.S. attorney said. “We should continue to direct all our resources to the prevention efforts that steer people, especially our youth, away from drug use and treatment protocols that truly save peoples’ lives from their addictions.”

Source: https://franklinobserver.town.news/g/franklin-town-ma/n/297912/just-say-no

As reports show highest rates of deaths after drug misuse among older people, experts take a look at the health risks

by Damon Syson – Daily Telegraph,  London – 12 April 2025

A recent report from the Office for National Statistics revealed that older people continue to register the highest rates of drug misuse mortality. According to the ONS, there were 1,118 deaths involving cocaine registered in 2023, which was 30.5 per cent higher than the previous year and nearly 10 times higher than in 2011.

“I actually think those figures are an underestimate,” says Dr Niall Campbell, a Priory consultant psychiatrist specialising in addictions. “When people die from drug-related causes, it’s often not recorded.”

Campbell is quick to point out that far from being the preserve of urban professionals, this phenomenon occurs throughout the UK: “A significant number of people will be partying on coke, whether it’s in central London or at a middle-class dinner party in the Cotswolds.

It’s a national problem. I have a patient in his sixties who was taking a lot of cocaine and ended up experiencing chest pains. He stopped, sought help, and he’s now much, much better. He lives in a small provincial town; he set up a Cocaine Anonymous support group there.”

The dangers of common drugs

Cocaine is by far the most serious source of concern when it comes to accidental death, but the other drugs that are commonly misused in the UK (according to the most recent ONS statistics) can also damage your health.

Used chronically, ecstasy (MDMA) depletes your serotonin levels, which can lead to depression, anxiety and lethargy.

Despite the growing numbers of people microdosing psilocybin as a treatment for depression, so-called “magic” mushrooms have been known to bring on panic attacks and can also exacerbate existing mental health problems.

Regular use of cannabis, especially when smoked together with tobacco, has been linked to chronic respiratory conditions, depression, impaired memory, motor skills and cardiovascular function – and its negative effects increase as the user gets older.

The dangers of excessive ketamine use, meanwhile, are well-documented, with chronic users risking bladder damage, cognitive impairment and personality change. But the over-50s have not embraced it as a drug of choice.

Aside from its toxicity, there are two other factors that make cocaine more of an immediate cause for concern than any of these drugs. Firstly, accessibility: it is the second-most used drug in the UK after cannabis; it’s easily available, and its relative cost has gone down over the past decade.

Secondly, cocaine is frequently – and incorrectly – perceived to be less harmful than it is. “Today, what we tend to see is a lot of intermittent cocaine users,” says Campbell, who is based at Priory Hospital Roehampton. “Often they’ve stopped regular use. But for whatever reason, it has caught up with them.”

Why are so many over-50s dying from cocaine poisoning?

The ONS reported in 2019 that the reason Generation X cohort are dying in greater numbers by suicide or drug poisoning is partly because “during the 1980s and ’90s more people started using hard drugs habitually”.

“These people still feel young at heart,” says Campbell. “They think they can still do what they used to do in the old days. Unfortunately, they can’t. Even if they’re aware of the health risk – say for example another person in their group has previously had an episode – they choose to ignore it.”

In essence, a certain group, now in their fifties, have either continued to take drugs since their twenties or now occasionally dabble “for old time’s sake”.

But the body of a 55-year-old is very different to that of a 25-year-old. The stakes become much higher because of the increased vulnerability of ageing bodies to the physiological and cognitive effects of cocaine.

“The typical scenario is a group of men in their fifties who say, ‘Come on, lads, let’s go to Ibiza and party like we did in 1999,’” says Campbell. “The trouble is, their bodies can’t take it, and they end up facing severe cardiac problems, or even death. As you get older, every time you take cocaine you’re playing Russian Roulette.”

The critical factor, he adds, is the cardiac toxicity of cocaine: “Cocaine gives you a massive release of dopamine from your limbic system into your brain, and it also speeds up your heart rate. That may be survivable if you’re 20 or 30, but as you get older, your heart isn’t as robust as it was. For them, doing a line of cocaine is like putting a supercharger onto a Ford Anglia.”

How does taking cocaine affect your brain and body – and how does this change as you get older?

Older adults are more susceptible to the effects of drugs and alcohol, because as the body ages, it cannot metabolise these substances as easily as it once did.

The short-term physical effects of using cocaine include constricted blood vessels, increased heart rate and high blood pressure. These factors can dramatically increase the risk of having a heart attack.

“What we commonly see when we’re called to A&E is arrhythmias, which are irregularities of heart rhythm,” says Dr Farhan Shahid, a consultant interventional cardiologist at The Harborne Hospital, part of HCA Healthcare UK.

“What happens when you take cocaine is that you’re stimulating the body’s flight and fight response, and the heart responds appropriately by speeding up. In the older population you’re often dealing with a patient who has other underlying medical problems – which makes treating them a lot less straightforward. They may be on blood pressure tablets, for example, or they might have had a stroke in the past.”

Long-term cocaine use brings with it a whole suite of potential health problems. It can increase an individual’s chances of suffering an aneurysm, because constricting the blood vessels over a long period may reduce the amount of oxygen the brain receives. It can raise the risk of strokes and lead to impaired cognitive function. And it can also cause damage to kidneys and liver, especially when used – as it almost invariably is – in tandem with excessive amounts of alcohol.

Shahid confirms that he frequently treats patients who display the chronic effects of taking cocaine: “It might, for example, be a 56-year-old who has high blood pressure as a background, regardless of the misuse. Taking cocaine on top of that will send their blood pressure off the chart, so to speak.

Over time, they become resistant to medication, and they may require admission into hospital and intravenous medication to bring their blood pressure down.

Cocaine causes a compromise in the demand and supply of the heart muscle: it causes a constriction of the arteries and a state where the blood is thicker and has a greater predisposition to clot.

It’s also worth noting that chronic cocaine use is linked with mental health issues like anxiety, panic attacks and psychosis. Even a one-off line at a party can cause an individual to behave erratically and recklessly, leading to accident and injury.

“Cocaine-induced paranoid states get worse as you get older,” says Campbell. “I had a patient who got together with friends to relive old times. They went away for the weekend, took cocaine, and as a result, he had a huge depressive crisis. He went back to the hotel and attempted suicide. Fortunately, he didn’t succeed.”

How to counteract the damage of cocaine

“The simple answer is – stop,” says Campbell. “If you’ve taken cocaine and you’ve experienced palpitations, for example, that’s a serious red flag. A user needs to get themselves checked out. If you’re worried, talk to your doctor and be honest about it. Your GP can perform an ECG and arrange a full cardio workup.”

Anyone concerned should also take encouragement from the fact that it’s never too late to take a positive step. “With the right treatment and the cessation of the misuse, you can reverse the effects of cocaine misuse,” says Shahid. “Cocaine drives up blood pressure, so if you stop the cocaine use, you can reduce that blood pressure change, and – with the correct medications in the background – bring it down to safe levels.”

Of course, not everyone can afford to seek treatment at Priory, but as a first port of call, Campbell advises contacting Cocaine Anonymous, which he says is “free and widespread, and staffed by people who really know what they’re talking about”.

“This phenomenon is certainly a matter for concern,” he says on a final note, “and it’s on the increase, as the generation comes through that were partying in 1999. Could it get worse? I think it will, because people are reluctant to seek help. Unfortunately, they have no idea how much of a risk they’re taking.”

 

Source: https://www.telegraph.co.uk/health-fitness/conditions/ageing/the-devastating-effects-of-drug-misuse-in-the-middle-aged/

 

Kara Alexander is jailed for life after drowning her sons, aged two and five, in a bath after smoking the drug

Kara Alexander has been sentenced to life imprisonment for murdering her children

Credit: Metropolitan Police/PA

 

A judge has warned against the dangers of drugs after a skunk-smoking mother drowned her young sons in the bath.

Kara Alexander, 47, of Dagenham, east London, murdered Elijah Thomas, two, and Marley Thomas, five, in the bath at their home in Cornwallis Road, on December 15 2022.

At Kingston Crown Court on Friday she was sentenced to life imprisonment with a minimum term of 21 years and 252 days.

The judge, Mr Justice Bennathan, referred to the children’s father finding his deceased sons next to one another as “the stuff of nightmares”.

He noted that Alexander had been smoking skunk – a stronger type of cannabis – on the night she killed her children and had been “doing so every night for weeks, probably much longer”.

In his sentencing remarks, he said: “The heavy use of skunk or other hyper-strong strains of cannabis can plunge people into a mental health crisis in which they may harm themselves or others.

“If any drug user does not know that, it’s about time they did.

“At your trial, Kara Alexander, the three psychiatrists who gave evidence disagreed about a number of things, but on that they were unanimous.

“It will comfort nobody connected to this case, but if these events bring home that message to even a few people, some slight good may come from what is otherwise an unmitigated tragedy.”

The bodies of Elijah, left, and Marley, were found by their father

 Credit: Central News/Facebook

 

He said he could not reach any conclusion but, in her state at that time, she intended to kill the boys, pointing out that she had “unspeakably” held the boys under water for “up to a minute or two”.

“The bath was probably still run from their normal evening routine and I do not think for a moment that your dreadful acts were pre-meditated,” he said.

The judge said Alexander dried the boys, put them in clean pyjamas and laid them together, tucked in under duvets, on the same bunk bed.

“The next morning, their father, worried by your unusual silence, came and found them. The stuff of nightmares,” he said.

The judge said there was every sign Alexander was a “caring and affectionate” mother to both children before the events of Dec 15.

He pointed out that their father said Alexander “never shouted or raised her voice at the boys” and “never showed violence to the boys”.

Psychotic state caused by cannabis 

Mr Justice Bennathan said Alexander was in a psychotic state when she killed her sons and that it was cannabis induced.

He said she had a previous psychotic episode in 2016 in which cannabis also probably played a part, but said he cannot be sure that she was aware that cannabis could trigger another psychotic state.

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The judge said he noted that in Dec 2022, Alexander spoke regularly with two members of her social circle about her heavy cannabis use, both of them knowing that she was looking after two small children.

“And at least one of them knew of your previous psychotic episode in 2016, yet neither of them warned you of any risk or sounded any note of caution at all,” he said.

The judge said Alexander will mourn her sons for the rest of her life.

“From all that I have read and seen of you, I have no doubt that every day when you awake you will remember and grieve for the little boys whose lives you snatched away,” he said.

 

Source: https://www.telegraph.co.uk/news/2025/04/11/cannabis-killer-mother-psychotic-state/

From NIHCM Newsletter / April 2025

Alcohol & Substance Use

Learn about the latest news on substance use, including views on alcohol, and how fentanyl deaths are declining.

  • Alcohol Awareness: April is alcohol-awareness month and an opportunity to reflect on the impacts of alcohol use and how alcohol-related deaths have increased over the last decade, with a sharp increase during early-pandemic years. A new Pew Research Center survey explores Americans’ views on the risks and benefits of alcohol consumption. A majority of routine drinkers, 59%, say their alcohol use increases their risk of serious physical health problems at least a little.
  • Fentanyl Deaths Declining: Recent preliminary data from the Centers for Disease Control and Prevention (CDC) indicates a 25% decrease in opioid overdose deaths for the 12-month period ending in October 2024, compared to the same timeframe in 2023. This is driven in large part by a reduction in the number of deaths involving fentanyl. The Wall Street Journal examines the decline in a series of charts. KFF Health News discusses how misinformation about fentanyl is impacting the overdose response.
  • Federal Funding: A federal judge has temporarily blocked the Department of Health and Human Services (HHS) from terminating a variety of public health funds that had been allocated to states during the Covid-19 pandemic, including funding that was being used to support opioid addiction and mental health treatments. The administration also closed the office that tracked alcohol-related deaths and harms and helped develop policies to reduce them.

Resources & Initiatives

  • The US Surgeon General’s 2025 Advisory, Alcohol and Cancer Risk, describes the scientific evidence for the causal link between alcohol consumption and an increased risk for cancer.
  • NPR dives into 8 theories from experts on why fentanyl overdose deaths are declining, including increased access to Naloxone, better public health, and the waning effects of the COVID pandemic.
  • The National Academy for State Health Policy’s State Opioid Settlement Spending Decisions tracker shares state-level settlement funding decisions and priorities.
  • With support from a $5.4 million Elevance Health Foundation grant, Shatterproof created an online training curriculum for healthcare professionals that aims to dispel myths and misunderstandings about substance use disorder, and promote person-centered, culturally responsive care.

Source: https://nihcm.org/newsletter/the-relationship-between-alcohol-and-health

This video illustrates findings of research by LHSC Canada, showing a potential biological link between cannabis use and psychosis – this can be seen by clicking the link shown below:

by Raminta Daniulaityte – College of Health Solutions, Arizona State University, Phoenix, AZ, United States et al.

“I don’t know how you can overdose smoking them:” 

Highlights

  • Smoking was viewed as protective against overdose compared to other routes of use.
  • Beliefs about inconsistency of blues drove concerns about the overdose risks.
  • Some believed that the quality of blues improved recently, and they became safer.
  • Many aimed to avoid the fentanyl in powder form to reduce their overdose risks.
  • Dosing-related strategies emphasized personal responsibility and victim blaming.

Abstract

Aims

Illicitly manufactured fentanyl (IMF) remains the primary driver of overdose mortality in the US. Western states saw significant increases in IMF-laced counterfeit pain pills (“blues”). This qualitative study, conducted in Phoenix, Arizona, provides an in-depth understanding of how overdose-related risks are viewed and experienced by people who use “blues.”

Methods

Between 11/2022–12/2023, the study recruited 60 individuals who used “blues” using targeted and network-based recruitment. Qualitative interviews were recorded, transcribed, and analyzed using NVivo.

Results

The sample included 41.7 % women, and 56.7 % whites. 55.3 % had prior overdose, but most (62.2 %) rated their current risk as none/low. Risk perceptions centered on a multi-level calculus of drug market conditions, individual vulnerabilities, and behavioral factors. Smoking was considered a “normative” way of using “blues”, and most viewed it as protective against overdose in comparison to injection and other routes of use. Drug market conditions and the unpredictability of “blues” were emphasized as important factor of overdose risk. However, some believed that over time, the quality/consistency of “blues” improved, and they became less risky. Many also expressed fears about the emerging local availability of powder fentanyl and its risk. Views about safer dosing, polydrug use, tolerance, and health emphasized personal responsibility and individual vulnerability to overdose risks. Discussions of protective behaviors, including take-home naloxone, varied bases on the perceptions of overdose risks.

Conclusions

The findings emphasize the need for close monitoring of local IMF markets and design of comprehensive interventions and risk communication strategies to address perceptions that minimize IMF-laced counterfeit pill risks.

Introduction

Illicitly manufactured fentanyl (IMF) remains a critical driver of overdose mortality in the US (Spencer et al., 2024), and there are emerging concerns about its proliferation in other regions of the globe (Friedman & Ciccarone, 2025; Piatkowski et al., 2025). The spread of IMF in the local drug markets in the US has shown increasing complexity with notable regional differences in the types of IMF products available, and associated contamination risks (Kilmer et al., 2022). While powder IMF has been the predominant form in the Eastern part of the US, western states, including Arizona, have seen significant increases in the availability of IMF in counterfeit pill form, most commonly 30 mg oxycodone, referred to as “blues” or “M30s” (Daniulaityte et al., 2022; O’Donnell et al., 2023; Palamar et al., 2022, 2024). For example, between 2017 and 2023, the total number of IMF pill seizures in the US increased by 8509.7 %, and the increase was the steepest in the West (an 11,266.7 % increase) (Palamar et al., 2024). Increases in IMF pill presence have been especially dramatic in Arizona with retail-level seizures of IMF pills increasing from about 1000 in 2017, to 18,004 in 2019, and 155,572 pills in 2020 (Mully et al., 2020). In 2023, Arizona had the highest number of IMF pill seizures in the country (n = 1638), and the second highest in the total number of IMF pills seized (n = 36,525,410) (Palamar et al., 2024).
Along with the increasing availability of IMF in counterfeit pill form, Arizona experienced significant rise in overdoses. Overdose deaths in Arizona increased from 1532 in 2017 to 2550 in 2020, and 2664 in 2022 (Centers for Disease Control & Prevention, 2022). Available data on seized drugs in Arizona indicate that in 2022 seized counterfeit pills contained 2.5 mg of fentanyl on average, with a range of 0.03 to 5.0 mg/tablet (Drug Enforcement Administration, 2024). Nationally, in 2022, an estimated 6 in 10 seized counterfeit pills were found to contain at least 2 mg of fentanyl, which is considered a potentially lethal dose (Glidden et al., 2024). Arizona currently does not have community-based drug checking programs, and there is limited up-to date information on the changes in potency of counterfeit pills or on the types of other substances that may be present in them. Data from other regions suggest that besides fentanyl, the pills may contain other fentanyl analogs, acetaminophen, and other drugs (Wightman et al., 2024).
Prior studies have identified a broad range of behaviors and conditions that are associated with an increased likelihood of opioid overdose. Some of these established risk factors include prior overdose experiences, concurrent use of benzodiazepines or alcohol, returning to high doses after losing tolerance (e.g., individuals recently released from prison or inpatient drug treatment), and physical and mental health comorbidities (Carlson et al., 2020; Darke & Hall, 2003; Darke et al., 2014; Kline et al., 2021; Park et al., 2016). However, established frameworks and “expert knowledge” that guide overdose prevention interventions may not align with the perceptions and experiences of people who use drugs (Chang et al., 2024; Moallef et al., 2019). Risk assessment is not an objective and value free enterprise, but it is embedded in the individual histories and experiences, underlying socio-cultural values, and broader structural and environmental conditions (Agar, 1985; Rhodes, 2002). There is a need for qualitative studies to help increase the understanding of how people who use IMF view, experience and judge their overdose-related risks.
Several prior qualitative studies have examined overdose risks in the era of IMF spread, aiming to characterize how people who use drugs (PWUD) experience IMF risks, what harm reduction strategies they employ, and how broader social and structural factors contribute to the local environments of risk (Abadie, 2023; Bardwell et al., 2021; Beharie et al., 2023; Ciccarone et al., 2024; Collins et al., 2024; Fadanelli et al., 2020; Gunn et al., 2021; Lamonica et al., 2021; Latkin et al., 2019; Macmadu et al., 2022; Victor et al., 2020). Many of the prior studies on IMF-related overdose risk perceptions and experiences were conducted at the initial stages of IMF spread, and primarily focused on overdose risks associated with inadvertent exposures to IMF contaminated heroin or other drugs (Abadie, 2023; Ataiants et al., 2020; Carroll et al., 2017; Lamonica et al., 2021; Latkin et al., 2019; Stein et al., 2019; Victor et al., 2020). More research is needed to understand the perceptions of IMF-related overdose risks in the context of high market saturation with IMF, and among individuals who intentionally seek and use IMF-containing drugs. Further, most prior studies were conducted in the regions where IMF is primarily available in powder form and as a contaminant of or replacement for heroin Carroll et al. (2017); Ciccarone et al. (2024, 2017); Latkin et al. (2019); Mars et al. (2018); Moallef et al. (2019). A few recent studies conducted in California described an increasing trend of individuals who use opioids switching from injection to smoking route of using IMF in powder form. These emerging studies have highlighted health-related benefits that were linked to this transition, including potential reduction in overdose risks (Ciccarone et al., 2024; Kral et al., 2021; Megerian et al., 2024). In the context of these important findings, there remains a lack of data on overdose risk perceptions related to the use of IMF in a counterfeit pill form. This qualitative study, conducted in Phoenix, Arizona, aims to address these key gaps and provide an in-depth understanding of how overdose-related risks are viewed and experienced by people who intentionally seek and use IMF-laced counterfeit pain pills (blues).

Section snippets

Methods

This paper draws on data collected for a study on counterfeit drug use in Phoenix, Arizona. Semi-structured, qualitative interviews were completed between 11/2022–12/2023. To qualify for the study, individuals had to meet the following criteria: 1) at least 18 years of age; 2) currently residing in the Phoenix, Arizona, metro area; and 3) use of illicit and/or counterfeit/pressed opioid and/or benzodiazepines in the past 30 days. The study was approved by the Arizona State University (ASU)

Participant characteristics and patterns of drug use

Out of 60 study participants, 58.3 % were men, and the age ranged from 22 to 66-years-old, with a mean of 39.0 (SD 11.2). More than half reported that they were unemployed, and 90 % had lifetime experiences of homelessness. Most (90 %) reported having health insurance, and 65 % had experiences of accessing local harm reduction services in Arizona (Table 1).
Most participants reported their first use of blues about 2–3 years ago (mean years since first use 2.7, SD 1.5) (Table 1). All participants

Discussion

Participants who use IMF pills reported deploying a range of calculated tactics to reduce their overdose risk. Many shared attitudes that tended to minimize the risks and reinforce a sense of personal invulnerability. Some of the contextual and behavioral factors of risk that were emphasized by the study participants align with the prior studies conducted in other regions of the US (Abadie, 2023; Beharie et al., 2023; Ciccarone et al., 2024; Collins et al., 2024; Fernandez et al., 2023; Victor

Role of funding source

This study was supported by the National Institute on Drug Abuse (NIDA) Grant: 1R21DA055640-01A1 (Daniulaityte, PI). The funding source had no further role in the study design, in the collection, analysis and interpretation of the data, in the writing of the report, or in the decision to submit the paper for publication.

Declaration of ethics

The study received ethics approval from the Arizona State University Institutional Review Board.

CRediT authorship contribution statement

Raminta Daniulaityte: Writing – original draft, Validation, Supervision, Resources, Project administration, Methodology, Investigation, Funding acquisition, Formal analysis, Data curation, Conceptualization. Kaylin Sweeney: Writing – review & editing, Project administration, Formal analysis, Data curation. Patricia Timmons: Writing – review & editing, Project administration, Formal analysis, Data curation. Madeline Hooten: Writing – review & editing, Project administration, Formal analysis,

Declaration of competing interest

All authors declare that there are no conflicts of interest.
Source: https://www.sciencedirect.com/science/article/abs/pii/S0955395925001070

Experts warn of rising dependence on anti-anxiety medications, which often start as short-term solutions but lead to addiction; with withdrawal posing serious risks, specialists stress need for medical oversight, alternative treatments, and early intervention

by Eitan Gefen – 17th March 2025
Victoria Ratliff awakens in her lavish suite, the Thai sun piercing through the curtains. She blinks slowly, her head heavy. Was it too much wine again last night? Or was it the lorazepam? From the adjacent bathroom, her husband showers, oblivious to the small internal struggle playing out in her mind. The children? They lost interest in their mother long ago.
She closes her eyes for a moment, takes a deep breath, and imagines herself as someone else—someone who doesn’t need a pill to get through the day. But reality waits. As anxiety creeps in, she reaches for the bottle, pops a pill, washes it down with a sip of water, and lets the familiar calm settle in.
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In the third season of HBO’s hit series The White Lotus, Victoria Ratliff grapples with a quiet addiction to lorazepam, a prescription sedative. Her character drifts through scenes in a daze, caught between sleep and wakefulness, her oversized sunglasses and bright smile masking the growing dependency beneath.
Though fictional, Ratliff’s story mirrors a harsh reality. In recent years, addiction to anti-anxiety medications such as Valium, Klonopin, and lorazepam (sold in Israel as Lorivan) has become a global concern, transcending age, class, and geography. What often starts as a “harmless pill for relaxation” can quickly spiral into dependence, making withdrawal a daunting challenge.
A growing crisis
The rise in prescription drug dependency highlights an alarming trend: an increasing reliance on medications to manage daily stressors. What begins as a short-term solution can become a chemical prison with devastating effects on mental and physical health. Why is quitting so difficult? How do people get hooked in the first place? And what can be done before the pills take over?
Dr. Chen Avni, a psychiatrist and deputy director of the psychiatric day treatment department at Ramat Hen Mental Health Center in Tel Aviv, explains that these medications belong to a class of drugs called benzodiazepines. “They enhance the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that slows down brain activity. In low doses, they induce relaxation, but in higher doses, they can cause drowsiness, memory impairment, confusion, and loss of balance.”
While the effects are similar to alcohol, benzodiazepines lack the intoxicating high. However, prolonged use can lead to cognitive impairment, decreased alertness, and, in elderly patients, an increased risk of dangerous falls.
From medical use to dependence
According to Avni, addiction often develops when usage extends beyond the prescribed timeframe. “Initially, these medications are intended for short-term relief—typically no more than six weeks,” he says. “The problem arises when patients feel they can’t function without them. That’s when we see cases of dependency, sometimes at alarmingly high doses.”
Shahar Cohen, a clinical social worker specializing in addiction treatment, has seen this trend intensify. “Anxiety levels across the population have been rising, especially in the past year and a half,” she says. “This isn’t just an individual issue—it affects families, workplaces, and entire communities.”
Prescription drug addiction cuts across all demographics. Some users first receive medication for legitimate issues like insomnia or acute anxiety. Others turn to them following major life stressors such as job loss, divorce, or a child’s military enlistment. In many cases, what starts as a doctor-prescribed solution escalates into self-medication, leading to dependency.
A dangerous market
For many, obtaining benzodiazepines legally isn’t enough. “One former patient of mine was using 16 times the recommended dose,” Avni recalls. “He bought part of his supply through his healthcare provider and the rest on the black market.”
This underground trade of prescription medication underscores a major challenge: when patients become addicted, they will go to great lengths to maintain their supply. “People often don’t realize they’re dependent until it’s too late,” Cohen warns. “When the thought of being without the drug becomes unbearable, that’s a red flag.”
Breaking free from addiction
Experts emphasize that addiction must be treated holistically, addressing not just the physical dependency but also the underlying emotional triggers. “Addiction is never just about the drug,” Cohen explains. “It’s often about pain—whether emotional or psychological. The drug becomes a coping mechanism.”
For those struggling with benzodiazepine dependency, gradual withdrawal under medical supervision is crucial. “Abrupt discontinuation can be dangerous, leading to severe withdrawal symptoms like seizures and psychosis,” Avni cautions. “I’m currently treating a patient who experienced vivid hallucinations after trying to quit cold turkey. We had to introduce a slow, controlled tapering process.”
Beyond physical detoxification, long-term recovery requires psychological support. “Cognitive behavioral therapy (CBT) is an effective tool, especially for sleep disorders,” Avni says. “For chronic anxiety or post-traumatic stress disorder, alternative psychiatric treatments that are non-addictive should be considered.”
Shifting medical practices
Awareness around prescription drug dependency is growing, but change is slow. “There are still doctors who hesitate to confront addicted patients and continue writing prescriptions out of convenience or pressure,” Avni notes. “But every physician prescribing these drugs should recognize the long-term risks. This isn’t just a temporary fix—it can become a lifelong struggle.”
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The Israeli Health Ministry is currently working on reforms to address prescription drug addiction, including establishing specialized treatment clinics within health maintenance organizations (HMOs). These initiatives aim to provide better oversight, education, and intervention before patients spiral into dependency.
The need for early intervention
Ultimately, the best way to combat prescription drug addiction is prevention. “It’s crucial to start with the lowest effective dose and treat the root cause of the anxiety, insomnia, or distress,” Avni advises. “No one is immune to addiction. The key is to monitor usage, avoid increasing dosages without medical guidance, and seek alternative therapies when possible.”
Cohen echoes this sentiment. “Science still can’t predict who will become addicted and who won’t, so awareness is critical,” she says. “If you suspect dependence—whether in yourself or someone close to you—don’t ignore it. Seeking help early can make all the difference.”
Victoria Ratliff’s story may be fictional, but the crisis it highlights is very real. For countless individuals, the journey from prescription to addiction is deceptively short. The challenge now is ensuring that those in need receive the right treatment—before their escape becomes their prison.
by Sean Murray – Mon, 17 Mar, 2025

“It’s important to realise, in terms of the harms of gambling, it’s not confined to a particular gender. Sometimes it’s considered that it ought to be a certain socioeconomic group or certain educational background. But it’s actually across the board.’

Towards the end of the Irish Examiner’s chat with Ireland’s first gambling regulator, talk had turned to a special edition of RTÉ radio’s Late Debate that had aired the previous night.

Anne Marie Caulfield had been listening to the show that featured a 40-minute segment on the impact of gambling on the women of Ireland, a problem that can remain a hidden harm in their lives for some time.

The hidden harm

It featured personal testimonies from women affected by problem gambling and commentary from Claire Donegan, the project lead for the EmpowerHer Recovery Network that was set up to support women in this situation.

Ms Caulfield, the chief executive of the Gambling Regulatory Authority of Ireland, which was formally established earlier this month, was keen to emphasise that her organisation would be listening to these voices as its work finally gets under way.

“What Claire would say to us is that there can be certain issues in terms of problem gambling for women that they feel more comfortable raising in a women’s group,” she said.

“For example, people might be talking in terms of having gambled the children’s allowance. And the whole stigma attached to problem gambling is so difficult anyway.

“It’s important people understand it as a health issue, and one that needs to be treated in terms of a health issue.”

Regulator’s wide-ranging role

On the day that Ms Caulfield spoke to the Irish Examiner from her office in central Dublin, she was also due to meet the seven-person board of the newly-established authority, all in-person, for the first time.

They have a hefty in-tray.

As well as licensing, supervising, and controlling gambling activities in the State, they’ll have to establish a national gambling exclusion register, administer a social impact fund that will support treatment and awareness initiatives, handle complaints, and enforce restrictions on advertising legislation.

“They have a lot of work to get through all that we’ve done already,” she said.

Advocates had been crying out for well over a decade for Ireland’s gambling laws to be brought into the 21st century.

The previous legislation, drafted in the 1950s, hadn’t accounted for people having mobile phones that they’d have on them them all the time that could double as a casino on their favourite gambling apps.

One of the dying acts of the last government was the passing of the Gambling Regulation Act 2024, steered through the Oireachtas by James Browne who is now the housing minister. It was 11 years after the Fine Gael-Labour government had first proposed new gambling laws.

Stark data from the ESRI

Prior to getting granted its full powers, Ms Caulfield and her team had enlisted the Economic and Social Research Institute (ESRI) to examine just how bad Ireland’s problem with gambling was, and its findings only reinforced the need to have the sector regulated.

“The extent of problem gambling in Ireland was much higher than previously thought,” she said. “It was 10 times higher than had been previously thought.

“That figure of 3.1% [of people] demonstrating significant harm from gambling and then a further 7% had moderate levels [of harm]. And then the fact that 47% of turnover is actually attributed to those two categories from that ESRI study was worrying.”

Furthermore, she said that evidence that children were twice as likely to become problem gamblers in later life if they bet before the age of 18 “really does justify clamping down very hard”.

Licensing is a priority

A key priority, now that the regulator is up and running, is getting the licensing regime operational.

Under the law, both in-shop and online gambling firms operating in the Irish market will have to register and be licensed by the Gambling Regulatory Authority of Ireland (GRAI).

It’ll replace the old system whereby betting operators were licensed by Revenue.

Once they’re licensed, they will be subject to the regulation of the authority with sweeping powers to impose fines of up to €20m or 10% of turnover — whichever is higher — for breaching the rules.

“A lot of the obligations and consumer protections flow from licensing in the sense that the act sets out what the obligations are on licensed entities,” Ms Caulfield said.

While they have not yet set the fees for companies to register, she said they’re trying to be “proportionate” and “fair” across the various types of gambling operators.

“We would expect it will be completed very soon, and then we’ll bring it to our seven-person board,” she said. “We will have a public consultation on it then and we also have to do some EU notifications.”

All that will take time, particularly the EU notifications, as another country could raise an issue that could delay the process. But, once that’s done, Ms Caulfield hopes that the authority will become self-sustaining and not reliant on taxpayer funding in the near future.

Regulator intends to be self-financing

“We absolutely intend to be self-financing,” she said.

“The legislation says within three years, but hopefully sooner than that, as there’ll be an application fee and then an annual fee to cover all the operational costs of the GRAI.”

As part of that licensing regime, gambling firms will have go through a corporate check, a financial check, and a technical check to make sure they’re up to scratch.

If a company is found to have breached its obligations in other countries, such as in the UK, where companies are routinely fined millions of pounds for breaches of anti-money laundering or consumer protection measures, that will be taken into account by Ireland’s regulator when they come calling for a licence.

Up to now, bookmakers were licensed by Revenue but the newly-established regulator will register and regulate both in-shop and online gambling firms operating in the Irish market. File picture: iStock

Ms Caulfield also said that, as part of the licensing, they’ll be vetting individuals as part of its corporate checks.

“It won’t just be a question of licensing and a once-off check,” she said. “I mean, the companies have assured us that absolutely they’re committed to respecting the Irish legislation, and they’ll work closely with us, but, from our perspective, it’ll be important that the compliance regime is robust, and that it picks up any breaches.

“In terms of the enforcement piece there are very severe penalties. There’s everything from a notice of improvement, to fines, to suspension of a licence, revoking a licence, and also —in terms of the particular officers, key decision-makers — there also can be consequences for them.”

Charities and sports clubs

In relation to charities, and the likes of sports clubs running lotteries, the regulator said the licensing regime for them likely won’t kick in for several years at least.

“That’s one of the last phases, so they’ll continue exactly as they are for the time being,” she said.

While charities have raised concerns about the impact of this process on their activities, Ms Caulfield said she would provide plenty of notice to the sector and try to ensure “as smooth a transition as possible”.

She also clarified that €2,000 will be the limit for prize money after which a charity will have to register with the GRAI.

“We have listened very carefully to the debates, and we hear the concerns of the various charities,” she said.

With the plethora of work now ahead of them, and a heavy responsibility to regulate an industry that causes harm to a significant proportion of the population, Ms Caulfield said this is something that isn’t lost on her or her organisation.

“It really does reinforce the fact that we’ve been given a very responsible role, and it’s important. We owe it to those people to do our job properly, and we’ll certainly be making every effort to do that over the coming years.”

Source: https://www.irishexaminer.com/news/arid-41593075.html

Sunday، 16 March 2025 – 12:40 PM

 

Medhat Wahba, the official spokesperson for the Fund for Combating and Treating Addiction and Drug Abuse, confirmed on Sunday, March 16, 2025, that the United Nations’ selection of Egypt as the first country in the world to implement the CHAMPS initiative for children under the age of 18 reflects the pivotal role of the Egyptian state and its commitment to its national commitments and responsibilities to combat drugs and illicit trafficking.

In an interview with Sada El Balad TV, Wahba said, “The initiative to strengthen child prevention systems aims to enhance their resilience from birth through adolescence, protect them from drug abuse, and raise their awareness about drugs.” He noted that “the initiative contributed to showcasing the Egyptian experience, particularly the National Strategy to Combat Drug Abuse, which was recently launched under the auspices of President Abdel Fattah El Sisi and received praise from all countries’ representatives.”

Wahba pointed out that “the Egyptian Drug Control and Addiction Treatment Fund has received numerous Arab and Gulf delegations over the past months to learn about the Egyptian experience, both in treating and rehabilitating drug addicts and in learning about preventive programs.” He emphasized that “the issue of combating addiction has received significant attention from President Abdel Fattah El-Sisi, and Egypt has achieved significant progress over the past ten years, making the Egyptian experience a global leader.”

It is worth noting that the Egyptian Drug Control and Treatment Fund participated in the meetings of the 68th session of the International Commission on Narcotic Drugs, held at the United Nations headquarters in Vienna, to present the Egyptian experience, which was praised by representatives of the participating countries. The meeting was attended by a number of foreign ministers, and was opened by Ghada Wali, Under-Secretary-General of the United Nations and Head of the United Nations Office at Vienna.

Source:https://www.sis.gov.eg/Story/205576/Egypt-Selected-as-First-Country-to-Implement-Child-Prevention-Systems-Initiative?lang=en-us

 

The world’s first injectable CBD product is raising concerns

By , Cannabis editor –

The Food and Drug Administration warned a California cannabis company on Monday that its injectable hemp CBD could be posing “serious harm” to public health, telling the company that its product is violating federal law.

Pico IV sells a purified version of CBD, a non-intoxicating compound produced by cannabis, that is designed to be injected into the bloodstream through an intravenous infusion. The Sacramento company has testimonials on its website that say the CBD IV therapy can help treat chronic pain, Crohn’s disease and arthritis.

The FDA, however, warned Pico IV in a Monday letter that it is breaking the law by marketing CBD as a “dietary supplement,” even though it is explicitly designed to not be ingested and instead be injected. The agency also said the product is “especially concerning” because injectable drugs “can pose risks of serious harm to users.” The FDA said injecting anything directly into a person’s bloodstream can “lead to serious and life-threatening conditions.”

Pico IV CEO Joe Young said in an emailed statement to SFGATE that “public safety is our top priority” and that the company’s product undergoes a process “designed to ensure sterility and safety.”

“We are confident in the safety profile of our product and are working diligently to provide the FDA with the necessary information to resolve their concerns,” Young’s statement said.

Pico IV’s website states that it offers the world’s first injectable CBD product. The product is produced from American-grown hemp plants, a legal category for some cannabis plants, and is “completely sterile and safe for intravenous use.” It is not available for regular retail sale; only “physicians, providers, and IV therapy clinics” can purchase vials of the injectable CBD, according to the company’s website.

Toxicologists have long been concerned about cannabis products because they do not face rigorous federal safety standards. Cannabis products are also at a higher risk of being contaminated with heavy metals and pesticides. Pico IV says on its website that all of its products are tested by third-party labs for purity.

Source: https://www.sfgate.com/cannabis/article/california-injectable-cbd-gets-fda-warning-20219801.php

United Nations – Office on Drugs and Crime

March 14th 2025

Ms. Ghada Waly, Executive Director of UNODC, welcomed the youth, reaffirming the organization’s steadfast commitment to their participation in drug prevention efforts. Encouraging them to fully embrace the experience, she stated, “I encourage you to make the most of this opportunity. Speak up. Ask questions. Challenge perspectives.”

Over the course of three days, participants attended interactive sessions focused on evidence-based prevention, rooted in the UNODC/WHO International Standards on Drug Use Prevention. Through collaborative activities, they exchanged best practices from their communities, analyzed challenges, and explored ways to strengthen youth-led prevention efforts. Utilizing the UNODC Handbook on Youth Participation in Drug Prevention Work, they shared past experiences of work and brainstormed on ways to be better be engaged and consulted as youth in prevention initiatives.

A new addition this year was the recently developed Friends in Focus programme, introduced as a resource and tool developed to support global youth be actively involved in evidence-informed prevention work. Youth participants had a sneak peek into some of the interactive activities, directly experiencing parts of the programme themselves. They reflected on the role that group dynamics have in peer selection, and learned to recognize risk and protective factors to drug use. Participants showed interest in being involved in Friends in Focus, including in their potential involvement in future pre-pilots or implementation of the programme. Participants also had the opportunity to attend CND side events, such as the event on “Engaging Youth as Agents of Change in Crime and Drug Use Prevention: Experiences of the Regional Youth Network for Central Asia” and “Ringing Out Hope and Unity: The Peace Bell’s 30-Year Message in Addressing Drug Abuse”.

Another key highlight of the Youth Forum was their collaboration for the creation of the Youth Statement, which captured the collective voices and recommendations of youth participants. The statement emphasized the urgent need for effective prevention, as new and emerging substances continue to impact individuals, families, and communities. Youth participants urged policymakers to invest in evidence-based prevention strategies, create protective environments at home, school, and in communities, and advocated for multiple sectors to converge and harmoniously work together.

UNODC congratulates the Youth Forum 2025 participants for their dedication, insightful contributions, and commitment throughout the three days. Their engagement throughout the Youth Forum highlights the crucial role that young people play in shaping effective drug prevention strategies and being implicated in the policy-making arena. Through the Youth Initiative and the growing alumni network, UNODC remains committed to fostering meaningful youth participation, providing opportunities for learning and development, and supporting young leaders in their efforts to create safer and healthier communities.

Read the Youth Statement below, and click here for more information about the Youth Forum 2025.

Youth Statement 2025 at the Opening Ceremony of the 68th Session of the CND

Your Excellencies, distinguished delegates, ladies and gentlemen,

As 32 youth from 25 countries, we gather here today as a unified voice to address the issue of substance use within our respective communities. This is not a new challenge, and has been tackled over the past decades. Despite efforts, everyday there are new substances that threaten not only individuals, but also society as a whole. It creates a ripple effect where individuals, families, communities are all directly and indirectly negatively affected. The consequences could lead to disruptive environments, higher rates of crime and violence, unemployment, economic challenges, and homelessness.

Therefore, prevention measures are essential to stop substance use before it takes hold. There are many risk factors that can lead to drug use, pushing a person to an extreme. Anyone could have these vulnerabilities, and thus none of them should be neglected. Effective prevention involves creating positive climates at school, home, and in the community to promote social, psychological and physical well-being. It cultivates opportunities, builds a brighter future, and represents a sustainable solution for a long-term problem. Moreover, it flourishes through collaboration among schools, families, communities, workplaces, the health sector, youth institutions, and social media – channels of communication which are closest to us. When prevention is a priority, resilience becomes a reality.

According to research, evidence-based prevention has proven to be, systematically, the most cost-effective. We urge Member States to prioritize funding to substance use prevention policies and solutions, and to invest in further research for drug prevention in aspects that do not have sufficient evidence, such as cultural, geographical, and demographical areas.

Our collective goal is to drive practical solutions, innovative strategies, and youth-led actions. Prevention efforts must not only be about us, but led by us. Why don’t we reflect: how many youth delegates do we have seated amongst us? How many youths have been directly involved in decision-making processes such as in this Commission? As youth, we are a key element of change: we urge you to actively involve young people in prevention efforts, and ensure that financial constraints do not exclude us. We have no political bias, we bring innovation and youth perspectives, and we care about our future. And this is not a one-time investment. Continuous engagement and co-creation can help us collectively reach our mission together.
Standing now in front of you, we ask you to help us have more access to capacity building, to voice our opinion, and to actively listen to us. Please be open to collaborating because we do want to create partnerships and evolve together. Every young person, regardless of their background, should have the opportunity to reach our full potential and positively impact our communities.
Source: https://www.unodc.org/unodc/drug-prevention-and-treatment/news-and-events/2025/March/youth-forum-2025_-when-prevention-is-a-priority–resilience-becomes-a-reality.html

National Crime Agency exposes increasing ketamine use in England amid surge in ‘drug cocktails’

by Tony Diver, Associate Political Editor, The Telegraph (London) 21 February 2025

 

Drug use in England

Ketamine

2023: 10,600 kilograms consumed

2024: 24,800 kilograms consumed

Hotspots: Norwich, Liverpool and Wakefield

Street value: Unknown

 

Cocaine

2023: 87,600 kilograms consumed

2024: 96,000 kilograms consumed

Hotspots: Liverpool and Newcastle

Street value: £7.7 billion

 

Heroin

2023: 25,300 kilograms consumed

2024: 22,400 kilograms consumed

Hotspots: Liverpool and Birmingham

Street value: £1.1 billion

 

Ketamine usage more than doubled in England last year amid the rising popularity of designer “drug cocktails”, The Telegraph can reveal.

The largest and most accurate study of its kind, conducted on behalf of the National Crime Agency (NCA), has exposed a dramatic rise in the popularity of the drug.

Almost 25 tonnes of ketamine were consumed in England last year, up from 10.6 tonnes in 2023.

The drug is now more popular than heroin, with the worst hotspots in Norwich, Liverpool, and Wakefield.

The findings are revealed in Home Office data, seen by The Telegraph, which will form part of the NCA’s annual threat assessment next week.

The agency, dubbed Britain’s FBI, will warn of a rise in the use of several recreational drugs in Britain, including a 10 per cent increase in cocaine.

The sharp increase in the prevalence of ketamine on Britain’s streets is thought to be driven by drug cocktails, including “pink cocaine” – a combination of ketamine and other substances taken by Liam Payne, the One Direction star, before his death last year.

Payne, who fell to his death from a hotel balcony in Argentina in October last year, had taken a mixture of methamphetamine, ketamine and MDMA along with crack cocaine and benzodiazepine before he died, a toxicology report found.

Liam Payne reportedly had ‘pink cocaine’ along with other drugs in his system when he fell to his death in Buenos Aires Credit: Marc Piasecki/GC Images

Mixing ketamine and other drugs can produce hallucinogenic effects, but presents a greater risk to partygoers because the substances can be laced with even stronger narcotics including fentanyl.

The Home Office sampled wastewater from 18 treatment plants across England and Scotland over three years to build the most accurate picture of drug consumption in Britain ever compiled.

The samples, which covered wastewater from more than a quarter of the population, were analysed and scaled up by scientists from Imperial College London.

Previous estimates were based on the quantity of drugs seized by police and self-reported drug surveys, which are less accurate.

The final report found that almost 100 tonnes of cocaine were consumed in England alone last year, up from 88 tonnes in 2023.

Liverpool and Newcastle were the heaviest consumers of cocaine. Usage peaked in London during Christmas, the Euro 2024 football tournament and the Eurovision song contest.

Adjusted for purity, quantities of cocaine consumed in England last year had an estimated street value of £7.7 billion.

That figure is almost double the NCA’s previous estimate and the equivalent of £100 spent on cocaine each year by every person in the country.

Over the same period, heroin consumption is estimated to have decreased by 11 per cent, from 25,300 kilograms in 2023 to 22,400 kilograms in 2024. The highest rates were measured in wastewater from Liverpool and Birmingham.

Experts have previously warned of the dangers of trendy designer drug cocktails, including pink cocaine and “Calvin Klein” or “CK”, which refers to a mixture of cocaine and ketamine.

The combination of drugs can make it more difficult for users to know what substances they have taken.

CK, which is growing in popularity in the UK, has been blamed for overdoses among young people in nightclubs.

It comes as in this week’s Crime and Policing Bill, the Government will propose banning “cuckooing” – when criminals seize a vulnerable person’s home and use it as a drug den or for other illegal activity.

The Home Secretary will also propose new measures to jail those convicted of using children for crime Credit: Jacob King

Yvette Cooper, the Home Secretary, will also propose a new offence of child criminal exploitation, which is thought to affect around 14,500 children each year.

Under the new measures, people convicted of using children for crime, including county lines drug dealing, will face ten years in prison.

Ms Cooper said: “The exploitation of children and vulnerable people for criminal gain is sickening and it is vital we do everything in our power to eradicate it from our streets.

“As part of our Plan for Change, we are introducing these two offences to properly punish those who prey on them, ensure victims are properly protected and prevent these often-hidden crimes from occurring in the first place.

“These steps are vital in our efforts to stop the grooming and exploitation of children into criminal gangs, deliver on our pledge to halve knife crime in the next decade and work towards our overall mission to make our streets safer.”

Ministers and the NCA are also concerned about the rise of drug importers, who bring classified substances into the UK through weaker entry points and sell them to distributors around the country.

Source: https://www.telegraph.co.uk/news/2025/02/21/true-scale-uk-illegal-drug-use/

by Lindsey Leake  August 27, 2024 at 4:30 PM EDT

While the modern marijuana consumer may be shedding that lazy stoner stereotype, new research shows that employees who use and abuse the drug are more likely to miss work.
The findings were published Monday in the American Journal of Preventive Medicine.

For the study, researchers at the UC San Diego School of Medicine and the New York University Grossman School of Medicine analyzed data from the 2021–22 National Survey on Drug Use and Health on 46,500 adults employed full-time in the U.S. Recent and frequent cannabis use, as well as cannabis use disorder (CUD), they found, was associated with greater workplace absenteeism.

Work absences included days missed due to illness or injury in addition to skipped days when employees “just didn’t want to be there.” Respondents were a majority or plurality white (62%), male (57%), ages 35 to 49 (35%), married (52%), had at least a college degree (42%), and had an annual household income exceeding $75,000 (55%). About 16% of employees had reported using cannabis within the last month, with about 7% of whom meeting CUD criteria (mild: 4%; moderate: 2%; severe: 1%).
People who said they had never used cannabis missed an average 0.95 days of work in the past 30 days due to illness/injury and skipped 0.28 days. Cannabis users, by comparison, recorded the following absences:
  • Past-month use: 1.47 illness/injury, 0.63 skipped
  • Mild CUD: 1.74 illness/injury, 0.62 skipped
  • Moderate CUD: 1.69 illness/injury, 0.98 skipped
  • Severe CUD: 2.02 illness/injury, 1.83 skipped

The results also showed that people who used cannabis most frequently skipped the most work. For instance, those who consumed it once or twice per month skipped 0.48 days, while those who consumed it 20 to 30 days per month skipped 0.7 days. People who used cannabis three to five days per month had the highest prevalence of missed days due to illness/injury (1.68). Cannabis use longer than a month ago had no bearing on employee absence.

“These findings highlight the need for increased monitoring, screening measures, and targeted interventions related to cannabis use and use disorder among employed adults,” researchers wrote. “Moreover, these results emphasize the need for enhanced workplace prevention policies and programs aimed at addressing and managing problematic cannabis use.”

Researchers said that while their latest work supports much of the existing literature on cannabis use and workplace absenteeism, it also contrasts with other studies. One previous study, for example, showed a decline in sickness-related absences in the wake of medical marijuana legislation, while another found no link between the two.

One limitation of the new study, the authors note, is that it relied on participants’ self-reported answers. In addition, the data don’t reflect whether cannabis was used for medicinal or recreational purposes, whether it was consumed during work hours, or address other factors that may have affected a person’s cannabis use patterns.

What are the signs of cannabis use disorder?

That marijuana isn’t addictive is a myth. People with CUD are unable to stop using cannabis even when it causes health and social problems, according to the Centers for Disease Control and Prevention (CDC). Cannabis consumers have about a 10% likelihood of developing CUD, a disorder impacting nearly a third of all users, according to previous research estimates. At higher risk are people who start using cannabis as adolescents and who use the drug more frequently.

The CDC lists these behaviors as signs of CUD:
  • Continuing to use cannabis despite physical or psychological problems
  • Continuing to use cannabis despite social or relationship problems
  • Craving cannabis
  • Giving up important activities with friends and family in favor of using cannabis
  • Needing to use more cannabis to get the same high
  • Spending a lot of time using cannabis
  • Trying but failing to quit using cannabis
  • Using cannabis even though it causes problems at home, school, or work
  • Using cannabis in high-risk situations, such as while driving a car
  • Using more cannabis than intended

In addition to interfering with everyday life, CUD has been linked to unemployment, cognitive impairment, and lower education attainment. People with CUD often have additional mental health problems, including other substance abuse disorders. In this study, for example, 14% of respondents reported having alcohol use disorder within the past year.

Source: https://fortune.com/well/article/marijuana-abuse-cannabis-use-disorder-workplace-absenteeism-sick-days/

visual abstract icon 

Visual

Abstract

 

Mindfulness Training vs Recovery Support for Opioid Use, Craving, and Anxiety During Buprenorphine Treatment

Key PointsQuestion  During buprenorphine treatment, does group-based mindfulness training reduce opioid use, craving, and anxiety compared with group recovery support?

Findings  In this randomized clinical trial including 196 adults prescribed buprenorphine for opioid use disorder, mindfulness was not superior at reducing illicit opioid use compared with an active group intervention with an evidence-based curriculum. Both arms experienced significantly reduced anxiety, and the reduction in opioid craving during mindfulness groups was greater than during recovery support groups, a significant difference.

Meaning  The findings of this study suggest that mindfulness groups may have utility during opioid use disorder treatment, especially for patients with residual opioid craving while prescribed buprenorphine.

 

Abstract

Importance  During buprenorphine treatment for opioid use disorder (OUD), risk factors for opioid relapse or treatment dropout include comorbid substance use disorder, anxiety, or residual opioid craving. There is a need for a well-powered trial to evaluate virtually delivered groups, including both mindfulness and evidence-based approaches, to address these comorbidities during buprenorphine treatment.

Objective  To compare the effects of the Mindful Recovery Opioid Use Disorder Care Continuum (M-ROCC) vs active control among adults receiving buprenorphine for OUD.

Design, Setting, and Participants  This randomized clinical trial was conducted from January 21, 2021, to September 19, 2023. All study procedures were conducted virtually. Participants were randomized 1:1 and blinded to intervention assignments throughout participation. This trial recruited online from 16 US states and was conducted via online platforms. Patients prescribed buprenorphine for OUD were recruited via social media advertisements, flyers, and health care professional referrals.

Interventions  The M-ROCC program was a 24-week, motivationally adaptive, trauma-informed, mindfulness-based group curriculum. Participants attended a 30-minute informal check-in and 60-minute intervention group each week. The recovery support group control curriculum used 4 evidence-based substance use disorder–focused nonmindfulness approaches and was time and attention matched.

Main Outcomes and Measures  The primary outcome was the number of 2-week periods with both self-reported and biochemically confirmed abstinence from illicit opioid use during study weeks 13 to 24, which was analyzed with an intention-to-treat approach using generalized estimating equations comparing between-group differences.

Results  This sample included 196 participants, predominantly female (119 [60.7%]). Mean (SD) age was 41.0 (10.3) years. Opioid use was 13.4% (95% CI, 6.2%-20.5%) in the M-ROCC group and 12.7% (95% CI, 7.5%-18.0%) in the recovery support group, a 0.6% difference (95% CI, −8.2% to 9.5%; P = .89). Cocaine and benzodiazepine use were also not significantly different. Anxiety T scores were reduced across both the M-ROCC and recovery support groups but were not significantly different between groups from baseline to week 24 (1.0; 95% CI, −2.4 to 4.3; P = .57). The M-ROCC participants demonstrated a larger reduction in opioid craving compared with the recovery support group participants: −1.0 (95% CI, −1.7 to −0.2; P = .01; Cohen d = −0.5).

Conclusions and Relevance  In this study, during buprenorphine treatment comparing mindfulness vs active control, both groups significantly reduced anxiety without significant differences in substance use outcomes. Mindfulness led to significantly greater reductions in residual opioid craving than control. The findings of this study suggest that mindfulness training groups may be recommended for people receiving buprenorphine maintenance therapy who have residual opioid craving.

Trial Registration  ClinicalTrials.gov Identifier: NCT04278586

 

Introduction

 

Opioid use is a major public health crisis in the US, with approximately more than 80 000 opioid overdose deaths in 2023.1 Buprenorphine treatment reduces illicit opioid use and overdose risk2,3; however, studies report that most patients discontinue buprenorphine medical management within 6 months.4,5 Several factors that may serve as treatment targets can increase the likelihood of poor outcomes. Comorbid substance use (eg, cocaine, methamphetamine) increases treatment dropout.6,7 Psychiatric symptoms (eg, anxiety), benzodiazepine misuse, and opioid craving increase relapse risk.8,9 Opioid craving is associated with subsequent use during buprenorphine treatment, is often preceded by negative affect or withdrawal states, and intensifies during exposure to drug cues or stressful life events.3,613 Behavioral interventions targeting these factors may improve outcomes, but, aside from contingency management, a systematic review identified no clear benefits to adjunctive individual counseling or cognitive-behavioral therapy.14 Unlike individual treatment, group treatment attendance has been associated with increased opioid treatment completion, and group-based opioid treatment appears feasible, acceptable, and may improve treatment outcomes.15

 

Mindfulness-based interventions are an increasingly popular evidence-based group treatment for substance use disorders.16,17 A recent fully powered randomized clinical trial found that a mindfulness program reduced opioid use and craving among people with both chronic pain and OUD during methadone maintenance.18 Mindfulness training appears to increase individuals’ capacities for self-regulation through enhanced attentional control, cognitive control, emotion regulation, and self-related processes.19 Mindful behavior change, a curriculum created to leverage those mechanisms, was shown to reduce anxiety symptoms, increase self-regulation, and catalyze health behavior change in trials of the Mindfulness Training for Primary Care program.20,21 The established Mindfulness Training for Primary Care curriculum was adapted for patients with OUD and a 24-week trauma-informed Mindful Recovery Opioid Use Disorder Care Continuum (M-ROCC) was created. A single-arm multisite pilot trial found M-ROCC feasible and acceptable during buprenorphine treatment.22 Additionally, participants experienced significant reductions in anxiety and decreased benzodiazepine and cocaine use but not opioid use.23

 

The present full-scale clinical trial compared the effectiveness of M-ROCC, delivered as an adjunctive live-online group during buprenorphine treatment, with an attention-balanced nonmindfulness control recovery support group using evidence-based approaches. We hypothesized that M-ROCC would be more effective than a recovery support group at reducing opioid use and anxiety.24

 

Methods

 

Design, Setting, and Recruitment

 

We designed this randomized clinical trial, approved by the Cambridge Health Alliance Institutional Review Board, to compare the effectiveness of live-online M-ROCC vs a recovery support group during outpatient buprenorphine treatment. Participants were recruited through social media (ie, Facebook), community partners (eg, Lynn Community Health, Boston Medical Center, North Shore Community Health), online telemedicine health care professionals (eg, Bicycle Health, Boulder Care), and quick response code flyers linking an online referral form, and participants provided informed consent.25,26 Participants received financial compensation. Study inclusion required participants to be aged 18 to 70 years with a stable buprenorphine dose prescribed (>4 weeks) for OUD, confirmed by participants signing a consent form for study personnel to contact their health care professional. Because some people receiving buprenorphine attain sustained remission of OUD, this study aimed to enroll individuals with a less clinically stable status, with residual symptoms of anxiety and/or substance use; therefore, participants had either mild or greater anxiety (Patient Reported Outcomes Measurement Information System–Anxiety Short Form 8a [PROMIS-ASF] T score >55) or recent substance use (<90 days of abstinence from alcohol, opioids, benzodiazepines, cocaine, or methamphetamine). Exclusion criteria included psychosis, mania, suicidality or self-injury, cognitive impairment, past mindfulness group experience, expected inpatient hospitalization or incarceration, or group-disruptive behaviors. Research coordinators (including H.G.) screened participants for eligibility through self-report surveys and telephone interviews.24 This trial followed the Consolidated Standards of Reporting Trials (CONSORT) reporting guideline. The trial protocol is available in Supplement 1.

 

Blinding and Randomization

 

The data coordinator (J.B.) randomized participants in random blocks of 4, 6, and 8 with a 1:1 ratio, using a random spreadsheet sequence (Excel; Microsoft Corp). The data coordinator concealed allocation in a password-protected file from personnel managing recruitment and screening until the randomization allocation was assigned. Participants and the primary investigator (Z.S.-O.) were blinded to intervention assignments.

 

Interventions

 

Groups were attention matched and offered at the same day and time as their comparator within each cohort. Each group started with a 30-minute informal check-in during which participants completed weekly surveys and research coordinators video-monitored oral toxicology tests in a video communications platform (Zoom; Zoom Video Communication) breakout rooms, recording results with screen capture (Droplr; Droplr Inc).27 Then, a 60-minute intervention group was led by 1 to 2 group leaders, including a lead instructor (A.K.F.) and with more than 4 years of group facilitation experience.24 Participants without reliable internet access received smartphones with unlimited data plans.

 

The M-ROCC curriculum had 3 components, starting with a 4-week orientation focused on fostering group engagement through comfort, curiosity, connection, and confidence. Participants continued into a 4-week low-dose mindfulness group, building a trauma-informed foundation for learning mindfulness and increasing daily formal mindfulness practice time. To provide choice about embarking on intensive mindfulness training, we offered those who successfully completed low-dose mindfulness the opportunity to continue into an intensive recovery-focused 16-week mindful behavior change program.20,21 This group focused on cultivating mindfulness of the body, breathing, thoughts, and emotions, plus mindful behavior change skills, interpersonal mindfulness practice, increasing self-compassion and emotion regulation, and developing OUD recovery skills, such as mindful savoring and urge surfing.24

 

We designed the recovery support group based on best practices in group-based opioid treatment, using evidence-based techniques while fostering a sense of accountability, shared identity, and supportive community.15,2830 It incorporated 8 weeks of group-building orientation followed by 16 weeks of evidence-based treatment techniques for substance use disorders, including cognitive behavioral therapy, motivational interviewing, community reinforcement, and 12-step facilitation.3135

 

Measures

 

All surveys were hosted by Research Electronic Data Capture (REDCap). During the screening and baseline periods, participants completed telephone screening interviews to report demographic characteristics (eg, race and ethnicity) and self-report surveys with substance use and buprenorphine dose information. The interventions in the study organize participants within group cohorts, which feature social elements. These are generally positive for many people, but the experience of group belonging and group cohesion may be influenced by participant experiences of minoritization, implicit bias, and microaggressions, which have been reported to lead to feelings of inclusion and exclusion related to race and ethnicity that might impact attrition or intervention adherence or continuation.36,37 In addition, studies have found that demographic variables have been underreported in mindfulness intervention research, leading to systemic bias and inclusion disparities in the field.38 Consequently, we report the racial and ethnic makeup of the study participants to contextualize the results and the limitations of generalizability.

 

Primary Outcome

 

Our primary outcome was the number of 2-week periods with both self-reported and biochemically confirmed abstinence from illicit opioid use during study weeks 13 to 24. During each 2-week period, participants completed at least one randomly assigned 14-panel oral toxicologic report via the video communications platform and 2 self-reported weekly surveys inquiring about past 7-day illicit opioid use. Participants were considered abstinent during each of the six 2-week periods if they had no self-reported opioid use and a negative oral toxicology test result for all illicit opioids tested. We hypothesized that participants in the M-ROCC arm would experience more abstinent periods compared with those in the recovery support group.

 

Secondary and Exploratory Outcomes

 

Participants completed the PROMIS-ASF at baseline and weeks 8, 16, and 24. PROMIS-ASF is an 8-item questionnaire using a 5-point scale asking about the past 7 days (1 = never to 5 = always).39 The T scores were calculated, with higher scores indicating greater symptoms of anxiety. We hypothesized that participants assigned to M-ROCC would experience greater reductions in anxiety than those in the recovery support group between baseline and week 24.

 

Secondary outcomes of benzodiazepine and cocaine use were collected for six 2-week periods in the same manner as described for opioids. We hypothesized that M-ROCC participants would experience greater reductions in benzodiazepine and cocaine use than those in the recovery support group.

 

As a prespecified exploratory outcome, changes in opioid craving during weekly surveys from weeks 1 to 24 were measured. The Opioid Craving Scale asked participants to rate 3 items assessing different aspects of opioid craving on a scale of 0 to 10. Mean ratings were calculated across these items, with higher ratings representing greater opioid craving. In previous research, the Opioid Craving Scale was positively associated with risk for opioid use in the following week.40 We hypothesized that participants assigned to M-ROCC would experience greater reductions in opioid craving between baseline and week 24 compared with those in the recovery support group.

 

Adverse Events

 

Staff monitored adverse events at each study visit and via a REDCap survey at weeks 8, 16, and 24, rated by severity, relatedness, and expectedness. Events were reviewed regularly by a National Center for Complementary and Integrative Health–approved data safety and monitoring board.

 

Statistical Analysis

 

Power analyses assumed randomization of 192 individuals, with an effective sample size of 156. This sample size provided 80% power to detect an effect size of 0.45 for negative toxicologic findings for illicit opioids between M-ROCC and the recovery support group, with a 2-sided significance level of P < .05, using an unpaired test.

 

For the primary outcome, we used an intention-to-treat approach to estimate differences between the M-ROCC and recovery support groups in biochemically confirmed illicit opioid abstinence over 6 biweekly time periods during weeks 13 to 24. We used generalized estimating equation logistic regression accounting for clustering at the individual participant level over weeks 13 to 24.

 

For the secondary outcome of anxiety and the prespecified exploratory outcome of opioid craving, we conducted a difference-in-differences intention-to-treat repeated-measures analysis using linear mixed-effects models with a study week by group interaction term to estimate the relative changes from baseline to week 24. For changes in anxiety, we included only participants with PROMIS-ASF T scores above 55 at baseline.39 We used the Benjamini-Hochberg false discovery rate procedure to account for multiple comparisons.41 Effect sizes (Cohen d) were calculated.

 

We used maximum likelihood estimation to address missingness for all analyses, adjusting the models to account for baseline covariates that differed between study groups after randomization (P < .10). We conducted a supplemental analysis using multiple imputation. We also conducted supplemental sensitivity analyses adjusting for all covariates associated with the outcome measure missingness. We conducted completer analyses for all outcomes among a subsample of intervention-adherent participants, defined as completing at least 15 of 24 sessions. For the number of adverse events, we conducted a negative binomial regression to evaluate between-group differences. All analyses were conducted in Stata, version 18 (StataCorp LLC).

 

Results

 

Participant Characteristics

 

Of 1728 patients referred between January 21, 2021, and February 15, 2023, 260 participants signed informed consent forms. We excluded 64 individuals for exclusion criteria (n = 18) or incomplete baseline assessments (n = 46) and randomized 196 participants to M-ROCC (n = 98) or the recovery support group (n = 98) (Figure 1). Of these individuals, 119 were female (60.7%), 75 were male (38.3%), and 1 (0.5%) was nonbinary. Mean (SD) age was 41.0 (10.3) years. Once 192 participants were randomized, recruitment ended, although 4 screened participants were able to complete the consent process and join the final cohort. Data collection was completed September 19, 2023. Baseline buprenorphine dose, cocaine use, and annual income differed between groups and were added to the models for primary, secondary, and exploratory outcomes (Table 1).

 

Outcomes

 

During weeks 13 to 24, mean illicit opioid nonabstinence time periods were 13.4% (95% CI, 6.2%-20.5%) in the M-ROCC group and 12.7% (95% CI, 7.5%-18.0%) in the recovery support group, a difference that was not statistically significant (0.6%; 95% CI, −8.2% to 9.5%; P = .89) (Table 2). During weeks 13 to 24, benzodiazepine use time periods did not differ significantly between the M-ROCC (22.1%) and recovery support (20.2%) groups (1.9%; 95% CI, −10.3%- 14.1%; P = .76) (Table 2). Similarly, there was no significant difference in cocaine use periods between the M-ROCC (8.4%) and recovery support (1.5%) groups (6.9%; 95% CI, −2.4%-16.2%; P = .15).

 

Large effect size reductions in anxiety from baseline to week 24 were observed in the recovery support group, with a mean T score change of −10.0 (95% CI, −12.0 to −8.0; P < .001; Cohen d = −1.3), and in the M-ROCC group, with a mean T score change of −9.0 (95% CI, −11.7 to −6.3; P < .001; Cohen d = −1.1). The interaction term for study group by week (weeks 0, 8, 16, and 24) was not significant (χ23 = 4.5; P = .31), and there was no significant difference between study groups at week 24 (95% CI, 1.0; −2.4 to 4.3; P = .57) (eFigure 1 in Supplement 2).

 

In exploratory analysis of change in opioid craving over time, we added baseline opioid craving to the other outcome covariates. The interaction term for study group by week was significant (χ224 = 56.5; P < .001). At week 24, the recovery support group mean opioid craving decreased by −44% (−1.3; 95% CI, −1.9 to −0.8; P < .001; Cohen d = −0.7) compared with a −67% (−2.3; 95% CI, −2.9 to −1.7; P < .001; Cohen d = −1.3) decrease in the M-ROCC group (Table 3). This represented a significant differential reduction among the M-ROCC group compared with the recovery support group (−1.0; 95% CI, −1.7 to −0.2; P = .01; Cohen d = −0.5) (Figure 2).

 

Results of the imputation analyses for primary, secondary, and exploratory analyses did not differ substantially from the maximum likelihood estimation analyses (eTable 1, eTable 2, and eFigure 2 in Supplement 2). Sensitivity analyses using all covariates associated with missingness (eg, COVID-19 Delta and Omicron wave cohorts) on the primary, secondary, and exploratory outcomes also had similar results (eResults 1, eTable 3, and eTable 4 in Supplement 2). Only 59% of the participants (116 of 196) completed week 24 of the study. Completer analyses also had similar results. A completer analysis found that women (52.9%) were more likely than men (41.3%) to continue after week 8 in both arms, and non-Hispanic White individuals who spoke English (48.8%) were more likely than others (6.3%) to continue into the intensive M-ROCC after week 8.

 

Adverse Events

 

There were no significant between-group differences in adverse events. One adverse event, which was of mild severity, was intervention-related (ie, pain during mindful movement practice in the M-ROCC group) (eResults 2 in Supplement 2).

 

Discussion

 

This geographically diverse randomized clinical trial recruiting from 16 states (eFigure 3 in Supplement 2) demonstrated that M-ROCC was not more effective than a nonmindfulness, evidence-based recovery support for reducing illicit opioid, benzodiazepine, or cocaine use. Infrequent opioid use in both groups may have limited the study’s power to detect between-group differences. This may have resulted from positive intervention effects, study attrition, missing data, or selecting a sample of participants receiving stable buprenorphine doses for at least 30 days. Additionally, both the M-ROCC and recovery support groups demonstrated similarly large reductions in anxiety, suggesting that, irrespective of theoretical approach, group-based live-online psychosocial interventions may have similar benefits for anxiety during buprenorphine treatment.

 

The M-ROCC participants experienced a differential reduction in opioid craving, a risk factor for illicit opioid use and treatment dropout during buprenorphine treatment.40,42,43 Similar craving reductions were observed in a recent study of mindfulness among opioid misusers with chronic pain.44 However, unlike this and other prior research,45 differential craving reductions among M-ROCC participants did not translate into significantly less opioid use than observed in the comparator intervention group. Participants were required to have stable buprenorphine doses for 30 days or more, which resulted in relatively low levels of baseline residual craving and possibly less opioid use.

 

Several mechanisms may explain the differential reduction in opioid craving among M-ROCC participants.46,47 Mindfulness-based interventions may ameliorate reward processing dysfunction through mindful savoring practices designed to resensitize people with OUD to natural reward signals.48,49 Craving involves interoceptive processing, and several mindfulness practices (eg, body scan) may impact craving by enhancing healthy interoceptive awareness and correcting interoceptive dysregulation.5056 Mindfulness enhances self-regulation capacity and improves emotion regulation, thereby reducing reactivity to negative affect and breaking associations between negative affect and substance use craving.19,21,57,58 Additionally, mindfulness training reduces attentional bias toward opioid-related cues, possibly reducing autonomic reactivity and enhancing cognitive control during a craving response.5961 Mindful urge surfing represents a resilient coping response, reducing craving elaboration and increasing awareness of early signs of craving.62,63 Repeated urge surfing with successful inhibition of craving-related responses paired with reconnection to deeply held values may uncouple activating drug-use cues from conditioned appetitive responses64,65 and realign motivation, helping sustain behavior change.19,66,67

 

Group-based opioid treatment is an increasingly common approach to providing concurrent behavioral health interventions during buprenorphine treatment.15,2830,68 Groups may facilitate improved treatment outcomes by teaching coping techniques and increasing social support, which has been associated with decreased substance use and improved retention in medications for opioid use disorder treatments.69 More research comparing group-based opioid treatment directly with individual care is needed, as well as understanding which implementation factors (eg, telehealth/in-person, delivery of evidence-based curriculum, and providing buprenorphine prescriptions during group) may support improved outcomes in group-based opioid treatment.28,30 The use of a group-based opioid treatment control arm incorporating evidence-based interventions for substance use disorder distinguishes this study from another recent randomized clinical trial18 for people with chronic pain during methadone maintenance that compared an adjunctive telehealth mindfulness group with an active supportive psychotherapy group control that did not provide any therapeutic skill training. In that study, the mindfulness arm demonstrated fewer drug use days and greater medication adherence, although anxiety was not significantly different between the groups.

 

The results of this present study align with meta-analyses suggesting that mindfulness, while often better than passive controls, does not differ substantially from other evidence-based interventions with respect to substance use and anxiety outcomes.70,71 In contrast, meta-analyses suggest that mindfulness outperforms active controls for reducing cravings among individuals with substance use disorders.72,73 This trial extends these findings, highlighting that mindfulness training may be helpful for patients with residual craving during buprenorphine treatment. The findings of this trial suggest the utility of mindfulness training as an evidence-based adjunctive approach for treating residual craving during opioid treatment with buprenorphine.

 

Limitations

 

This study has limitations. Higher levels of attrition in the M-ROCC group were noted compared with the pilot study,23 especially between weeks 8 and 16, when the intensive mindfulness program started. To be trauma informed, M-ROCC leaders encouraged participants at week 8 to consider their personal motivations for continuing into the more intensive Mindfulness Training for Primary Care OUD curriculum, emphasizing the choice to continue or withdraw from the group. The recovery support group did not have similar warnings about changing intervention intensity. Studies of trigger warnings suggest they do not typically lead to therapeutic avoidance in the general population74; however, levels of experiential avoidance can be higher among patients with OUD.75 Women were more likely than men to continue in both arms, and non-Hispanic White individuals who spoke English were most likely to continue into the intensive M-ROCC, suggesting that these warnings might have been experienced differently based on gender, identity, and culture. Additionally, the significant difference between groups in opioid craving changes over time could have resulted from a smaller, more committed group of engaged individuals continuing in M-ROCC compared with recovery support. Future multivariate analyses will be conducted to examine the effects of differential attrition on craving outcomes.

 

Stress, illness, and changes in lifestyle or employment changes due to the COVID-19 pandemic created barriers for multiple participants to engage with this study, resulting in higher than expected attrition particularly during cohorts overlapping with the Delta and Omicron waves of COVID-19 infections. Nevertheless, intention-to-treat analysis using maximum likelihood estimation methods allowed all 196 participants to be included in the final analyses.

 

The study’s predominantly White sample reflects national statistics on buprenorphine treatment engagement, but the study enrolled fewer Black participants than expected, allowing the possibility that findings may not generalize to all populations. Geographic and regional diversity was a unique strength of this study (eFigure 3 in Supplement 2), but integration of geographically diverse populations with different racial and ethnic and cultural backgrounds into common live-online groups added complexity during an intense period of national racial unrest that started in 2020.7678 This study also lacked a control condition with no behavioral treatment; therefore, it is unclear whether specific behavioral interventions, general group effects, or time in buprenorphine treatment were the primary factors of anxiety reduction.

 

Conclusions

 

In this randomized clinical trial, the impacts of a trauma-informed mindfulness-based group intervention during buprenorphine treatment on opioid use, substance use, and anxiety were similar to a recovery support group with a curriculum using evidence-based substance use treatment approaches. While further research is required, the study suggests that mindfulness-based groups may be particularly useful for reducing craving among patients with OUD who are experiencing residual opioid craving during buprenorphine treatment.

PLOS ONE | https://doi.org/10.1371/journal.pone.0317036 March 7, 2025 1 / 24

Citation: Onohuean H, Oosthuizen F (2025)
1 Biopharmaceutics Unit, Department of Pharmacology and Toxicology, Kampala International University
Western Campus, Ishaka-Bushenyi, Uganda, 2 Discipline of Pharmaceutical Sciences, School of Health
Sciences, Westville Campus, University of KwaZulu-Natal, Durban, South Africa
* onohuean@gmail.com

Abstract

Introduction
There is an ongoing global upsurge of opioid misuse, fatal overdose and other related
disorders, significantly affecting the African continent, due to resource-limited settings and
poor epidemiological surveillance systems. This scoping review maps scientific evidence
on epidemiological data on unlawful opioid use to identify knowledge gaps and policy
shortcomings.

Method
The databases (PubMed, Scopus, Web of Sciences) and references were searched
guided by Population, Concept, and Context (PCC) and PRISMA-ScR. The extracted
characteristics examined were author/year, African country, epidemiological distribution,
age group (year), gender, study design and setting, common opioid/s abused, sources of
drugs, reasons for misuse, summary outcomes and future engagement.

Results

A population of 55132 participated in the included studies of 68 articles, with the
largest sample size of 17260 (31.31%) in a study done in South Africa, 11281(20.46%)
in a study from Egypt and 4068 (7.38%) in a study from Ethiopia. The gender of the
participants was indicated in 65(95.59%) papers. The mean and median age reported
in 57(83.82%) papers were 15.9-38, and 22-31years. The majority of study-designs
were cross-sectional, 44(64.71%), and the most used opioids were heroin, 14articles
(20.59%), tramadol, 8articles (11.76%), and tramadol & heroin, 6 articles (8.82%)
articles. Study-settings included urban community 15(22.06%), hospital 15(22.06%),
university students 11(16.18%), and secondary school learners 6(8.82%). The highest
epidemiological distributions were recorded in the South African study, 19615(35.60%),
Egyptian study, 14627(26.54%), and Nigerian study 5895(10.70%). Nine (13.24%)
papers reported major opioid sources as black market, friends, and drug dealers. To
relieve stress, physical pain and premature ejaculation, improve mood and sleep-related
PLOS ONE | https://doi.org/10.1371/journal.pone.0317036 March 7, 2025 2 / 24
PLOS ONE The burden of unlawful use of opioid and associated epidemiological characteristics in Africa
problems and help to continue work, were the major reasons for taking these drugs as
reported in twenty articles (29.41%).

Conclusion
The findings of this scoping review show significant knowledge gaps on opioid usage in
the African continent. The epidemiological distribution of unlawful use of opioids among
young adults, drivers, and manual labourers in both genders is evident in the findings.
The reason for use necessity scrutinises the role of social interaction, friends and family
influence on illicit opiate use. Therefore, there is a need for regular epidemiological
surveillance and investigations into multilevel, value-based, comprehensive, and strategic
long-term intervention plans to curb the opioid problem in the region.

Introduction
Opiate use disorders and overdoses are an emerging global health concern. Both prescriptions
and non-clinical indications contribute to the escalating global opioid use disorder
problem (OUD). The opioid crisis has metamorphosed through the Use of: methadone in
1999, heroin in 2010, and the current wave of a combination of heroin, counterfeit pills,
and cocaine [1–8]. An estimated 62 million people globally used opioids in 2019, and
36.3 million were impacted by its associated problems [9]. In the US estimated use has
increased from 70029 in 2020 to 80816 in 2021 [10], and in Canada, 7560 opioid-related
fatalities occurred in 2021 [11]. In Italy opioid addiction affects more than five people per
1000 [12], while a regional study in Germany conducted amongst 57 million adults, found
opioid prescription prevalence of 38.7 or 12.8/1000 persons of low- and high-potency
opioids in 2020 [13]. However, little is known about the epidemiological characteristics in
Sub-Saharan Africa.
There are reports of opioid abuse, although not specifically on opioid fatal overdose or
its related disorders, in some African countries, including Egypt, Nigeria, Kenya, Tanzania,
and South Africa [14–24]. Some of these studies report the increasing use of tramadol
and heroin among university and secondary school students, factories and site workers,
long-distance drivers, sex workers, as well as unemployed youth [14–16,23,24]. However,
in many other African countries, there is scanty or no information regarding the ongoing
opioid crisis.
The findings on the reason for illicit opioid use includes; pleasure-seeking, craving, habits,
impulsivity, improving energy [25], relieving stress [26], peer pressure from friends [27],
engendering “morale” and “courage” to engage in sex work and “fight” potentially abusive
clients [28]. Some of the reported sources are the black market [29], friends and drug dealers
[30], roadways, bus terminals or intercity stands, low-income residential areas, abandoned or
unfinished buildings, and fishing camps along the Indian Ocean [31].
Global opioid trafficking channels exist from Afganistan, through the india ocean and
East Africa to the west [19,32,33]. This impacts heroin use among the population living in the
coastal region of Comoros, Tanzania, Kenya, northern Mozambique, Madagascar, Mauritius
and Seychelles [34–36]. Unlawful use of opioids could aggravate the already sporadic spread
of infectious diseases like malaria, cholera, and HIV [37–41]. In 2018, the UNODC [42,43]
predicted with insufficient evidence that another opioid crisis was developing in Africa. Inadequate
vital record-keeping and surveillance systems make it challenging to comprehend the
incidence burden and effects of opioid overdose in Africa [44].

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