Vaping

by Barbara A. Preston | www.themontynews.orgJune 6, 2025

Montgomery Police and Health Department officials are partnering to raise awareness about the dangers of vaping and substance abuse. They sponsored a program at Montgomery High School on Friday, June 6, aimed at educating teens about the risks.

Experts say vaping weed, and nicotine, are very popular with teens across the country — however, users are often uninformed about the risks and harm associated with the trend.

According to the CDC and the Food and Drug Administration (FDA), Tobacco companies and e-cigarette companies are targeting youth. The problem goes beyond nicotine. The delivery device, commonly referred to Electronic Nicotine Delivery Systems (ENDS) is a major part of the problem. Also called electronic cigarettes, e-cigarettes, vaping devices, or vape pens, ENDS are battery-powered devices used to smoke or “vape” a flavored or unflavored solution which usually contains nicotine or marijuana, or both. The American Academy of Family Physicians (AAFP) recognizes the increased use of ENDS, especially among youth and young adults.

Montgomery Township Police Chief Silvio Bet said the Vaping Program at the high school is one of many important initiatives the police and health department plan to roll out.
“Our continued initiatives symbolize our commitment to fostering a culture of awareness that benefits all community members,” Chief Bet said. The programs also build a stronger relationship between the police department, the health department, and the community, he said.

ThinkFast Interactive, an educational consultant company based in Kent County, Michigan, led the assembly portion of the program. They gave a lively, loud, and fun interactive presentation to the MHS freshman and sophomores in the school auditorium.

The ThinkFast MCs and DJs raised student awareness on everything from the harmful chemicals found in e-cigarettes to the potency of today’s marijuana.

Chemicals Found in Vapes

According to ThinkFast and Prevention Resources Inc data, the following chemicals are commonly found in vape devices:
       – Diacetyl (The chemical associated with the disease “popcorn lung.”)
       – Heavy Metals ( Lead and nickel can build-up in the body to fatal levels.)
       – Formaldehyde (A toxic chemical component used in the embalming process.)

Potency of Today’s THC (Marijuana)

Teens are overdosing from vaping THC in our community, according to Prevention Resources. They have ended up in local hospitals for emergency care because of the very high concentration of THC in today’s weed.
Some studies show the percentage of THC in cannabis has more than quadrupled since 1995. Samples seized by the Drug Enforcement Administration in 1995 contained 3.96% of THC. By 2022, the percent of TCH increased to 16.14%, according to The National Institute on Drug Abuse.
Addictive Drugs such as nicotine and THC (marijuana), are known to cause brain changes, which are most harmful to adolescents. Research shows that about one in six teens who repeatedly use cannabis can become addicted, as compared to one in nine adults
Marcantuono summed up the program, telling The Montgomery News, “Our goal is to educate, raise awareness, and change the trajectory to prevent ENDS device initiation and ultimately, to end tobacco and marijuana use.”

Source:  https://www.themontynews.org/single-post/teens-learn-about-the-many-risks-of-vaping-nicotine-and-thc-more-potent-addictive-and-dangerous-t

by Pat Aussem, L.P.C., M.A.C., Vice President, Consumer Clinical Content Development – June 2025

Teen substance use trends are always changing, and staying informed can help parents have better conversations with their kids. The good news? Teen substance use is at an all-time low! According to the Monitoring the Future survey, fewer teens are drinking, vaping, or using drugs compared to previous years.1 So, the next time your teen says, “Everyone is doing it,” you can ask how they’re seeing substance use in their world and what their peers are saying. The truth is, most teens are making healthy choices.

That said, it’s still important to keep an eye on emerging trends. New products, shifting laws, and the influence of social media continue to shape how young people perceive and access substances. What was true when we were growing up may no longer apply today. This article breaks down the key trends for 2025—no scare tactics, just real information to help you guide and support your teen. Let’s explore what’s on the horizon together.

Trend #1: VAPING EVOLUTION

Vaping is not new, but it’s evolving. Today’s e-cigarettes are more discreet than ever, often resembling USB drives, pens, or even watches.

The biggest concerns? Flavors that mask the harshness of nicotine make it easier for first-time users. And nicotine concentrations have skyrocketed, as one pod can contain as much nicotine as an entire pack of cigarettes.

Signs of vape use can include increased thirst, sweet smells, unfamiliar tech devices, small cartridges or pods.

You can start a conversation with your child by asking, “Vaping devices keep changing. What are you seeing at school these days?”

Trend #2: NICOTINE POUCHES

Nicotine pouches are one of the fastest-growing nicotine products among young people. These small, tobacco-free pouches are placed between the lip and gum and contain nicotine powder delivered directly into the bloodstream.

Nicotine pouches come in small white pouches the size of Mentos or Chicklets gum. They are packaged in circular containers. In addition to seeing packaging, be aware of white stains on clothing and frequent spitting that are signs of use.

With flavors like mint and fruit, they’re designed to appeal to teens and young adults. In addition, because they’re tobacco-free, they face fewer regulations than traditional tobacco products.

If you see people using nicotine pouches or brands like Zyn on social media or TV shows, you could ask your child, “What have you heard about nicotine pouches?”

Trend #3: CANNABIS LANDSCAPE

With more states legalizing adult use of marijuana (cannabis), many people no longer see it as being risky. But today’s cannabis is not what it was decades ago.

Modern strains can have THC levels more than 3-4 times higher than in the 1990’s. And the ways to use it have expanded beyond smoking with options like edibles, vapes, drinks, salves and concentrates.

Marijuana use during adolescence has been linked to negative impacts on brain development and mental health problems like depression, anxiety, suicidal thinking and psychosis. And at the age when teens are becoming new drivers, remember that driving under the influence of marijuana is illegal, not to mention extremely dangerous.  It can impact a person’s ability to make split-second decisions, even to stay in their lane without weaving.

You can talk about safety with your child by offering options should they be in a situation where the driver is impaired. For example, you can come up with an emoji symbol that they can text you to let you know they need to be picked up with no questions asked until the next day.

Trend #4: ALCOHOL AWARENESS

Even today, alcohol is still the most commonly used substance among teens. While overall use has declined in recent years, the way teens consume alcohol has changed dramatically.

Today’s alcohol landscape is dominated by sweet, flavored options that mask the taste of alcohol, like hard seltzers, alcopops and coolers, and spirit-based ready-to-drink cocktails. Many teens don’t even consider these to be “real alcohol.” And social media-driven drinking games and challenges have made dangerous drinking patterns like binge drinking more normalized.

You may be able to use yourself as a way to open a conversation. Think back to when you first tried alcohol or share a situation you experienced with alcohol. Ask about what types of alcohol kids your age are talking about.

Trend #5: PRESCRIPTION DRUG MISUSE

Prescription medications—particularly ADHD stimulants like Adderall—continue to be misused, often for studying or weight loss.  School pressure can be intense, and some teens see these medications as performance enhancers rather than drugs of misuse.

Parents should secure medications, count pills regularly, and be aware of “study drug” culture. Teens often consider these medications “safe” because doctors prescribe them. But no one should take medication unless it is prescribed to them.

You may consider asking: “I’ve heard about students using medications to help with studying. What’s that like at your school?”

Trend #6: FENTANYL CRISIS

Fentanyl—a lab-made opioid 50 times stronger than heroin—is being found in counterfeit pills and mixed with other drugs like heroin and methamphetamine. These fake pills are flooding the U.S. and can look nearly identical to prescription medications like Xanax and Oxycontin.  Even one counterfeit pill can be fatal.

One way to support your child is by practicing or role playing with them how to manage peer pressure and how to decline a potential offer of any pills.

Trend #7: SOCIAL MEDIA INFLUENCE

Social media has transformed how substances are marketed and normalized. Content providers can push content making substance use look fun and cool, and teens are often exposed to misinformation.

What’s concerning? “Challenges” (like the Benadryl challenge) involving substances can go viral, and influencers may promote alcohol brands or cannabis products.

It’s helpful to stay familiar with your teen’s social platforms. Follow some of the same accounts they do. Create a family social media plan that includes critical thinking about sponsored content.

A conversation starter can be: “I noticed some of those social media videos show people partying with certain drinks or substances. Do you and your friends ever talk about whether that stuff is real or staged?”

Practical Tips:

What can you actually do with this information?

  1. Build trust through ongoing conversations, by finding opportunities to talk about substance misuse and risk – not just one big “drug talk”
  2. Focus on health and safety, not just rules
  3. Always stay curious, not judgmental
  4. Educate yourself on warning signs of substance use and mental health symptoms
  5. Roleplay scenarios involving peer pressure, saying “no” and planning an exit plan
  6. Identify trusted adults that your child can go to if you’re not available

The reality is that young people are going to encounter substances. Your goal isn’t to create fear around substance use, but to build trust and communication. With honest dialogue and good information, you’re giving them the tools to make better decisions.

 

Source:  https://drugfree.org/article/top-7-teen-substance-use-trends-parents-need-to-know-in-2025/

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Published by NIH/NIDA 14 May 2025

 

Cannabis vaping is making headlines worldwide, often promoted as a “safer” alternative to smoking. Meanwhile, Drug Trends data from Australia reveal that non-prescribed cannabis use remains high among people who regularly use drugs. But are wider permission models and positive propaganda about cannabis leading to greater engagement, especially among those most at risk? This article dives into Australian data from the Ecstasy and Related Drugs Reporting System (EDRS) and Illicit Drugs Reporting System (IDRS), exploring what’s really happening with cannabis products, vaping, and why honest health education is more critical than ever.

Cannabis Vaping and Drug Trends in Australia (2014–2024): What the Data Tells Us

Cannabis vaping, once an afterthought, now claims a growing share of the global market. Many believe vaping to be less harmful, with marketers highlighting vaping’s lack of smoke and alleged respiratory benefits. However, recent Drug Trends research in Australia challenges some of these assumptions and uncovers troubling patterns.

The Rise of Electronic Vaping Products

Electronic vaping products started as oversized gadgets in the late 1990s. Initially intended to vaporise dried cannabis herb, they eventually shrank, morphing into today’s sleek e-cigarettes. While vaping nicotine products has become mainstream, cannabis vaping is following close behind, spurred in part by changes to medicinal and recreational cannabis laws overseas.

A North American review found a seven-fold increase in monthly cannabis vaping among adolescents, with notable shifts from dried herb to potent cannabis oils. However, the situation in Australia is different, shaped by stricter regulations and unique market conditions.

Drug Trends in Non-Prescribed Cannabis Use

Australia’s EDRS and IDRS surveys collect real-world data on non-prescribed cannabis and cannabinoid-related products. Between 2014 and 2024, most participants in both systems reported using cannabis recently, with rates as high as 90% in the EDRS and 74% in the IDRS.

Hydroponic and Bush Cannabis Still Dominate

  • Hydroponic cannabis was the most popular, with usage rates ranging from 63%–83% among EDRS respondents, and a remarkable 88%–94% for IDRS participants.
  • Bush cannabis also stayed common, with 51%–77% (EDRS) and 37%–54% (IDRS) reporting use.
  • Other cannabis products, such as THC extracts and commercially-prepared edibles, have appeared in recent years, showing increased product diversity—but are far less popular than traditional forms.

Cannabis Vaping Emerges, But Smoking Prevails

Despite media attention around cannabis vaping, the majority of Australians captured in these studies still smoke cannabis. From 2014 to 2024:

  • Smoking remained the dominant route of administration (ROA) in both groups.
  • Cannabis vaping (inhaling/vaporising) trended upward, but stayed a minority choice. Vaporising among EDRS participants increased from 12% to 25%, and from 2% to 9% for IDRS.

Notably, few users chose vaping as their only method. Most combined it with smoking, suggesting the rise in vaping hasn’t replaced traditional habits.

Concerns About Cannabis Vaping and Permission Models

The Problem with Changing Perceptions

There is growing concern that permission models and positive messaging around cannabis use (whether through legislation or social media) may downplay its risks. Vaping, in particular, is surrounded by claims of being a “safer” alternative to smoking. While it’s true that vaping doesn’t involve combustion and may expose users to fewer toxic chemicals, it’s not risk-free.

Key Issues Include:

  • Potency extremes: Some vape oils and extracts reach THC concentrations of 70–90%, far higher than the average 10%–20% in cannabis herb. Highly potent products carry greater risks for dependence, anxiety, and psychosis.
  • Unknown health risks: The long-term effects of inhaling cannabis vapour, especially from unregulated or home-made devices, are not fully understood.
  • Discreet use and normalisation: Portability and subtlety make vaping easier to hide, particularly from parents and teachers. For some users, this can enable more frequent use or uptake at a younger age.
  • Unhealthy dual use: Most vapers continue smoking, increasing overall exposure to both methods. (for complete research WRD News)

Source: https://www.dalgarnoinstitute.org.au/index.php/resources/drug-information-sheets/2672-cannabis-vaping-and-drug-trends-among-youth-in-australia-2014-2024-a-growing-concern?

Statement by the Queensland Cabinet and Ministerial Directory

Published Tuesday, 06 May, 2025 at 10:09 AM

The Honourable Tim Nicholls – Minister for Health and Ambulance Services

Record-breaking raids in war on illicit tobacco and dangerous vapes

  • Queensland has seized the nation’s largest ever haul of illegal cigarettes and vapes by a health authority, under Queensland Health-led Operation Appaloosa. 
  • More than 30 locations were raided, with 76,000 vapes, 19 million cigarettes and 3.6 tonnes of loose tobacco seized.
  • The raids come as more than $5 million in fines were issued in the first week of the Government’s nation-leading fines – over $1 million more than in the final four months of Labor. 

Queensland has stepped up the war against illicit tobacco and dangerous vapes, with the nation’s largest ever haul of illegal products by a health authority, in an effort to keep them out of the hands of kids.  

More than 76,000 vapes, 19 million illicit cigarettes and 3.6 tonnes of loose illicit tobacco – with a combined estimated street value of $20.8 million – were seized during the record-breaking Operation Appaloosa in March.

Queensland Health raided more than 30 locations across Central Queensland, Wide Bay, Metro North, Metro South, and West Moreton, supported by the Queensland Police Service and the Therapeutic Goods Administration.

This crackdown came ahead of the 3 April 2025 commencement of the nation’s toughest on-the-spot fines for the sale of illicit tobacco and vapes, which means individuals can be fined $32,260 and businesses up to $161,300 if caught selling illicit tobacco and vapes.

In just the very first week of these new fines, illegal traders were hit with fines totalling $5,094,560. To put that into perspective, Labor averaged less than $250,000 in fines per week in their final months in office. 

Minister for Health Tim Nicholls said the Crisafulli Government was determined to keep dangerous vapes out of the hands of children by stamping out illegal chop shops.

“Labor allowed organised crime gangs to set up illegal chop shops in plain sight across the State, putting our kids at great risk,” Minister Nicholls said.

“We need to do everything possible to keep dangerous illegal vapes away from Queensland’s young people, which is why we’ve boosted enforcement and introduced serious new fines. 

“We’re hitting these illegal traders where it hurts most, by seizing their illicit goods to deprive them of generating a profit and hitting them with the nation’s toughest fines.

“The is the latest in our crackdown on illegal chop shops and we’ll continue to target this organised crime and keep dangerous vapes out of the hands of kids.”

Illicit tobacco or vape sales can be reported via the Queensland Health website or calling 13 QGOV (13 74 68). 

 

Source: https://statements.qld.gov.au/statements/102504#:~:text=Queensland%20has%20s

Dangerous but common misconceptions can prevent crucial early addiction treatment.

Key points:

  • Misconceptions and the ignoring of research-based evidence prevent crucial early treatment of addiction.
  • Drugs of abuse cause health, life, and relationship problems with many long-lasting effects.
  • Teen and young adult drug prevention is necessary and needs funding.

Research published in high-quality peer-reviewed journals reveals key information on the realities of addiction, exposing pervasive myths and misconceptions, as in these examples.

False Belief 1: Drug experimentation is normal for teens and shouldn’t alarm parents.

Drug use and experimentation among teens often is ignored by many—even parents, who then may be unaware that any use places adolescent brains in jeopardy. For today’s teens, life often feels overwhelming, but avoiding alcohol, tobacco, marijuana, and other drugs is their one best choice to promote continued healthy physical and mental development. Preventing or delaying all teenage substance use not only reduces their current risks for depression, psychosis, and school/learning problems, but it also significantly decreases their probability of addiction as adults.

Harvard’s Sharon Levy, MD, MPH, and founding National Institute of Drug Abuse Director Robert DuPont, MD, strongly advocate a zero-tolerance approach to youth substance use. They emphasize that no amount of drug use is safe for young people. They promote the One Choice initiative encouraging adolescents to avoid substance use: alcohol, tobacco, marijuana, and other drugs.

It’s now known that THC in marijuana interferes with the developing brain circuits responsible for regulating behavior, leading to increased risk-taking and poor decision-making. Even infrequent teen use can impede judgment, increasing the probability of risky behaviors and accidents. Adolescents also are more likely than adults to develop cannabis use disorder (CUD) due to their heightened neuroplasticity during this developmental stage. The resulting impairment may lead to academic underperformance and problematic interpersonal relationships.

False Belief 2: Addiction is a personal weakness.

Addiction is not about people being weak-minded. It’s far more complicated. Becoming addicted depends on the drug used, dose, route, frequency, and risk factors like ages of users. Also, the same drug at the same dose affects people differently because of personal differences, as well as the presence/absence of traumatic past life experiences.

Yale’s Joel Gelernter identified genetic variants associated with vulnerability to addictions. However, genetic characteristics themselves interact with environmental factors in developing substance use disorders (SUDs). As Nora Volkow, director of NIDA, has said, “Addiction is a complex disease of a complex brain; ignoring this fact will only hamper our efforts to find effective solutions …”

False Belief 3: People must hit “rock bottom” to recover from addiction.

No, no, and no! Roadside alcohol testing has prevented thousands of deaths and helped many people with alcohol use disorders (AUD) obtain help, sometimes by coercion of courts. About 50 percent of those arrested for DUI have an AUD. Users often deny they have a problem with drugs or alcohol and believe they are truthful. But they are lying to themselves.

Addiction is a chronic, relapsing condition driven by changes in brain circuitry, particularly in areas controlling reward, stress, and decision-making. While some people seek help after suffering dire consequences, others are compelled into treatment by the courts, based on a past offense. Waiting to hit “rock bottom” increases major risks of harming the person’s relationships, job, and health—and strengthens the hold of the drug over the person.

False Belief 4: Addiction treatment never works.

Researchers from the University of British Columbia and Harvard Medical School recently analyzed survey data from nearly 57,000 participants in 21 countries over 19 years, providing clear data. They discovered that the number-one barrier to treatment was addicted people themselves: Most were in denial and did not recognize they needed treatment.

Alcoholics Anonymous is often successful, non-judgmentally providing new members a roadmap, role models, hope, and social connections. Successful people actively involved in AA complain that their friends kept asking them why they “weren’t cured yet” since they went to so many meetings. But going to meetings is what works.

Even among experts, there’s no consensus on what constitutes successful treatment. To some, success is that the person is still alive and hasn’t been rushed to the emergency room because of an overdose in the past 6 months or year. To others, it is taking treatment medications. And to still others, only abstinence and a full resumption of all family and work obligations counted as success.

Another issue is that most people with SUDs have multiple addictions. Even when they overdosed, most took multiple drugs. It’s also true that many people come to treatment also needing treatment for other medical, addiction, and psychiatric problems. Yet only rarely are patients evaluated and treated for all issues.

False Belief 5: Overdoses of drugs don’t cause brain damage.

Drugs of abuse can harm the brain. Overdose survivors may suffer from undetected brain damage and hypoxic brain injury caused by opioid-induced respiratory depression. As a society, we better understand hypoxia as associated with drowning or choking than its much more common occurrence in drug overdoses with loss of consciousness.

Recent studies estimate that at least half of people using opioids have illicitly experienced a non-fatal overdose or witnessed an overdose. People who regularly use drugs are at elevated risk of brain injury due to accidents, fights, and overdoses. A single fentanyl overdose could cause hypoxia, brain injury, and memory and concentration problems.

Overdoses with counterfeit pills, cocaine, methamphetamine, xylazine, or heroin usually also include fentanyl, making neurologically compromising overdoses more common.

Summary

Myths and misconceptions increase stigma and decrease the likelihood that someone with an addictive illness will receive prompt, effective treatment. We need early intervention and treatment during the preaddiction phase. Bottom line: Preventing teen and young adult use is crucial.

Mark Gold M.D.

Mark S. Gold, M.D., is a pioneering researcher, professor, and chairman of psychiatry at Yale, the University of Florida, and Washington University in St Louis. His theories have changed the field, stimulated additional research, and led to new understanding and treatments for opioid use disorders, cocaine use disorders, overeating, smoking, and depression.

Source: https://www.psychologytoday.com/intl/blog/addiction-outlook/202502/5-common-false-beliefs-about-drug-use-users-and-addiction

(1)    Use of Alternative Payment Models for Substance Use Disorder Prevention in the United States: Development of a Conceptual Framework

Journal: Substance Abuse Treatment, Prevention, and Policy, 2025, doi: 10.1186/ s13011-025-00635-z

Authors: Elian Rosenfeld, Sarah Potter, Jennifer Caputo, Sushmita Shoma Ghose, Nelia Nadal, Christopher M. Jones, … Michael T. French

Abstract:

Background: Alternative payment models (APMs) are methods through which insurers reimburse health care providers and are widely used to improve the quality and value of health care. While there is a growing movement to utilize APMs for substance use disorder (SUD) treatment services, they have rarely included SUD prevention strategies. Challenges to using APMs for SUD prevention include underdeveloped program outcome measures, inadequate SUD prevention funding, and lack of clarity regarding what prevention strategies might fit within the scope of APMs.

Methods: In November 2023, the Substance Abuse and Mental Health Services Administration (SAMHSA), through a contract with Westat, convened an expert panel to refine a preliminary conceptual framework developed for utilizing APMs for SUD prevention and to identify strategies to encourage their adoption.

Results: The conceptual framework agreed upon by the panel provides expert consensus on how APMs could finance a variety of prevention programs across diverse populations and settings. Additional efforts are needed to accelerate the support for and adoption of APMs for SUD prevention, and the principles of health equity and community engagement should underpin these efforts. Opportunities to increase the use of APMs for SUD prevention include educating key groups, expanding and promoting the SUD prevention workforce, establishing funding for pilot studies, identifying evidence-based core components of SUD prevention, analyzing the cost effectiveness of APMs for SUD prevention, and aligning funding across federal agencies.

Conclusion: Given that the use of APMs for SUD prevention is a new practice, additional research, education, and resources are needed. The conceptual framework and strategies generated by the expert panel offer a path for future research. SUD health care stakeholders should consider ways that SUD prevention can be effectively and equitably implemented within APMs.

To read the full text of the article, please visit the publisher’s website.

(2)     Quitline-Based Young Adult Vaping Cessation: A Randomized Clinical Trial Examining NRT and mHealth

Journal: American Journal of Preventive Medicine, 2025, doi: 10.1016/j.amepre.2024 .10.019

Authors: Katrina A. Vickerman, Kelly M. Carpenter, Kristina Mullis, Abigail B. Shoben, Julianna Nemeth, Elizabeth Mayers, & Elizabeth G. Klein

Abstract:

Introduction: Broad-reaching, effective e-cigarette cessation interventions are needed.

Study design: This remote, randomized clinical trial tested a mHealth program and nicotine replacement therapy (NRT) for young adult vaping cessation.

Setting/participants: Social media was used from 2021 to 2022 to recruit 508 young adults (aged 18-24 years) in the U.S. who exclusively and regularly (20+ days of last 30) used e-cigarettes and were interested in quitting.

Intervention: All were offered 2 coaching calls and needed to complete the first call for full study enrollment. Participants were randomized to one of 4 groups in the 2×2 design: mailed NRT (8 weeks versus none) and/or mHealth (yes versus no; stand-alone text program including links to videos and online content).

Main outcome measures: Self-reported 7-day point prevalence vaping abstinence at 3 months.

Results: A total of 981 participants were eligible and randomized; 508 (52%) fully enrolled by completing the first call. Enrolled participants were 71% female, 31% non-White, and 78% vaped daily. Overall, 74% completed the 3-month survey. Overall, 83% in the mailed NRT groups and 24% in the no-mailed NRT groups self-reported NRT use. Intent-to-treat 7-day point prevalence abstinence rates (missing assumed vaping) were 41% for calls only, 43% for Calls+mHealth, 48% for Calls+NRT, and 48% for Calls+NRT+mHealth. There were no statistically significant differences for mailed NRT (versus no-mailed NRT; OR=1.3; 95% CI=0.91, 1.84; p=0.14) or mHealth (versus no mHealth; OR=1.04; 95% CI=0.73, 1.47; p=0.84).

Conclusions: This quitline-delivered intervention was successful at helping young adults quit vaping, with almost half abstinent after 3 months. Higher than anticipated quit rates reduced power to identify significant group differences. Mailed NRT and mHealth did not significantly improve quit rates, in the context of an active control of a 2-call coaching program. Future research is needed to examine the independent effects of coaching calls, NRT, and mHealth in a fully-powered randomized control trial.

To read the full text of the article, please visit the publisher’s website.

(3)     The Alcohol Exposome

Journal: Alcohol, 2025, doi: 10.1016/j.alcohol.2024.12.003

Authors: Nousha H. Sabet, & Todd A. Wyatt

Abstract:
Science is now in a new era of exposome research that strives to build a more all-inclusive, panoramic view in the quest for answers; this is especially true in the field of toxicology. Alcohol exposure researchers have been examining the multivariate co-exposures that may either exacerbate or initiate alcohol-related tissue/organ injuries. This manuscript presents selected key variables that represent the Alcohol Exposome. The primary variables that make up the Alcohol Exposome can include comorbidities such as cigarettes, poor diet, occupational hazards, environmental hazards, infectious agents, and aging. In addition to representing multiple factors, the Alcohol Exposome examines the various types of intercellular communications that are carried from one organ system to another and may greatly impact the types of injuries and metabolites caused by alcohol exposure. The intent of defining the Alcohol Exposome is to bring the newly expanded definition of Exposomics, meaning the study of the exposome, to the field of alcohol research and to emphasize the need for examining research results in a non-isolated environment representing a more relevant manner in which all human physiology exists.

To read the full text of the article, please visit the publisher’s website.

(4)     Neural Variability and Cognitive Control in Individuals with Opioid Use Disorder

Journal: JAMA Network Open, 2025, doi: 10.1001/jamanetworkopen.2024.55165

Authors: Jean Ye, Saloni Mehta, Hannah Peterson, Ahmad Ibrahim, Gul Saeed, Sarah Linsky, … Dustin Scheinost

Abstract:

Importance: Opioid use disorder (OUD) impacts millions of people worldwide. Prior studies investigating its underpinning neural mechanisms have not often considered how brain signals evolve over time, so it remains unclear whether brain dynamics are altered in OUD and have subsequent behavioral implications.

Objective: To characterize brain dynamic alterations and their association with cognitive control in individuals with OUD.

Design, setting, and participants: This case-control study collected functional magnetic resonance imaging (fMRI) data from individuals with OUD and healthy control (HC) participants. The study was performed at an academic research center and an outpatient clinic from August 2019 to May 2024.

Exposure: Individuals with OUD were all recently stabilized on medications for OUD (<24 weeks). Main outcomes and measures: Recurring brain states supporting different cognitive processes were first identified in an independent sample with 390 participants. A multivariate computational framework extended these brain states to the current dataset to assess their moment-to-moment engagement within each individual. Resting-state and naturalistic fMRI investigated whether brain dynamic alterations were consistently observed in OUD. Using a drug cue paradigm in participants with OUD, the association between cognitive control and brain dynamics during exposure to opioid-related information was studied. Variations in continuous brain state engagement (ie, state engagement variability [SEV]) were extracted during resting-state, naturalistic, and drug-cue paradigms. Stroop assessed cognitive control.

Results: Overall, 99 HC participants (54 [54.5%] female; mean [SD] age, 31.71 [12.16] years) and 76 individuals with OUD (31 [40.8%] female; mean [SD] age, 39.37 [10.47] years) were included. Compared with HC participants, individuals with OUD demonstrated consistent SEV alterations during resting-state (99 HC participants; 71 individuals with OUD; F4,161 = 6.83; P < .001) and naturalistic (96 HC participants; 76 individuals with OUD; F4,163 = 9.93; P < .001) fMRI. Decreased cognitive control was associated with lower SEV during the rest period of a drug cue paradigm among 70 participants with OUD. For example, lower incongruent accuracy scores were associated with decreased transition SEV (ρ58 = 0.34; P = .008). Conclusions and relevance: In this case-control study of brain dynamics in OUD, individuals with OUD experienced greater difficulty in effectively engaging various brain states to meet changing demands. Decreased cognitive control during the rest period of a drug cue paradigm suggests that these individuals had an impaired ability to disengage from opioid-related information. The current study introduces novel information that may serve as groundwork to strengthen cognitive control and reduce opioid-related preoccupation in OUD.

To read the full text of the article, please visit the publisher’s website.

Source: https://drugfree.org/drug-and-alcohol-news/research-news-roundup-february-13-2025/

Author(s):  Hannah Elmore, PharmD,John Handshaw, PharmD, BCACP  –  December 23, 2024

Pharmacists can help address nicotine addiction by recommending FDA-approved smoking cessation methods and educating on the risks associated with electronic cigarette use.

Electronic cigarettes (E-cigarettes) have emerged as a popular alternative to traditional smoking. This method, known as vaping, involves inhaling an aerosol that contains nicotine, flavorings, and harmful chemicals including carcinogens, toxic substances, and metals. Nicotine is a highly addictive compound that activates the brain’s reward center by increasing dopamine levels, which creates sensations of pleasure and satisfaction. These euphoric feelings are often what leads to nicotine addiction.1

Although vaping is often perceived as a safer option, it actually carries significant health risks similar to those of traditional cigarettes. Pharmacists can play a vital role in educating patients on the dangers of vaping and providing guidance on safe and effective smoking cessation methods.

E-cigarettes trace back to the 1960s when British American Tobacco created a smoking device under the codename Ariel. At that time, researchers were already aware of nicotine’s addictive properties, but new evidence linking smoking to lung cancer prompted cigarette companies to try and explore alternative products with less risks. They aimed to create an inhalation device with filters to reduce carcinogens and tar. However, it was discovered that filtered cigarettes were not a healthier alternative because all components of cigarette smoke have proven to be harmful. Additionally, if the device only contained pure nicotine, it would warrant classification as a drug-delivery system, subjecting it to stricter regulations. The company wanted to avoid this in order to bypass the stringent safety evaluations and extensive clinical trials required by drug delivery systems, which would allow the company to reduce their manufacturing costs, speed up production, and take this device to the market quicker. They were able to produce a product with 24% nicotine, which is 6 times the concentration found in traditional cigarettes. Despite this innovation, Ariel was discontinued to protect the company’s profitable traditional cigarette market. This marked the first instance of companies exploring the manipulative potential of nicotine.2

E-cigarettes were officially authorized for sale by the FDA in 2007 with over 460 brands. The most popular brand is Juul, accounting for nearly 75% of the e-cigarettes on the market.3,4 In 2022, the FDA banned the sale of Juul products due to conflicting evidence regarding its associated risks, including the potential to cause strokes, respiratory failure, seizures, and cases of e-cigarette or vaping-use-associated lung injury (EVALI).4 EVALI is a condition in which the lungs become severely damaged and often results in admission to the intensive care unit (ICU) on mechanical ventilation.3,4

Additionally, there is also a lack of long-term safety data for these products.5 Although originally marketed as a healthier alternative to cigarettes, e-cigarettes have not demonstrated efficacy as a smoking cessation aid and rather, have led to a rise in the youth vaping epidemic.1

There has been a lack of data correlating successful smoking cessation rates among those who use e-cigarettes. There have been a few studies that suggest that vaping may aid in quitting tobacco but is not effective for quitting nicotine use altogether.6 One study found that those who utilized e-cigarettes in combination with nicotine replacement therapy (NRT) and counseling were 24.3% less likely to quit smoking compared to those who used only NRT and counseling. Additionally, those who used e-cigarettes were 15.1% more likely to become dual users utilizing both tobacco and vaping products. Those who are considered dual users are at an even higher risk for health complications including myocardial infarction and a 4-fold increase in developing lung cancer.6

In another survey of 800 people who utilized vaping as a smoking cessation agent, it was reported that only 9% successfully quit when asked 1 year later, compared to 19.8% who utilized NRT.1,7 These findings help highlight that vaping is not a reliable method for eliminating nicotine use entirely and can even lead to utilizing both traditional and electronic cigarette products.8

Vaping is now the most commonly used form of nicotine among adolescents. A study was conducted that showed high schoolers who had used e-cigarettes were 16.7% more likely to start smoking cigarettes within the next year.9 Nicotine’s impact on the developing brain can cause mood disorders, affect attention and learning, and amplify the desire for other mood-enhancing drugs such as cocaine or methamphetamine.1 In 2018, e-cigarette use among high school students increased by 78%, which led the FDA to enforce stricter regulations on the sale of nicotine products. Despite their efforts, vaping remains a leading challenge that teens face today as they have already fallen victim to nicotine addiction.4

The FDA currently lists 7 approved quit aids that are safe and effective for smoking cessation. These include several forms of NRT as well as pharmacologic therapy with bupropion and varenicline. Some of the agents, including the NRT gum, patch, and lozenge, are even available OTC. Pharmacists can play a vital role in smoking cessation, especially in patients who lack access to a primary care provider to obtain prescription medications. Therefore, it is crucial for pharmacists to stay up to date on the current smoking cessation guidelines, dosing recommendations, and counseling points for these agents.

The primary goal of pharmacist-driven smoking cessation should always be to support the patient’s desire to quit smoking. Pharmacists should guide patients toward the FDA-approved agents, either prescription medications through a provider, or OTC therapies in the pharmacy, rather than electronic cigarettes due to lack of supportive data and increased risk for adverse health events. The appropriate selection of FDA-approved agent should be individualized based on the patient’s specific factors, contraindications, and goals of therapy. Pharmacists should educate the patient extensively on the appropriate options for smoking cessation and should not recommend the use of e-cigarettes. However, if a patient decides to use e-cigarettes, pharmacists should still serve as a support system for the patient by being the primary educator and providing extensive counseling on the associated risks of vaping. Patients should be made aware of both the known and unknown adverse reactions associated with electronic cigarettes as well as highlighting that the goal of vaping should be to achieve complete smoking cessation.10

Vaping e-cigarettes has become a popular alternative to traditional cigarettes, with unknown efficacy and safety surrounding these products.10 Pharmacists should continue to stay up to date on new literature published on e-cigarettes and should follow the FDA’s suggestions on smoking cessation methods. Pharmacists are the most widely accessible health care professionals available to patients. Therefore, pharmacists have the power and knowledge to be the most influential providers available to advise patients on the correct paths to smoking cessation. By offering education and support, pharmacists can help patients live healthier lives and take steps towards reversing the youth smoking epidemic one education at a time.

Source: https://www.pharmacytimes.com/view/clearing-the-air-the-influence-of-vaping-on-smoking-cessation

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