2025 October

Source: https://learnaboutsam.org/wp-content/uploads/2017/09/27Sep2017-opioids-one-pager.pdf September 2017

By Onuora Aninwobodo  – Sunday, 5 October 2025 

 

The National Drug Law Enforcement Agency (NDLEA) has smashed two major cocaine cartels responsible for six UK-bound shipments and arrested their suspected kingpin, Alhaji Hammed Taofeek Ode, alongside five others, in a string of intelligence-led operations across Lagos spanning three weeks.

The operations, which uncovered 20.5 kilograms of cocaine concealed in stainless steel cups, body cream, and hair gel containers, also led to large-scale seizures of cannabis and tramadol in several states, including Edo, Osun, Kaduna, Ogun, and Kwara.

According to NDLEA spokesperson Femi Babafemi, the breakthrough came on September 16, 2025, when operatives at the Murtala Muhammed International Airport (MMIA) in Lagos intercepted 174 parcels of cocaine weighing 13.4kg hidden inside cocoa butter containers. 

A cargo agent was immediately arrested, leading investigators to uncover Alhaji Ode as the mastermind.

After weeks of coordinated intelligence and cooperation with the police, Alhaji Ode, who claimed to be a businessman and estate developer, was apprehended. 

During interrogation, he allegedly confessed ownership of the drug, which he said cost him over ₦150 million. 

Ode, who had lived in several European countries before returning from the UK in 2024, is believed to be the head of a long-running export syndicate.

In a related operation, another cartel’s bid to export multiple cocaine consignments to the United Kingdom was foiled between September 26 and October 2. 

NDLEA operatives arrested Smith David Korede, a furniture maker from Oshodi, Lagos, after intercepting cocaine hidden in hair cream containers. 

Further raids led to the seizure of additional consignments weighing over 4kg and the arrest of Ogunbiyi Oluseye Taiwo and Popoola Francis Olumuyiwa, both linked to the exports.

The Agency also intercepted a shipment from Thailand containing 6.3kg of Loud, a potent strain of cannabis, concealed in bedsheets and hibiscus flowers. 

In separate operations nationwide, NDLEA teams seized over 24,897kg of skunk, destroyed vast cannabis farms in Edo and Osun forests, and recovered thousands of bottles of codeine syrup, tramadol pills, and expired pharmaceuticals.

Among those arrested were:

     – John Igbe, alias SammyBless, caught with 550g of Colorado in Lekki, Lagos

     – Blessing Ovaka, with 498.5kg of skunk in Kaduna  

     – 25-year-old Salisu Abubakar, with 27,700 tramadol pills in Kwara

     – And Abubakar Audu, nabbed with 112kg of skunk in Ogun.

In Edo, two suspects,  Michael Ayang and Bernard “Don” New Year,  were arrested after NDLEA operatives destroyed over 10,897kg of cannabis on more than four hectares of farmland.

NDLEA Chairman and Chief Executive, Brig. Gen. Mohamed Buba Marwa (Rtd.), praised the operations, describing them as a testament to the agency’s renewed determination to crush drug networks nationwide.

“We’ll continue to target and dismantle every identified drug cartel, from the mules to the masterminds,” Marwa stated.

“Every arrest, seizure, and forfeited asset means lives saved and communities protected, both here in Nigeria and abroad.”

The NDLEA also continued its War Against Drug Abuse (WADA) sensitization campaigns in schools, markets, and communities across several states during the week, reaffirming its dual focus on enforcement and prevention.

Source: https://www.nigeriainfo.fm/lagos/news/homepage/ndlea-crushes-two-cocaine-cartels-arrests-drug-kingpin/

7th September 2024
Substance abuse among children is a significant concern, with various studies indicating that it often begins from adolescence.

According to the National Institute on Drug Abuse, which is part of the United States National Institutes of Health, factors influencing drug use in children include peer pressure, mental health issues, and accessibility to substances.

It further noted that early exposure can lead to dependency and long-term health consequences.

Addressing your child’s substance abuse can be one of the most challenging and daunting experiences a parent or caregiver faces.

A recent study conducted by Samuel Bunu, Ronari Charles, Oyintari Charles, and Patricia Okafor on the assessment of teenagers’ involvement in drug and substance abuse in Nigeria showed a rapid increase in the unhealthy use of drugs among teenagers, with more than 66.50 per cent, including both males and females, engaging in the misuse of substances to enhance their physical activities and for other reasons.

To solve this problem, understanding the complexities of addiction and its impact on a young person’s life is crucial for effective intervention. Experts say it is important to approach the situation with empathy, patience, and a willingness to seek help.

Every child’s journey with substance use is unique, and recognising the signs early can significantly improve the chances of recovery.

Here are six ways to handle the situation if your child is struggling with substance abuse.

Sit them down and discuss

According to mental health practitioners, the first step for any parent or guardian is to sit the child down and discuss the adverse implications of substance abuse.

Experts agree that conducting joint research online or using the story of a known substance addict can help the child understand the impacts of substance abuse.

Behaviour analyst, Ibukunola Afolabi, said parents should remain calm during the conversation about substance abuse, noting that such discussions can prevent further crises that might worsen the addiction.

“When a child abusing substances feels heard by the parents, it can help the child reveal secrets that will assist in navigating the recovery process. Many children abusing substances often feel neglected or unheard of by their families, which is why they go along with the crowd.

The first step in handling a child with substance abuse is to sit down as a family and talk about it,” the expert said.

Go for family counselling

After having a heart-to-heart conversation with the child, a psychologist, Idris Abayomi, said parents should also enrol in counselling sessions to understand how to interact positively with the child. He said this would help prevent ill feelings between them and the child.

“To address dysfunctional dynamics, enhance communication, and support the child’s recovery, it is critical for the entire family to set an example and participate in thorough and continuous counselling sessions, in addition to involving a professional.

Long-term success may depend on positive family actions, as this fosters a supportive environment,” he said.

Invite an expert

Abayomi said professional help should be sought to address the underlying triggers of substance abuse. He explained that employing a mental health specialist for the child will support recovery efforts and create a nurturing environment.

“Cognitive behavioural therapy is one therapeutic strategy that can assist in addressing underlying difficulties, creating coping mechanisms,” he added.

Establish discipline

The psychologist further said parents should create a structured and supportive environment at home and establish clear rules and consequences related to substance use, while also providing positive reinforcement for healthy behaviours.

This will help the child understand that there are consequences for certain actions and rewards for good conduct.

He added that parents should “encourage the child to associate with peers who have a positive influence and allow them to join support groups.”

Afolabi also advised parents to reassess their values and rebuild character within the home. He said this would help reorient the child and other family members, leading them to adopt new morals and realign their lives for better living.

Never abandon them

Afolabi advised that when a child struggles with substance abuse, it is crucial for parents to provide consistent support and understanding, even in the face of setbacks.

“Abandoning the child during difficult times can increase feelings of shame and isolation, making recovery more challenging. Instead, parents should maintain open lines of communication, express unconditional love, and reinforce the idea that setbacks are part of the recovery journey,” she said.

Get medical help

Additionally, consulting a medical doctor for any complications arising from a child’s substance abuse is essential for their overall health and safety. Substance abuse can lead to various physical and mental health issues, including withdrawal symptoms and damage to vital organs. A healthcare professional can conduct comprehensive evaluations to identify any health complications and recommend appropriate treatments.

Source: https://punchng.com/6-ways-to-handle-a-child-with-substance-abuse/

LONDON DAILY MAIL

by Sam Lawley, News Reporter –  5 October 2025 | 

Laying bare the extent of Glasgow‘s substance crisis, a disturbing video showed the drug-taking hotspot in grim detail with needles, spoons and other drug paraphernalia strewn over the ground – and all just round the corner from a popular student accommodation.

Glasgow is home to the UK’s first and only drug consumption facility, The Thistle, less than half a mile from the location of the clip, posted to X on Saturday by Reform councillor Thomas Kerr.

The centre is already open 365 days a year from 9am to 9pm but its operators told MSPs this week that they may have to extend hours as so many addicts are bingeing on cocaine later in the day and evening.

Run jointly by Glasgow City Council and the NHS, The Thistle allows users to inject hard drugs under medical supervision without fear of prosecution.

More than 400 addicts have so far had 5,000 ‘injecting episodes’, with cocaine taken three times as much as heroin. There have also been 60 ‘medical emergencies’ on site.

But it seems drug use is still spilling onto the streets and parks of Scotland’s largest city.

A squalid drug den featuring a tree covered in dirty heroin syringes has been discovered just yards from Scotland’s only ‘safe’ consumption room in Glasgow

‘But as you can see this is student accommodation and look at this,’ he says.

The camera pans from a block of student flats towards a tree loaded with syringes like darts lodged on a board.

Speaking with hundreds of pieces of rubbish scattered across the ground, Ms Dempsey adds: ‘To think this is what we are driving people to is just outrageous. It’s worse than outrageous.’

Seemingly criticising The Thistle consumption room, she sayd: ‘This is where the road to recovery comes right in. The right to enable should not count, it should not be a factor in it.

‘And that’s what we’re doing because all this equipment here, the packaging, the boxes, the syringes, the spoons for burning and the naloxone packages. These are all stuff that is given out freely in the safe consumption room.’

Mr Kerr adds: ‘Scotland’s drug crisis is here for everybody to witness. We need to start focussing on recovery as Audrey said, and not driving into despair where they’re sitting taking needles apparently safely down in the Calton, where you can see the state that people have been driven into.

‘This is absolutely scandalous and this is what’s going on in the streets of Glasgow, just around the corner from a so-called safe consumption facility.’

Ms Dempsey says: ‘This is outrageous. This makes you physically sick to think this is what we are pushing people into, and it tells you all the more that the Right to Recovery Bill should stand because people have a right to recover from this. They shouldn’t be driven to this, it’s just awful.’ 

The Right to Recovery Bill, if passed, would ‘establish a right in law to treatment for addiction for anyone in who is addicted to either alcohol, or drugs or both’. It is currently at stage one, the committee stage, of the process.

The Daily Mail has approached Cllr Casey for comment. 

The Thistle, which opened in January, also stepped up demands for an ‘inhalation space’ for people to smoke crack. 

Responding to calls for longer opening hours, Glasgow Tory MSP Annie Wells said: ‘Local residents will be terrified at the prospect of a 24/7 drug room on their doorsteps. 

‘The Thistle is making lives a misery for those living near it, with dirty needles and anti-social behaviour plaguing the community.

‘Expanding state-sponsored drug taking is not the answer – that’s why it’s crucial that MSPs back our Right to Recovery Bill which would enshrine in law a right to life-saving rehab.’

SNP drugs policy minister Maree Todd later MSPs she was confident the Thistle had already saved lives.

She said: ‘We’re seeing more smoking than we have before, more inhalation routes, so we just need to remain agile. Things are not static.

‘It’s a challenging situation to stay ahead of, quite a dynamic situation that’s out there.’

Tricia Fort, chair of Calton Community Council, said the Thistle was ‘doing good’, but there were concerns about it drawing drug dealers to the area.

Morrisons security boss Steve Baxter said the chain’s nearby supermarket had seen a 94 per cent drop in dirty needles in its car park since the Thistle opened.

Source: https://www.dailymail.co.uk/news/article-15163757/drug-den-tree-heroin-syringes-Scotland-glasgow-consumption-room.html

Press Office, Media Relations – press-office@brunel.ac.uk

The UK’s science minister, Sir Patrick Vallance, has sounded the alarm over the country’s declining investment in medicines. He warned that the NHS risks losing out on important treatments and the country could lose its place at the cutting edge of medical research if spending does not recover. It comes at a sensitive time – this year drug-makers including Merck and AstraZeneca have backtracked on plans to invest in the UK.

Vallance is correct that there is a need to encourage pharmaceutical firms to keep investing and launching new medicines in the UK. On the other side, there is a need to protect public funds from being wasted on treatments that do not offer enough benefit for their cost.

At the moment, just 9% of NHS healthcare spending goes on medicines. This is less than Spain (18%), Germany (17%) and France (15%). At a time when some experts believe the UK is getting sicker, this might come as a surprise.

But the UK is unusual among major health systems in how carefully it regulates drug spending. The National Institute for Health and Care Excellence (Nice) has, since its creation, judged new treatments not only on clinical evidence but on cost-effectiveness.

That means asking whether a drug’s health benefits – measured in quality-adjusted life years (QALYs) – justify its price compared with existing care. For most treatments the threshold is about £20,000 to £30,000 per QALY. This is not a perfect measure, but it gives the NHS a consistent way of deciding whether the health gained is worth the money spent.

The value of this approach is clear. Nice’s record shows that medicines that pass its tests have added millions of QALYs to patients in England, while also preventing waste on drugs that bring only marginal improvements at high cost.

A study published earlier this year in medical journal The Lancet found that many of the new medicines recommended by Nice between 2000-2020 brought substantial benefit to patients. But it also noted that some high-cost drugs deliver much less health gain than investments in prevention or early diagnosis could.

The study emphasises that maintaining rigorous thresholds around cost-effectiveness ensures that public funds go to treatments that really improve lives. In other words, the discipline of cost-effectiveness has protected the public purse while ensuring access to genuine innovations.

This regulatory strength is reinforced by national pricing schemes for branded medicines. These cap overall growth in the NHS drugs bill and require companies to pay rebates if spending rises too fast. In practice, this means that if total spending on branded medicines exceeds an agreed annual limit, pharmaceutical companies must pay back a percentage of their sales revenue to the Department of Health.

In recent years that rebate rate has been as high as 20–26% of sales, effectively lowering the price the NHS pays. This is made possible by the buying power of the health service.

Together with Nice’s appraisals, these measures have helped the NHS maintain relatively low medicines spending compared with many countries. At the same time, it still secures access to major advances in cancer therapy, immunology and rare disease treatment.

For a publicly funded service under constant financial strain, these protections are vital. Despite the pressure on its budget, the NHS has secured meaningful access to new therapies. For example, by March 2024, nearly 100,000 patients in England – many of whom would otherwise face long delays or rejection – had benefited from early access via the Cancer Drugs Fund to more than 100 drugs across 250 conditions.

The balance with Big Pharma

However, strict controls on price and access can have unintended consequences. If companies see the UK as a low-return market, they may choose to launch new drugs elsewhere first, or to limit investment in research and early trials here.

There is a danger that patients could face delays in receiving new treatments. Or the scientific ecosystem, which relies on steady collaboration with industry, could weaken.

Still, the answer is not to abandon cost-effectiveness. Without it, the NHS would risk paying high prices for small gains. This would divert money from staff, diagnostics or prevention – areas that often bring more health benefit per pound spent.

In such cases, raising thresholds or relaxing scrutiny would do more harm than good. Cost-effectiveness is not just about saving money. It is about fairness, ensuring that treatments funded genuinely improve lives relative to their cost.

The challenge, then, is balance. The UK should continue to hold firm on value for money, while finding ways to encourage investment. That might mean improving the speed and clarity of Nice processes, so that companies know where they stand earlier and patients can access good drugs more quickly.

It could involve reviewing thresholds periodically to account for inflation and medical progress, without undermining the principle that treatments must show sufficient benefit. And it certainly means supporting research and development through stable partnerships with universities, tax incentives and grants.

What should not be underestimated is the UK’s scientific strength. The country remains home to world-class universities, skilled researchers and an innovative biotech sector. The rapid development of the Oxford–AstraZeneca COVID vaccine showed what UK science can deliver at scale and speed.

Pharmaceutical companies know this, and many – including AstraZeneca, GSK, Novo Nordisk, Pfizer, Johnson & Johnson and most recently Moderna – continue to invest in British labs and trials because of the talent and infrastructure. Danish firm Novo Nordisk has strengthened its ties with the University of Oxford, committing £18.5 million to fund 20 postdoctoral fellowships as part of its flagship research partnership.

The UK’s approach to assessing value has won respect internationally. That discipline must be preserved. Reversing the decline in investment means creating a predictable, transparent environment for industry while maintaining the protections that safeguard patients and taxpayers alike. If done well, the UK can continue to be both a responsible buyer of medicines and a world leader in science.

Source: https://www.brunel.ac.uk/news-and-events/news/articles/The-UK-must-invest-in-medicines

From open communication to community involvement, strategies help families tackle teenage substance abuse head-on

Teenage drug use remains one of the most pressing concerns for parents across America, with recent studies showing that experimentation often begins in middle school. While the challenge can feel overwhelming, experts agree that proactive parenting and strategic interventions make a significant difference in keeping teens away from harmful substances.

Establish open and judgment-free communication early

The foundation of drug prevention starts with creating an environment where teenagers feel comfortable discussing difficult topics. Parents who begin conversations about substances before experimentation occurs give their children the tools to make informed decisions when peer pressure arises.

Rather than waiting for a crisis, families should integrate these discussions into everyday life. Talking about news stories, television shows or situations involving drugs provides natural opportunities to explore consequences and share values without making teens feel interrogated or lectured.

Research consistently shows that adolescents who believe their parents would be extremely upset by drug use are less likely to experiment. However, this doesn’t mean ruling through fear. The key lies in expressing genuine concern while maintaining an open door for honest conversations, even when mistakes happen.

Creating this safe space means responding thoughtfully rather than reactively. When teens share information about their peers or express curiosity about substances, parents who listen first and lecture less build trust that pays long-term dividends.

Monitor activities while respecting growing independence

Effective supervision doesn’t mean helicopter parenting or invading privacy at every turn. Instead, it involves knowing where teenagers spend their time, who their friends are and what activities fill their schedules.

Parents should maintain relationships with other families in their teen’s social circle. This network provides valuable perspective on group dynamics and allows adults to coordinate supervision during gatherings and events. When multiple families share expectations about substance-free environments, teens receive consistent messages across their social sphere.

Setting clear boundaries about unsupervised time, particularly during high-risk periods like after school and late evenings, helps reduce opportunities for experimentation. Studies indicate that teens with structured activities and parental awareness of their whereabouts show lower rates of drug use compared to those with minimal oversight.

Technology offers both challenges and solutions in this arena. While social media can expose teens to drug culture, monitoring apps and parental controls provide tools for staying informed without constant confrontation. The balance lies in being present and aware without becoming invasive or controlling.

Build strong connections with schools and communities

Prevention extends far beyond the home. Partnering with schools, coaches, religious organizations and community programs creates a comprehensive support system that reinforces anti-drug messages.

Parents should actively engage with school counselors and administrators to understand prevention programs and warning signs staff might observe. Many schools offer parent education nights focused on substance abuse, providing current information about trends and available resources.

Encouraging participation in extracurricular activities gives teenagers positive outlets for stress and belonging. Whether through sports, arts, volunteering or clubs, structured programs fill time productively while connecting teens with positive role models and peer groups.

Community-based prevention programs often provide peer support groups where teens can discuss challenges with others facing similar pressures. These programs normalize the choice to remain substance-free and demonstrate that saying no doesn’t mean social isolation.

Recognize warning signs and seek professional help early

Even with strong prevention efforts, some teenagers experiment with drugs. Early intervention dramatically improves outcomes, making it essential for parents to recognize warning signs without dismissing concerning changes as typical adolescent behavior.

Significant shifts in friend groups, declining academic performance, changes in sleep patterns, unexplained money issues or loss of interest in previously enjoyed activities warrant attention. Physical signs like bloodshot eyes, unusual smells or coordination problems shouldn’t be ignored.

When concerns arise, parents should consult with pediatricians, school counselors or addiction specialists promptly. These professionals can assess whether experimentation has progressed to problematic use and recommend appropriate interventions.

Many families hesitate to seek help due to stigma or hoping issues will resolve independently. However, substance abuse disorders respond better to early treatment, and waiting often allows problems to deepen. Professional support provides families with strategies tailored to their specific situation while offering teenagers therapeutic tools for addressing underlying issues driving substance use.

Source: https://rollingout.com/2025/10/13/ways-parents-protect-teens-from-drugs/

guardin-logo

 By : Ijeoma Nwanosike –  16 Oct 2025

Experts and policymakers have called on Nigeria to harness technology not only as a tool for innovation but also as a means of combating drug and substance abuse, particularly among young people increasingly exposed to both digital and chemical dependencies.

The call was made at the seventh National Conference and yearly General Meeting of the International Society of Substance Use Professionals (ISSUP) Nigeria, held at the Lagos Chamber of Commerce and Industry (LCCI), Lagos, with the theme: “Impact of Technology on Addiction: Innovations in Prevention, Treatment, Advocacy, and Research.”

Delivering the keynote address, Director of Research, Training and Head of the Drug Abuse Unit at the Neuropsychiatric Hospital, Aro, Dr Sunday Amosu, described technology as a paradox, a force for progress and, simultaneously, a trigger for new forms of addiction.

He observed that while digital tools have expanded access to healthcare and prevention resources, they have also intensified compulsive behaviours, particularly among youth navigating the pressures of modern life.

“Technology can be a double-edged sword. The same innovation that helps us track recovery and connect patients to help can also fuel gaming, gambling, and social media addictions. Our task is to strike a balance, leveraging tech for good while mitigating its harms,” Amosu said.

Representing the Minister of Youth Development, Ayodele Olawande, the Senior Technical Adviser on Youth Health and Policy Research, Dr Obinna Chinonso, commended ISSUP Nigeria for sustaining national dialogue on addiction and mental health.

He reaffirmed the government’s commitment to addressing drug and substance use among the youth, who constitute nearly 70 per cent of Nigeria’s population.

“When a young person falls into addiction, whether to drugs, alcohol, or technology, they are robbed of the clarity and creativity needed to seize available opportunities,” he said.

Chinonso outlined several initiatives, including the YoHealth Initiative, a youth-focused programme that prioritises mental health and substance abuse prevention.

He also announced the establishment of a technical working group bringing together government agencies, development partners, and civil society to strengthen preventive interventions.

He added that the ministry would collaborate with ISSUP Nigeria and other stakeholders on national sensitisation campaigns, including the forthcoming Sensitisation Against Drug Abuse, Crime, and HIV Parliament Course, in partnership with the United Nations Office on Drugs and Crime (UNODC), the National Drug Law Enforcement Agency (NDLEA), and the National Agency for the Control of AIDS (NACA).

In his remarks, President of ISSUP Nigeria, Dr Martin Agwogie, reaffirmed the organisation’s commitment to building professional capacity and promoting cross-sector collaboration to reduce drug demand.

According to him, sustainable prevention “goes beyond rhetoric” and requires systems that integrate community participation, youth engagement, and mental health support at all levels.

Chairman of ISSUP’s Board of Trustees and chief host of the event, Prof. Musa Wakil, commended the collaborative spirit of the conference, describing it as “a critical moment for aligning Africa’s response to addiction with global trends in digital health and behavioural science.”

As Nigeria faces the growing challenge of both drug and technology-related addictions, participants agreed that the future of prevention lies not only in policy but in rethinking how technology itself can be repurposed as part of the solution.

Source: https://guardian.ng/features/health/experts-policymakers-seek-tech-driven-solutions-to-combat-drug-abuse/

 

The UK government has launched a new campaign to alert young people to the dangers of ketamine, counterfeit medicines and adulterated THC vapes.
  • New campaign to alert young people to the dangers of ketamine, counterfeit medicines and adulterated THC vapes
  • Ketamine use and drug poisonings highest on record with 8 times more people seeking treatment since 2015
  • Government investing £310 million into drug treatment services alongside awareness campaign

Young people are being warned that they risk irreparable bladder damage, poisoning and even death if they take ketamine, synthetic opioids or deliberately contaminated THC vapes, as part of a new anti-drugs campaign.

Launching today (16 October 2025), the campaign, which includes online films, will target 16 to 24 years olds and social media users, following a worrying rise in the number of young people being harmed by drugs. There has been an eight-fold increase in the number of people requiring treatment for ketamine since 2015.

Supported by £310 million investment in drug treatment services, this initiative directly supports the government’s Plan for Change mission to create safer streets by reducing serious harm and protecting communities from emerging drug threats.

Health Minister Ashley Dalton said:

Young people don’t always realise the decision to take drugs such as ketamine can have profound effects. It can destroy your bladder and even end your life.

We’ve seen a worrying rise in people coming to harm from ketamine as well as deliberately contaminated THC vapes and synthetic opioids hidden in fake medicines bought online.

Prevention is at the heart of this government’s approach to tackling drugs and this campaign will ensure young people have the facts they need to make informed decisions about their health and safety, so they think twice about putting themselves in danger.

As part of the campaign, experts will highlight particular risks, including the:

  • potentially irreparable damage ketamine can cause to your bladder
  • dangers of counterfeit medicines containing deadly synthetic opioids purchased online
  • risks from so-called ‘THC vapes’ that often contain dangerous synthetic cannabinoids like spice rather than THC

Resources will be available for schools, universities and local public health teams with content available on FRANK, the drug information website.

There are growing concerns about novel synthetic opioids, particularly nitazenes, which are increasingly appearing in counterfeit medicines sold through illegitimate online sources. Users purchasing these products are typically younger and more drug-naïve.

Reports of harms from THC vapes have also increased, with many products containing synthetic cannabinoids (commonly known as ‘spice’) that have higher potency and unpredictable effects.

Katy Porter, CEO, The Loop, said:

The Loop welcomes the further investment in evidence-based approaches and support to reduce drug-related harm.

Providing accurate, non-judgemental information equips and empowers people to make safer choices and can help reduce preventable harms.

Drug poisoning deaths reached 5,448 in England and Wales in 2023, the highest number since records began in 1993. The campaign emphasises that while complete safety requires avoiding drug use altogether, those who may still use substances should be aware of the risks and know how to access help and support.

The campaign underlines that ketamine’s medical applications do not make illicit use safe, with urologists increasingly concerned about young people presenting with severe bladder problems from recreational ketamine use.

Resources will be distributed to local public health teams, drug and alcohol treatment services, youth services, schools and universities. The campaign provides clear information on accessing help and support for those experiencing drug-related problems or mental health issues.

This year the Department of Health and Social Care is also providing £310 million in additional targeted grants to improve drug and alcohol treatment services and recovery support in England, including specialist services for children and young people.

For information and support on drug-related issues, visit www.talktofrank.com or call the FRANK helpline on 0300 123 6600.

Background information

How to watch this YouTube videoThere’s a YouTube video on this page. You can’t access it because of your cookie settings.You can change your cookie settings or watch the video on YouTube instead:Ket: while each high lasts minutes, for some the damage to their bladder could last forever

How to watch this YouTube videoThere’s a YouTube video on this page. You can’t access it because of your cookie settings.You can change your cookie settings or watch the video on YouTube instead:Synthetic opioids: what are they and why are they so dangerous?

Additional resources for professionals and educators will be available through local public health networks.

The £310 million additional funding for drug treatment services is separate from the public health grant.

Source: https://www.gov.uk/government/news/young-people-given-stark-warning-on-deadly-risks-of-taking-drugs

 

17 October 2025

Sleep is essential for human survival; it affects an individual’s physical and mental health. Although the amount of sleep required varies throughout a person’s lifetime, the quality of it remains essential. Quality sleep restores the body, consolidates memories, supports emotional regulation, and plays a key role in maintaining the immune system. When sleep quality is compromised—such as in cases of insomnia—it can significantly disrupt daily life, prompting many to seek alternative remedies for relief.

One substance often misrepresented as a sleep aid is marijuana; however, research consistently shows that tetrahydrocannabinol (THC) interferes with the very sleep processes it claims to improve. A recent randomized controlled trial examining the effects of a single dose of THC and cannabidiol (CBD), the two primary compounds in marijuana, on individuals with clinical insomnia raised serious concerns about using marijuana as a treatment for sleep problems.

THC and REM sleep

In this study, those who took a one-time dose of 10mg of THC and 20mg of CBD experienced significantly less total sleep time and spent less time in rapid eye movement (REM) sleep, the phase associated with dreaming, emotional processing and memory consolidation, supporting previous research that pointed to THC disrupting deep REM sleep. THC also disrupted restorative stages, meaning that individuals may fall asleep faster but may never get the kind of sleep the body truly needs.

Those who took this THC and CBD combination also took about an hour longer to reach REM sleep compared to placebo. Studies have shown that the suppression of REM sleep can have long term consequences. While in this study a single dose did not affect next-day function, researchers cautioned that regular use may lead to tolerance and eventual withdrawal symptoms that could lead to worse quality sleep over time. Withdrawal from marijuana can also cause more sleep issues that may lead to relapse, adding challenges for people struggling with substance use or mental health.

While CBD is often marketed as the “calming” component of marijuana, in this formulation it may have intensified THC’s effects due to unknown metabolizing processes of both substances together. As marijuana and CBD products become more widely available and socially accepted—often under misleading claims—more people may turn to them as “natural” sleep remedies. However, as this study underscores, natural does not necessarily mean safe or effective. Just because something is derived from a plant does not mean it is harmless or beneficial.

Source: Drug Free America Foundation | 333 3rd Ave N Suite 200 | St. Petersburg, FL 33701 US

 

Kateena Haynes’s smile warms the room as she weaves through playing children at her feet to get to the computer room, chatting with staff as she goes. There, the walls are lined with desktop computers for kids to do their homework. A few minutes later, walking around back under the hot Appalachian sun, she notes the outstanding construction tasks for the new Boys & Girls Club gymnasium, which would officially open later that year, and beams at the progress. Haynes runs the youth development center in Harlan, Kentucky, but even if you didn’t know her official title, you’d quickly figure out that she’s the heart of this place.

During the winter of 2010, 13 of the approximately 60 kids in the Boys & Girls Club of Appalachia had a parent die of a drug overdose. One was a young girl whose father had just returned from prison and asked her to inject opioids into his arm. She said no, knowing he had already had too much.

“He wound up getting out and coming back home and overdosing in the bed with his daughter in the bed with him,” Haynes said in a 2024 interview with Encyclopaedia Britannica.

From opium to Oxy: How history set the stage for the opioid epidemic

According to the U.S. Centers for Disease Control and Prevention (CDC), more than 800,000 Americans died of opioid overdoses between 1999 and 2023. The drug that drove the initial phase of the epidemic was OxyContin, or oxycodone hydrochloride, a narcotic painkiller that can produce a euphoria similar to that of heroin. For its part in producing and distributing OxyContin, pharmaceutical giant Purdue Pharma agreed in 2025 to pay $7.4 billion to all 50 U.S. states, Washington, D.C., and four federal territories. Harlan is expected to receive at least $10 million over 18 years to establish treatment, recovery, and prevention efforts throughout the community.

In the complex evolution from the opium plant to widespread synthetic opioids, the 19th century was a critical turning point. American dental surgeon William Thomas Green Morton first demonstrated opioids’ use for anesthetic purposes when combined with ether in 1846, not long after the popular and wildly powerful pain medications morphine and codeine were isolated from opium. These drugs were widely available and could be used without a prescription. Then in the latter half of the century, heroin was synthesized; it also didn’t require a prescription until 1914.

Before 1874 all opium-related drugs were considered natural opioids. Heroin, synthesized via chemical manipulation of natural opium, was the first in a class of semisynthetic opioids. It is much more powerful than natural opioids—and much more addictive. Though heroin would be a scourge for the second half of the 20th century, the perilous power of morphine dominated the first half.

Learn more about the difference between opioids and opiates.

In 1929 the National Research Council’s Committee on Drug Addiction was created with a very specific first target: morphine. While their researchers were at work on understanding addiction and regulating the use of morphine, meperidine, the first entirely synthetic opioid, was created, ushering in a new era of increasingly potent drugs that carry massive overdose risks. At the same time access to other addictive opioids became more common. While the early-to-mid-20th century brought the use of hydromorphone and hydrocodone for pre- and postoperative pain, the distribution of opioids entered a new era in World War II.

The U.S. gave members of its military medical kits that each included single-use morphine injections to provide pain relief to injured troops waiting for advanced medical personnel. Though they had labels that read “Warning: May be habit-forming,” those labels far understated the drug’s addictive potential. After the war some medical kits were sold or stolen by those seeking morphine doses, and others who’d become addicted turned to heroin when morphine wasn’t available.

In 1947 the Committee on Drug Addiction and Narcotics was established, revamping the effort begun in the 1920s. This renewed focus on controlling the manufacture and distribution of drugs was, in part, spurred by the creation by German researchers of methadone. Methadone had shown potential to mitigate symptoms of opioid withdrawal, a potential that had yet to be fully realized. Though research funding began to trickle in, progress stalled as no stream of financial support was established until the 1960s.

That decade was known for massive societal shifts in the United States driven by the civil rights movement, feminist advocacy, and the rise of a distinct counterculture grounded in the questioning of long-held beliefs. For some, this attitude of rebellion led them to try—and in some cases become dependent on—illicit drugs. The increased use of marijuana, LSD, and eventually cocaine, heroin, and amphetamines led to crackdowns on pharmacies that distributed these drugs as well as a greater focus on prevention and treatment.

In 1962 the White House Conference on Narcotic and Drug Abuse was convened with the goal of determining how to better collect data about drug use, how to manage the use of both narcotic and nonnarcotic drugs, and what treatments could help those facing addiction. That year federally funded mental health centers were established nationally.

The next major move, the Controlled Narcotics Act of 1970, sorted drugs into five schedules, or categories, based on addictive potential and harmfulness, as well as their medical utility. Heroin, which had a spike in use in the late 1960s and early ’70s, was classified as a Schedule I drug, meaning it had a high potential for addiction and no accepted medical use. Cocaine was labeled a Schedule II drug, meaning it had some medical utility. Despite growing attention throughout the presidencies of John F. Kennedy and Lyndon B. Johnson, the official War on Drugs was not launched until 1971, when Pres. Richard Nixon declared “drug abuse” to be “public enemy number one.” The Drug Abuse Council was founded the same year, as the result of the Ford Foundation’s research, and helped to provide funding for research through 1978.

Initially the War on Drugs was praised as a long-awaited intervention for a serious public safety issue, but in hindsight many have called the effort a failure, both ethically and politically. Even with increased attention on the country’s drug problem, the use of crack cocaine soared throughout the 1980s. It was affordable and provided quick access to euphoria, and its ability to be smoked allowed people to receive smaller portions—all of which made it more cost-effective than powder cocaine, which has historically been seen as a symbol of wealth.

Instead of going after large dealers or manufacturers, Nixon’s War on Drugs led to mass incarceration because it targeted people selling relatively small quantities of drugs, which often meant prison time for young Black men in urban areas who were charged with low-level drug offenses. The War on Drugs also brought the use of mandatory minimum sentences, which disproportionately affected Black communities. Those found with five grams of crack cocaine received a mandatory five-year prison sentence. It took 100 times that amount of powder cocaine to earn the same sentence, meaning that a high-level powder dealer could receive a lesser punishment than a low-level crack dealer. Though statistics show that overall drug use is similar between white and Black communities, four in five crack cocaine users were Black. Nixon’s former White House counsel, John Ehrlichman, gave an interview in 1994 in which he explained the intentional targeting of these communities:

The Nixon campaign in 1968, and the Nixon White House after that, had two enemies: the antiwar left and black people.… We knew we couldn’t make it illegal to be either against the war or black, but by getting the public to associate the hippies with marijuana and blacks with heroin, and then criminalizing both heavily, we could disrupt those communities. We could arrest their leaders, raid their homes, break up their meetings, and vilify them night after night on the evening news. Did we know we were lying about the drugs? Of course we did.

Today many see the War on Drugs as having meted out the disproportionate impact of incarceration on historically underserved communities—a pattern that the quickly emerging opioid epidemic would only exacerbate. While the War on Drugs perpetuated stereotypes about Black communities, public response to the opioid epidemic capitalized on and furthered derogatory caricatures of rural white communities before the epidemic spread to all corners of the country.

As cocaine use grew across the United States, so did addiction. The number of cocaine users increased by approximately 1.6 million people between 1982 and 1985 alone. So when Purdue Pharma’s OxyContin (its brand name for oxycodone) was approved by the U.S. Food and Drug Administration (FDA) in December 1995, concerns about drug addiction were prevalent—which made Purdue Pharma’s marketing of OxyContin as less addictive all the more appealing, even if it wasn’t true.

The epidemic

The major problem with OxyContin extended beyond the drug itself. In fact, studies at the time of its release showed that it wasn’t more effective than other opioid analgesics on the market. What set OxyContin apart and led to the opioid epidemic was the marketing and publicity around it.

In the five years after the FDA approved OxyContin, Purdue Pharma trained more than 5,000 medical professionals at all-expenses-paid conferences, often in resort locations, to aggressively promote the drug. While there, these clinicians were trained and recruited for a Purdue Pharma speaker’s bureau that encouraged promoting OxyContin use to colleagues in environments such as grand round presentations in hospitals. The company studied physicians’ prescribing patterns in order to better tailor their sales pitch to individual doctors—especially those with the highest rates of opioid prescriptions. Though this strategy was not unique, the amount of money spent on incentives and aggressive, misleading marketing campaigns were distinctive. The company spent $200 million in 2001 alone marketing OxyContin. Sales representatives also earned bonuses that sometimes outweighed their annually salary, incentivizing them to find physicians who would overprescribe the medication.

Before this period opioids had traditionally been reserved for severe acute pain, used in the palliative care of cancer patients, for example. But Purdue Pharma’s marketing focused on expanding the conditions for which doctors would prescribe OxyContin, leading to a tenfold increase in prescriptions for pain unrelated to cancer in just five years.

This gave rise to the targeting of rural areas such as Harlan. Mining and logging in these regions often led to workplace injuries, making them hotbeds for marketing of pain relief medications. Still, that wasn’t all that made Appalachian communities vulnerable. Since the 1990s Harlan had struggled with addiction and unemployment as the coal industry declined, with more than 25 percent of Harlan county’s population of about 25,000 falling below the poverty line as of 2025. As feelings of hopelessness spread, so did the drug epidemic.

Tom Vicini, president and CEO of Kentucky drug prevention and recovery organization Operation UNITE, explained in a 2024 interview with Encyclopaedia Britannica how this can happen. In early drug roundups law enforcement discovered that people selling opioids in the area needed money to feed their addiction, he said. If they were able to buy and resell others’ prescriptions, both parties could potentially make a profit off the drug.

Why is OxyContin called “hillbilly heroin”?

As the opioid epidemic spread, it quickly became associated with Appalachian communities. Hillbilly is a pejorative term used to describe those living in often low-income rural communities in the Appalachian Mountains. Given that OxyContin had overtaken both heroin and cocaine in becoming the new face of the drug crisis, it was often referred to as “hillbilly heroin” by national media outlets.

Though there is evidence that marketing of OxyContin may have been less aggressive in cities, they were far from immune. Doctors in New York City and other large metropolitan areas received funding from opioid giants and in turn promoted their products as a gold standard for pain relief. And with TV and other advertisements repeating claims of a 1 percent addiction rate, OxyContin advertising appealed to both new patients and longtime chronic pain sufferers. As the country would learn, the actual rate of addiction is much, much higher, with some researchers reporting it as high as 26 percent.

According to the National Institute on Drug Abuse, prescriptions were the most common entry to opioid addiction throughout the 1990s and 2000s—up to 75 percent of all addictions began this way. And prescriptions became more prevalent: Annual opioid prescriptions grew from between 2 and 3 million in 1990 to 11 million by 1999. Even as the addictive potential of OxyContin was publicized, other pharmaceutical companies followed suit in manufacturing generic or brand name pills, including the firms Johnson & Johnson, Endo, Teva, and Allergan. By the 21st century, Purdue Pharma alone had made $1.1 billion in OxyContin sales, more than 20 times the sales of 1996.

With the War on Drugs rhetoric weighing heavily on people’s minds, there is intense stigma associated with drug use and dependency. Through the 1990s and 2000s, the public began to shift from viewing addiction as a moral failing to seeing it as a disease—but this change has been gradual. For some the spread of addiction to all corners of the country, including to cities’ most “elite” residents, prompted this change. Highly publicized deaths involving opioid overdoses—including that of Australian actor Heath Ledger, which was caused by an accidental overdose of a mix of oxycodone and other drugs—further influenced public perception, leading to a renewed awareness of the addictive potential of prescription drugs. Although drug overdoses have long plagued Hollywood, Ledger’s death hit the public differently in light of the rising opioid crisis, especially given OxyContin’s role in his death.

Despite shifting attitudes on the subject, a 2017 study by researchers from Johns Hopkins University found that nearly four in five people think that those struggling with addiction are themselves at fault. Stigma and feelings of shame not only incentivize individuas to hide their addiction, but it can also keep many people from getting help by generating of a network of barriers. Structural stigma, for example, includes negative views held by society that influence the creation of policies that discriminate against those struggling with addiction, such as limiting the development of local treatment centers and the availability of medication for opioid use disorder (MOUD), reducing access to quality care. Self-stigma is internalized shame that can prevent someone from seeking treatment, either because they do not feel they deserve help, are embarrassed about their addiction, or because they lack systems of support.

Long after the opioid epidemic was widely recognized in the early 2000s, rates of opioid overdoses continued an unbridled rise across the country, reaching a peak during the COVID-19 pandemic and its aftermath. In 2022 more than 81,000 Americans lost their lives to opioid overdose, likely because of interruptions in treatment and psychological hardships caused by isolation, boredom, illness, or loss of work. This was especially prominent in people 20 to 39 years old, with opioid overdoses causing more than 20 percent of overall deaths in this age group in 2022, according to a study in The Lancet. Overdoses were the largest accidental cause of death for this cohort.

The physical withdrawal symptoms associated with quitting opioids make it hard to recover from opioid use disorder. Withdrawal can range from extreme physical symptoms such as vomiting and muscle spasms to emotional symptoms such as anxiety and depression. To help people recover, there has been a growing movement to make MOUD accessible.

MOUD includes methadone, buprenorphine, and naltrexone—with the former two considered by the World Health Organization to be “essential medicines” to treat opioid use disorder. MOUD normalizes neural chemistry and blocks the euphoria of opioids and is often paired with behavioral therapy to provide a comprehensive treatment plan that addresses both the physical and psychological effects of addiction and withdrawal.

That doesn’t mean these two approaches are mutually exclusive—in fact, many people rely on multipronged approaches to treatment and community support to recover from drug addiction. In Harlan numerous peer support specialists come from their day jobs to support AA or NA group meetings, which are held every evening in a building just down the alleyway bordering a bank.

Though significant gaps still remain, the shift in understanding opioid use as a public health epidemic rather than a personal moral failing has ultimately advanced the accessibility of recovery care across the country. But meeting the urgent need for support also requires funding—and there were companies that made a lot of money as a result of mass addiction and suffering.

Lawsuits and repairing communities

Large-scale lawsuits, often initiated by state attorneys general, began in the early 2000s, when West Virginia claimed that Purdue Pharma had misled medical professionals about the addictive potential of OxyContin in their aggressive marketing of the drug. The company admitted no fault but chose to settle, paying $10 million to the state over four years, to be used for drug recovery and prevention services.

That was just the beginning. In 2007 Purdue Pharma and three of the company’s top executives were fined a total of $634 million for lying to the public about OxyContin’s risk of addiction. Later that year Kentucky sued the company, and they eventually settled, with Purdue agreeing to pay $24 million to the state. But there was a pivotal clause in that agreement: The judge granted a request to unseal the court documents, making Purdue Pharma’s strategies public and unveiling the marketing strategies that propelled the spread of addiction.

Over the next decade a series of other high-profile cases involving Purdue Pharma were settled. They were brought by state and federal governments alike, including one suit brought by Canada that took more than a decade to settle, with the company ultimately agreeing to pay $20 million to individuals and health providers. Purdue Pharma declared bankruptcy in 2019.

No single settlement was as large as the $7.4 billion agreement Purdue Pharma reached with all 50 states, Washington D.C., and four U.S. territories in June 2025, to be paid out over 15 years to support prevention, treatment, and recovery programs. This resolution to pending lawsuits came just a year after the U.S. Supreme Court overturned what would have been a $6 billion settlement paid out to state and local governments. A large portion of the $7.4 billion is to come from the Sackler family, the former owners of Purdue Pharma.

Although the bell can’t be unrung, there is a breadth of research about how best to invest these abatement funds—and early evidence shows the funding may be helping to change the future of the opioid crisis. In the United States deaths from drug overdoses decreased approximately 27 percent in 2024 from the year prior, with opioid-related overdose deaths dropping by 30,365 cases. One of the states most exemplary of this change is Kentucky, where overdose deaths decreased more than 30 percent the same year.

In Harlan these abatement funds have been used to establish a position for a case manager and advocate for Casey’s Law, which allows family or friends to commit to treatment a loved one struggling with addiction. Van Ingram, executive director for the Kentucky Office of Drug Control Policy, told Encyclopaedia Britannica that there are more mental health resources now than ever, but that there’s never enough—not just in Harlan County, but in rural America as a whole.

What is Casey’s Law?

Officially known as the Matthew Casey Wethington Act for Substance Abuse Intervention, Casey’s Law was passed by Kentucky legislators in 2004 to allow relatives or friends of someone struggling with drug addiction to petition the court for that person to be involuntarily entered into a treatment program. The decision to admit someone to treatment without their consent remains a controversial subject, and many in the recovery space believe that someone must choose to enter recovery and cannot be forced into it. Before Casey’s Law was enacted, there was no way to force an adult to get help unless they committed a crime and were required by the court to enter treatment. The law is named for 23-year-old Casey Wethington, who died of a heroin overdose in 2002. His family believed his death could have been prevented if there had been another route to court-mandated treatment.

As Haynes, CEO of the Boys & Girls Club of Appalachia, and others work to provide mental health resources for their community, Ingram said he is impressed by the growth of Harlan’s recovery community.

Said Haynes: “We started a counseling program, grief counseling, before it actually became a program of Boys and Girls Clubs of America. We were doing it first because the need was there, and we couldn’t wait for them to develop a curriculum.”

Haynes and her colleagues developed a protocol for the kids if a relative died, taking them out to dinner and keeping them occupied while the family managed funeral arrangements.

She tries to mentor these children and give them opportunities that level the playing field, Haynes told Encyclopaedia Britannica: “It’s hard for some people to see beyond these mountains…especially these kids, who are seeing their parents use drugs, and they’re just hopeless.”

Simultaneously, other Harlan organizations have been working on prevention. Both Vicini and Haynes go into schools to provide education about drugs and addiction, as well as opportunities such as field trips and mentoring partnerships to keep kids engaged in their own futures.

The city’s small size enabled the opioid epidemic to spread quickly, but the intimate, close-knit relationships that the community provides have also allowed it to be a safe haven for many, including some who came there for recovery and never left.

With a combination of local efforts led by the city’s drug court and various recovery programs, including some focused on job reentry, Harlan has become an example of what an engaged recovery community can look like—and advocates believe that overdose rates are declining because of it.

Overdoses are decreasing on the national level, as well. According to a study published in the Journal of the American Medical Association, 2023 marked the beginning of “a new wave of sustained deceleration [in overdose rates]…after 2 decades of increase.”

The new wave: Dangers of fentanyl

The epidemic entered a new—and perhaps even deadlier—phase with the introduction of fentanyl. Though it has been around since 1959 as a pain reliever, illicitly manufactured fentanyl has grown increasingly popular since it became a major part of the U. S. illegal drug market in 2013. Drugs such as methamphetamines or cocaine are increasingly laced with fentanyl. In 2022, 6 out of every 10 of the millions of fentanyl-laced fake prescription pills collected by the U.S. Drug Enforcement Administration (DEA) contained a potentially lethal amount of the opioid, up 50 percent from the year before. Though a small segment of people who use drugs seek out fentanyl, many of those buying laced pills are unaware of its presence until it is too late.

Fentanyl is the one of the most potent pharmaceutical opioids and is 100 times more powerful than morphine. A dose of the drug equivalent to just five to seven grains of salt can be lethal, which is partially why it’s responsible for 70 percent of overdose-related deaths. And growing numbers of illegally obtained drugs are laced with fentanyl because its potency allows smaller doses of the pure drug to be sold while providing the same level of euphoria and even higher addictive potential, increasing both profits and demand. Even if it puts customers in danger, the money outweighs the risk for some sellers.

In a February 2025 U.S. Senate hearing, Sen. Dick Durbin of Illinois spoke about the growing risk of fentanyl:

In just a decade this synthetic opioid [fentanyl] has emerged as the deadliest drug in American history. All it takes is two milligrams—that’s a fraction of the size of a penny—to cause an overdose. It is so cheap that dealers are lacing lethal amounts into street drugs like cocaine and heroin, and their buyers are none the wiser.

Yet if communities can harness the growing concern about fentanyl for change, it may give a second chance to those struggling with substance use disorder. Since 2022 Harlan county has held an annual drug summit to bring together more than two dozen exhibitors with a focus on continuing to bring down overdose rates, even in the face of fentanyl.

Along with increased efforts to provide those struggling with addiction transitional housing, reemployment, and improved treatment accessibility, Harlan and other communities hit hard by opioids have another key tool: love.

“There’s people that came here for treatment and never left, because they were loved,” said Dan Mosley, Harlan county judge executive. “That’s truly what makes our place special.”

Source: https://www.britannica.com/topic/How-the-Opioid-Crisis-Devasted-Families-Communities-and-Ultimately-a-Country

 

Press Release – Washington, DCOctober 09, 2025

A popular class of therapies for treating diabetes and obesity may also have the potential to treat alcohol and drug addiction, according to a new paper published in the Journal of the Endocrine Society.

The therapies, known as Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs), present an encouraging approach to treating alcohol and other substance use disorders.

“Early research in both animals and humans suggests that these treatments may help reduce alcohol and other substance use,” said lead researcher Lorenzo Leggio, M.D., Ph.D., of the National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA), both part of the National Institutes of Health (NIH) in Bethesda, Md. “Some small clinical trials have also shown encouraging results.”

Current Treatment Options Are Limited

Substance use disorders are diagnosed based on criteria that can be grouped into four categories: physical dependence, risky use, social problems, and impaired control.

The negative consequences of substance use disorders represent a global problem, affecting individuals, families, communities, and societal health at large. For instance, research indicates that alcohol is the most harmful drug, with consequences that extend beyond individual health to include related car accidents as well as gun and domestic violence, researchers note.

Despite the high prevalence and consequences of alcohol and other substance use disorders, less than a quarter of people received treatment in 2023.

Underutilization is due to a variety of barriers at the patient, clinician, and organizational levels, not the least of which is the stigma associated with substance use disorders, according to the study. “Current treatments for [alcohol and other substance use disorders] fall short of addressing public health needs,” the researchers wrote.

GLP-1s and Their Potential to Treat Addiction

GLP-1 therapies have gained widespread renown in recent years for their ability to address obesity and significantly reduce weight.

In addition to its inhibitory effects on gastrointestinal systems, GLP-1 has key functions in the central nervous system, the study notes. Among them, GLP-1R activation within the central nervous system curbs appetite and encourages individuals to eat when hungry and stop eating when they are full.

Some forms of obesity have been shown to present biochemical characteristics that resemble addiction, including neurocircuitry mechanisms, the study says, acknowledging that such conclusions are controversial.

“Pathways implicated in addiction also contribute to pathological overeating and obesity,” the study says.

With this pathway in mind, researchers in recent years have looked at GLP-1s as a potential therapy to address substance use disorders. Preclinical and early clinical investigations suggest that GLP-1 therapies modulate neurobiological pathways underlying addictive behaviors, thereby potentially reducing substance craving/use while simultaneously addressing comorbid conditions.

Studies that examine GLP-1 effects on substance use disorders include:

  • Alcohol use disorder (AUD): A randomized controlled trial with exenatide, the first GLP-1receptor agonist approved for diabetes, showed no significant effect on alcohol consumption, although a secondary analysis indicated reduced alcohol intake in the subgroup of people with AUD and comorbid obesity. A more recent randomized controlled trial showed that low-dose semaglutide — a newer GLP-1 receptor agonist approved for both diabetes and obesity —reduced laboratory alcohol self-administration, as well as drinks per drinking days and craving, in people with AUD.
  • Opioid use disorder: In rodent models, several GLP-1 receptor agonists have been shown to reduce self-administration of heroin, fentanyl and oxycodone. The studies also found that these medications reduce reinstatement of drug seeking, a rodent model of relapse in drug addiction.
  • Tobacco use disorder: Preclinical data show that GLP-1 receptor agonists reduce nicotine self-administration, reinstatement of nicotine seeking, and other nicotine-related outcomes in rodents. Initial clinical trials suggest the potential for these medications to reduce cigarettes per day and prevent weight gain that often follows smoking cessation. 

Leggio and his colleagues caution that more and larger studies are needed to confirm how well these treatments work. Additional studies will help unveil the mechanisms underlying GLP-1 therapies in relation to addictive behaviors and substance use.

But that hasn’t dampened the optimism for these therapies to address the serious problems found in substance use disorders.

“This research is very important because alcohol and drug addiction are major causes of illness and death, yet there are still only a few effective treatment options,” Leggio said. “Finding new and better treatments is critically important to help people live healthier lives.”

Other study authors are Nirupam M. Srinivasan of the University of Galway in Galway, Ireland; Mehdi Farokhnia of NIDA and NIAAA; Lisa A. Farinelli of NIDA; and Anna Ferrulli of the University of Milan and Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) MultiMedica in Milan, Italy.

Research reported in this press release was supported in part by NIDA and NIAAA. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Source: https://www.endocrine.org/news-and-advocacy/news-room/2025/glp1s-show-promise-in-treating-alcohol-and-drug-addiction

by Gabrielle Humphreys &  Natalie Finch – BMC (BioMedCentral) –

Abstract

Background

Lived experience recovery organisations (LEROs) are social support services facilitated by those who have shared lived experience. Typically, they aim to build shared identity and reducing stigma in this area, although there is limited knowledge on the experiences of those using LEROs, with research rarely permitted into these groups. The current study aims to provide insight into these groups, examining the experiences of service users in a UK-based LERO focussed on substance use disorder recovery.

Methods

Fifteen service users were interviewed about their experiences attending this LERO. Transcripts from these semi-structured interviews were thematically analysed by authors, with an inductive approach adopted.

Results

Eight themes and 10 sub-themes were identified. Themes were; Feeling supported in recovery, Experiencing life outside of substance use disorder, Fun, Skills acquisition, Preventing relapse by filling time, Gaining a sense of community, Psychological impact, and Changes in public perception. Participants reported having a positive experience within this LERO, particularly in comparison to traditional treatment pathways. Specifically, participants highlighted feelings of self-worth, belongingness, and enjoyment from this LERO – experiences they felt made this treatment pathway unique.

Conclusion

This paper highlighted the importance of peer support in substance use disorder recovery. Embedding those with lived experience into services was highly valued by participants and generated a unique culture of comfort, hope and opportunity. Although the scope of this study was limited to participants only currently attending this organisation, those interviewed significantly valued this LERO, highlighting their future potential to alleviate the lack of satisfaction reported by some around traditional treatment methods.

 

To access the full article, please click on the ‘Source’ link below:

Source: https://substanceabusepolicy.biomedcentral.com/articles/10.1186/s13011-025-00671-9

Received: 09 October 2025 

The American College of Obstetricians and Gynecologists (ACOG) has released new clinical consensus guidance recommending universal screening for cannabis use across all reproductive stages—pre-pregnancy, pregnancy, and postpartum—with a clear message: there is no safe level of cannabis use for mothers or infants.

Despite mounting evidence of risk, cannabis use during pregnancy and lactation is increasing, fueled by legalization, social acceptance, and a lowered perception of harm. ACOG emphasizes that no medical indications exist for cannabis use during pregnancy or after birth.

To support prevention and care, ACOG’s clinical consensus on Cannabis Use in Pregnancy and Lactation provides evidence-based guidelines for screening, counseling, and reducing use.

Below are key takeaways from ACOG’s new clinical consensus.

Risks to Fetus and Newborn

·    THC, the psychoactive component, crosses the placenta and reaches the fetus; THC also transfers into breast milk.

·    Prenatal cannabis exposure is associated with:

·    Increased risk of low birth weight, small-for-gestational-age infants, NICU admission, perinatal mortality

·    Altered neonatal behaviors (arousal, regulation, excitability)

·    Possible long-term neurocognitive, behavioral, and memory challenges, ADHD, and greater susceptibility to psychiatric disorders or substance use later in life

·    While more research is needed, existing evidence shows clear cause for concern.

Risks During Lactation

·    Data on cannabis use while breastfeeding are limited; ACOG discourages use during lactation due to THC transfer into breast milk and potential developmental impacts.

·    Clinicians should encourage cessation while continuing to support breastfeeding.

Recommendations for Clinicians

1.     Universal Screening & Counseling

·    Screen all patients (pre-pregnancy, pregnancy, postpartum) via interview or validated tools (e.g. TAPS, CRAFFT, S2BI).

·    Avoid biologic testing (urine, hair, etc.) as a routine screening tool.

·    Educate that cannabis has no medical indication during pregnancy or postpartum.

2.     Advise Cessation or Reduction

·    Encourage patients to stop or reduce cannabis use during pregnancy and breastfeeding, offering nonjudgmental support.

3.     Supportive Behavior Change Strategies

·    Use motivational interviewing, address social determinants, and identify barriers to quitting.

·    Provide access to home visits, CBT, and digital or text-based supports for behavior change.

4.     Legal, Ethical, and Equity Considerations

·    Policies on drug testing, child protective services (CPS) reporting, and criminalization vary widely.

·    Black and minority birthing people are disproportionately subject to drug testing and CPS referrals, despite similar substance use rates. 

·    Clinicians should ensure informed consent, understand local policies, and work to reduce bias in maternal care.

Source: Drug Free America Foundation | 333 3rd Avenue N Ste 200 7278280211101 | Saint Petersburg, FL 33701 US

Received from AALM Americans Against Legalising Marijuana – 09 October 2025

On The Ingraham Angle, Fox News medical contributor Dr. Marc Siegel responded to a recent video from President Donald Trump, who appeared to endorse CBD use among seniors.

Dr. Siegel’s reaction was both clear and alarming:

“Marijuana is the most dangerous drug in America.”

He cautioned that while CBD is often marketed as a harmless wellness product, the truth is far more complicated. Many CBD items sold today are unregulated and frequently contain undisclosed levels of THC, the psychoactive compound found in marijuana. Dr. Siegel explained that modern marijuana is 20 to 30 times stronger than it was in decades past, creating unpredictable effects—especially for older adults who may already be taking multiple medications. For seniors, the combination of high-potency THC and prescription drugs can lead to confusion, anxiety, and dangerous interactions.

Siegel emphasized that Americans are being lulled into a false sense of safety by clever marketing and political endorsements that blur the line between medicine and addiction. Despite being sold as “natural” and “therapeutic,” these products remain largely untested, inconsistent, and risky, particularly for vulnerable populations.

🚨 Why It Matters

President Trump’s public support for CBD among seniors raises serious concerns about normalizing drug culture under the guise of health and wellness. When national figures promote substances without FDA oversight or long-term safety data, the result is confusion, not compassion. Seniors deserve real medical protection, not another gateway to unregulated drug exposure.

At Americans Against Legalizing Marijuana (AALM), we stand with medical professionals like Dr. Siegel in calling out this dangerous trend. We are urging policymakers to investigate how CBD and marijuana marketing is targeting older Americans and to hold those responsible accountable.

To access the full article, please click on the ‘Source’ link below.

Source: https://static1.squarespace.com/static/599a426ee45a7ccab72c77d2/t/63b361cb6350f410413b2878/1672700379514/Risks+of+Marijuana+Use+%28AALM%29.9.1.2022.pdf

Adolescence is a critical stage of growth, a time when young people begin to make their own independent choices in preparation for adulthood. However, it is also a time of vulnerability, especially when it comes to exposure to drugs and other harmful substances.

Because the brain is still developing, particularly in areas that control decision-making and impulse regulation, adolescents face unique risks that can affect their health and overall well-being. 

It is a well-established fact that the human brain does not fully mature until around the age of 25, leaving adolescents and young adults more vulnerable to the harmful effects of harmful substances. When exposure occurs during these critical years of development, it can cause both immediate harm and long-term consequences that may follow individuals well-into adulthood. 

One of the key reasons for this vulnerability lies in the development of the brain itself. According to the Harvard Health article “Adolescence: A high-risk time for substance use disorders” by Sharon Levy and Siva Sundaram, “the adolescent brain is ‘deliberately’ set up for risk-taking.” 

Areas such as the prefrontal cortex, a part of the brain which plays a central role in judgment, impulse control, and decision-making, are still “under construction” during adolescence. Because of this, younger individuals are more likely to engage in risky behaviors, including experimenting with drugs, often without fully understanding the dangers. The earlier drug use begins, the greater the potential for lasting harm. 

Substance use during this developmental period primes the brain for addiction and chronic health problems. Addiction occurs when the brain’s pleasure receptors are overstimulated, creating an artificial “reward system” that encourages repeated drug use.

For adolescents, this effect is magnified due to their still-developing neural pathways. With a heightened sensitivity to pleasure and a weaker ability to assess long-term consequences, teens are more likely to fall into cycles of use and dependency. 

What further exacerbates this issue is the limbic system, the part of the brain that processes emotions and rewards. Unlike the prefrontal cortex, the limbic system matures earlier, meaning teens often experience intense emotional responses and a stronger drive for immediate gratification.

Drugs offer that instant burst of dopamine, which quickly reinforces use through a “use-reward-repeat” pattern. 

Over time, this can disrupt the brain’s natural ability to feel pleasure, making ordinary activities less satisfying and increasing reliance on substances. 

The health risks tied to early drug use extend far beyond the brain. Adolescents who use drugs, as noted in the article “Teen drug abuse: Help your teen avoid drugs” published by Mayo Clinic, face heightened risks of heart attacks, strokes, organ damage, and worsening mental health conditions. 

Early experimentation can also serve as a gateway to more harmful substances, escalating the risks over time. Adding to the concern, research published in Neuropharmacology reports that patterns of substance use can pass down genetically, making future generations more susceptible to addiction as well.

Ultimately, drug use during adolescence is not just a temporary risk, but one that can set the stage for a lifetime of consequences. By understanding the unique vulnerabilities of the developing brain, it becomes clear why prevention and education are important. 

Protecting adolescents from early exposure to drugs is not only about safeguarding their present, but about preserving their future health as well. 

Source: https://www.pleasantonweekly.com/alameda-county/2025/10/06/how-drugs-alter-the-developing-brain-priming-adolescents-for-risk-and-dependency/

 

  by Jessica Williams –  October 6, 2025

Every October, Substance Use and Misuse Prevention Month provides a reminder of the lives at stake in the fight against substance use disorders (SUDs). For New Hampshire, this year brings signs of real progress.

After nearly a decade of drug-related mortality rates falling above the national average, the Granite State is now experiencing record declines in drug-related fatalities. A closer look at the data suggests that sustained investments in prevention, treatment, and recovery may be paying off.

Drug-related deaths in New Hampshire, once among the highest fatality rates in the country, have begun to fall sharply. From 2013 to 2020, Granite Staters experienced drug-related fatality rates well above the national average, peaking in 2017 when an estimated 490 people died from drug-related causes, nearly five times higher than the number killed in traffic-related accidents in the state. But by 2024, deaths had declined to 287, the smallest number recorded since 2014 and the sharpest year-over-year decline across the previous decade. Early data suggests that this trend may continue into 2025: an estimated 77 Granite Staters died from drug-related fatalities the first half of this year, a decline from the 122 people during the same period in 2024.

These declines follow a decade of increasing state and federal investments in SUD prevention, treatment, and recovery services. Since 2014, New Hampshire has invested more than $835 million in SUD services, with spending increasing by an estimated 450% from 2014 to 2024.

Medicaid, the single largest payer of SUD services, has been vital for increasing access. The passage of Medicaid expansion in 2014, now commonly known as Granite Advantage in New Hampshire, expanded health coverage for adults up to 138% of the federal poverty guidelines. Of the almost $58 million spent on Medicaid-funded SUD services in 2024, nearly 80% was financed services under Granite Advantage. Opioid abatement funds resulting from legal settlements with drug manufacturers have also added funding support. By late 2024, New Hampshire had received close to $96 million in settlement money, although around half remained unspent. As of January 2025, it is estimated by the Kaiser Family Foundation that New Hampshire will receive more than $168 million in future payments, combined with a large continuing balance allowing for more spending flexibility across the state.

Yet despite these gains, access to treatment remains uneven, and many Granite Staters are still left behind. In 2022-2023, nearly 3 out of 4 Granite Staters who needed SUD treatment did not receive it, due in part to barriers such as provider shortages, regional disparities, coverage limits, and housing instability. Social determinants of health also play a role in which services people are able to obtain and can impact engagement with treatment and sustained recovery. Nationally, people identifying as Black or Native American experience disproportionate health outcomes from substance misuse. Research also shows that communities with greater income inequality experience higher drug-related fatality rates.

In New Hampshire, over half of drug-related deaths in 2024 occurred among people age 30 to 49, although shifting demographics have impacted fatalities, with older adults age 65 and older comprising around 13 percent of drug-related deaths. Men have accounted for around two-thirds of fatalities each year across the previous decade, and rural counties, including Coös and Sullivan counties, also report higher mortality rates, likely reflecting limited service availability resulting from workforce shortages.

In addition to better health outcomes, an investment in SUD services contributes to longer-term economic and social benefits. Increased prevention, treatment, and recovery services can reduce costly emergency health care spending, decrease burdens on the criminal legal system, and help keep more people engaged in the workforce.

However, new federal and state policy changes could undermine this progress. Although Medicaid has remained the largest source of funding for SUD services, new state and federal changes could impact access to health care across New Hampshire. Both the new federal reconciliation law and the latest state budget add work requirements for Granite Advantage adults, requiring people to prove employment or engagement in an eligible community engagement activity to obtain health coverage. While people in SUD treatment are exempt from the new requirements, differing state interpretations of the law, as well as difficulties with exemption paperwork and redeterminations could mean coverage losses for people in treatment and recovery. Early national research suggests that as many as 156,000 people across the country could lose access to medication-assisted treatment, resulting in an estimated 1,000 additional opioid-related deaths each year. These Medicaid changes come at a time when access to services is already limited.

As this year’s Substance Use and Misuse Prevention Month arrives, New Hampshire’s recent experience demonstrates that sustained investments in prevention, treatment, and recovery services can save lives. This progress, however, may be fragile. Without continued investment and innovation, the advances made in reducing drug-related deaths could stall, or even reverse, putting more families and communities at risk.

Source: https://newhampshirebulletin.com/2025/10/06/record-declines-in-drug-related-deaths-follow-decade-of-investment-in-prevention-and-treatment/

United Nations

United Nations – Office on Drugs and Crime

07 October 2025

Practical, Digital and Tailored to Help You Grow

The United Nations Office on Drugs and Crime (UNODC) has officially launched its dynamic new Learning and Innovation Programme and with it, the new powerful digital training platform called SPARK.

SPARK brings flexible, high-impact learning to professionals worldwide – from bustling capitals to remote field stations.

In many low-resource or remote settings, criminal justice institutions face significant challenges, such as fragmented access to training, language barriers and geographical isolation. As a result, many practitioners lack training altogether, while those who do receive it often rely on sporadic training or outdated courses, leaving them underprepared for rapidly evolving threats.

UNODC, through the eLearning platform SPARK, addresses these challenges by providing multilingual online and offline courses and fostering a global community of practice. This approach bridges gaps and makes knowledge on justice more accessible worldwide.

Meet SPARK: Learn Anytime, Anywhere

This new Programme reflects a growing institutional shift toward digitalization and innovation not just as tools, but as essential strategies for building safer, more secure societies.

The Learning and Innovation Programme now focuses on three core areas:

  1. Digital training delivery across all UNODC thematic areas, i.e. the world drug problem, transnational organized crime; terrorism; corruption; and criminal justice.
  2. Pedagogical support to enhance the quality and impact of training provided by partners;
  3. Digital transformation for the internal operations and processes of criminal justice institutions and academies.

“This Programme introduces a new approach to capacity-building,” said Aimée Comrie, Chief of UNODC’s Crime Prevention and Criminal Justice Section. “It is practical, digital and tailored to help institutions grow stronger through innovation.”

At the heart of the Programme is SPARK – a powerful, modern digital learning platform that offers cost-effective, flexible interactive and accessible training tools for professionals across the criminal justice system. It includes self-paced eLearning courses, with interactive scenarios and simulations, as well as eClasses, which support both in-person and virtual training formats. Knowledge hubs, including webinars, online libraries, forums and podcasts are also featured. Moreover, content is localized, tailored to regional, national or local needs. 

Digital Transformation: From the Ground Up

Many criminal justice institutions, particularly in remote or underserved regions, continue to face serious barriers to modernization: limited internet access, power outages, outdated administration systems and low levels of digital literacy. These challenges not only hinder operational efficiency but also limit the ability of institutions to adapt to rapidly changing criminal justice threats.

The Programme directly addresses these obstacles by helping institutions digitalize core operations such as data management, administration, communication and training coordination. The Programme also providers basic digital literacy training, from device operation and email use to safe web navigation and online collaboration.

“Digital transformation is not just about technology – it is about empowering institutions to function more effectively, securely and inclusively,” said Nicolas Caruso, Head of the Learning and Innovation Programme. “By addressing infrastructure and skill gaps, we are helping justice institutions become more resilient and better equipped to meet the need of their communities.”

To ensure learning reaches even the most remote locations, the Programme has introduced  Mobile Training Units (MTUs) – portable kits containing a server, laptops and a router that can run for five hours without external power and be deployed in just 20 minutes. The MTUs have been deployed in 30 locations across West, Central and Eastern Africa, Latin America, South Asia and Southeast Asia, and North Africa and the Middle East.

Moreover, over 60 eLearning Centres have already been established globally, blending in-person instruction and creating local hubs for outgoing training.

Source: https://www.unodc.org/unodc/en/news/2025/October/unodc-ignites-innovation-with-new-learning-programme-and-spark-elearning-platform.html

by Flagstaff Business News, Arizona, USA –  

By Roy DuPrez – Roy DuPrez, M.Ed., is the CEO and founder of Back2Basics Outdoor Adventure Recovery in Flagstaff. DuPrez received his B.S. and M.Ed. from Northern Arizona University. Back2Basics helps men, ages 18 to 35, recover from addiction to drugs and alcohol.

The challenge is real, but so is the opportunity: together, we can make prevention a priority and create healthier, more resilient communities.

Substance abuse continues to be one of the most pressing challenges facing families and communities today. While issues such as alcohol and illicit drug use are well known, prescription drug abuse has become a growing concern in recent years. The easy access to medications in many households, combined with misconceptions about their safety, makes prevention more important than ever.

A holistic approach – grounded in education, family support and healthy development – can go a long way in reducing the risks of substance misuse, particularly with prescription drugs.

The Importance of Early Prevention

Prevention starts long before young people are confronted with the temptation to experiment with drugs or alcohol. Building resilience, confidence and strong family connections early in life can provide powerful protection against substance abuse.

Here are some proven prevention strategies:

Developing Skills and Talents
Encouraging children to pursue sports, arts, music or other hobbies gives them positive outlets for their energy and creativity. These activities not only foster a sense of accomplishment but also help build healthy peer groups, reducing the influence of negative social pressures.

Building Self-Esteem
Confidence is one of the strongest safeguards against risky behaviors. When children feel good about who they are, they are less likely to seek validation through dangerous choices like substance use.

Fostering Family Connections
Open, honest communication within families makes it easier to address difficult topics, including substance abuse. Parents who create a safe space for discussion – and even role-play peer pressure situations – can help their children feel prepared to handle real-world challenges.

Educational Programs
Schools and community organizations play a key role in prevention. Beyond simply warning about the dangers of drugs, the best programs focus on building self-esteem, strengthening family relationships and giving students practical tools to make healthy decisions.

Understanding Prescription Drug Abuse

Even with preventive measures in place, prescription drug abuse remains a significant concern. Many families underestimate the dangers of medications that may already be in their own homes.

Commonly Misused Medications

  • Painkillers: Percocet (oxycodone), Vicodin (hydrocodone)
  • Anti-anxiety medications: Valium (diazepam)
  • Stimulants: Adderall, Ritalin and other ADHD medications

Safe Practices for Families

  • Secure Storage – Medications should be kept in locked cabinets, out of reach from children, teens and visitors.
  • Proper Disposal – Use local drug take-back programs or approved disposal sites. Throwing medications in the trash or flushing them can create environmental hazards and accidental risks.
  • Education and Awareness – Families should understand that “prescribed” doesn’t always mean “safe.” Community workshops, brochures and forums can provide helpful tools to increase awareness.

A Path Forward

Substance abuse prevention – especially when it comes to prescription drugs – requires a community-wide effort. Addiction does not discriminate; it impacts families across every socioeconomic and cultural background.

By strengthening family connections, building self-esteem, encouraging positive outlets and practicing safe medication habits, we can give the next generation the tools they need to thrive.

The challenge is real, but so is the opportunity: together, we can make prevention a priority and create healthier, more resilient communities. 

Source: https://www.flagstaffbusinessnews.com/substance-abuse-prevention-and-the-challenge-of-prescription-drug-abuse/

In a world where alcoholic drinks are seemingly ever-present and sold by even the makers of Sunny D and Mountain Dew, it can seem like a daunting task to raise kids who can withstand the societal pressures and avoid the harms of substance use disorder. 

But a recent speaker in the GPS Parent Series broke down the science of prevention and offered tips parents can use to help their children grow up to be competent, engaged, and sober. 

Jessica Lahey, an author, educator, and substance use prevention expert, shared best practices from her research, focusing on risk factors for substance use disorder and ways parents can use a basic understanding of the adolescent brain to help young people steer clear. 

“Risk and prevention is like the scales of justice,” Lahey said. “If your risk is really heavy, then your protections will have to be heavier to zero those out.”

Risk factors for substance use disorder

While there is no single “addiction gene,” Lahey — who has been in recovery from alcohol use disorder for the past 10 years — said genetics accounts for between 50 and 60% of a person’s risk for developing substance use disorder. Another major risk factor is occurrences known as ACEs, or adverse childhood experiences — things like neglect, abandonment, physical or sexual abuse, trauma, violence, separation, or divorce. 

But Lahey also pointed out several lesser-known risk factors, including early childhood aggression, under-managed learning differences, academic failure, social ostracism or identifying as LGBTQ+. Certain time periods can bring about higher risk as well, such as transitional phases like summers, moves between schools, or the weeks and months when a divorce is taking place. 

Prevention tips to raise sober kids

Lahey’s talks to the GPS audience, including several groups hosting watch parties, were full of proven prevention tactics that help youth not only avoid alcohol and drugs — but protect their developing brains in the process. Here are five of the top strategies she shared: 

Start early: As early as preschool, parents can start talking about substance safety with things like toothpaste and adult medicines to help children learn “to be safe about what you’re eating, and what you’re not putting in your body,” Lahey said.

Understand the adolescent brain: “The adolescent brain is wired for novelty,” Lahey said. So when a risk factor occurs, such as moving or starting a new school, parents can reframe this to meet their teen’s need for encountering new things. This allows teens to feel “hits of dopamine, mastery and competence that give a boost to their brain,” Lahey said. 

Know that drinking is different for adolescents: Because brain development is still taking place until the early 20s, youth brains are wired to weigh the potential positives of a situation more heavily than the risks. Research proves teens are more likely to engage in risky behavior if they believe their peers are watching, Lahey said. And they’re less likely to understand how impaired they are if they do start drinking. This can be a dangerous mix, but parents can counteract it by emphasizing the value of brain development. “Your brain is too important to mess with,” Lahey said.

Have a clear and consistent message: Delaying drug or alcohol use can allow ample time for healthy brain development, and Lahey said this results in a major decrease in lifelong risk for substance use disorder. So, the message from parents should be, “I just need you to delay,” she said. This can help create a family culture in which drinking isn’t an option until it’s legal. If teens don’t like that rule because it feels arbitrary, Lahey encourages parents to try this line about drinking: “No. Not until your brain is done developing.” 

Be preventive, not permissive: Behaviors that create a permissive culture around alcohol, such as allowing children and teens to take sips of alcoholic beverages in the home, or hosting parties where young people are allowed to drink, have been proven to increase risk for substance use disorder — not encourage moderation, Lahey said. “It is not inevitable that kids are going to drink,” she said. “Permissiveness results in kids with much higher levels of substance use disorder.” 

Parenting with the science of prevention

Jordan Esser, Project Coordinator of the DuPage County Prevention Leadership Team, introduced Lahey before the free online talks she gave on Sept. 25 and thanked her for sharing “the science of motivation, parenting and substance abuse prevention — because we as adults have the power to help our kids become more competent and fulfilled.”

Source: https://www.nctv17.org/news/how-to-raise-sober-kids-outweigh-risks-with-prevention-expert-says/

 

 

The steady increase in drug abuse worldwide is a reality that affects us, even in the Caribbean. On this island, as in many other places, synthetic cannabinoids are the most widely available and easiest to obtain.

Why is this? Among other reasons, their low cost and the quantities available. This type of drug is more addictive and harmful to the body, yet it is consumed in greater quantities than natural drugs.

Las Tunas is no stranger to this increase. In the second half of 2024, the province saw a spike in consultations for both acute intoxication and patients addicted to cannabinoids and other types of drugs.

 

Toxicology and psychiatry experts find it encouraging that the territory is currently at a plateau. Alejandro Mestre Barroso, a toxicologist at Ernesto Guevara Hospital, explains to 26 that this means that we do not have a peak in consumption, but neither do we have a decrease.

He also notes that the detection of cases is advancing and, due to promotional activities and the support of the various factors involved in this process, a decrease in the number of patients is expected.

“We will not see it suddenly, but gradually. This plateau phase is one of the most important for achieving a decrease in the detection of acute cases and new users.”

“We predict that, starting in the last quarter of this year, these statistics will begin to decline gradually if we continue our prevention efforts, because once consumption begins, it is so difficult to quit.”

NEED TO RAISE AWARENESS

With words of encouragement and concrete actions, health specialists in this area are always seeking to reach everyone, especially young people, who are the most vulnerable when it comes to addiction.

For this reason, the University of Medical Sciences has a Multidisciplinary Chair for the Prevention of Drug Use, promoted by a group of professionals who focus on prevention-related issues.

“This chair is part of the country’s drug surveillance network,” explains Mestre Barroso, “because it provides statistics on the age groups, gender, days of the week, and times of day when substances of abuse are most commonly consumed. All this monitoring allows us to develop an action plan that makes it possible to work on eradicating these patterns.”

 

The presence and prominence of the students enable this association to have a wide reach; they can connect with the public due to their less formal and less technical language. Adriana de la Caridad López Lora, medical student

One of those voices is Adriana de la Caridad López Lora, a fourth-year medical student, who says that through her work, she can reach many young people and warn them in time.

“I enjoy giving talks, explaining, and teaching what drugs can do, because we’re not just talking about addiction, but also the excessive increase in teenage pregnancy and the spread of sexually transmitted diseases.

“Thanks to outreach projects, we have talked to patients undergoing detoxification at the Psychiatric Hospital; we have also contributed to communities, secondary schools, and pre-university institutions. We have been able to reach large groups of people.”

Talking to her own classmates is now part of her daily routine. It is her vocation to impact as many people as possible with this issue; Adriana feels the need to raise awareness.

Through science and innovation, university professors and local experts are seeking to eradicate the use of these substances that cause so much damage to society and the body.

Source: https://www.periodico26.cu/index.php/en/principal-en/23117-prevention-the-watchword-against-drugs

 

by Ryan Hesketh – Talking Drugs – Posted on September 15, 2025

In November, the World Health Organisation (WHO) will issue its long-awaited recommendation on whether the coca leaf should remain listed under the UN’s most restrictive drug controls.

For decades, the coca leaf has been treated in international law as little more than raw material for cocaine. The 1961 Single Convention on Narcotic Drugs, following the advice of a deeply flawed 1950 WHO report, placed coca in Schedule I, equating its potential harm from use with that of heroin. This decision criminalised traditional use by Indigenous peoples in the Andes, despite millennia of practice, ignoring both its cultural and medical significance. 

Now, with WHO experts due to report their findings in September, attention is turning to whether the organisation can finally correct the record.

Critical timeline

Bolivia’s government initiated the review in 2023, arguing that coca’s scheduling was based on flawed information and infringed on indigenous rights. Since then, the WHO has tasked independent experts with conducting research on coca, its harms, and the potential impacts of change. Those experts are due to report their findings to the Executive Committee in late September, a crucial step on the pathway to potential change.

From there, the Expert Committee will meet in late October, finalising its report and recommendation in time for member states to consider ahead of the UN Commission on Narcotic Drugs’ (CND) reconvened session in December. The formal vote on coca’s scheduling, however, won’t take place until March 2026 in Vienna.

Luis Arce, the former president of Bolivia, holding coca leaves in 2022. Author: Vice Ministry of Communication of Bolivia

Uncertain outcomes

There are essentially three potential outcomes from the review. First, no action. Either the WHO makes no recommendation, which would result in no possibility of a vote, or states vote to maintain coca’s current Schedule I classification. Few expect the WHO to recommend keeping coca in its current schedule. “It’s hard to imagine they’d come to the conclusion that coca belongs where it is,” according to John Walsh, Director for Drug Policy and the Andes at the Washington Office on Latin America (WOLA).

If the review recommends a change in Coca’s scheduling, it would likely move down to either a Schedule II or III – still keeping its classification as a ‘narcotic drug’ subject to most treaty provisions. However, such a move would allow for certain traditional uses of coca and could be seen as a political compromise between those favouring full rescheduling and those favouring prohibition. This would create a clear difference in the scheduling for Coca and cocaine, similar to how opium products and the opium poppy are scheduled. Opium poppies are in Schedule II, while heroin is in Schedule I, reflecting the differing harms of the plant and its derivatives. Though rescheduling might be the most politically expedient outcome, and may align more closely with the UN’s Declaration on the Rights of Indigenous Peoples, it would still be very short of full removal, according to Walsh.

Finally, the result hoped for by many states and drug policy reform advocates: coca could be completely removed from the drug control treaties. This would mean that coca “would no longer be considered a controlled substance. It would open the way to legal natural commerce,” according to Walsh. 

While the size of such a market is hard to estimate, its significance would be massive. Coca teas, flours, and medicinal extracts already circulate domestically in the Andes – only legally within Bolivia as the country had left and re-joined the UN drug control conventions in 2013 – but international markets remain blocked by treaty restrictions. 

Yet there are also risks. Walsh cautions: “There’s a concern, even among those who want coca removed, that those who have guarded the tradition could be undermined.” Comparisons to the cannabis market loom large, where capital from the Global North has quickly moved into spaces originally meant by marginalised communities. The vision of a future un-criminalised market for coca opens future concerns, such as control mechanisms that avoid biopiracy and endorse fair benefit-sharing, particularly with communities that have been destroyed by the plant’s prohibition. The Nagoya Protocol, which addresses protections against the exploitation of genetic resources and Indigenous knowledge, is often cited as a model for future control.

Even in the case of full removal, coca wouldn’t be completely free of international prohibition. “Coca destined to become cocaine would still be illegal; that wouldn’t be optional,” according to Walsh. Better controls to determine the end use of coca would have to be developed.

Politics and removal

In theory, removing coca from Schedule I requires only a simple majority of CND member states. In practice, however, bloc politics loom large. “As a formal matter, there’s no veto. But in a practical matter, the EU looms large,” Walsh explains, given the bloc’s significant role in driving global demand for cocaine. If European states vote together against rescheduling, the motion would be unlikely to pass. However, if the EU allows states to vote individually, the change is much more likely to happen.

The United States’ position is also critical. As Walsh puts it, “It would be difficult to imagine if the US would be supportive of removing coca entirely.” But, though the US was once the world’s biggest supporter of draconian drug laws, its international influence may be waning. The current administration’s defunding of global aid, much of which supported harm reduction and drug prevention programmes, have reduced the US’ ability to enact soft power internationally. President Trump’s “transactional” politics, according to Walsh, may be a signal to countries that they can go their own way on policy while the US is pursuing a more isolationist approach to international relations.

Russia, too, will be notably absent. Having not achieved sufficient votes to remain part of the CND in April 2025, Russia will not be voting on UN drug-related matters from 2026 onwards. Walsh said that “Russia has taken the mantle from the US as ‘drug warrior’” and could’ve stood staunchly against coca’s reclassification. Their absence, therefore, may open new horizons.

The coca review is primarily supported by Bolivia and Colombia, with Canada, Czechia, Malta, Mexico, and Switzerland publicly supporting their position. Some coca-producing nations, notably Peru, are not in favour of reclassification. The country’s drug control agency, DEVIDA, recently argued that reclassifying coca “could become a perverse incentive to increase its diversion to the production of cocaine,” as well as increasing deforestation and food insecurity, especially for indigenous people.

But for some, Peru’s lack of support for the review has more to do with its political priorities than any attempt at harm reduction. “Peru’s denial to support this is indeed very odd, but is a reflection of the kind of political regime it is living under,” says Pien Metaal of the Transnational Institute (TNI). “The Boluarte government is the typical white Lima elite that has ruled Peru over the past decades, with no connection to the hearts and minds of the Peruvian people.”

Indigenous resistance

The roots of the current review go back to decades of Indigenous advocacy. The UN Declaration on the Rights of Indigenous Peoples recognises the right to maintain and protect traditional medicines and cultural practices. Yet international drug treaties continue to criminalise coca chewing and related practices in many countries. 

“There has never been a credible medical or scientific basis for the prohibition of coca leaf,” according to Metaal. “Its inclusion in the 1961 Convention was a political act, not a scientific one.”

Underlying the review is a reckoning with the colonial assumptions that shape global drug control to this day. The 1950 WHO study that underpinned coca’s prohibition dismissed Indigenous practices as harmful and regressive, ignoring evidence of its benign cultural role. For many advocates, the current review is an overdue opportunity to correct that record. As Metaal argues, “This is not just about drug policy. It is about dignity, cultural survival, and Indigenous rights.”

Impending Change

For coca-using and growing communities, the implications are immediate. Continued criminalisation undermines cultural practices, justifies militarised eradication, and fuels human rights abuses. Removing the plant from international control could finally legitimise its traditional use, defund eradication policies, and unlock new economic opportunities grounded in heritage rather than prohibition.

As Walsh reflects: “In five years, I hope that we’re able to see a genuinely growing understanding of how natural coca products can really bring a lot of help to people around the world. I hope those markets can open up and can be beneficial to those communities that are most identified with coca.”

With the WHO’s deadlines fast approaching, the question is whether the international drug control system can rise to meet the moment—or whether it will once again fall back on outdated prejudices, leaving another generation of Indigenous peoples to fight for recognition of what they already know: that prohibition, not the coca leaf, is the problem.

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Source:  https://www.talkingdrugs.org/upcoming-who-coca-review-a-turning-point-for-global-drug-policy/

 

Authors: Cyntia Duval, Brandon A. Wyse, Noga Fuchs Weizman, Iryna Kuznyetsova, Svetlana Madjunkova & Clifford L. Librach

Published by: Nature Communications

Published: 09 September 2025

 

Abstract

Cannabis consumption and legalization is increasing globally, raising concerns about its impact on fertility. In humans, we previously demonstrated that tetrahydrocannabinol (THC) and its metabolites reach the ovarian follicle. An extensive body of literature describes THC’s impact on sperm, however no such studies have determined its effects on the oocyte. Herein, we investigate the impact of THC on human female fertility through both a clinical and in vitro analysis. In a case-control study, we show that follicular fluid THC concentration is positively correlated with oocyte maturation and THC-positive patients exhibit significantly lower embryo euploid rates than their matched controls. In vitro, we observe a similar, but non-significant, increased oocyte maturation rate following THC exposure and altered expression of key genes implicated in extracellular matrix remodeling, inflammation, and chromosome segregation. Furthermore, THC induces oocyte chromosome segregation errors and increases abnormal spindle morphology. Finally, this study highlights potential risks associated with cannabis use for female fertility.

Introduction

Cannabis consumption for both medicinal and recreational use and legalization have been rising globally1. Cannabis contains several classes of chemicals with cannabinoids being the most prominent; among these, tetrahydrocannabinol (THC) is the primary psychoactive compound and the most studied2. Notably, the concentration of THC in cannabis products has increased significantly, from an average of 3% (by weight) in the 1980s to around 15% in 2020, with some strains reaching 30% of THC2. The increase in frequency, ease of availability, and escalation in potency raises concerns about broader impacts on global human health, including reproductive health. Indeed, the main apprehension regarding THC and reproductive health stems from the importance of the endocannabinoid system in human reproduction3. Endocannabinoids, including N-arachidonoylethanolamide and 2-arachidonoylglycerol, are endogenous cannabinoids that play a central role in both male and female reproduction3, whereas THC is an exogenous cannabinoid. Extensive research has documented the effects of THC on male reproduction, highlighting an impact on sperm deoxyribonucleic acid (DNA) methylation  4,5,6,7 and sperm parameters8 including sperm concentration  9,10,11, morphology  12,13,14 and motility14. As for female health, literature reports the impact of cannabis use during pregnancy on pregnancy outcomes  15,16,17,18, placental development  18,19,20 and offspring health  18,20,21,22. However, to our knowledge, no studies have investigated the impact of cannabis on the human female gamete, the oocyte, a gap partly due to the challenge associated with obtaining these samples.

During in vitro fertilization (IVF) treatment, exogenous gonadotropins are administered in a process called “controlled ovarian hyperstimulation” which recruits multiple follicles and induces follicle growth. These recruited follicles, each containing an oocyte, are then collected by a physician in a procedure called oocyte retrieval. Oocytes are collected along with their surrounding microenvironment, including follicular fluid (FF) and supportive somatic cells (granulosa cells). The oocytes are isolated, and mature oocytes are used for subsequent in vitro fertilization. Using FF, our group has previously quantified Δ9-THC and its metabolites, 11-OH-THC and 11-COOH-THC  23,24, demonstrating that these compounds could reach the follicular niche. This is significant as it suggests that THC may directly alter the microenvironment where the oocyte matures. Furthermore, our group has shown that THC exposure altered human granulosa cell methylation in a concentration dependent manner23, and in vitro exposure modulated cannabinoid receptor dynamics in granulosa cells24. However, no human studies and only a few animal model studies have investigated the impact of cannabis directly on oocyte development with conflicting results  25,26,27,28,29.

Maturation of the oocyte is a unique and highly specialized process beginning in utero during fetal development. It is widely accepted that female neonates are born with a finite number of oocytes, which, following menarche, are recruited to mature in cohorts with each menstrual cycle30. Although oocytes are protected in the ovary by the blood-follicle-barrier, they remain highly sensitive to environmental factors31. Given their essential role in reproduction, any perturbations in their development and maturation could have profound effects on fertility and on future generations. Thus, understanding the impact of THC on oocyte health is critical for providing informed guidance and counseling to patients of the potential risks to their fertility and future offspring.

In this study, we determine the impact of physiologically relevant concentrations of THC on oocyte maturation, elucidate the transcriptomic changes induced by THC exposure and its effect on chromosome segregation, and compare our findings with a retrospective cohort study. Our investigation will aid in bridging the knowledge gap in our understanding of the sex-specific reproductive consequences of cannabis use and contribute to more effective and evidence-based patient counseling.

 

To read the full article, please click on the source link below

Source:  https://www.nature.com/articles/s41467-025-63011-2

 

by Allysia Finley       Wall Street Journal          Sept. 14, 2025

What causes a young man to spiral from success toward loneliness, self-destruction and violence?

A police officer guards Tyler Robinson’s apartment complex in Washington, Utah, Sept. 12. Photo: andrew hay/Reuters

The descent of Tyler Robinson, the 22-year-old man suspected of murdering Charlie Kirk, is itself a tragedy worth mourning. How did a high-school whiz kid devolve into an assassin?

Such spirals aren’t so uncommon among young men, even if Mr. Robinson’s played out in a more calamitous and public way than most. Political violence is a problem. But so is the atomized culture in which young men retreat into confused inner worlds and virtual realities, which can be as addictive and destructive as any drug.

Mr. Robinson’s relatively normal background makes his actions jarring. He came from a good middle-class family. Having excelled in high school, he was awarded a scholarship to Utah State University, though he dropped out after one semester.

At some point, he appears to have become steeped in a dark digital world and videogames. He inscribed ammunition with obscure online memes (“Notices bulges OwO what’s this?”), lyrics to an anti-Fascist Italian song, and an apparent reference to the videogame “Helldivers 2,” a satire of a fascist interstellar empire inspired by the 1997 movie “Starship Troopers.”

Marinating in an internet cesspool can’t be good for the young and malleable male mind. Might killing villains in videogames desensitize the conscience? Studies have found an association between playing violent videogames and aggressive behavior, though most people who assume online avatars and fight monsters don’t become violent.

A broader problem, as Jonathan Haidt explains in his book “The Anxious Generation,” is that videogames cause boys to get lost in cyberspace. They have “put some users into a vicious cycle because they used gaming to distract themselves from feelings of loneliness,” Mr. Haidt notes. “Over time they developed a reliance on the games instead of forming long-term friendships.” They “retreat to their bedrooms rather than doing the hard work of maturing in the real world.”

The same is true of social-media platforms like Discord and Reddit, where young men often seek fraternity under pseudonyms. The platforms become substitutes for real-world camaraderie and can lead men down dark holes. Frequent social-media use has been found to rewire neurological pathways in young brains and compromise judgment.

Mr. Robinson’s spiral recalls Luigi Mangione, the 27-year-old University of Pennsylvania graduate who allegedly shot and killed UnitedHealthcare CEO Brian Thompson on a New York City street. Attractive and athletic, Mr. Mangione developed an obsession with self-improvement even as he suffered bouts of excruciating back pain. He was also an avid videogame player and active on Reddit.

Prior to the shooting, he cut off communications with family and friends. Men in their late teens and 20s sometimes experience psychotic breaks. Mr. Mangione’s apparent mental-health struggles, however, seem to have gone unnoticed as he got lost in a digital wilderness.

Or consider Thomas Crooks, the 20-year-old who attempted to assassinate President Trump at a rally last summer. Crooks graduated high school with high honors and scored 1530 on the SAT, then enrolled in an engineering program at a community college. His father said his mental health began declining in the year before the shooting.

Crooks lost social connections as he started spending more time online, visiting news sites, gaming platforms, Reddit and weapons blogs. He at one point searched for information on “major depressive disorder” and “depression crisis,” suggesting he suspected he had a mental illness. Instead of psychiatric treatment, he turned to the internet.

Like drugs, the internet can fuel delusions. Patrick Joseph White, 30, last month opened fire on the Centers for Disease Control and Prevention headquarters in Atlanta, then fatally shot himself. He was apparently exercising his rage against Covid shots, which he wrote were “always meant to indiscriminately murder as many as possible” and believed had caused his depression.

He had threatened self-harm numerous times in the previous year. In April police officers came to his home after he called a veterans’ crisis line and said he had been drinking and taking medication. White told officers he had called the crisis line “just to talk to someone.”

Videogames and the digital world may not cause mental illness, but they can be a form of self-medication that provides illusory relief from emotional troubles even as they propel antisocial behavior. The solution isn’t to ban them, but to create social structures that prevent young men from falling through the cracks.

Lost boys pose a broader cultural problem. The share of men 20 to 34 who work has been declining over the past 30 years, even as employment among young women has increased. Too many young men spend their days playing videogames, watching porn, smoking pot and trolling the internet rather than engaging with the real world.

Mr. Kirk sought to bring young people like Mr. Robinson out of their virtual caves. It’s harder to hate someone you meet in the flesh than an avatar in a digital dystopia.

Source:  Drug Watch International – www.drugwatch.org

Publication: American Journal of Psychiatry – 10 September 2025

Authors: Lara N. Coughlin, Ph.D. , Devin C. Tomlinson, Ph.D., Lan Zhang, Ph.D., H. Myra Kim, Sc.D., Madeline C. Frost, Ph.D., M.P.H., Gabriela Khazanov, Ph.D., James R. McKay, Ph.D., Dominick De Philippis, Ph.D., and Lewei (Allison) Lin, M.D., M.S.

Abstract

Objective:

While opioid overdose has begun to decrease in recent years, stimulant overdose has continued to increase and has not been adequately addressed. Unlike opioid use disorder, there are no medications approved by the U.S. Food and Drug Administration to treat stimulant use disorder (StUD). The most effective treatment is contingency management (CM), a behavioral intervention that provides tangible rewards to reinforce target behaviors, such as biochemically verified abstinence. Despite the effectiveness of CM on near-term substance use behaviors, the long-term impact on key outcomes such as mortality are unclear. The objective of this work was to examine whether patients with StUD who receive CM have a decreased risk of mortality.

Methods:

This was a retrospective cohort study of patients with StUD who received or did not receive CM, using linked electronic health records and death records in the largest integrated health system in the United States, the Veterans Health Administration (VHA), from July 2018 through December 2020. The primary outcome was mortality in the year following the index CM visit. All-cause mortality data were obtained from the National Death Index and linked to electronic health record data. Adjusted hazard ratios were estimated using stratified Cox proportional hazards models.

Results:

A total of 1,481 patients with StUD who received CM were included alongside 1,481 matched control subjects. Over the 1-year follow-up period, those who received CM were 41% less likely to die (adjusted hazard ratio=0.59, 95% CI=0.36, 0.95) than those who did not receive CM.

Conclusions:

This study provides the first evidence that CM use in real-world health care settings is associated with reduced risk of mortality among patients with StUD.

Source:  https://www.psychiatryonline.org/doi/10.1176/appi.ajp.20250053

by Jack Fenwick – BBC Political correspondent – 16 September 2025

Hilary’s son Ben died from a heroin overdose in 2018, but his death was never included on official opioid death statistics

More than 13,000 heroin and opioid deaths have been missed off official statistics in England and Wales, raising concerns about the impact on the government’s approach to tackling addiction.

Research from King’s College London, shared exclusively with BBC News, found that there were 39,232 opioid-related deaths between 2011 and 2022, more than 50% higher than previously known.

The error has been blamed on the government’s official statistics body not having access to correct data and it is understood ministers are now working with coroners to improve the reporting of deaths.

A former senior civil servant said fewer people might have died if drug policies had been based on accurate statistics.

The number of opioid deaths per million people in England and Wales has almost doubled since 2012, but this new study means the scale of the problem is likely to be even greater.

Researchers from the National Programme on Substance Use Mortality at King’s used data from coroners’ reports to calculate a more accurate estimate of opioid-related deaths.

Opioids include drugs such as heroin that come from the opium poppy plant, as well as synthetically-made substances like fentanyl.

The Liberal Democrats have said the government needs to “urgently investigate” how the error was made.

The reliability of the Office for National Statistics (ONS) data relies on coroners naming specific substances on death certificates, something which often does not happen.

Specific substances such as heroin are instead sometimes only included on more detailed post-mortem reports or toxicology results, which the ONS does not have access to.

Government data on overall drug deaths, which does not name specific substances, is not affected by the error, but ministers’ decision-making is generally influenced by the more granular statistics.

The body that oversees police commissioners says correct data on opioid deaths could have led to more funding and better treatment for front-line services such as police forces and public health.

Sir Philip Rutnam, who was the most senior civil servant at the Home Office between 2017 and 2020, told the BBC it was “quite possible” that fewer people would have died, if the government’s drug policies had been based on accurate statistics.

He told BBC Radio 4’s PM programme: “It really does matter, first of all the level of attention given to these issues, but then specifically it will affect decisions on how much funding to put into health-related programmes, treatment programmes, or into different bits of the criminal justice system.”

“My son’s death is one of thousands missed from official stats”

Ben was 27 when he died from a heroin overdose in 2018, but his death was ruled as “misadventure” and was never included on the official opioid death statistics.

His addiction began with cannabis when he was a teenager and progressed to using aerosols and eventually heroin.

“Ben was just a very kind person. We miss him, we all miss him every day,” said his mother Hilary.

At one point, she said Ben appeared to “turn a corner”.

He was awarded a place in a rehab facility, but shortly before he was set to move in, Hilary got the phone call she had always dreaded.

“I think what happened is, he wasn’t using,” she said. “They think probably about three months and his tolerance had gone down.”

Ben’s family believe that different treatment and support for drug addicts could have helped him.

Dr Caroline Copeland, who led the new research, said drug policies “will not have the desired impact unless the true scale of the problem is known”.

She added: “We need to alert coroners to the impact that not naming specific drugs as the cause of death has on the planning and funding of public health policies.”

The research, which has been peer-reviewed and published in the International Journal of Drug Policy, focused specifically on opioid deaths, but similar undercounts are thought to exist in data about deaths from other drugs too.

Further work by King’s College London has found that 2,482 cocaine-related deaths have also been missed off ONS statistics over the last 10 years.

David Sidwick, the drugs lead for the National Association of Police and Crime Commissioners, told the BBC the organisation would “be pushing hard” for more treatment funding, in light of the faulty statistics.

Mr Sidwick, who is also a Conservative police and crime commissioner, said more accurate data would lead to “better decisions about the amount of funding required for treatment” and suggested “new treatment methods” such as buprenorphine, a monthly injection that can help heroin users overcome addiction.

Helen Morgan, the Liberal Democrat health spokesperson, said: “I dread to think of the lives that may have been lost due to damaging policies based on faulty stats.”

She added: “The government now needs to step up, launch an investigation and ensure that the ONS is given access to the data it needs so that it can never make this error again.”

The ONS, which helped with the research, said it had warned that “the information provided by coroners on death registrations can lack detail” on the specific drugs involved.

A spokesperson added: “The more detail coroners can provide about specific drugs relevant to a death will help further improve these statistics to inform the UK government’s drug strategy.”

The flaw in the ONS system is not present in Scotland, where there are no coroners and where National Records Scotland (NRS) is responsible for collating official statistics.

Unlike the ONS, the NRS does receive more detailed pathology reports, but differences in how deaths are reported across the UK make it difficult to compare.

The opioid undercounting raises further questions about the under-fire ONS, which has been accused of failing on several statistical fronts recently.

Data sets on job markets and immigration have been criticised and earlier this year a government review said the ONS had “deep-seated” issues which needed tackling.

A spokesperson for the Department of Health and Social Care said: “We continue to work with partners across health, policing and wider public services to drive down drug use, ensure more people receive timely treatment and support, and make our streets and communities safer.”

 

Source:  https://www.bbc.co.uk/news/articles/cg7dzmyjrjzo

 

by Liz Mineo – Harvard Staff Writer -September 16, 2025

Study examining potential solution to treatment gap — especially in rural areas — gets federal funding cut

Between 1999 and 2023, approximately 806,000 Americans died from opioid overdoses, according to the Centers for Disease Control and Prevention. Yet of the estimated 2.4 million U.S. adults with opioid use disorder, only one in four receives medications that can reduce overdose risk.

Telehealth has shown promise as a potential tool to prevent opioid overdose deaths, but funding for a study launched last year by health economist Haiden Huskamp examining its use and impact was terminated as part of the mass cancellation of federal research grants by the Trump administration in May.

“A lot of our research, including that for this grant, is looking at why so few people are getting evidence-based treatments for substance use disorder,” said Huskamp, Henry J. Kaiser Professor of Health Care Policy at Harvard Medical School. “Medications for opioid use disorder are highly efficacious. They reduce opioid use; they reduce overdose risk and other negative outcomes. These medications save lives.”

A shortage of clinicians specialized in treating opioid use disorders — particularly in rural areas — presents a major barrier to receiving care, she said.

“Our work has been trying to understand, since the pandemic in particular, who was using telemedicine for opioid use disorder,” said Huskamp, “and whether the availability of care, via telemedicine, has meant that clinicians who treat substance use disorders are now seeing more patients in areas where there aren’t enough doctors who do this work.”

217Americans, on average, died each day from an opioid overdose in 2023, according to the CDC

For the past five years Huskamp, Ph.D. ’97, has been studying telemedicine as a strategy to expand access to opioid use disorder treatment and life-saving medications such as methadone, buprenorphine, and the quick overdose-reversal drug naloxone.

“Given the opioid epidemic that we are still in the middle of, telemedicine might be an answer because it could address a number of barriers to treatment access,” said Huskamp.

Although in May the CDC reported that opioid overdose deaths dropped from 83,140 in 2023 to 54,743 in 2024, the death toll remains high. According to the CDC, in 2023, on average, 217 people died each day from an opioid overdose.

The goal of Huskamp’s terminated four-year study, launched last year with a team of 15 researchers, was to provide evidence-based information on the efficacy of telemedicine that can guide policymakers as they address the opioid epidemic. It was a renewal of a previous grant, which yielded 24 different publications whose findings have informed new rules by the Drug Enforcement Agency to expand telemedicine access for treating opioid dependence. Funded by the National Institute on Drug Abuse, the latest research sought to examine quality of care and clinical outcomes by analyzing data from Medicare, Medicaid, commercial insurance, and national pharmacy claims.

Telemedicine for opioid use disorder became more widespread across the country during the COVID-19 pandemic, and researchers have been eager to probe the data to find out if it improved access to care for patients in remote areas, and how the quality of care compared to traditional in-person care.

“Anything we can do to try to improve the healthcare system to more effectively allow people to access care and to do so in a more efficient way is really important,” said Huskamp. “We need research like this to guide policymaking, so that we can improve the system as much as possible for people to get the treatment that they need.”

 

Source:  https://news.harvard.edu/gazette/story/2025/09/only-1-in-4-addicted-to-opioids-takes-life-saving-meds-why/

Received from DFAF – 16 September 2025

The swift legalization of marijuana across the United States is impacting the rates of use and increasing the social acceptance among veterans 65 and older. A recent study is shining a light on this group of individuals whose struggle with marijuana use had largely flown under the radar.

The study included more than 4,500 Veterans Health Administration (VHA) patients nationwide, revealing a concerning picture of marijuana use and cannabis use disorder (CUD) in this population. Over half of respondents (57%) reported having used marijuana at some point in their lives, and 1 in 10 had used it within the past 30 days—a rate nearly double the national average for adults 65 years or older in the general population. Among these recent users, more than half were frequent users (defined as using on 20 or more days in the past month), and the majority (72%) consumed marijuana by smoking.

Perhaps most concerning was the prevalence of CUD. Among those who reported recent use:

  • One-third (36.3%) met the criteria for CUD, including 10.9% with moderate CUD and 2.5% with severe disorder CUD.

The risks were even higher among those who consumed marijuana through smoking or vaping, those who reported anxiety symptoms, and those with functional impairments in daily activities. Veterans aged 65–75 were also more likely to meet criteria for CUD compared to those over 76, and risk increased among individuals who used other substances or faced economic hardship.

Geography mattered as well: veterans living in states with legal recreational marijuana use were more than twice as likely to report use compared to those in non-legal states. In contrast, living in a medical-only state did not significantly increase odds of use—suggesting that broader legalization may be a key driver of accessibility and behavior.

The findings highlight the need for veterans to understand the risks associated with use and to receive screening for CUD, which could help identify problematic use early and connect patients with evidence-based treatment.

 

Source:  Drug Free America Foundation | 333 3rd Ave N Suite 200 | St. Petersburg, FL 33701 US

By Sara Goldenberg  –  Sep. 23, 2025

CLEVELAND, Ohio (WOIO) – Illegal drug use continues to send young adults to the hospital.

Eighteen to 25 year olds make up 11 percent of nearly 8 million drug-related emergency room visits in the United States every year, according to a national report.

Many of those cases involve college students.

The Drug Enforcement Administration just launched a campaign to prevent drug abuse on campus.

As college students get settled into a routine for the new school year, their parents hope that routine doesn’t include illegal drugs.

Illegal drug use over the past year was highest among young adults 18 to 25 years old at 39 percent, according to a 2023 report with the most recent government data.

The report was published by the Substance Abuse and Mental Health Services Administration, a federal agency known as SAMHSA.

We spoke with Joseph Dixon, Special Agent in Charge of the DEA Detroit field division, which includes Ohio.

“So those students who are, you know, transitioning from high school and going into college, being out on their own, not having as much parental oversight, we feel that it’s our duty to ensure that we’re providing them the resources and tools to ensure that they have a great college experience, but also a safe college experience,” he said.

The DEA is traveling to campuses across the state, educating students about the dangers that can be disguised in just one pill.

“Fentanyl is one of the deadliest drugs we’ve ever seen. And we know that as these young men and women begin to really grow into themselves and start to engage with these new groups that they might ask for a prescription Percocet or a Valium or a Xanax,” Dixon said.

Those prescription drugs should only be taken by the person their prescribed to.

You never know what’s in it if you’re getting those pills another way.

We asked what parents can do.

“The best tool is just to be engaged in your child’s life, now your adult’s life. Your young adult’s life. Have a conversation with them. See how things are going. You know, if they don’t sound right, ask them what’s wrong,” Dixon said.

Educators and mentors on campus can really help too.

“Have conversations, prepare your students, your future students, your future leaders, you know, your future graduates, prepare them to go out and be successful and have these conversations and just know that, you know, one pill can kill,” he said.

Nearly one quarter of college students reported using an illegal drug in the past 30 days, according to the national study we referenced above.

Source:  https://www.cleveland19.com/2025/09/23/dea-launches-campaign-campuses-across-ohio-prevent-drug-abuse/

Received from DFAF –

 23 September 2025

 

A new report shows fentanyl is increasingly appearing in workplace drug tests, particularly among employees who have already passed pre-employment screening. Understanding what’s going on and taking proactive steps can help protect your team, your reputation, and your bottom line.

A recent study by Quest Diagnostics provides a clear picture of the issue. Quest analyzed over eight million workforce drug tests across the U.S. In 2024, random and unannounced drug tests (tests not tied to hiring) found fentanyl more than seven times as often as pre-employment screenings.1 Even more concerning, nearly 60% of fentanyl-positive tests also involved other substances, such as marijuana and amphetamines.1 Fentanyl use on the job, especially when combined with other substances, increases the risk of accidents, impairment, and even overdose.

The impact on small businesses can be serious. Fentanyl exposure in the workplace can lead to accidents and injuries, particularly in roles involving machinery, vehicles, or other safety-sensitive tasks.2 Beyond immediate safety risks, there are potential legal and financial consequences. If an employee under the influence causes harm, your business could face liability, workers’ compensation claims, or insurance complications. Incidents also create operational disruption, affecting productivity, morale, and your overall reputation. Substance misuse can reduce performance, increase absenteeism, and contribute to higher employee turnover, which can be especially challenging for small businesses.3

Small business owners can take practical steps to reduce these risks. Reviewing and updating your drug-free workplace policy is a critical first step. Policies should clearly outline expectations, consequences, and testing procedures, while staying compliant with state laws. Random or periodic testing can help detect fentanyl use that pre-employment screenings might miss. Employee education is equally important; staff need to understand the dangers of fentanyl, especially when combined with other substances.

Providing support is also key. Offering Employee Assistance Programs, connecting employees with treatment services, and fostering a culture where staff feel safe seeking help can make a major difference. Training supervisors to recognize signs of impairment and respond appropriately is critical to preventing accidents. Additionally, preparing for emergencies with overdose reversal tools, like naloxone, and clear response protocols can save lives. Check out this Overdose Emergency Planning Tool from the National Safety Council for help! Additionally, reviewing test data and incidents periodically will help you adapt policies and safety measures as needed, ensuring your workplace remains safe and productive.

Even one case of fentanyl exposure can have devastating consequences, but small business owners can take action now. By combining clear policies, employee education, and supportive measures, you can reduce risk, protect your employees, and maintain a safe and productive workplace.

Source:  Drug Free America Foundation | 333 3rd Ave N Suite 200 | St. Petersburg, FL 33701 US

Event date: 30 Sep 2025

Event location: Online

Organisers: UNODC

Event type: Meeting

The 2025 Thematic Discussions on the implementation of all International Drug Policy Commitments, following up on the 2019 Ministerial Declaration, include a session on “Prevention as a core element of the public health response to drug use”, which takes place online on 30 September.

More details can be found on the UNODC-CND webpage: https://www.unodc.org/unodc/en/commissions/CND/Mandate_Functions/thematic-discussions.html

Source: https://www.euda.europa.eu/event/2025/09/2025-cnd-thematic-discussions-prevention-core-element-public-health-response-drug-use_en

By Neuroscience – September 21, 2025

The findings were significant, Thanos explains, because not only did the HIIT animals exhibit a preference for the saline chamber, they exhibited a clear aversion to the cocaine chamber. Credit: Neuroscience News

Summary: A new study shows that high-intensity interval training (HIIT) is more effective than moderate exercise at protecting adolescent lab animals from cocaine use. Animals exposed to HIIT developed a preference for non-drug environments and an aversion to cocaine, linked to increases in ΔFosB, a molecular switch involved in addiction.

These results suggest exercise intensity matters in shaping the brain’s reward system and its response to drugs. The findings may inform new strategies for using exercise as a personalized tool in substance use disorder prevention and treatment.

Key Facts

  • HIIT Impact: High-intensity exercise made animals avoid cocaine and prefer safe environments.
  • Molecular Mechanism: HIIT raised ΔFosB levels, a transcription factor tied to addiction pathways.
  • Personalized Tool: Exercise may act as dose-dependent medicine for addiction prevention.

Source: University at Buffalo

People with substance use disorder who participate in recovery running programs have shown improved success in maintaining their sobriety and reducing their risk for relapse.

Those observations led Panayotis Thanos, a University at Buffalo neuroscientist who studies the brain’s reward system, to try to figure out the brain mechanisms behind that phenomenon.

In a new study published today in PLOS One, Thanos, PhD, senior research scientist in the Clinical and Research Institute on Addictions in the Jacobs School of Medicine and Biomedical Sciences at UB, and co-authors reveal that high-intensity interval training (HIIT) was more effective than moderate exercise in making adolescent lab animals avoid cocaine.

The researchers used adolescent lab animals because this is the age when most people who develop substance use disorder begin their exposure. The study focused on male rats only because previous observations have revealed some gender differences in drug-seeking behaviors between males and females. The researchers plan a future study on how HIIT affects females with regard to cocaine. 

HIIT as personalized medicine

“The study shows that HIIT exercise, rather than moderate exercise, during adolescence may protect against cocaine abuse,” says Thanos, a faculty member in the Department of Pharmacology and Toxicology in the Jacobs School.

The findings provide evidence that HIIT could become a personalized medicine tool in drug abuse intervention.

“The key take-home is that not all exercise is created equal in terms of outcome,” Thanos says. “Exercise is not a binary therapeutic tool but rather we need to think about exercise as dose-dependent, the way we think of medicine as dose-dependent.”

In the study, rats exposed to HIIT exercise on a treadmill were compared to rats exposed to moderate treadmill exercise. Both groups then underwent a behavioral test called cocaine place preference, which trains the animal to discriminate between two chambers: one where they can access cocaine and one where they can access saline. Cocaine preference is when the animal spends more time in the cocaine chamber, while cocaine aversion is when the animal chooses to spend more time in the saline chamber.

The findings were significant, Thanos explains, because not only did the HIIT animals exhibit a preference for the saline chamber, they exhibited a clear aversion to the cocaine chamber.

Increase in a molecular switch for addiction

“We believe that the increase in aversion to cocaine happens in the HIIT animals,” Thanos says, “because of this exercise dose-dependent effect on the brain’s reward circuit that involves an increase we observed in ΔFosB.” ΔFosB is a transcription factor commonly referred to as a molecular switch for addiction and known to boost sensitivity to drugs of abuse.

“Our study showed that HIIT increased ΔFosB levels causing an aversion to consuming cocaine,” he adds.

The findings reveal new avenues that Thanos and his colleagues plan to explore, including how HIIT may affect brain metabolism.

“We know from recent studies in our lab with steady, moderate treadmill running that compared to sedentary animals, exercise decreased metabolism in the somatosensory cortex of the brain while activating other brain regions involved in planning and decision,” he says. “That activation may help dampen various aspects of cocaine abuse and relapse.”

The paper also discusses the need to better understand gender differences in preference for cocaine. “Future studies need to explore how HIIT affects cocaine preference in female rats,” Thanos says, adding that the literature in the field includes evidence that females seem to be more vulnerable to certain phases of addiction.

UB co-authors are Teresa Quattin, MD, UB Distinguished Professor in the Department of Pediatrics and senior associate dean for research integration in the Jacobs School; Nikki Hammond, a former graduate student; and Nabeel Rahman and Sam Zhan, former undergraduate students in Thanos’ lab. Other co-authors are from Washington University School of Medicine and Western University of Health Sciences.

Source: https://neurosciencenews.com/hiit-exercise-addiction-neuroscience-29715/

By Sage Journals – September 19, 2025

 Abstract

This article presents a study exploring the prevention of alcohol and drug (AOD)-facilitated sexual violence. A participatory action research/appreciative inquiry method, World Café Forum, was used to take a multi-stakeholder approach to explore prevention initiatives. Thirty-two individuals from 14 stakeholder organizations attended. Analysis established five recurring themes, overlayed by power imbalances: education and training; policy-led initiatives; holding people accountable; social information campaigns; and cultural change. Responsibility for addressing the issue is contested. The greatest opportunity to address AOD-facilitated sexual violence lies with organizations, with a focus on restorative justice. Policy frameworks and place-based initiatives are required.

Introduction

Sexual violence is a global health issue mostly affecting women (World Health Organisation, 2021). In Australia, 23% of women will experience sexual violence across their lifetime, compared to 8% of men (Australian Bureau of Statistics, 2021). Sexual violence is reported to be higher in rural than urban areas, although prevalence is still relatively unknown, particularly for young women (Australian Bureau of Statistics, 2017; Hooker et al., 2019).

The World Health Organisation defines sexual violence as “any sexual act, attempt to obtain a sexual act, unwanted sexual comments or advances, or acts to traffic, or otherwise directed, against a person’s sexuality using coercion, by any person regardless of their relationship to the victim” (World Health Organisation, 2013). It has significant psychological and physical health impacts for women, including posttraumatic stress disorder (PTSD) and gastrointestinal issues (Dworkin, 2020; Tarzia et al., 2017; World Health Organisation, 2014). Sexual violence is most frequently experienced by women and LGBTQ+ people (Ison et al., 2025a), and those who face intersecting forms of inequality can experience higher rates of sexual violence. For example, women with disabilities or trans women of color have experienced higher rates of sexual violence (Australian Institute of Health and Welfare, 2024; Hindes et al., 2025; Ledingham et al., 2022).

Increasingly, it is being recognized that alcohol and drugs (AOD) are used to facilitate sexual violence. Alcohol and other drug facilitated sexual violence includes what is often colloquially known as “drink spiking” (Ison et al., 2024). Perpetration can be opportunistic, such as where the perpetrator takes advantage of a person who is intoxicated, and/or proactive, such as intentionally administering a substance to incapacitate a person (Gee et al., 2006). The victim may consume AOD voluntarily or be unaware that they have been administered them (Caluzzi et al., 2025). Alcohol and other drug facilitated sexual violence can also include the perpetrator encouraging the victim to become further intoxicated (Ison et al., 2025b). Available evidence indicates the most likely substance used by perpetrators is alcohol, but they may also use other sedative substances such as flunitrazepam (Rohypnol) or other benzodiazepines and gamma-hydroxybutyrate (GHB) (Anderson et al., 2017; Recalde-Esnoz et al., 2024; Wolitzky-Taylor et al., 2011).

Responses to AOD-facilitated sexual violence have often been piecemeal. The service system response often lacks continuity of care, and while staff may be passionate and caring, they are often overworked and have limited knowledge or training on AOD-facilitated sexual violence (Ison et al., 2025c). There have been some attempts at programs to address AOD-facilitated sexual violence, though there have been limited rigorous evaluations. These interventions have tended to focus on bars and clubs, particularly through training bar staff as bystanders (Davis et al., 2024), including a resource for bar staff that we designed for the larger project that this study is part of (detailed below) (Hooker et al., 2024). Interventions also include “solutions” to drink spiking, such as a scrunchie to cover one’s drink, or nail polish to test whether there are substances in your drink. These supposed solutions often place the onus on women to keep themselves safe through feminized products, which have troubling victim-blaming undertones (Clinnick et al., 2024).

Beyond such examples, the vast majority of interventions are focused on alcohol consumption in US college settings. While they may have some specific focus on AOD-facilitated sexual violence, they are generally concerned with minimizing the intake of alcohol. Very few interventions are focused on prevention (Hooker et al., 2020) or on response that goes beyond individuals to consider how to change broader sociocultural contexts (Dworkin & Weaver, 2021).

Study Context

There has been growing interest in and reporting on “drink spiking” in the media. In 2021, the media highlighted “drink spiking” as an issue in a regional town in Victoria (Cunningham & Koob, 2021; Lawrence & Findlay, 2021). Some young women came forward to talk to journalists about their experiences of drink spiking in a local club and the subsequent negative interactions they had with health and justice services. These media reports also indicated that drink spiking is an issue in rural communities broadly and that victims face significant barriers when seeking assistance through health and justice services. As with sexual violence broadly, increased media reporting does not necessarily mean there is an increased prevalence, but rather that people may feel empowered to come forward (Clinnick et al., 2024). The stories of the young women in the media reports inspired the research team to conduct a study focused on regional and rural experiences of AOD-facilitated sexual violence. To date, little research has been conducted on rural and remote communities’ experiences of AOD-facilitated sexual violence. However, research has shown that rural and regional Australia have distinct issues relating to sexual violence compared to urban areas, such as dominance of rural hegemonic masculinity and sexual violence revictimization (Corbett et al., 2023; Saunders & Easteal Am, 2013). The study underpinning this paper explored how a regional community could respond to, and ultimately prevent, AOD-facilitated sexual violence (Hooker et al., 2024). This article reports the findings from one part of the study: the use of a multi-stakeholder participatory action method known as a World Café Forum.

Methods

The World Café Forum is a collaborative qualitative method used to foster “constructive dialogue, accessing collective intelligence, and creating innovative possibilities for action” (Brown, 2005). It derives from participatory action research and appreciative inquiry methods that aim to guide a large group of diverse stakeholders toward solutions (Aldred, 2011). It has been used in community development (Aldred, 2011) and where interprofessional collaboration is required, for example, in healthcare and violence against women (Breitbach et al., 2017; Forsdike & Fullagar, 2021). The method brings together multiple small conversational groups to build one collective conversation of different perspectives (Brown, 2005). To build a collective conversation, participants are required to move between groups and discussion topics, so that previous conversations are built upon and include new perspectives for action (Brown, 2005).

A World Café forum was held in 2022 in a regional town in Victoria, Australia, bringing together multiple stakeholders to consider AOD-facilitated sexual violence and how it could be prevented in the region. The forum was conducted over the course of a full day and consisted of two parts. The first half of the day included presentations by members of the research team on sexual violence and AOD-facilitated sexual violence, as well as evidence of the issue in the local community. The presentations were used to engage participants and disseminate existing knowledge about the phenomena and focus on the local region. The second half of the day, the results of which this article reports, incorporated World Café method discussion groups informed by the information provided earlier in the day. The project received ethical approval from the first author’s institution (approval reference: HEC22254).

One of the key features of the World Café method is that participants rotate around the tables every 20–30 min (Fouché & Light, 2011). A host remains at their designated table to support discussion, continuity, and the development of ideas arising from previous conversations (Brown, 2005). Such varied perspectives on issues and the ideas developed are unlikely without facilitated interaction between a broad and diverse range of participants (Brown, 2005).

There are seven principles in the method’s application which were followed on the day (see Table 1).

Firstly, two questions informed by the earlier presentations were posed to the discussion groups to introduce AOD-facilitated sexual violence and establish a collective understanding of what it is in the region and how it is currently responded to by the organizations participants were representing (Brown, 2005).

Secondly, the key question then posed to the discussion groups, and which we present in the results below, was “What can we do?” Records of participants’ ideas were pinned to the walls to enable participants to reflect upon the discussions in other groups (Fouché & Light, 2011). Research team members took photos of these records for analysis.

Analysis

Analysis was informed by the socioecological model. The model was originally developed by Bronfenbrenner to reflect the relational and multiple forces that shape experience across individual, relationship, community, and sociocultural levels (Bronfenbrenner, 1977). It was further developed by Heise to provide a framework for understanding violence against women (Heise, 1998). Heise argued that we need to understand the different levels and their integration to improve responses to a complex issue (Heise, 1998). The model has since been adapted to consider imbalances of power within and between the socioecological levels (Forsdike & Giles, 2024).

The records were transcribed by co-author Jessica Ison and thematically analyzed by co-authors Kirsty Forsdike and Elena Wilson (Braun & Clarke, 2022), with co-authors Jessica Ison and Kirsty Forsdike meeting to finalize themes once co-author Jessica Ison had reviewed the initial themes developed.

Results

Thirty-two stakeholders from 14 different organizations attended the World Café Forum, with an additional seven facilitators attending from the project team. Of the 32 stakeholder attendees, 78% (n = 25) were women. The range of organizations or services from which they derived is presented in Table 2, and included specialist violence prevention and response services, health services, police and justice representatives, students, and student services.

We generated five recurring themes through analysis: (a) training and education, (b) policy-led initiatives, (c) holding people accountable, (d) social information campaigns, and (e) cultural change. When aligning these with the socioecological model (Table 3), it is clear that forum participants considered the organizational level to be the area of greatest opportunity for initiatives, followed by the sociocultural level. The individual and relational levels of the model were not identified as providing many pathways for addressing AOD-facilitated sexual violence in the community.

Education and Training

Unsurprisingly, education and training were dominant themes in discussions. Education refers to building understanding around AOD-facilitated sexual violence, while training refers to skill capacity building to respond to AOD-facilitated sexual violence. Some of the educational measures proposed addressed how people relate with each other, aligning with the relational level of the socioecological model. Here, participants discussed parenting education, engaging with the parent–child relationship to address AOD-facilitated sexual violence. Participants also referred to embedding such education within existing education programs, such as Respectful Relationships and sexual consent: “Comprehensive sexual consent education embedded into all educational institutions, i.e., what consent looks like and the nuances around this when using AOD.”

There was a focus by participants on peer education so that boys would educate boys in understanding and addressing AOD-facilitated sexual violence. Education of AOD-facilitated sexual violence also sits within the organizational level of the socioecological model, whereby it should form part of lifelong learning throughout early years education, primary school, secondary, and tertiary education.

Skills development within organizations such as police and healthcare, and places such as the workplace, at music events, sports clubs, and LGBTQIA+ events were also identified by participants. At the individual level, training was identified as essential for those working in hospitality security specifically (including developing the skills in “identifying and acting on AOD-facilitated sexual violence”), bystander training and safe substance use training for individuals.

Policy-Led Initiatives

Participants identified an absence of policy frameworks and initiatives in relation to AOD-facilitated sexual violence and argued that this was required at the organizational level and across various domains, including hospitality, health systems, and taxation. Discussions among participants produced some specific suggestions for initiatives such as “bringing alcohol service in line with food service (quality control, etc.)” and “align planning laws with hospitality, e.g., co-located supports for AOD-facilitated sexual violence.”

The latter initiative of a co-located support referred to venues being close to support services. Participants discussed co-location at length, detailing planning applications for hospitality venues such as pubs requiring recognition of where there were support services or requiring new venues to co-locate with support services. There were several participants in attendance who worked in specialist violence prevention and response, and women’s services, and they raised that alcohol and other drug services should be integrated with family violence, sexual violence, and mental health services at both the policy and service system levels.

Threaded throughout these discussions was the need for culturally specific responses to alcohol and drug issues. Tax policy initiatives proposed related to a “big alcohol tax” and the profits from tax being “used in harm minimization.” The remaining subthemes within policy-led initiatives align more with the sociocultural level of the socioecological model. This incorporated suggestions such as decriminalizing illicit drugs, normalizing safe substance use, limiting or regulating alcohol, and reporting guidelines for the media.

Holding People Accountable

The discussions were particularly forceful when considering the need to hold people accountable. At the organizational level, participants were most concerned with holding licensed venues accountable or requiring them to take some responsibility for preventing AOD-facilitated sexual violence. Harsher enforcement of penalties for venues where AOD-facilitated sexual violence takes place was proposed alongside an independent body (“watch dog”) to hold venues accountable, which includes “access to CCTV—and allow it to be viewed openly.” But more often, the participants discussed the need for initiatives that were led by or took place in licensed venues; for example, mandated AOD-facilitated sexual violence programs for licensed venues and safety officers located at venues. Another specific initiative suggested bringing licensed venues together “to create a shared onus of responsibility/plan.” In relation to perpetrators, at the individual level, participants considered the need to hold “abusers accountable within systems that actually rehabilitate” and ensuring that there are sufficient resources “to speed up processing perpetrators of AOD-facilitated sexual violence.” Linked to this was the focus on victim-led responses, for example, local restorative justice or “alternative pathways for justice for victim survivors.”

Social Information Campaigns

Participants specified initiatives for their local region when discussing social information campaigns. While general ideas were generated and proposed for public health campaigns around male behaviors, or awareness-raising campaigns in venues and public toilets, taxis, and social media, the rural focus of the project generated interesting locations for such campaigns. The need to focus on male behaviors was emphasized rather than what was seen as the current focus on women’s behaviors. For example, participants reported on an art exhibition they had seen in the news that was held at the United Nations Headquarters in New York City. The exhibition showcased the variety of clothing women who have been raped were wearing to dispel long-held rape myths. Participants attending the World Café Forum wanted campaigns on the back of toilet doors that directly questioned men: “have you used substances to manipulate some into sex?”

The region where the World Café was conducted has a well-known recreation area [Rosalind Park] where major events are held, and participants suggested that campaigns could be linked to popular events in this location. They suggested that including safe space tents should be required when holding an event. Similarly, participants suggested encouraging the city council “to focus on this as part of community safety week.”

Cultural Change

Cultural change, as part of the sociocultural level, was recognized across the discussion groups as difficult but necessary to address AOD-facilitated sexual violence. Cultural change was argued to be needed around gender inequality. It was well recognized by the specialist and women’s health services in the room that gender inequality is associated with sexual violence. In particular, participants highlighted male entitlement and control with the need to “address male entitlement in relation to respect for women,” “change ideas of male ownership/control,” and “believing women.” Participants also reflected on shifting narratives, for example, “shift the narrative” in relation to cultural attitudes around drugs and alcohol, “changing alcohol culture,” and “shifting student culture so people can speak out.” These narrative shifts identify two concepts: the Australian collective attitude toward AOD, and the ability of an individual within the culture to speak up, particularly in rural and regional areas. One participant group specifically noted that there was a “Reluctance among men to dob mates in and this is a bigger challenge in rural towns where men can then be ostracized from their community.”

Power

In recognition of the development of the socioecological model and its adaptation to consider imbalances of power within and between the socioecological levels, we were sensitive to this concept as we considered the themes detailed above (Forsdike & Giles, 2024).

Throughout the forum, power was a recurring topic discussed overtly in terms of who holds power over victims of AOD-facilitated sexual violence. For example, participants discussed how licensed venues hold power over their patrons, particularly over women who frequent them and are subjected to AOD-facilitated sexual violence. Alongside discussion of power imbalances, participants drew out some of the more covert power imbalances. In particular, participants talked about how the broader patriarchal cultural contexts see men holding power over women, which is at times heightened in rural communities and for minorities. We reflect on this more in the discussion below.

Discussion

The World Café method brings together people from a variety of perspectives and backgrounds to discuss an issue of importance. Our forum produced important findings on how to respond to and prevent AOD-facilitated sexual violence, particularly in regional and rural communities. Participants were candid about how AOD-facilitated sexual violence is a topic that can be challenging to tackle. Even those from specialist services can struggle to integrate the two issues of (a) alcohol and other drugs and (b) sexual violence. Those working in AOD-facilitated sexual violence need support for greater understanding of the term and to be able to tackle it from a cohesive perspective rather than from either an AOD or a sexual violence perspective.

As noted in the results, power was a recurring topic in terms of who holds power, for example, licensed venues holding power over women patrons. Yet, venues are unlikely to be expected to deal with or be held accountable for AOD-facilitated sexual violence that occurs at their venue. An unwillingness to assume responsibility is reflected in broader gender-based violence. For example, organizations such as universities or workplaces are often reluctant to acknowledge, let alone take responsibility for, preventing and responding to sexual harassment. As a result, victims struggle to find integrated service systems and are often forced to engage with multiple services when seeking support, resulting in poor continuity of care (García-Moreno et al., 2015). The issue of who is responsible for preventing, responding to, and supporting victims of AOD-facilitated sexual violence needs further exploration, discussion, and recognition, given the number of stakeholders involved (Ison et al., 2025c).

With regard to covert power imbalances, there are often troubling power imbalances that victim-survivors of sexual violence face at all levels of the socioecological model (Tarzia, 2020). This was identified through Australia’s patriarchal cultural context, recognized as particularly dominant in rural communities and for minorities. This understanding of sexual violence allowed participants to consider how to address AOD-facilitated sexual violence beyond just standard approaches of behavioral change to considering how to prevent sexual violence through broader cultural change, often referred to as primary prevention (Hooker et al., 2020).

One suggestion for addressing power imbalances was to implement transformative justice responses to victim-survivors. This reflects the demographics of the participants, with many working in the gender-based violence sector and in feminist advocacy, which has engaged in transformative justice work (Rasmussen, 2022). Transformative justice, as used in feminist advocacy, comes from anticarceral approaches, particularly those led by Indigenous people and people of color (Davis, 2019). Approaching sexual violence perpetration from a noncarceral perspective is something being taken up—though at times removed from these decolonial and antiracist approaches—by universities and other institutions (McMahon et al., 2024). To date, transformative justice for victim-survivors of AOD-facilitated sexual violence has been underexplored and offers a possible new avenue of research and advocacy. Restorative justice processes could also be an opportunity for perpetrators of AOD-facilitated sexual violence to recognize their behaviors and their impact. Transformative justice response broadly highlights the investment from those working with victim-survivors to considering alternative approaches outside of the current criminal-legal approach. Participants advocated for such an approach to focus on restoring power to victim-survivors.

Integrated prevention and response systems that are place-specific while also addressing both specific initiatives and broader issues, such as gender inequality, are key across all ages, stages, and places. Participants talked about needing responses to AOD-facilitated sexual violence that were culturally specific, particularly to the regional and rural context. Such an interconnected prevention approach system must consider the nuanced and place-specific, addressing both specific initiatives and broader issues such as gender inequality. It is crucial to develop strategies that are adaptable to the unique needs of different communities to be effective.

Given that participants were predominantly from regional areas, it is unsurprising that they advocated for location-specific responses relevant to their local community. They suggested embedding responses to and preventing AOD-facilitated sexual violence at key local events as well as having them embedded in community hubs, co-located service spaces. Community responses to sexual violence have been identified as an important approach for prevention (Hooker et al., 2021). However, to date, community-based responses have been underresourced with limited evaluations (DeGue et al., 2016). Existing programs tend to focus on troubling victim-blaming approaches such as drink cover (Clinnick et al., 2024) or training bar staff (Davis et al., 2024; Hooker et al., 2024). Given that drink spiking often garners significant media attention (Clinnick et al., 2024), including in the region where this study took place, it offers an opportunity for large-scale community engagement in prevention.

One of the limitations of the World Café Forum was the voices that were missing in the room. Despite invitations, no one from hospitality attended. Given this is a prominent location for AOD-facilitated sexual violence, it was disappointing that those working in hospitality locally did not attend, but it is perhaps reflective of their unwillingness to see a role in addressing the issue. The other limitation of a World Café Forum is the potential imbalance of power in the room. This can lead to dominant voices, reduced opportunity for dissenting voices, and the potential for certain voices to be silenced. For example, those facilitating discussions were aware that older and more experienced people in the work tended to dominate some of the conversations. This meant that facilitators based at each group discussion needed to deftly negotiate the voices, but there could have been some voices lost in the process.

Conclusion

This article reports findings from a World Café forum that brought together stakeholders from a variety of perspectives and backgrounds to discuss AOD-facilitated sexual violence. The aim of the forum was to produce conditions whereby participants could share knowledge and views on what ought to be done to respond to the issue in their regional area. The findings from discussions have implications for public health. Reflecting a shared view that sexual violence signals deeply embedded gendered power imbalances in society, participants overwhelmingly saw that responding to and preventing AOD-facilitated sexual violence should be chiefly undertaken at the organizational and sociocultural level. A dearth of policy frameworks and initiatives responding to the problem was identified, and it was evident there was a lack of agreement concerning who should assume responsibility for tackling the problem, alongside concern that powerful stakeholders such as licensed venues were rarely held to account. A range of measures were suggested, with a particular focus on the implementation of restorative justice approaches—reflecting the view that social policy and service delivery should restore power to victim-survivors. The importance of community-based responses relevant to local communities was also emphasized alongside targeting the behavior of men (not women)—a perspective that locates responsibility for AOD-facilitated sexual violence with perpetrators.

The full study can be accessed by clicking the ‘Source’ link below

Source: https://journals.sagepub.com/doi/10.1177/10778012251379421

by Boston Herald editorial staff – September 17, 2025

There’s a renewed push to legalize overdose prevention centers  on Beacon Hill, with advocates touting supervised drug use as harm prevention.

That depends on how one defines harm.

At these centers, trained health care workers would supervise individuals who use pre-obtained illicit drugs — and they could intervene and prevent fatal overdoses.

Yes, addicts could avoid overdosing and live another day — another day in which they’d steal or prostitute themselves to buy drugs, another day in which opioids could further damage their mind and body, and another day to stumble through the degradation of a life ruled by drugs.

The real winners? Drug dealers and traffickers. Their clientele may have access to rehabilitative services through these centers, but that cry for help may not come for a long time. Meanwhile, they are willing customers for those “pre-obtained” drugs.

In these progressive parts, the law is to be followed except if you don’t like it. Therefore, these proposals would provide legal protections for workers, drug users accessing the facilities, government officials and other stakeholders. Because the drugs being injected are, of course, illegal.

Rep. Mindy Domb, co-chair of the Joint Committee on Mental Health, Substance Use and Recovery, said Massachusetts last year recorded fewer than 2,000 fatal overdoses, breaking a grim years-long trend.

Yes, naloxone is an amazing thing, and distribution of Narcan has saved many lives from overdoses. But making drug addiction safer with the added net of Narcan is like putting a bandage on a deep wound.

One can’t fight the opioid crisis by prolonging addiction. Keeping up the demand for drugs fuels the supply and the crime that comes with trafficking. And the drug market only gets worse.

Nitazenes have entered the chat.

Last year, a state-funded drug checking program in Massachusetts has found opioids up to 25 times stronger than fentanyl, according to WBUR. In a bulletin, public health officials say the number of drug samples testing positive for nitazenes is small — but growing quickly.

“The more that we crack down on things like fentanyl and heroin, that’s going to lead to the rise of other things that are infiltrating the drug supply,” said Sarah Mackin, director of harm reduction at the Boston Public Health Commission.

“Nitazenes is just the newest thing to come through,” after xylazine, the animal tranquilizer found in 9% of overdose deaths in 2023.

However, an investigation of records from hospital emergency departments published by the JAMA Network found it often takes more doses of naloxone to reverse an overdose when nitazene is involved than it would take to reverse a fentanyl overdose. Further study is needed.

Keeping the drug cycle going, however “safely,” isn’t a step in the right direction, it’s just another foot forward on the addiction treadmill.

We need addiction reduction, stat. We need to fund programs such as Boston Medical Center’s Faster Paths to Treatment, its substance use disorder urgent care program. And we need more of them.

True harm reduction comes from helping addicts get clean so they can live full, productive lives.

Source: https://www.bostonherald.com/2025/09/17/editorial-rehab-is-the-best-harm-prevention-for-addicts/?

by Renata Glavak-Tkalić, Mara Šimunović, Katarina Perić Pavišić, Josip Razum, Desirèe Colombo – – 22 August 2025

 

ABSTRACT

Background

Substance abuse (SA) imposes a significant global health burden, demanding innovative and accessible interventions. Virtual reality (VR) offers a promising approach, providing engaging and personalized treatment experiences. However, rigorous evidence from randomized controlled trials (RCTs) on VR’s efficacy in the treatment and prevention of SA remains limited. This systematic review aimed to characterize VR interventions for substance-related disorders and evaluate their effectiveness.

Methods

To conduct this review, two researchers independently performed a comprehensive literature search across four databases using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Results

Twenty RCTs met the inclusion criteria, focusing on alcohol, nicotine and illicit drug use. These studies utilized diverse VR modalities, most frequently exposure therapy (n = 10) and cognitive-behavioural therapy (n = 5), followed by approach bias modification, skills training, cognitive rehabilitation, counterconditioning and psychoeducation. Interventions varied in level of immersion and interactivity. Although the evidence was mixed, 17 studies demonstrated positive effects on at least one outcome variable. Most studies focused on proximal outcomes (e.g., craving), which frequently showed improvement. Clinically meaningful outcomes (e.g., substance use reduction and abstinence) were less frequently assessed, with seven of 10 studies reporting improvement.

Conclusions

VR shows promise in addressing substance-related disorders, particularly for alcohol and nicotine. However, substantial heterogeneity in VR interventions highlights the need for further research to standardize methodologies, optimize treatment parameters and explore the underlying working mechanisms of VR interventions. Additional research is also needed to assess VR’s application to illicit drug use.

Summary

Virtual reality (VR)–based interventions, particularly those that integrate cue exposure therapy and cognitive behavioural therapy, show significant promise in reducing cravings and improving abstinence among individuals using alcohol and nicotine.

VR intervention and prevention programmes have positively impacted attitudes, intentions, cognitive function and physiological responses in substance users, indicating a broader therapeutic potential that extends beyond simply addressing addiction symptoms.

The considerable variability among VR interventions emphasizes the need for greater standardization in methodologies, treatment parameters and outcome measures.

Additional research is necessary to evaluate the applicability and efficacy of VR in the prevention and treatment of illicit drug use.

The full article can be accessed by clicking the ‘Source’ link below:

Source: https://onlinelibrary.wiley.com/doi/10.1002/cpp.70144?af=R

by JENNIFER PELTZ Associated Press – September 25, 2025

Every year, tons of heroin, cocaine, methamphetamine and other drugs flow around the world

UNITED NATIONS — Every year, tons of heroin, cocaine, methamphetamine and other drugs flow around the world, an underground river that crisscrosses borders and continents and spills over into violence, addiction and suffering. Yet when nations’ leaders give the U.N. their annual take on big issues, drugs don’t usually get much of the spotlight.

But this was no usual year.

First, U.S. President Donald Trump touted his aggressive approach to drug enforcement, including decisions to designate some Latin American cartels as foreign terrorist organizations and to carry out deadly military strikes on speedboats that he says said were carrying drugs in the southern Caribbean.

“To every terrorist thug smuggling poisonous drugs into the United States of America: Please be warned that we will blow you out of existence,” he boasted at the U.N. General Assembly on Tuesday.

Hours later, his Colombian counterpart fired back that Trump should face criminal charges for allowing an attack on unarmed “young people who were simply trying to escape poverty.”

The U.S. “anti-drug policy is not aimed at the public health of a society, but rather to prop up a policy of domination,” Colombia’s Gustavo Petro bristled, accusing Washington of ignoring domestic drug dealing and production while demonizing his own country. The U.S. recently listed Colombia, for the first time in decades, as a nation falling short of its international drug control obligations.

The barbs laid bare, on global diplomacy’s biggest stage, the world’s wide and pointed differences over how to deal with drugs.

“The international system is extremely divided on drug policy,” said Vanda Felbab-Brown, who has followed the topic as a senior fellow at the Washington-based Brookings Institution think tank. “This is not new, but it’s really just very intense at this UNGA.”

While the wars in Gaza and Ukraine, climate change and other crises got much of the focus in the U.N.’s marathon week of speeches and meetings, the topic of drugs turned up from Trump’s and Petro’s tough talk to side events on such themes as gender-inclusive drug policy and international cooperation to fight organized crime.

Some 316 million people worldwide used marijuana, opioids and/or other drugs in 2023, a 28% rise in a decade, according to the most recent statistics available from the U.N. Office on Drugs and Crime. The figures don’t count alcohol or tobacco use.

The specifics vary by region, with cocaine use growing in Europe, methamphetamine on the rise in Southeast Asia, and synthetic opioids making new inroads in West and Central Africa and continuing to trouble North America, though opioid-related deaths have been falling.

The U.N. drug office says trafficking is increasingly dominated by organized crime groups with tentacles and partnerships around the world, and nations need to think just as broadly about trying to tackle the syndicates.

“Governments are increasingly seeing organized crime and drug trafficking as threats to national and regional security and stability, and some are coming around to the fact that they need to join up diplomatic, intelligence, law enforcement and central-bank efforts to push back,” agency chief of staff Jeremy Douglas said by email.

Although organized crime hasn’t featured very prominently in top-level discussions at the General Assembly to date, he said, “we’re at a point where this needs to, and hopefully will, change.”

Nations pair up in various joint counternarcotics operations and working groups and sometimes form regional coalitions, but some experts and leaders see a need to go global.

Countries need to “pool resources in a fight that must be a common cause among all nations,” Panamanian President José Raúl Mulino told the assembly. He said his nation had seized a “historic and alarming” total of 150 tons of cocaine and other drugs this year alone.

To be sure, there is already some global-scale collaboration on drug control. The U.N. Commission on Narcotic Drugs decides what substances are supposed to be internationally regulated under decades-old treaties, and it can make policy recommendations to the U.N.’s member countries. The International Narcotics Control Board monitors treaty compliance.

But the U.N. is big-tent politics at its biggest, so even as some components of the world body deal with drug enforcement, others emphasize public health programs — substance abuse treatment, overdose prevention and other services — over prohibition and punishments.

The U.N. High Commissioner for Human Rights, Volker Türk, has advocated for decriminalizing at least some drug use while clamping down on illegal markets. Given that policing hasn’t reduced substance use or crime, “the so-called war on drugs has failed, completely and utterly,” he said last year.

Separately, a U.N. Development Programme report last week said punitive drug control had led to deaths and disease among users who shied from seeking help, racial disparities in enforcement, and other societal downsides.

At a gathering marking the report’s release, former Mexican President Ernesto Zedillo deplored that “the global drug control regime has become a substantial part of the problem.”

“The question is: Do governments have the wisdom and courage to act?” asked Zedillo, now a Yale professor and a commissioner of the Global Commission on Drug Policy, a Geneva-based anti-drug-war advocacy group.

The other question is whether they could ever agree on what action to take.

Even if countries agree — or say they do — with ending the drug trade and resulting ills, “the objectives might be different, and certain means, tools, resources they’re willing to devote to them, are different,” Felbab-Brown said.

Nations’ own drug laws vary widely. Some impose the death penalty for certain drug crimes. Others have legalized or decriminalized marijuana. At least one — Thailand — legalized it only to have second thoughts and tighten the rules. Countries’ openness to needle exchange programs, safe injection sites and other “harm reduction” strategies is similarly all over the map.

As leaders took their turns at the assembly rostrum this week, observers got occasional glimpses of the world’s different views of its drug problem.

Tajikistan’s president, Emomali Rahmon, called drug trafficking “a serious threat to global security.” Guyanese President Irfaan Ali endorsed international efforts to address drug trafficking, which he counted among the ”crimes that are destroying the lives of our people, especially young people.”

Syria’s new president, Ahmad al-Sharaa, noted that his administration closed factories that produced the amphetamine-like stimulant Captagon, also known as fenethylline, during his now-ousted predecessor’s time. Costa Rican Foreign Minister Arnoldo André Tinoco said drug smuggling networks are exploiting routes traveled by migrants and “taking advantage of the vulnerability of those seeking international protection.”

“Isolated responses are insufficient,” as the traffickers just go elsewhere and create new hotspots of crime, Tinoco said.

Reviewing the challenges facing Peru, President Dina Boluarte listed transnational organized crime and drug trafficking alongside political polarization and climate change.

“None of these problems is merely national, but rather global,” she said. “This is why we need the United Nations to once again be a forum for dialogue and cooperation.”

Source: https://abcnews.go.com/Health/wireStory/issue-drugs-showcased-general-assembly-year-125919663

by Kaitlin Durbin, cleveland.com  – Sep. 27, 2025

A graph from the Cuyahoga County Medical Examiner’s Officer shows that cocaine overdoses are expected to kill more residents this year than fentanyl and other opioids, marking a major shift in drug patterns that Dr. Thomas Gilson says requires new prevention and treatment strategies.(Courtesy of the Cuyahoga County Medical Examiner’s Office)

CLEVELAND, Ohio — For the first time in decades, cocaine is killing more people in Cuyahoga County than opioids, including fentanyl.

The news marks a historic shift that Medical Examiner Dr. Thomas Gilson says should spark an urgent change in prevention strategies.

“This is earth-shattering,” Gilson told cleveland.com and The Plain Dealer. “I don’t think that’s been true in the entire 21st century.”

His office has only certified overdose deaths for the first half of the year, representing about 169 cases, but early numbers show that cocaine was involved in 63% of them, compared with 46% involving opioids – including some overlap from drug mixtures.

Projected out for the year, Gilson’s office expects total overdose deaths will top around 415, which would be another slight drop from the year before, indicating numbers are heading in the right direction. Fentanyl overdoses, in particular, are expected to fall to a near 10-year low.

But that progress could largely be offset by an increase in cocaine deaths – again, some mixed with opioids – which is projected to kill 399 Cuyahogans by the end of the year.

“This is the problem that we’re living with now,” Gilson said of the moment. “Opiates aren’t going to go away, but if you define an epidemic as a disease that’s occurring at a higher incidence rate in the population than baseline, well, we’ve had two years of decline; so, it’s pretty hard to say, ‘I’m still living in the opioid epidemic.’”

The shift

Opioid-related deaths, especially involving fentanyl, have been falling sharply over the last three years. Last year, overdose deaths dropped below 500 for the first time in a decade. The reason still isn’t clear.

It could be that the fentanyl supply is shrinking, or that what is circulating on the street is less potent, with smaller amounts showing up in drug mixtures, Gilson said. It could also be intervention strategies and overdose reversal drugs are working to curb deaths. Gilson suspects younger generations have started shying away from the drug, after years of warnings about its lethal effects.

Regardless, he worried that the lull was only leaving the door open for something else. Something new. It turns out, it was actually something old – though thankfully less lethal: cocaine.

Gilson recalled the crack cocaine epidemic of the 1980s and early 1990s, which devastated many urban communities and coincided with a major crime wave. The crisis helped fuel the “tough-on-crime” era, leading to harsh sentencing laws and mass incarceration that disproportionately affected Black Americans.

Back then the drug was killing 100-150 people a year in the county – a number which pales in comparison to the 600-700 who were dying at the peak of the opioid crisis. Now, though, the numbers are ticking upward again, and faster, partly fueled by cocaine-opioid mixtures.

In August, the Centers for Disease Control and Prevention published a report noting a rise in overdose deaths involving stimulants, like cocaine and methamphetamine, since 2011. Though it primarily attributed the increase to opioid mixtures, it noted that “stimulant-involved deaths without opioid co-involvement have also increased.”

The CDC urged expanded access to evidence-based treatment for stimulant use disorder, along with outreach to people “who might be missed by opioid-focused prevention efforts.”

After seeing the shift locally, Gilson is sounding his own alarm.

“Things are changing, and the demographics of who’s affected by it is changing, too,” Gilson said.

New strategies?

In the early phases of the opioid epidemic, particularly with prescription painkillers, white communities bore the brunt of overdose deaths. Even as the crisis evolved and overall numbers leveled out, Gilson’s office continued to record higher rates of fentanyl and opioid fatalities among white residents.

Overdose data through the first half of the year shows a rise in cocaine-related deaths, especially among Black men.(Courtesy of the Cuyahoga County Medical Examiner’s Office)

However, the rise in cocaine overdoses is disproportionately affecting the Black community, echoing patterns seen in the 1980s and 1990s. In the first half of this year, overdose deaths among white residents declined compared to 2024, while the share among Black residents rose from 42% to 48%. Black men, in particular, were impacted.

“We’re reverting back to a pre-opioid phase,” Gilson said. “And that means we’re going to see another racial disparity develop like we did before.”

That makes directing prevention and treatment outreach specifically to Black communities both more urgent and more challenging, he said. He noted it was harder to reach Black communities with prevention messaging during the opioid epidemic.

And that challenge raises a bigger question: whether current prevention and treatment strategies would be adequate, given decades of opioid-focused efforts. Unlike fentanyl, which can be reversed with naloxone, there is no antidote for cocaine overdoses, which often result in sudden heart attacks or strokes.

(Earlier this year, Gilson also flagged the need for better prevention strategies to address rising suicide rates.)

One strategy Gilson said he knows can help save lives is reminding people not to use drugs alone. He reiterated a recent study by Case Western Reserve University that found that about 75% of overdose victims over a five-year period were using alone, increasing death rates.

But what other strategies may be needed to save lives remains an open question.

“The winds are changing,” Gilson said. “If we want to really be effective, we need to start pivoting to these stimulants as enemy number one.”

Source: https://abcnews.go.com/Health/wireStory/issue-drugs-showcased-general-assembly-year-125919663

Filed under: Cocaine,Fentanyl,Prevalence,USA :

Outdated views of addiction hurt patients. Dr. Roger Starner Jones, Jr. and others are working to change that.

Despite decades of medical research, public awareness campaigns, and growing national concern, many people still see addiction through a distorted lens. “Addict” remains a pejorative label. Misconceptions persist that addiction is a choice, a character flaw, or the result of bad parenting. These outdated ideas don’t just misinform—they actively harm. They delay care, deepen stigma, and make recovery even more complicated to reach.

But addiction is not a moral failing. It is a complex brain disease, and understanding it as such is crucial to saving lives.

A Medical Diagnosis, Not a Personal Weakness

Addiction, clinically known as substance use disorder (SUD), alters brain chemistry in ways that impact decision-making, impulse control, and the experience of pleasure and reward. According to the National Institute on Drug Abuse (NIDA), addiction is a chronic, relapsing disorder characterized by compulsive drug seeking, continued use despite harmful consequences, and long-lasting changes in the brain.

Yet societal attitudes lag behind the science. More than three-quarters of Americans surveyed believe that substance use disorder (SUD) is not a chronic medical illness, and more than half said they believe SUD is caused by bad character or lack of moral strength, according to findings from the 2024 Shatterproof Addiction Stigma Index Report. This belief system creates barriers to treatment by fueling shame, encouraging secrecy, and often leading families and employers to distance themselves rather than lean in with support.

The Real Risks of Misunderstanding

Misconceptions don’t just alienate people—they endanger them. Fear of judgment keeps many individuals from seeking help until their condition worsens. Delayed treatment can lead to job loss, relationship breakdowns, homelessness, overdose, and even death.

“Shame is one of the biggest enemies of recovery,” says Dr. Roger Starner Jones, Jr., a board-certified emergency and addiction medicine physician based in Nashville. “When patients think they’ll be judged instead of treated, they wait too long. They spiral. By the time they reach us, their situation is often much more severe than it needed to be.”

Dr. Jones has seen this pattern play out thousands of times. After a decade in emergency medicine, he pursued a fellowship in addiction medicine at Vanderbilt University Medical Center, driven by both clinical experience and personal history. Starner Jones’ father, who once faced 11 DUIs in seven years, found lasting sobriety after being committed to a state hospital and undergoing physician-led detox. That experience changed the course of both their lives—and led Dr. Jones to dedicate his career to compassionate, customized addiction care.

Rewriting the Narrative: Care That Meets Patients Where They Are

Through his practices—Nashville Addiction Recovery and Belle Meade AMP—Starner Jones delivers concierge-level, judgment-free care. His model includes in-home detox, private hotel suite treatment, and office-based services designed to remove as many barriers as possible between a patient and their recovery. His focus is on meeting patients where they are, not where the system dictates they should be.

“There’s no one-size-fits-all in addiction treatment,” Dr. Jones says. “Some people need a quiet, safe space to detox privately. Others need a highly structured plan for relapse prevention. What they don’t need is bureaucracy or blame.”

Starner Jones’s approach is part of a broader shift happening in the addiction medicine field. More physicians are advocating for low-threshold treatment models—services that reduce wait times, eliminate unnecessary paperwork, and avoid rigid abstinence requirements. According to the Substance Abuse and Mental Health Services Administration (SAMHSA), these models have been shown to increase engagement and retention in care, particularly among people with co-occurring mental health conditions.

While not a clinician in the traditional sense today, Dr. Gabor Maté is one of the most influential voices advocating for a trauma-informed approach to addiction. His book, In the Realm of Hungry Ghosts, explores how early childhood trauma, not moral weakness, underpins most substance use. He argues that addiction is not the problem itself, but rather a misguided attempt to solve internal pain. His philosophy underpins many treatment programs worldwide.

The Hazelden Betty Ford Foundation is one of the most established names in addiction treatment and has evolved to embrace an integrated model that combines medical detox, medication-assisted treatment (MAT), therapy, and mental health services. They openly reject the idea of addiction as a character flaw and emphasize long-term support and relapse prevention, rooted in compassion, not control.

Dispelling Common Myths

Several deeply ingrained myths continue to distort how addiction is viewed and treated. Let’s set the record straight:

  • Myth: Addiction is a choice.
    Reality: While the initial decision to use a substance may be voluntary, the progression to addiction is driven by changes in brain circuitry, not moral weakness.

  • Myth: You have to hit “rock bottom” to recover.
    Reality: Early intervention improves outcomes. Waiting for someone to “bottom out” can be fatal, especially in the era of fentanyl-laced street drugs.

  • Myth: Medication-assisted treatment is trading one addiction for another.
    Reality: FDA-approved medications like buprenorphine and methadone reduce cravings and withdrawal, allowing patients to stabilize their lives. They’re widely considered best practice in treating opioid use disorder.

  • Myth: Recovery is rare.
    Reality: Millions of Americans are living in recovery today. In the United States, 9.1%, or 22.35 million adults have reported resolving a substance use problem.

Compassion Is Evidence-Based

What ultimately works in addiction care isn’t punishment or shame—it’s connection. “When you treat addiction like the disease it is, you empower people to get better,” Dr. Starner Jones says. “You stop asking ‘What’s wrong with you?’ and start asking ‘What happened to you?’”

At Nashville Addiction Recovery, the ethos of compassion is baked into every interaction. From discreet intake to 24/7 physician supervision, the patient experience is defined by dignity and respect. Many of the patients Dr. Jones sees are high-profile professionals—athletes, musicians, executives—whose careers demand confidentiality. But the underlying need is universal: to be seen, respected, and supported through one of the most complex challenges a person can face.

A Call for Better Understanding

Changing how society views addiction won’t happen overnight, but it starts with how we talk about it. Swapping judgment for empathy, punishment for treatment, and generalizations for science can change not just conversations—but lives.

Source: https://www.bbntimes.com/science/what-most-people-get-wrong-about-addiction

by Jan Hoffman – Published Aug. 25, 2025

Jan Hoffman is a health reporter for The New York Times covering drug addiction and health law.

San Francisco, Philadelphia and others are retreating from “harm reduction” strategies that have helped reduce deaths but which critics, including Trump, say have contributed to pervasive public drug use.

Safe drug-consumption materials distributed in the Tenderloin district of San Francisco, including naloxone, pipes and plastic straws.Credit…Mike Kai Chen for The New York Times

As fentanyl propelled overdose deaths to ever more alarming numbers several years ago, public health officials throughout the United States stepped up a blunt, pragmatic response. Desperate to save lives, they tried making drug use safer.

To prevent life-threatening infections, more states authorized needle exchanges, where drug users could get sterile syringes as well as alcohol wipes, rubber ties and cookers. Dipsticks that test drugs for fentanyl were distributed to college campuses and music festivals. Millions of overdose reversal nasal sprays went to homeless encampments, schools, libraries and businesses. And in 2021, for the first time, the federal government dedicated funds to many of the tactics, collectively known as harm reduction.

The strategy helped. By mid-2023, overdose deaths began dropping. Last year, there were an estimated 80,391 drug overdose deaths in the United States, down from 110,037 in 2023, according to provisional data from the Centers for Disease Control and Prevention.

Now, across the country, states and communities are turning away from harm reduction strategies.

Last month, President Trump, vowing to end “crime and disorder on America’s streets,” issued a far-flung executive order that included a blast at harm reduction programs which, he said, “only facilitate illegal drug use and its attendant harm.”

But his words, implicitly linking harm reduction to unsafe streets, echoed a sentiment that had already been building in many places, including some of the country’s most liberal cities.

San Francisco’s new mayor, Daniel Lurie, a Democrat who campaigned on a pledge to tackle addiction and street chaos, announced this spring that the city would step away from harm reduction as its drug policy and instead embrace “recovery first,” aspiring to get more people into treatment and long-term recovery. He banned city-funded distribution of safe-use smoking supplies such as pipes and foil in public places like parks. A year earlier, San Francisco voters had signaled their restiveness with pervasive drug use by approving a measure stipulating that some recipients of public assistance who repeatedly refused drug treatment could lose cash benefits.

Philadelphia stopped funding syringe services programs, which the C.D.C. has called “proven and effective” in protecting the public and first-responders as well as drug users. The city put restrictions on mobile medical teams that distribute overdose reversal kits and provide wound care for people who inject drugs, and stepped up police sweeps in Kensington, a neighborhood long known for its open-air drug markets and a focal point of the city’s harm reduction efforts.

Santa Ana, Calif., shut down its syringe exchanges; Pueblo, Colo., tried to do the same but a judge blocked enforcement of the ordinance.

Mayor Daniel Lurie of San Francisco, center, often walks through the Tenderloin district, where people experiencing addiction, mental illness and homelessness gather.Credit…Mike Kai Chen for The New York Times

Republican-dominated states have also been retreating from the approaches. In 2021, West Virginia legislators said that needle exchange programs had to limit distribution to one sterile syringe for each used one turned in and could only serve clients with state IDs. Last year, Nebraska lawmakers voted against permitting local governments to establish exchanges.

“Harm reduction” is a decades-old concept, grounded in the reality that many people cannot or will not stop using drugs. Since the 1980s, when AIDS activists began distributing sterile syringes to drug users to slow the spread of diseases, the expression has moved to the mainstream of addiction medicine and public health.

Over time, it has become shorthand for a wide range of approaches. Some are broadly popular and will certainly continue. In April, the White House’s office of drug control policy released priorities reaffirming support for drug test strips and naloxone, the overdose reversal medication that has become an essential item in first-aid kits in homes, restaurants and school nurse offices.

But critics contend that making drug use safer, with distribution of supplies and pamphlets directing how to use them, normalizes drug use and undercuts people’s motivation to quit and seek abstinence.

“The more you’re sort of funding and feeding the addiction, you’re going to get more addiction,” Art Kleinschmidt, now the head of the federal agency that oversees grants for substance abuse, said on a podcast last year. Such programs, he said, “definitely are breeding dependency.”

Others argue for nuance.

“Harm reduction is neither the singular solution to the overdose crisis nor a primary cause of public drug use and disorder,” said Dr. Aaron Fox, president of the New York Society of Addiction Medicine. “It’s one component of a spectrum of services necessary to prevent overdose deaths and improve the health of people who use drugs. But if communities want long-term solutions to homelessness, they need to work on expanding access to housing.”

Harm reduction supporters reject the notion that protecting people from the worst consequences of drugs encourages use.

“I don’t think the availability of sterile supplies really makes a difference about whether someone is going to start or continue using drugs,” said Chelsea L. Shover, an epidemiologist at the University of California, Los Angeles, who oversees Drug Checking Los Angeles, which tests the contents of drugs for individuals and public health agencies. “But I do think it will make a difference in terms of whether that person is going to be alive in a week or a month or a year, during which time they might get into recovery, whatever that may mean for them.”

Some addiction experts fear that a retreat from harm reduction will reverse the falloff in deaths from injection-related diseases.

“Hepatitis C and H.I.V. numbers will go up, and more people are going to die,” said Dr. Kelly Ramsey, a harm reduction consultant who practices addiction medicine at a South Bronx clinic.

While overdose deaths have fallen, it is unclear whether drug use itself has also slowed. In neighborhoods across the country, from Portland, Maine, to Portland, Ore., many residents complain that the harm to them from drug use, including crime and syringe street litter, has not been reduced.

Mr. Trump particularly called out a type of harm reduction known as “safe consumption sites” — sometimes labeled “overdose prevention centers.” They are supervised locations where people can inject drugs without fatally overdosing, found in Europe, Canada and Mexico. Often drug users can test their supplies right away and staff members can quickly administer overdose reversal medication if needed.

There are only three in the United States, and they make for easy political targets. In addition to many Republicans, prominent Democratic governors, including Gavin Newsom of California, Kathy Hochul of New York and Josh Shapiro of Pennsylvania, oppose them. The Pennsylvania senate voted to ban them. One, in Rhode Island, is protected by state and local law. But the other two, in New York City, which provide treatment referrals and support services, operate in a legal gray zone and could face federal scrutiny.

Opponents of harm reduction offer few specifics about how to get more people to stop using drugs and into treatment. Mr. Trump’s order directs the health secretary and the attorney general to explore laws to civilly commit addicted people who cannot care for themselves into residential treatment “or other appropriate facilities.” But it is silent about how such programs would be paid for.

The administration has already made major cuts to the Substance Abuse and Mental Health Services Administration, the federal agency that awards grants for prevention, treatment and recovery. It has slashed the agency’s staff and the grants it gives for a wide variety of prevention, intervention and treatment services.

Cuts to Medicaid included in the sweeping domestic policy bill enacted this summer are also likely to affect many people’s access to treatment and states’ ability to cover it. Robert F. Kennedy Jr., the health secretary, who is in recovery from a substance use disorder, has focused on nutrition, chronic disease and vaccines during his first six months in office and has said little about plans to address the drug crisis.

The battle over whether harm reduction should remain a primary goal or be secondary to getting users into treatment and restoring order to public streets has been joined most intensively in San Francisco.

There, ample social services and ferociously expensive housing had contributed to a large population living on the streets, many struggling with mental illness and addiction. Then, by 2020, fentanyl and Covid had slammed into the city.

At public meetings this spring, angry residents brandished signs, some reading “Harm Reduction Saves Lives” and others “Drug Enablism Kills.”

Although the city has adhered to regulations for state-funded Housing First programs, which offer permanent housing for homeless people without requiring them to be drug-free, Mr. Lurie recently presided over the opening of the city’s first transitional sober living residence, with 54 units for adults committed to abstinence.

The drive to adjust the city’s drug policy to recovery first has been led by Matt Dorsey, a member of the San Francisco Board of Supervisors, who is in recovery from a substance use disorder.

In an interview, Mr. Dorsey said he supports aspects of harm reduction, including the distribution of safe supplies. But he sees the strategy as more of a floor than a ceiling. “We need to make clear that the objective of our drug policy is a healthy, self-directed life free of illicit drug use,” he said.

The difficult challenge, he said, was how to attend to the rights of pedestrians who daily confront drug use, while also trying to “help people addicted to life-threatening drugs.”

To pay for additional treatment and services, he said, city officials are working on ballot measures to redirect tax revenue.

“Part of what gives me confidence that we will ultimately find the funding,” Mr. Dorsey added, “is that the alternative is unthinkable.”

 

Source: https://www.nytimes.com/2025/08/25/health/harm-reduction-san-francisco-trump.html

By Jennie Taer – New York Post – Published Aug. 28, 2025, 6:00 a.m. ET

The US is “behind the curve” on fighting a deadly new synthetic narcotic that’s dramatically more lethal than fentanyl and resistant to Narcan, a top DEA agent warns.

Just as authorities in the US and China increase efforts to tackle the scourge of fentanyl, the drug manufacturers, who are motivated by “greed,” shifted to start producing nitazenes — an even deadlier poison, said Drug Enforcement Administration Houston Division Special Agent in Charge Jonathan C. Pullen.

The Trump administration has hit Mexico and China with sanctions and tariffs to force the foreign governments to act against illicit drug producers responsible for the poisonings of thousands of Americans each year.

Nitazenes and other synthetic drugs are often disguised to look like prescription pills.Getty Images

Additionally, with President Trump’s effort to close the southern border, the feds have seen a significant drop in the flow of illicit fentanyl into the US.

But the Chinese pharma companies and cartels have already moved to introduce a new and stronger drug that many authorities are just now learning about, Pullen said.

“And if we get into a place where then we are able to issue controls or China issues more controls on the precursor chemicals that go to these, they’ll just change the analog and it’ll go to another precursor chemical. China’s already done that,” he added.

Nitazenes are produced in China, often with the help of Mexican cartels that finish the product and move it north across the border, according to Pullen.

The potent narcotic can be up to 43 times stronger than fentanyl depending on the formula, according to the Inter-American Drug Abuse Control Commission.

Nitazenes are not included in routine drug tests or toxicology screenings, making them all the more challenging to detect.

While the feds are “making headway” to tackle the new threat, there’s still more work to be done, said Pullen.

“So it’s very very difficult to stay ahead of it, so we’ve got to continue to step up our enforcement along the border,” he said.

“I think that the number of overdose deaths being reduced in the United States is a testament to that. The enforcement is not the only reason its reduced. Naloxone [aka Narcan] is a huge piece too, but we’re definitely making some headway and we’re gonna keep pushing on that.”

There were 80,000 overdose deaths in the US in 2024 — a 27% drop from the 110,000 deaths estimated in 2023, according to the Centers for Disease Control and Prevention.

While the wider use of Narcan has contributed to the drop in overdose deaths, nitazenes is often resistant to the drug antidote — adding a terrifying new pitfall, Pullen warned.

“It’s incredibly deadly and normal treatment methods like naloxone … don’t work as well on nitazenes because it’s so much stronger,” said Pullen.

“It’s really hard to overcome if you’ve taken one.”

In the Houston-area, there were 15 deaths related to nitazenes and 11 seizures of the drug between November and February, according to the DEA.

Two of the victims were best friends Lucci Reyes-McCallister, 22, and Hunter Clement, 21, who ingested pills marketed as Xanax and Percocet that actually contained N-pyrrolidino protonitazene, a form of nitazenes that is 25 times stronger than fentanyl.

An illustration that highlights the U.S. cities with the highest rates of nitazene-related overdoses.Jared Larson / NY Post Design

And their mothers are warning America’s youth in the hopes of saving lives.

“They could think something is clean or rather safe when it’s actually pressed for something that’s 20 to 40 times stronger, more deadly than fentanyl,” Lucci’s mother Grey recently told The Post.

“It just really lit a fire under me. There was no way Lucci was going to die in vain,” she added.

The drug was developed 60 years ago as a possible alternative to morphine, but was outlawed for medical use over its high overdose risk.

Authorities in Europe have already seen several overdoses from the synthetic narcotic. It was first detected in the US in 2019.

Last January, a Florida man confessed to distributing protonitazene that he received in mailed shipments from China, according to the IRS.

Customs officers at Kennedy are also seeing the drug coming through the airport “at least a few times a week in quantities ranging from just a few grams to upwards of a pound or more,” Andrew Renna, assistant port director for cargo operations at the airport, said in May.

Source: https://nypost.com/2025/08/28/us-news/america-not-ready-to-combat-nitazene-synthetic-opioids-dea-agent/

Marijuana is one of the most widely used drugs globally. Rising legalization has fueled greater social acceptance and lowered perceptions of risk even as research continues to highlight its harms. A recent study published in Pediatric Research reviewed years of evidence from both animal models and human studies, examining how marijuana impacts pregnant women and their babies.

How marijuana affects the body during pregnancy

One of the critical human body systems is the Endocannabinoid System (ECS), which helps regulate memory, appetite, emotions, and even fetal development. During pregnancy, the ECS is especially active, influencing hormonal signaling, fetus brain development, and placental development.

When marijuana is used, cannabinoids such as THC enter and interfere with the ECS, disrupting its natural processes. Because THC is lipophilic, meaning it binds strongly to fat, THC crosses into fatty tissues and can be stored there for weeks. This is especially concerning during pregnancy because the membrane of the placenta, which is the critical organ that supplies the developing baby with nutrients and oxygen, is mostly made of fatty molecules enabling THC to enter with ease. About one-third of the THC in the mother’s body reaches the fetus and once there, it can accumulate in the developing brain and other fatty tissues. Animal studies show that even after marijuana use stops, the developing fetus continues to be exposed to THC, potentially altering how organs and systems grow.

Long term effects extend beyond infancy

Research finds that marijuana use during pregnancy is associated with:

Fetal growth problems: Babies exposed to marijuana in the womb are more likely to be born small for their gestational age, be admitted to the NICU, and face a 75% increased risk of low birth weight. Even short-term exposure during early pregnancy can impact fetal growth.
Developmental delays: Long-term studies show that marijuana-exposed children may struggle with memory, attention, problem-solving, and emotional regulation.
Higher risk of metabolic and heart problems: Prenatal marijuana exposure may change how the body processes insulin and stores fat which could increase the risk of obesity, diabetes, and heart disease later in life.
Increased vulnerability to addiction: Prenatal marijuana exposure changes the brain pathways involved in reward and impulse control which may increase the risk of substance use and mental health challenges during adolescence and adulthood.
 

In some studies, girls’ exposure to marijuana in the womb showed more behavioral problems including aggression and attention issues, as early as 18 months of age.

With the marijuana industry falsely promoting products as “natural” and safe remedies for various health conditions, it is critical that women of childbearing age understand that marijuana use is not risk-free. Research consistently shows that marijuana can affect fetal development, leading to long-lasting consequences for a child’s physical and mental health.

For science-based resources on marijuana use during pregnancy, as well as tools for parents and fathers, click here to visit our dedicated webpage on this topic. If you are in Florida, our grant program allows us to provide and distribute these resources to you free of charge. Complete this request form to access materials ranging from Go-to-Guides to Fast Facts for Fathers.

Prevention starts with education, and staying informed can help protect future generations.

Source: Drug Free America Foundation | 333 3rd Ave N Suite 200 | St. Petersburg, FL 33701 US

A new non-opioid pain reliever developed in Japan shows early success in clinical trials, offering hope for safer pain management. If effective, it could help curb the opioid crisis by providing a powerful alternative. Credit: Stock

The discovery of a new painkiller offers relief with fewer side effects.

Morphine and other opioids are commonly used in medicine because of their strong ability to relieve pain. Yet, they also pose significant risks, including respiratory depression and drug dependence. To limit these dangers, Japan enforces strict rules that allow only specially authorized physicians to prescribe such medications.

In contrast, the United States saw widespread prescribing of the opioid OxyContin, which fueled a rise in the misuse of synthetic opioids like fentanyl. By 2023, deaths from opioid overdoses had exceeded 80,000, marking the escalation of a nationwide public health emergency now known as the “opioid crisis.”

A new analgesic approach

Opioids may soon face competition. Researchers at Kyoto University have identified a new analgesic, named ADRIANA, that provides pain relief through a completely different biological pathway. The drug is now moving through clinical development as part of an international research collaboration.

“If successfully commercialized, ADRIANA would offer a new pain management option that does not rely on opioids, contributing significantly to the reduction of opioid use in clinical settings,” says corresponding author Masatoshi Hagiwara, a specially-appointed professor at Kyoto University.

Targeting adrenoceptors for safer pain relief

The researchers drew their initial inspiration from compounds that imitate noradrenaline, a chemical released during life-threatening situations that activates α2A-adrenoceptors to reduce pain. While effective, these compounds carry a high risk of destabilizing cardiovascular function. By examining the relationship between noradrenaline levels and α2B-adrenoceptors, the team proposed that selectively blocking α2B-adrenoceptors could increase noradrenaline activity, stimulate α2A-adrenoceptors, and provide pain relief without triggering cardiovascular instability.

To test this idea, the scientists used a specialized method called the TGFα shedding assay, which allowed them to measure the function of different α2-adrenoceptor subtypes. Through compound screening, they succeeded in identifying the world’s first selective α2B-adrenoceptor antagonist.

Promising clinical results and future trials

After success in administering the compound to mice and conducting non-clinical studies to assess its safety, physician-led clinical trials were conducted at Kyoto University Hospital. Both the Phase I trial in healthy volunteers and the Phase II trial in patients with postoperative pain following lung cancer surgery yielded highly promising results.

Building on these outcomes, preparations are now underway for a large-scale Phase II clinical trial in the United States, in collaboration with BTB Therapeutics, Inc, a Kyoto University-originated venture company.

As Japan’s first non-opioid analgesic, ADRIANA has the potential not only to relieve severe pain for patients worldwide but could also play a meaningful role in addressing the opioid crisis — a pressing social issue in the United States — and thus contribute to international public health efforts.

“We aim to evaluate the analgesic effects of ADRIANA across various types of pain and ultimately make this treatment accessible to a broader population of patients suffering from chronic pain,” says Hagiwara.

Source: https://scitechdaily.com/the-end-of-opioids-new-drug-could-change-the-way-we-treat-severe-pain/

Although I’ve been deeply concerned about this problem since my days in Sacramento, over the past nearly 8 years, I’ve focused mainly on education, on prevention, and on the need to change attitudes.

NANCY REAGAN
Remarks at the White House Conference for a Drug Free America Washington, D.C. 02/29/1988

The White House

People finally are facing up to drug abuse. They’re banding together, and they’re making real progress. And I just want to say a heartfelt ‘thank you’ to all those people out there who are working so hard to get drug abuse under control.

NANCY REAGAN
Radio Address to the Nation on Federal Drug Policy 10/02/1982

As First Lady, Nancy Reagan focused on fighting drug and alcohol abuse among youth. She expanded the drug awareness campaign to the international level when she invited First Ladies from around the world to the First Lady Conference on Drug Abuse April 24-25, 1985.

“Just Say No”

Thank you for being part of the first international ‘Just Say No’ walk. Look around at how many young people are walking with you today. And just think, there are groups as big as yours, or even bigger, doing the same thing all over the world! Can you imagine just how many children are saying ‘Just Say No’ today? Children everywhere are learning about drug abuse at an early age. And that’s a good thing.

NANCY REAGAN
Remarks at the Just Say No International Walk 05/22/1986

First Lady Nancy Reagan urged the nation’s youth to “just say no.” She appeared on television talk shows, attended rallies and sporting events, taped public service announcements, and wrote guest articles.

Signings

This legislation allows us to do even more. Nevertheless, today marks a major victory in our crusade against drugs – a victory for safer neighborhoods, a victory for the protection of the American family.

President Ronald Reagan
Remarks on Signing the Anti-Drug Abuse Act of 1986 10/27/1986

The United Nations

In your deliberations, I urge you not to be diplomatic for the sake of diplomacy, but to speak the truth about the effects of drugs on our peoples and our governments. I urge you to be tough and firm in the recommendations you make.

Nancy Reagan
Remarks to the Third Committee of the United Nations General Assembly 10/25/1988

On October 21, 1985, during the United Nation’s 40th anniversary, Nancy Reagan hosted a second international drug conference.

On October 25, 1988, she addressed the Third Committee of the United Nations General Assembly where she spoke about the illegal use of drugs and its impact on families.

The picture below shows the various trips Nancy Regan made in promoting her campaign.

DAYTON, Ohio (WDTN) — The Drug Enforcement Administration is launching a major campaign to combat drug abuse on college campuses.

Officials say it’s an effort to talk directly with students and raise awareness about the dangers of drugs.

“One pill can kill” is the message the Drug Enforcement Administration is pushing in a state that’s a victim of its own geography with the I-70/I-75 interchange.

“Ohio is kind of uniquely positioned. It’s great for commerce, but just like it’s great for commerce is great for drug traffickers as well,” says Brian McNeal.

Brian McNeal is the DEA’s Public Information Officer for the Detroit Division, covering Michigan, Ohio, and Northern Kentucky.

His visit to college campuses comes after a major bust in September where a large amount of drugs — including fentanyl — were seized after being brought into the region from China.

“It’s a demonstration that what happens in other parts of the world can have an impact here in Ohio,” states McNeal.

McNeal says a lot of times, you don’t know what’s in a synthetic opioid. Sometimes it’s filler — like aspirin or caffeine. But other times it’s methamphetamine or even a lethal dose of fentanyl.

McNeal says a big trend they’re seeing now are counterfeit pills, and they’re easier than ever to get.

“Gone are the days where you have to meet somebody in a weird part of town. You can just sit on your phone and order these pills,” states McNeal.

He says half of the counterfeit pills they’re seizing contain two milligrams of fentanyl, which is a deadly dose.

That’s why they’re bringing the campaign to campus to promote drug prevention and provide free resources, and in turn, decrease drug related deaths. 

“A lot of times, college students whether they’re on campus or off campus, there’s this misnomer that maybe if I pop a Percocet or an Adderall, it’ll help me study,” says McNeal. “The only pill that you should take is one prescribed by your doctor, obtained at a legitimate pharmacy, that has your name on it.”

The DEA says young adults ages 18 to 25 make up 11 percent of drug-related emergency room visits. 

Source: https://www.wdtn.com/news/local-news/dea-launches-campaign-on-campuses-warning-of-drug-dangers/

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